郑巧霞，研究员，博士生导师

北京大学基础医学院生理学与病理生理学系研究员/副教授

中国科学院生物物理研究所大分子国家重点实验室张宏院士组高访客座教授

地址：北京市海淀区学院路38号北京大学医学部生理楼207

zhqiaoxia@bjmu.edu.cn

教育与工作经历：

2004.09 - 2008.06，中南大学湘雅医学院，生物科学，学士

2008.09 - 2012.07，中国科学院动物研究所，细胞生物学，硕士

2013.09 - 2018.07，北京大学，整合生命科学（生物学），博士

2018. 07 - 2024. 05，中国科学院生物物理研究所大分子国家重点实验室副研究员

2024. 06 - 北京大学基础医学院病理生理系研究员

 中国科学院生物物理研究所大分子国家重点实验室张宏院士组高访客座教授

研究方向：

钙离子信号的生理、病理条件下的生物学功能研究。主要方向：1）钙信号以及钙离子通道在心脏以及心脑血管相关生理、病理过程中的机制研究；2）局部空间钙离子在调控特殊细胞中自噬及其相关疾病中的作用。自噬是由自噬体包裹胞质组分并运送到溶酶体降解的过程，自噬异常与多种人类疾病密切相关。钙离子信号广泛参与自噬的各个步骤。

主持的国家自然科学基金项目/课题：

(1) 国家自然科学基金委员会优秀青年科学基金项目,2024-01-01至2026-12-31,200万元。

(2) 国家自然科学基金委员会青年科学基金项目,2020-01-01至2022-12-31,26万元,资助期满。

代表性论著：

(1) Qiaoxia Zheng, Yong Chen, Di Chen, Hongyu Zhao, Yun Feng, Quan Meng, Yan Zhao, Hong Zhang. Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites. Cell, 2022, 185(22): 4082-4098

(2) Di Chen, Qiaoxia Zheng, Long Sun, Mingming Ji, Yan Li, Hongyu Deng, Hong Zhang. ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress. Development Cell, 2021, 56(23): 3259-3263

(3) Jianwei Li, Caizhi Liu, Yuheng Li, Qiaoxia Zheng, Youjia Xu, Beibei Liu, Weijia Sun, Yuan Li, Shuhui Ji, Mingwei Liu, Jing Zhang, Dingsheng Zhao, Ruikai Du, Zizhong Liu, Guohui Zhong, Cuiwei Sun, Yanqing Wang, Jinping Song, Shu Zhang, Jun Qin, Shukuan Ling, Xianhua Wang, Yingxian Li. TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling. Nature Communications, 2019, 10(1589): 1-14

(4) Fujian Lu, Jianwei Sun, Qiaoxia Zheng, Jinghang Li, Yuanzhao Hu, Peng Yu, Huifang He, Yan Zhao, Xianhua Wang, Shengyuyang, Heping Cheng. Imaging Elemental Events of Store-operated Ca2+ Entry in Invading Cancer Cells with Plasmalemmal Targeted Sensors. Journal of Cell Science, 2019,132(6): 1-10

(5) Jingjing Ye, Qiaoxia Zheng, Shijia, Xue Qiao, Yangpo Cao, Chunling Xu, Lin Weng, Lifang Zhao, Yingyu Chen, Jian Liu, Tianbing Wang, Heping Cheng, Ming Zheng. Programmed Cell Death 5 Provides Negative Feedback on Cardiac Hypertrophy Through the Stabilization of Sarco/Endoplasmic Reticulum Ca2+-ATPase2a Protein. Hypertension, 2018, 72(4): 889-901             

(6) Qiaochu Wang, Qiaoxia Zheng, Haiyan Tian, Bing Zhang, Xiaoling Li, Yuxiu Yang, Jie Yu, Yang Liu, Hao Chai, Xi Wang, Zhongshuai Sun, Jiu-Qiang Wang, Shu Zhu, Fengli Wang, Maojun Yang, Caixia Guo, Heng Wang, Qingyin Zheng, Yang Li, Quan Chen, Aimin Zhou, Tieshan Tang. TMCO1 Is an ER Ca2+ Load-Activated Ca2+ Channel. Cell, 2016, 165(6): 1454-1466

(7) Yong Liu, H Cheng, Y Zhou, Yushan Zhu, R Bian, Y Chen, C Li, Qi Ma, Qiaoxia Zheng, Quan Chen, Dahai Zhu. Myostatin induces mitochondrial metabolic alteration and typical apoptosis in cancer cells. Cell Death & Disease, 2013, 4(e494): 1-11

(8) Lei Liu, Du Feng, Guo Chen, Ming Chen, Qiaoxia Zheng, Pingping Song, Qi Ma, Chongzhuo Zhu, Rui Wang, Wanjun Qi, Lei Huang, Peng Xue, Baowei Li, Xiaohui Wang, Haijing Jin, Jun Wang, Fuquan Yang, Pingsheng Liu, Yushan Zhu, Senfang Sui, Quan Chen. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nature Cell Biology, 2012, 14(2): 177-185             

(9) Yanmin Huang, Jianguo Cui, Qiaoxia Zheng, Chun Zeng, Quan Chen, Aimin Zhou. 6- Hydroximino-4-aza-A-homo-cholest-3-one and related analogue as a potent inducer of apoptosis in cancer cells. Steroids, 2012, 77(8-9): 829-834