Prof. Jinpeng Sun

Contact Information

Email: sunjinpeng@bjmu.edu.cn

Research Interests

GPCR Ligand Discovery, Biased Signaling, and Targeted Drug Development.

Personal Profile

Professor Jinpeng Sun is a New Cornerstone Investigator (2023). He has been awarded the National Science Fund for Distinguished Young Scholars (Pharmacology, 2018), the Sustained Funding for National Distinguished Young Scholars (Pharmacology, 2023), and key projects from the National Natural Science Foundation of China, among others. His honors include the Third National Award for Innovation and Excellence, the Tan Jiazhen Life Science Innovation Award, the 17th China Pharmaceutical Development Award for Clinical Medicine Research, inclusion in China's Top 10 Science and Technology News Stories of 2023, and China's Top 10 University Science and Technology Advances of 2023.

Professor Sun has long been engaged in pharmacological research, focusing on G protein-coupled receptors (GPCRs). He has achieved systematic and original results in ligand-receptor recognition, drug target validation, and membrane receptor drug development. He established novel systems for endogenous ligand capture and highly sensitive multi-pathway GPCR activity detection, enabling the characterization of transient and weak ligand-receptor interactions. He discovered membrane receptors for key hormones and metabolites involved in major diseases, such as membrane receptors for steroid hormones, ceramides, and other important metabolites including insulin fragments and matricellular proteins. Additionally, he developed innovative methods like microscale biomechanical activation, identified GPCRs responsible for sensing balance and hearing, and elucidated the molecular mechanisms by which these receptors mediate force and various sensations such as itch, smell, and pH perception, thereby expanding the boundaries of GPCR ligand recognition. By effectively applying new technologies such as structural biology combined with AI-assisted ligand design, he has achieved high-resolution biased GPCR ligand design and developed bioactive substances with potential medicinal value. More than 20 small molecules and peptides have completed pharmacokinetic and toxicological studies at the animal level.

As a corresponding author (including co-corresponding authorship), Professor Sun has published papers in top-tier journals, including  Nature  (9 papers),  Science  (2 papers, one featured as a cover story),  Cell  (5 papers, one featured as a cover story),  Cell Metabolism  (2 papers),  Nature Metabolism  (2 papers),  Nature Chemical Biology  (4 papers),  Molecular Cell  (2 papers),  Cell Research  (3 papers),  PNAS  (6 papers), and  Nature Communications  (10 papers), among others. He has published 152 SCI-indexed papers in total, 13 of which received special commentaries—including three in  Nature Reviews Drug Discovery  and one in  Nature Reviews Cardiology . Five papers are highly cited, and five were selected as journal covers. His work has an h-index of 43, with 16 papers cited over 100 times. His research findings have been incorporated into textbooks such as  Pharmacology  and  Fundamentals of Disease and Pharmaceutical Intervention .

Professor Sun has been frequently invited to deliver presentations at domestic and international academic conferences and research institutes. He has given 17 keynote speeches at international conferences, including serving as a Section Chair (Drug development according to signaling diversities of GPCRs) and delivering a keynote at the 19th World Congress of Basic & Clinical Pharmacology (Glasgow, UK, 2023), as well as presenting an invited plenary lecture on the opening day of the 11th International Adhesion GPCR Workshop (Mexico City, 2024). He has also participated in organizing several international conferences, such as the Annual International Conference on Ion Channels, and exerts extensive influence in the field of international pharmacology.

Group Members

Faculty：Lu Tie (Co-PI), Yang Liu (Research Assistant), Juxiang Ye (Research Assistant), Yingli Jia (Chief Technician), Jiale Wang (Postdoctoral Fellow), Shuhua Zhou (Postdoctoral Fellow), Yao Long (Postdoctoral Fellow).

Students：Baiyang Cai, Jinhui Ding, Kui Cai, Jingyu Rui, Yihe Xie, Wanping Zhuang, Yanjun Liu, Xiaojing Jiang, Zili Liu.

