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张永鹤 教授

发布日期:2014-10-15    浏览次数:

 

张永鹤,药理学博士

教授,博士生导师

北京大学基础医学院药理学系副主任

北大医学部睡眠医学中心副主任

兼任中国药理学会副秘书长/常务理事;中国睡眠研究会睡眠生理与药理专业委员会副主任;中国药理学会补益药专业委员会副主任;科技部863项目审评专家;科技部科技型中小企业技术创新基金评审专家;国家自然科学基金审评专家;教育部高校专家;Biomolecules & Therapeutics(SCIE) 编委;《药理学通报》编委;《药理学通讯》编委;北京市科学技术奖励评审专家。先后主持了国家自然科学基金、“重大新药创制”科技重大专项“十一五”计划-候选药物项目、教育部基金、美国中华医学基金——人才专项基金、北京大学“十五”211和985工程项目等科研项目。自1983年以来,分别从事天然药物化学,神经药理和心血管药理的研究工作。已在国内外杂志上发表论文80余篇,其中SCI收录论文60余篇,参编出版著作8本,获美国专利授权1项。

研究方向:

1.神经精神药理学——睡眠障碍共病(抑郁、AD、PTSD)模型建立及其神经环路机制;

2.中药与天然产物新药筛选与开发。

联系方式:

办公地址:生理楼222室

电话:82801112

Email: zhyh@hsc.pku.edu.cn

 

通讯作者论文:(2012-

1)        Huang Yuan-Li, Cui Su-Ying, Cui Xiang-Yu, Cao Qing, Ding Hui, Song Jin-Zhi, Hu Xiao, Ye Hui, Yu Bin, Sheng Zhao-Fu, Wang Zi-Jun, Zhang Yong-He*. Tetrandrine, an alkaloid from S. tetrandra exhibits anti-hypertensive and sleep-enhancing effects in SHR via different mechanisms. Phytomedicine. 2016;23(14):1821-1829.

2)        Cao Qing, Jiang Yong, Cui Su-Ying, Tu Peng-Fei, Chen Yue-Mei, Ma Xiao-Li, Cui Xiang-Yu, Huang Yuan-Li, Ding Hui, Song Jin-Zhi, Yu Bin, Sheng Zhao-Fu, Wang Zi-Jun, Xu Ya-Ping, Yang Guang, Ye Hui, Hu Xiao, Zhang Yong-He*. Tenuifolin, a saponin derived from Radix Polygalae, exhibits sleep-enhancing effects in mice. Phytomedicine. 2016;23(14):1797-1805.

3)        Cui Su-Ying, Li Sheng-Jie, Cui Xiang-Yu, Zhang Xue-Qiong, Yu Bin, Huang Yuan-Li, Cao Qing, Xu Ya-Ping, Yang Guang, Ding Hui, Song Jin-Zhi, Ye Hui, Sheng Zhao-Fu, Wang Zi-Jun, Zhang Yong-He*. Ca2+ in the dorsal raphe nucleus promotes wakefulness via endogenous sleep-wake regulating pathway in the rats. Mol Brain. 2016;9(1):71. doi: 10.1186/s13041-016-0252-0.

4)        Yu Bin, Cui Su-Ying, Zhang Xue-Qiong, Cui Xiang-Yu, Li Sheng-Jie, Sheng Zhao-Fu, Cao Qing, Huang Yuan-Li, Xu Ya-Ping, Lin Zhi-Ge, Yang Guang, Song Jin-Zhi, Ding Hui, Zhang Yong-He*. Mechanisms Underlying Footshock and Psychological Stress-Induced Abrupt Awakening From Posttraumatic "Nightmares". Int J Neuropsychopharmacol. 2016;19(4). pii: pyv113. doi:10.1093/ijnp/pyv113.

5)        Cui Su-Ying, Li Sheng-Jie, Cui Xiang-Yu, Zhang Xue-Qiong, Yu Bin, Sheng Zhao-Fu, Huang Yuan-Li, Cao Qing, Xu Ya-Ping, Lin Zhi-Ge, Yang Guang, Song Jin-Zhi, Ding Hui, Wang Zi-Jun, Zhang Yong-He*. Phosphorylation of CaMKII in the rat dorsal raphe nucleus plays an important role in sleep-wake regulation. J Neurochem. 2016;136(3):609-19.

