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【院长论坛】Chromatin Structure as a Determinant of DNA Repair and Cancer Susceptibility

发布日期:2013-08-19    浏览次数:

北京大学基础医学院院长论坛

报告1,题目:Chromatin Structure as a Determinant of DNA Repair and Cancer Susceptibility

  报 告 人:Roger Greenberg,PhD,MD

                Associate Professor,                                               

                Abramson Family Cancer Research Institute

                University of Pennsylvania, School of Medicine

  时    间:2013年8月20日(星期二)下午1:30-4:00

  地    点:医学部生化楼三楼中厅

  主 持 人:邵根泽 教授

  报告人简介:

  Dr Roger Greenberg is an associate professor at AFCRI, University of Pennsylvania School of Medicine and serves as the Chair of American Cancer Society in DNA Mechanisms in Cancer Study Section; and the program leader of Abramson Cancer Center Breast Cancer Program, the Director of Basic Science at Basser Research Center for BRCA in University of Pennsylvania. His laboratory investigates basic mechanisms of genome integrity maintenance that impact breast and ovarian cancer, focusing on understanding how BRCA dependent DNA double strand break repair mechanisms affect breast and ovarian cancer etiology and response to radio- and chemotherapies, as well as on the relationship between DNA repair dysfunction and bone marrow failure syndromes. He was awarded as Harrington Discovery Institute Scholar-Innovator, Kimmel Scholar. He is reviewer for New England Journal of Medicine,Science,Nature,Nature Communications,Nature Structural and Molecular Biology,Nature Reviews Molecular and Cellular Biology,Cancer Cell, Molecular Cell,Genes & Development,PNAS, Current Biology, EMBO Reports.

  Publications:

  1.      Tang J, Cho NW, Cui G, Manion EM, Shanbhag NM, Botuyan MV, Mer G, Greenberg RA: TIP60 limits   53BP1 accumulation at DNA double-strand breaks to promote BRCA1-dependent homologous recombination. Nat Struct Mol Biol 20:317-25 2013.

  2.      Aressy B and Greenberg RA: Placing BRCA1 E3 ligase activity in the proper context. Current Biology 22(18): R806-8 2012

  3.      Greenberg RA: BRCA1, Everything but the RING? Science 334 (6055): 459-460.

  4.      Shanbhag NM, Rafalska-Metcalf IU, Balane-Bolivar C, Janicki SM, and Greenberg RA. ATM dependent chromatin changes silence transcription in cis to DNA double-strand breaks. Cell 141(6): 970-81. 2010.

  5.      Shao G, Patterson-Fortin J, Messick TE, Feng D, Shanbhag N, Wang Y, and Greenberg RA. MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. Genes Dev. 23(6): 740-54, 2009

  6.      Shao G, Lilli DR, Patterson-Fortin J, Messick TE, Feng D, Shanbhag N, Wang Y, and Greenberg RA. The Rap80-BRCC36 Deubiquitinating Enzyme Complex Antagonizes RNF8-UBC13 Dependent Ubiquitination Events at DNA Double Strand Breaks. PNAS 106(9): 3166-71. 2009

  7.      Sobhian B, Shao G, Lilli DR, Culhane AC, Moreau L, Xia B, Livingston DM* and Greenberg RA*. RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science 316(5828): 1198-202, 2007 (PMC2706583) * co-corresponding authorship.