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【院长论坛】Novel Genes and Pathways Contributing to Pathogenesis of Alzheimer’s and Related Neurodegenerative Diseases

发布日期:2017-11-02    浏览次数:

北京大学基础医学院

院长论坛

报告题目:Novel Genes and Pathways Contributing to Pathogenesis of Alzheimer’s and Related Neurodegenerative Diseases

报告人:Dr. Huaxi Xu

              Professor & Director of Neuroscience Initiative

              The Jeanne & Gary Herberger Leadership Chair in Neuroscience

              Sanford Burnham Prebys Medical Discovery Institute

时间:2017年11月7日(星期二)上午11:00

地点:生化楼三层中厅

主持人:张 勇 研究员

报告简介:

Alzheimer’s disease (AD) is an incurable and fatal brain-wasting disorder that causes memory loss and progressive dementia in the elderly. Although aging is the main risk factor for AD, several causal gene mutations and genetic risk factors linked to AD expression have been identified. However, the mechanism of action and significance of these risk factors to AD pathophysiology have yet to be fully explored. I will present evidence describing known and novel genetic risk factors linked to AD and related tauopathies; and will discuss their respective contribution to beta-amyloid production and deposition in brain, tau-containing neurofibrillary tangles formation, synaptic failure and cognitive decline. I will also discuss our recent findings of novel signaling pathways that regulate tau metabolism/neurofibrillary tangles formation in tauopathies such as progressive supranuclear palsy (PSP) and AD. Finally, I will discuss novel mechanisms for preserving and protecting the structural and functional integrity of synapses against beta-amyloid-mediated synaptoxicity in AD and Down syndrome. I will conclude by presenting new ideas and directions for drug discovery strategies aimed at regulating the expression and function of these novel genes and pathways in AD and tau-related disorders.

 

欢迎各位老师及同学参加!