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邢国刚 教授

发布日期:2014-10-23    浏览次数:

  

  

        邢国刚

        电话:(010)-82801067

  E-mail: ggxing@bjmu.edu.cn

  个人简介:

  邢国刚,博士,北京大学教授,博士生导师。中华医学会疼痛学分会中青年委员,中国针灸学会针刺麻醉分会委员。中国疼痛医学杂志,临床医学进展,神经药理学报,The World Journal of Anesthesiology等专业杂志编委。2001年于西安交通大学生理系获博士学位,2003年北京大学神经科学研究所博士后出站。2004年至2006年在美国Burnham医学研究所和威斯康星大学做访问学者。2003年至今任北京大学神经生物学系副教授、教授。负责国家自然科学基金5项(31171063,30370470,81072951,61027001,81371237)、北京市自然科学基金1项(7112079)、教育部留学回国人员科研启动基金1项(2008890);参加科技部“973”课题3项(2009CB522003,2007CB512501,2013CB531905)、卫生部行业专项基金1项(201302013-01)。发表研究论文64篇,其中SCI收录论文33篇(第一/通讯作者论文20篇)。系列文章发表在Pain, Molecular Pain, Molecular Brain, Neurobiology of Disease等专业杂志上。参加编写教材3部,获得“2010年中国针灸学会科学技术奖(二等奖)”(中医针灸学理论指导下针刺镇痛的神经生物学机制研究,ZJ2010003-2-03,第3完成人)和“2012年度北京市科学技术奖” (二等奖) (针刺治疗慢性痛的神经生物学机制研究,2012医-2-002-03,第3完成人)。

  研究方向:

  离子通道与慢性痛的记忆、认知和情绪机制研究:采用分子生物学、细胞生物学、形态学、电生理学和行为药理学等方法,从分子、细胞水平,突触水平,以及神经网络水平来研究离子通道与慢性痛的记忆、认知和负性情绪发生的分子神经生物学机制,包括恐惧记忆、认知功能障碍、焦虑和抑郁。

  痛与痛觉调制的高级神经网络机制:运用清醒自由活动大鼠多通道神经元放电同步记录技术以及多通道脑电与诱发电位同步记录技术等微创技术手段,研究痛觉信息在高级脑区的传递通路、组成的神经网络以及痛觉信息在高级脑区的编码过程;在此基础上,进一步研究与针刺镇痛相关的脑区核团及其神经网络,以及针刺对这些核团与神经网络的影响。

  少弱精子症的发病机制与防治措施研究:采用分子生物学、细胞生物学、形态学、电生理学和行为药理学等方法,研究精子表达的特异性离子通道在少弱精子症发生的作用及机制。

  科研基金:

  (1).2014.01-2017.12: 国家自然科学基金(面上项目)“KCNQ/M(Kv7)钾通道的转录抑制调控及其在大鼠骨癌痛中的作用研究”(81371237,项目负责人);

  (2).2013.01-2017.12:“973”课题“针药复合麻醉镇痛机制研究”(2013CB531905,分题负责人);

  (3).2013.01-2015.12: 卫生部行业专项基金:“经皮穴位电刺激技术在生殖医学中的应用研究”(201302013-01,分题负责人);

  (4).2012.01-2015.12: 国家自然科学基金(面上项目)“KCNQ/M电压门控钾通道在骨癌痛发生中的作用及其机制研究”(31171063,项目负责人);

  (5).2011.01-2011.12: 国家自然科学基金(面上项目)“生精散激活精子特异性钙通道蛋白CatSper治疗弱精子症的临床与基础研究”(81072951,项目负责人);

  (6).2011.01-2013.12: 国家自然科学基金(仪器专项)“高通量神经信息检测分析仪器研制”(61027001,合作申请项目,分题负责人);

  (7).2011.01-2013.12: 北京市自然科学基金(面上项目)“BDNF激活NMDA受体2B亚基磷酸化在神经病理痛中的作用”(7112079,项目负责人)

  (8).2009.01-2013.12:“973”子课题“阿片类物质精神依赖的神经生物学机制”(2009CB522003,研究骨干);

  (9).2008.06-2011.06:教育部留学回国人员科研启动基金“背根神经节神经元超极化激活电流(Ih)参与大鼠神经病理痛的分子机制”(2008890,项目负责人);

  (10).2007.07-2011.08:“973”子课题“针麻镇痛中高级中枢痛觉信息调制回路的作用”(2007CB512501,分题负责人);

  (11).2004.01-2006.12: 国家自然科学基金(面上项目)“脊髓背角突触传递的长时程抑制在电针治疗神经病理痛中的作用及其机理研究”(30370470,项目负责人);

  近年发表的代表性论著(*通讯作者):

  1.Xu Ding,Jie Caia,Song Li,Xiao-Dan Liu,You Wan,Guo-Gang Xing*. BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation. Neurobiology of Disease . 2014 (in press).

  2.Xiao-Dan Liu,Jing-Jing Yang,Dong Fang,Jie Caia,You Wan,Ji-Sheng Han,Guo-Gang Xing*. Increased functional Nav1.8 on the membrane of dorsal root ganglia contributes to the development of rat bone cancer pain. PLoS One . 2014 (in press).