Publications

1. Zhao Yang, Yu-Qi Ping, Ming-Wei Wang, Chao Zhang, Shu-Hua Zhou, Yue-Tong Xi, Kong-Kai Zhu, Wei Ding, Qi-Yue Zhang, Zhi-Chen Song, Ru-Jia Zhao, Zi-Lu He, Meng-Xin Wang, Lei Qi, Christian Ullmann, Albert Ricken, Torsten Schöneberg, Zhen-Ji Gan, Xiao Yu^#, Peng Xiao^#, Fan Yi^#, Ines Liebscher^#, and Jin-Peng Sun^#. Identification, structure, and agonist design of an androgen membrane receptor.  Cell . 2025 Mar 20;188(6):1589-1604.e24.

2. Hui Lin, Chuanshun Ma, Kui Cai, Lulu Guo, Xuemei Wang, Lin Lv, Chao Zhang, Jun Lin, Daolai Zhang, Chuan Ye, Tengwei Wang, Shenming Huang, Jifei Han, Zihao Zhang, Junyan Gao, Mingxiang Zhang, Zhao Pu, Fengyang Li, Yongyuan Guo, Xiaojun Zhou, Chengxue Qin, Fan Yi, Xiao Yu^#, Wei Kong^#, Changtao Jiang^#，Jin-Peng Sun^#. Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis.  Science . 2025 May;388(6746):eado4188.

3. Siting Zhang, Hui Lin, Jiale Wang, Jingyu Rui, Tengwei Wang, Zeyu Cai, Shenming Huang, Yanxiang Gao, Tianfeng Ma, Rui Fan, Rongbo Dai, Zhiqing Li, Yiting Jia, Qiang Chen, HaoMing He, Jiaai Tan, Shirong Zhu, Rui Gu, Zhigang Dong, Meihong Li, Enmin Xie, Yi Fu, Jingang Zheng^#, Changtao Jiang^#, Jinpeng Sun^# & Wei Kong^#. Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis.  Nature . 2025 May;641(8062):476-485.

4. Chunyou Mao, Peng Xiao, Xiao-Na Tao, Jiao Qin, Qing-Tao He, Chao Zhang, Sheng-Chao Guo, Ya-Qin Du, Li-Nan Chen, Dan-Dan Shen, Zhi-Shuai Yang, Han-Qiong Zhang, Shen-Ming Huang, Yong-Hao He, Jie Cheng, Ya-Ni Zhong, Pan Shang, Jun Chen, Dao-Lai Zhang, Qian-Lang Wang, Mei-Xia Liu, Guo-Yu Li, Yongyuan Guo, H. Eric Xu, Chuanxin Wang, Cheng Zhang, Shiqing Feng^#, Xiao Yu^#, Yan Zhang^#, Jin-Peng Sun^#. Unsaturated bond recognition leads to biased signal in a fatty acid receptor.  Science . 2023 Apr 7;380(6640):eadd6220.

5. Yu-Qi Ping, Chunyou Mao, Peng Xiao, Ru-Jia Zhao, Yi Jiang, Zhao Yang, Wen-Tao An, Dan-Dan Shen, Fan Yang, Huibing Zhang, Changxiu Qu, Qingya Shen, Caiping Tian, Zi-jian Li, Shaolong Li, Guang-Yu Wang, Xiaona Tao, Xin Wen, Ya-Ni Zhong, Jing Yang, Fan Yi, Xiao Yu, H. Eric Xu^#, Yan Zhang& Jin-Peng Sun^#. Structures of the glucocorticoid-bound adhesion receptor GPR97-G_o complex.  Nature . 2021 Jan;589(7843):620-626.