6)        Yu Bin, Cui Su-Ying, Zhang Xue-Qiong, Cui Xiang-Yu, Li Sheng-Jie, Sheng Zhao-Fu, Cao Qing, Huang Yuan-Li, Xu Ya-Ping, Lin Zhi-Ge, Yang Guang, Song Jin-Zhi, Ding Hui, Zhang Yong-He*. Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like "nightmares" in rats. Sci Rep. 2015;5:15976. doi: 10.1038/srep15976.

7)        Li Sheng-Jie, Cui Su-Ying, Zhang Xue-Qiong, Yu Bin, Sheng Zhao-Fu, Huang Yuan-Li, Cao Qing, Xu Ya-Ping, Lin Zhi-Ge, Yang Guang, Cui Xiang-Yu, Zhang Yong-He*. PKC in rat dorsal raphe nucleus plays a key role in sleep-wake regulation. Prog Neuropsychopharmacol Biol Psychiatry. 2015;63:47-53.

8)        Sheng Zhao-fu, Cui Xiang-yu, Cui Su-ying, Yu Bin, Zhang Xue-qiong, Li Sheng-jie, Cao Qing, Huang Yuan-li, Xu Ya-ping, Song Jin-zhi, Ding Hui, Lin Zhi-ge, Yang Guang, Zhang Yong-he*. Involvement of adrenoceptors, dopamine receptors and AMPA receptors in antidepressant-like action of 7-O-ethylfangchinoline in mice. Acta Pharmacol Sin. 2015;36(8):949-56.

9)        Wang Zi-Jun, Zhang Xue-Qiong, Cui Xiang-Yu, Cui Su-Ying, Yu Bin, Sheng Zhao-Fu, Li Sheng-Jie, Cao Qing, Huang Yuan-Li, Xu Ya-Ping, Zhang Yong-He*. Glucocorticoid receptors in the locus coeruleus mediate sleep disorders caused by repeated corticosterone treatment. Sci Rep. 2015;5:9442. doi: 10.1038/srep09442.

10)    Wang Zi-jun, Yu Bin, Zhang Xue-qiong, Sheng Zhao-fu, Li Sheng-jie, Huang Yuan-li, Cao Qing, Cui Xiang-yu, Cui Su-ying, Zhang Yong-he*. Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats. Acta Pharmacol Sin. 2014;35(7):879-88.

11)    Zhang Juan, Yu Bin, Zhang Xue-Qiong, Sheng Zhao-Fu, Li Sheng-Jie, Wang Zi-Jun, Cui Xiang-Yu, Cui Su-Ying, Zhang Yong-He*. Tetrandrine, an antihypertensive alkaloid, improves the sleep state of spontaneously hypertensive rats (SHRs). J Ethnopharmacol. 2014;151(1):729-32.

12)    Wang Li-En, Zhang Xue-Qiong, Yin Yan-Qi, Zhang Yong-He*. Augmentative effect of spinosin on pentobarbital-induced loss of righting reflex in mice associated with presynaptic 5-HT1A receptor. J Pharm Pharmacol. 2012;64(2):277-82.

13)    Cui Xiang-Yu, Cui Su-Ying, Zhang Juan, Wang Zi-Jun, Yu Bin, Sheng Zhao-Fu, Zhang Xue-Qiong, Zhang Yong-He*. Extract of Ganoderma lucidum prolongs sleep time in rats. J Ethnopharmacol. 2012;139(3):796-800.

14)    Zhang Xue-Qiong, Kim Jin-Hwa, Lee Geun-Soo, Pyo Hyeong-Bae, Shin Eun-Young, Kim Eung-Gook, Zhang Yong-He*. In vitro antioxidant and in vivo anti-inflammatory activities of Ophioglossum thermale. Am J Chin Med. 2012;40(2):279-93.