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【院长论坛】Cyclic nucleotide phosphodiesterase-4 (PDE4) subtypes as potential targets for neuropsychiatric drugs.

发布日期:2017-05-25    浏览次数:

北京大学基础医学院

院长论坛(一)

报告题目 Cyclic nucleotide phosphodiesterase-4 (PDE4) subtypes as potential targets for neuropsychiatric drugs.

报告人Dr. James M. O'Donnell,

             Professor and Dean of the School of Pharmacy and Pharmaceutical Sciences at the State University of New York (SUNY) at Buffalo, NY, USA.

时间2017年6月2日(星期五)上午10:00

地点生化楼三层中厅

主持人杨宝学教授

报告人简介:

Considerable preclinical and clinical evidence suggests that inhibitors of PDE4 have effects on central nervous system function and behavior, consistent with therapeutic utility for treating disorders such as depression and dementia. Despite this promise, dose-limiting side effects such as nausea and emesis have slowed drug development. Limiting drug action to specific PDE4 subtypes (i.e., PDE4A, B, C, and D) offers a means to produce therapeutic effects while minimizing side effects. However, the highly conserved catalytic site, to which classical PDE4 inhibitors bind, has limited the discovery of subtype-selective inhibitors. Recently, it has been shown that allosteric inhibitors, which do not bind to the catalytic site, can demonstrate subtype selectivity. Our research has shown distinct pharmacological profiles for selective inhibitors of PDE4B and PDE4D in models to assess antidepressant and memory-enhancing efficacy. 

 

院长论坛(二)

 

报告题目: Educational program at the School of Pharmacy and Pharmaceutical Science, University at Buffalo, State University of New York

报告人Dr James M. O'Donnell,

              Professor and Dean of the School of Pharmacy and Pharmaceutical Sciences at the State University of New York (SUNY) at Buffalo, NY, USA.

时间2017年6月2日(星期五) 下午2:00

地点:生化楼三层中厅

主持人杨宝学教授

欢迎各位老师及同学参加!