6. Lulu Guo, Jie Cheng, Shuo Lian, Qun Liu, Yan Lu, Yuan Zheng, Kongkai Zhu, Minghui Zhang, Yalei Kong, Chao Zhang, Naikang Rong, Yuming Zhuang, Guoxing Fang, Jingjing Jiang, Tianyao Zhang, Xiang Han, Zili Liu, Ming Xia, Shangming Liu, Lei Zhang, Stephen D. Liberles, Xiao Yu, Yunfei Xu^#, Fan Yang^#, Qian Li^# & Jin-Peng Sun^#. Structural basis of amine odorant perception by a mammal olfactory receptor.  Nature . 2023 Jun;618(7963):193-200.

7. Fan Yang, Lulu Guo, Yu Li, Guopeng Wang, Jia Wang, Chao Zhang, Guo-Xing Fang, Xu Chen, Lei Liu, Xu Yan, Qun Liu, Changxiu Qu, Yunfei Xu, Peng Xiao, Zhongliang Zhu, Zijian Li, Jiuyao Zhou, Xiao Yu, Ning Gao^# & Jin-Peng Sun^#. Structure, function and pharmacology of human itch receptor complexes.  Nature . 2021 Dec;600(7887):164-169.

8. Pan Shang, Naikang Rong, Jing-Jing Jiang, Jie Cheng, Ming-Hui Zhang, Dongwei Kang, Lei Qi, Lulu Guo, Gong-Ming Yang, Qun Liu, Zhenzhen Zhou, Xiao-Bing Li, Kong-Kai Zhu, Qing-Biao Meng, Xiang Han, Wenqi Yan, Yalei Kong, Lejin Yang, Xiaohui Wang, Dapeng Lei, Xin Feng, Xinyong Liu, Xiao Yu, Yue Wang^#, Qian Li^#, Zhen-Hua Shao^#, Fan Yang^#, and Jin-Peng Sun^#. Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.  Cell . 2023 Nov 22;186(24):5347-5362.e24.

9. Xin Wen, Pan Shang, Haidi Chen, Lulu Guo, Naikang Rong, Xiaoyu Jiang, Xuan Li, Junyan Liu, Gongming Yang, Jiacheng Zhang, Kongkai Zhu, Qingbiao Meng, Xuefei He, Zhihai Wang, Zili Liu, Haoran Cheng, Yilin Zheng, Bifei Zhang, Jiaojiao Pang, Zhaoqian Liu, Peng Xiao, Yuguo Chen, Lunxu Liu, Fengming Luo, Xiao Yu, Fan Yi^#, Pengju Zhang^#, Fan Yang ^#, Cheng Deng^#, and Jin-Peng Sun^#. Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4.  Cell . 2025 Feb 6;188(3):653-670.e24.

10. Yu-Qi Ping, Peng Xiao, Fan Yang, Ru-Jia Zhao, Sheng-Chao Guo, Xu Yan, Xiang Wu, Chao Zhang, Yan Lu, Fenghui Zhao, Fulai Zhou, Yue-Tong Xi, Wanchao Yin, Feng-Zhen Liu, Dong-Fang He, Dao-Lai Zhang, Zhong-Liang Zhu, Yi Jiang, Lutao Du, Shi-Qing Feng, Torsten Schöneberg, Ines Liebscher^#, H. Eric Xu^# & Jin-Peng Sun^#. Structural basis for the tethered peptide activation of adhesion GPCRs.  Nature . 2022 Apr;604(7907):763-770.

11. Peng Xiao, Shengchao Guo, Xin Wen, Qing-Tao He, Hui Lin, Shen-Ming Huang, Lu Gou, Chao Zhang, Zhao Yang, Ya-Ni Zhong, Chuan-Cheng Yang, Yu Li, Zheng Gong, Xiao-Na Tao, Zhi-Shuai Yang, Yan Lu, Shao-Long Li, Jun-Yan He, Chuanxin Wang, Lei Zhang^#, Liangliang Kong^#, Jin-Peng Sun^#, Xiao Yu^#. Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4.  Nature . 2022 Apr;604(7907):771-778.