  3.Hong Jiang,Ling-Yu Kong,Zi-Run Jin,Jie Cai,Xue-Jing Kang,You Wan and Guo-Gang Xing*. Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats. Molecular Brain . 2014 Oct 4;7(1):72. [Epub ahead of print]

  4.Ming-Jia Lia, Lin Chena, Ling-Yu Liu, Jie Cai, You Wana*, Guo-Gang Xing*. Pain-related sensitization of the central amygdala in spare nerve injury model of chronic neuropathic pain. Neuroscience Bulletin . 2014 (under revision).

  5.Lei Ding,Jie Cai,Xiang-Yang Guo,Xiu-Li Meng,Guo-Gang Xing*. The anti-allodynic action of pregabalin may depend on the suppression of spinal neuronal hyperexcitability via decreasing the dorsal horn N-methyl-D-aspartate receptors in rats with spared nerve injury. Pain Research & Management . 2014 19(4): 205-211.

  6.Min Liu,Huan Yang,Dong Fang,Jing-Jing Yang,Jie Cai,You Wan,De-Hua Chui,Ji-Sheng Han,Guo-Gang Xing*. Up-regulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglion contributes to the bone cancer pain. Pain. 2013; 154(9):1551-1568.

  7.Qin Zheng,Dong Fang,Ming Liu,Jie Cai,You Wan,Ji-Sheng Han,Guo-Gang Xing*. Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model. Pain . 2013; 154(3): 434-448.

  8.Ya-Nan Wang,Bo Wang,Min Liang,Cai-Yan Han,Bin Zhang,Jie Cai,Wei Sun*,Guo-Gang Xing*. Down-regulation of CatSper1 channel in epididymal spermatozoa contributes to the pathogenesis of asthenozoospermia,while up-regulation of the channel by Sheng-Jing-San treatment improves the sperm motility of asthenozoospermia in rats. Fertility and Sterility . 2013; 99(2):579-587.

  9.Qin Zheng,Dong Fang,Jie Cai,You Wan,Ji-Sheng Han,Guo-Gang Xing*. Enhanced excitability of small dorsal root ganglion neurons in rats with bone cancer pain. Molecular Pain . 2012; 8(1):24-41.

  10.Feng-Yu Liu,Yan-Ni Sun,Fa-Tian Wang,Qian Li,Li Su,Zi-Fang Zhao,Xiang-Ling Meng,Hong Zhao,Xi Wu,Qian Sun,Guo-Gang Xing*,You Wan*. Activation of satellite glial cells in lumbar dorsal root ganglia contributes to neuropathic pain after spinal nerve ligation. Brain Research . 2012; 1427:65-77.

  11.Ying-Ying Wang,Jiong Qin*,Ying Han,Jie Cai,Guo-Gang Xing*. Hyperthermia induces epileptiform discharges in cultured rat cortical neurons. Brain Research . 2011; 1417C: 87-102.

  12.Shan-Jing Geng,Fei-Fei Liao,Wen-Hao Dang,Xu Ding,Xiao-Dan Liu,Jie Cai,Ji-Sheng Han,You Wan,Guo-Gang Xing*. Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation. Experimental Neurology. 2010; 222:256-266.

  13.Feng-Yu Liu,Xiao-Xiu Qu,Xu Ding,Jie Cai,Hong Jiang,You Wan,Ji-Sheng Han,Guo-Gang Xing*. Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation. Brain Research . 2010; 1330:45-60.

  14.Tianran Song,Yue Wang,Guian Chen* and Guogang Xing*. Tyrosine hydroxylase- positive cells and dopaminergic neuronal function in human embryonic stem cells: An electrophysiological validation. Neural Regeneration Research . 2010; 5(3):185-190.

  15.Xiao-Xiu Qu,Jie Cai,Ming-Jia Li,Ye-Nan Chi,Fei-Fei Liao,Feng-Yu Liu,You Wan,Ji-Sheng Han,Guo-Gang Xing*. Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain. Experimental Neurology . 2009; 215(2):298-307.

  16.Lu Yu,Fei Yang,Hao Luo,Feng-Yu Liu,Ji-Sheng Han,Guo-Gang Xing* and You Wan*. The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant. Molecular Pain . 2008; 4(1): 61-70.

  17.Guo-Gang Xing*,Feng-Yu Liu,Xiao-Xiu Qu,Ji-Sheng Han,You Wan. Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain. Experimental Neurology . 2007; 208(2):323-332.

  18.Feng-Yu Liu?,Guo-Gang Xing?,Xiao-Xiu Qu,Isabella S. Xu,Ji-Sheng Han,You Wan. Roles of 5-HT receptor subtypes in the inhibitory effects of 5-HT on C-fiber responses of spinal wide dynamic range neurons in rats. The Journal of Pharmacology and Experimental Therapeutics ,2007; 321(3): 1046-1053. (? equal contribution)

       19.Guo-Gang Xing?,Rengang Wang?,Bo Yang,Dongxian Zhang. Postnatal switching of NMDA receptor subunits from NR2B to NR2A in rat facial motor neurons. European Journal of Neuroscience. 2006; 24(11):2987-2992. (? equal contribution)

        20.Qian Sun?,Guogang Xing?,Huiyin Tu,Ji-Sheng Han,You Wan. Inhibition of hyperpolarization- activated current by ZD7288 suppresses ectopic discharges of injured dorsal root ganglion neurons in a rat model of neuropathic pain. Brain Research . 2005; 1032(1-2): 63-9. (? equal contribution)