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【院长论坛】The role of innate lymphoid cells in gut homeostasis in response to pathogens, diet and commensals.

发布日期:2012-07-05    浏览次数:
 

基础医学院庆祝北医百年庆典系列活动

基础医学院院长论坛系列十六

报告题目:The role of innate lymphoid cells in gut homeostasis in response to pathogens, diet and commensals. 

报告人: Yang-Xin Fu Professor, MD/PhD

                 Professor of Pathology, Department of Pathology, University of Chicago, Chicago, IL

时间:2012719日下午3:00-4:00

地点:逸夫教学楼310

主持人:韩文玲教授

报告人简介:

Prof. Fu’s group is interested in defining the essential components of the lymphoid microenvironment required for the development and function of the immune system. Using a comprehensive system of knockout mice and receptor fusion proteins, they have found that lymphotoxin (LT) and TNF are essential for immune cell migrations and formation of lymphoid structures. In addition, their recent work indicates that ligands for LT receptor are essential for the generation and migration of autoreactive T cells. They are currently extending our research areas into other LT/TNF family members.

代表性论著:

1.         Lo JC, Wang Y, Tumanov AV, Bamji M, Yao Z, Reardon, CA, Getz GS, and Fu YX. Lymphotoxin beta receptor-dependent control of lipid homeostasis. Science 316:285-288, 2007.

2.         Chen L, Park SM, Tumanov AV, Hau A, Sawada K, Feig C, Turner JR, Fu YX, Romero IL, Lengyel E, Peter ME. CD95 promotes tumour growth. Nature. 465(7297):492-6, 2010

3.         Qiu J, Heller JJ, Guo X, Chen ZM, Fish K, Fu YX, Zhou L. The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells. Immunity. 36(1):92-104, 2012

Moseman EA, Iannacone M, Bosurgi L, Tonti E, Chevrier N, Tumanov A, Fu YX, Hacohen N, von Andrian UH.  B Cell Maintenance of Subcapsular Sinus Macrophages Protects against a Fatal Viral Infection Independent of Adaptive Immunity. Immunity. 36(3):415-26, 2012