12. Jun Lin, Qixing Nie, Jie Cheng, Ya-Ni Zhong, Tianyao Zhang, Xiuying Zhang, Xiaoyan Ge, Yong Ding, Canyang Niu, Yuhua Gao, Kai Wang, Mingxin Gao, Xuemei Wang, Weixuan Chen, Chuyu Yun, Chuan Ye, Jinkun Xu, Weike Shaoyong, Lijun Zhang, Pan Shang, Xi Luo, Zhiwei Zhang, Xin Zheng, Xueying Sha, Jinxin Zhang, Shaoping Nie, Xuguang Zhang, Fazheng Ren, Huiying Liu, Erdan Dong, Xiao Yu^#, Linong Ji^#, Yanli Pang^#, Jin-Peng Sun^#, and Changtao Jiang^#. A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE.  Cell . 2025 10.1016/j.cell.2025.05.010.

13. Zheng Xu, Lulu Guo, Jingjing Yu, Siyuan Shen, Chao Wu, Weifeng Zhang, Chang Zhao, Yue Deng, Xiaowen Tian, Yuying Feng, Hanlin Hou, Lantian Su, Hongshuang Wang, Shuo Guo, Heli Wang, Kexin Wang, Peipei Chen, Jie Zhao, Xiaoyu Zhang, Xihao Yong, Lin Cheng, Lunxu Liu, Shengyong Yang, Fan Yang, Xiaohui Wang, Xiao Yu^#, Yunfei Xu^#, Jin-Peng Sun^#, Wei Yan^#, Zhenhua Shao^#. Ligand recognition and G-protein coupling of trace amine receptor TAAR1.  Nature . 2023 Dec;624(7992):672-681.

14. Fan Yang, Chunyou Mao, Lulu Guo, Jingyu Lin, Qianqian Ming, Peng Xiao, Xiang Wu, Qingya Shen, Shimeng Guo, Dan-Dan Shen, Ruirui Lu, Linqi Zhang, Shenming Huang, Yuqi Ping, Chenlu Zhang, Cheng Ma, Kai Zhang, Xiaoying Liang, Yuemao Shen, Fajun Nan, Fan Yi, Vincent C. Luca, Jiuyao Zhou, Changtao Jiang, Jin-Peng Sun^#, Xin Xie^#, Xiao Yu^# & Yan Zhang^#. Structural basis of GPBAR activation and bile acid recognition.  Nature . 2020 Nov;587(7834):499-504.

15. Xiaolong Hu, Weizhen Ao, Mingxin Gao, Lijie Wu, Yuan Pei, Shenhui Liu, Yiran Wu, Fei Zhao, Qianqian Sun, Junlin Liu, Longquan Jiang, Xin Wang, Yan Li, Qiwen Tan, Jie Cheng, Fan Yang, Chi Yang^#, Jinpeng Sun^#, Tian Hua^#, Zhi-Jie Liu^#. Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.  Nature . 2024 Jul;631(8020):459-466.

16. Peng Xiao, Wei Yan, Lu Gou, Ya-Ni Zhong, Liangliang Kong, Chao Wu, Xin Wen, Yuan Yuan, Sheng Cao, Changxiu Qu, Xin Yang, Chuan-Cheng Yang, Anjie Xia, Zhenquan Hu, Qianqian Zhang, Yong-Hao He, Dao-Lai Zhang, Chao Zhang, Gui-Hua Hou, Huanxiang Liu, Lizhe Zhu, Ping Fu, Shengyong Yang, Daniel M Rosenbaum, Jin-Peng Sun^#, Yang Du^#, Lei Zhang^#, Xiao Yu^#, Zhenhua Shao^#. Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.  Cell . 2021 Feb 18;184(4):943-956.e18.

