丛馨 副教授，博士生导师

Email: congxin@bjmu.edu.cn

电话：010-82802403

研究方向：细胞间连接的调控机制

北京大学基础医学院生理学与病理生理学系副教授。2007年7月于北京大学获医学学士学位；2012年7月于北京大学基础医学院病理生理学专业获医学博士学位；2012年7月至2014年7月于北京大学医学部神科所从事博士后工作。一直从事细胞间紧密连接蛋白在唾液腺上皮和血管内皮中的功能研究。主持国自然青年和面上项目共3项，北京市自然基金2项，国家博士后面上基金1项，参加国自然重大项目1项；首批中国科协“青年人才托举工程”入选者，获得2015年教育部科技进步二等奖和2016年华夏医学奖一等奖（均第5完成人）、2016年国际生理学大会青年优秀论文报告会一等奖、2015年全国唾液腺疾病学术研讨会优秀论文一等奖、2015年第十届中国病理生理学会全国代表大会优秀论文二等奖等。以通讯（含共同）作者在免疫学经典杂志 Arthritis Rheumatol 和口腔研究专业著名期刊 Int J Oral Sci 等发表SCI论文6篇，以第一（含共同）作者在口腔研究专业顶级期刊 J Dent Res 、细胞生物学经典杂志 J Cell Sci 以及综合类著名期刊 BBA 等发表SCI论文11篇，责任/第一发表中文综述8篇，英文专著章节1篇。

论文发表（通讯与第一作者）：

1. Zhu M*, Min S, Mao X, Zhou Y, Zhang Y, Li W, Li L, Wu L, Cong X^#, Yu G^#. Interleukin-13 promotes cellular senescence through inducing mitochondrial dysfunction in IgG4-related sialadenitis.  Int J Oral Sci . (in publication)

2. Li Z*, Cong X^#, Kong W^#. Matricellular proteins: potential biomarkers and mechanistic factors in aortic aneurysms.  J Mol Cell Cardiol . 2022, 169: 41-56. Review

3. Mao X*, Min S, He Q^#, Cong X^#.  In vivo vascular permeability assessment in mouse submandibular gland.  J Vis Exp . (in publication)

4. Min SN*, Zhu MQ, Mao XD, Li W, Wei T, Mei M, Zhang Y, Wu LL, Yu GY^#, Cong X^#. Contribution of interleukin-4-induced epithelial cell senescence to glandular fibrosis in IgG4-related sialadenitis.  Arthritis Rheumatol . 2022, 74(6): 1070-1082.

5. Min SN*, Wu LL, Zhang YY, Zhu WX, Cong X^#, Yu GY^#. Disruption of tight junction structure contributes to secretory dysfunction in IgG4-related sialadenitis.  J Mol Histol . 2020, 51(1): 33-46.

6. Yang NY*, Ding C, Li J, Zhang Y, Xiang RL, Wu LL, Yu GY, Cong X^#. Muscarinic acetylcholine receptor-mediated tight junction opening is involved in epiphora in late phase of submandibular gland transplantation.  J Mol Histol . 2017, 48(2): 99-111.

7. Cong X*, Kong W^#. Endothelial tight junctions and their regulatory signaling pathways in vascular homeostasis and disease.  Cell Signal . 2020, 66: 109485. (IF 4.315) Review

8. Min SN*, Cong X*, Zhang Y, Xiang RL, Zhou Y, Yu GY^#, Wu LL^#. Tricellulin modulates transport of macromolecules in the salivary gland.  J Dent Res . 2020, 99(3): 302-310.

9. Cong X*, Zhang XM, Zhang Y, Wei T, He QH, Zhang LW, Hua H, Lee SW, Park K, Yu GY^#, Wu LL^#. Disruption of endothelial barrier function is linked with hyposecretion and lymphocytic infiltration in salivary glands of Sjögren's syndrome.  Biochim Biophys Acta Mol Basis Dis . 2018, 1864(10): 3154-3163.  

10. Ding C*, Cong X*, Zhang XM, Li SL, Wu LL^#, Yu GY^#. Decreased interaction between ZO-1 and occludin is involved in alteration of tight junction in transplanted epiphora submandibular glands.  J Mol Hist. 2017, 48(3): 225-234.  

11. Qi W*, Cong X*, Zhang XM, Wang ZY, Yang NY, Ding C, Shan XF, Wu LL, Yu GY^#. Parasympathectomy increases resting salivary secretion in normal and irradiated submandibular glands of rats.  Eur J Oral Sci . 2017, 125(2): 110-118.  

12. Cong X*, Zhang Y, He QH, Wei T, Zhang XM, Zhang JZ, Xiang RL, Yu GY^#, Wu LL^#. Endothelial tight junctions are opened in cholinergic-evoked salivation  in vivo .  J Dent Res . 2017, 96(5): 562-570.   Cover image

13. Zhang LW*, Cong X*, Zhang Y, Wei T, Su YC, Serrão AC, Brito AR Jr, Yu GY, Hua H^#, Wu LL^#. Interleukin-17 impairs salivary tight junction integrity in Sjögren's syndrome.  J Dent Res . 2016, 95(7): 784-792.  

14. Cong X*, Zhang Y, Li J, Mei M, Ding C, Xiang RL, Zhang LW, Wang Y, Wu LL^#, Yu GY^#. Claudin-4 is required for modulation of paracellular permeability by muscarinic acetylcholine receptor in epithelial cells.  J Cell Sci . 2015, 128(12): 2271-2286.  

[Highlighted article并获得F1000Prime机构评选的F1000文章推荐（Reviewed by Faculty of 1000. http://www.F1000Prime.com/725478358）]

15. Cong X*, Zhang Y, Yang NY, Li J, Ding C, Ding QW, Su YC, Mei M, Guo XH, Wu LL^#, Yu GY^#. Occludin is required for TRPV1-modulated paracellular permeability in the submandibular gland. J Cell Sci . 2013, 126(Pt5): 1109-1121.

16. Cong X*, Zhang Y*, Shi L, Yang NY, Ding C, Li J, Ding QW, Su YC, Xiang RL, Wu LL^#, Yu GY^#. Activation of transient receptor potential vanilloid subtype 1 increases expression and permeability of tight junction in normal and hyposecretory submandibular gland.  Lab Invest . 2012, 92(5): 753-768.   

17. Zhang Y*, Cong X*, Shi L, Xiang B, Li YM, Ding QW, Ding C, Wu LL^#, Yu GY. Activation of transient receptor potential vanilloid subtype 1 increase secretion of the hypofunctional, transplanted submandibular gland. Am J Physiol Gastrointest Liver Physiol . 2010, 299(1): G54-G62.