17. Hui Lin, Chuanshun Ma, Xiao Zhuang, Shuo Liu, Dong Liu, Mingxiang Zhang, Yan Lu, Guangjian Zhou, Chao Zhang, Tengwei Wang, Zihao Zhang, Lin Lv, Daolai Zhang, Xiong-Zhong Ruan, Yunfei Xu^#, Renjie Chai^#, Xiao Yu^#, Jin-Peng Sun^# ,Bo Chu^#. Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury.  Cell Metabolism . 2024 Nov 5;36(11):2402-2418.e10.

18. Jie Cheng, Zhao Yang, Xiao-Yan Ge, Ming-Xin Gao, Ran Meng, Xin Xu, Yu-Qi Zhang, Rui-Zhe Li, Jing-Yu Lin, Zhao-Mei Tian, Jin Wang, Shang-Lei Ning, Yun-Fei Xu, Fan Yang, Jing-Kai Gu, Jin-Peng Sun^#, Xiao Yu^#. Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism.  Cell Metabolism . 2022 Feb 1;34(2):240-255.

19. Ting Zhou, Jie Cheng, Shuo He, Chao Zhang, Ming-Xin Gao, Li-Jun Zhang, Jin-Peng Sun^#, Yi Zhu^#, Ding Ai^#. The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid.  Nature Metabolism . 2024 Aug;6(8):1566-1583.

20. Jia-Le Wang, Xiao-Dong Dou, Jie Cheng, Ming-Xin Gao, Guo-Feng Xu, Wei Ding, Jin-Hui Ding, Yu Li, Si-Han Wang, Zhao-Wei Ji, Xin-Yi Zhao, Tong-Yu Huo, Cai-Fang Zhang, Ya-Meng Liu, Xue-Ying Sha, Jia-Rui Gao, Wen-Hui Zhang, Yong Hao, Cheng Zhang, Jin-Peng Sun^#, Ning Jiao^#, Xiao Yu^#. Functional screening and rational design of compounds targeting GPR132 to treat diabetes.  Nature Metabolism . 2023 Oct;5(10):1726-1746.

21. Zhao Yang, Jun-Yan Wang, Fan Yang, Kong-Kai Zhu, Guo-Peng Wang, Ying Guan, Shang-Lei Ning, Yan Lu, Yu Li, Chao Zhang, Yuan Zheng, Shu-Hua Zhou, Xin-Wen Wang, Ming-Wei Wang, Peng Xiao, Fan Yi, Cheng Zhang, Peng-Ju Zhang, Fei Xu, Bao-Hua Liu, Hua Zhang, Xiao Yu^#, Ning Gao^#, Jin-Peng Sun^#. Structure of GPR101-Gs enables identification of ligands with rejuvenating potential.  Nature Chemical Biology . 2024 Apr;20(4):484-492.

22. Hui Lin, Peng Xiao, Rui-Qian Bu, Shengchao Guo, Zhao Yang, Daopeng Yuan, Zhong-Liang Zhu, Chuan-Xin Zhang, Qing-Tao He , Chao Zhang, Yu-Qi Ping, Ru-Jia Zhao, Chuan-Shun Ma, Chang-Hao Liu, Xiao-Ning Zhang, Dan Jiang, Shaohui Huang, Yue-Tong Xi, Dao-Lai Zhang, Chen-Yang Xue, Bai-Sheng Yang, Jian-Yuan Li, Hao-Cheng Lin, Xu-Hui Zeng, Han Zhao, Wen-Ming Xu, Fan Yi^#, Zhongmin Liu^#, Jin-Peng Sun^# and Xiao Yu ^#. Structures of the ADGRG2-G_s complex in apo and ligand-bound forms.  Nature Chemical Biology . 2022 Nov;18(11):1196-1203.

23. Fan Yang, Peng Xiao, Chang-xiu Qu, Qi Liu, Liu-yang Wang, Zhi-xin Liu, Qing-tao He, Chuan Liu, Jian-ye Xu, Rui-rui Li, Meng-jing Li, Qing Li, Xu-zhen Guo, Zhao-ya Yang, Dong-fang He, Fan Yi, Ke Ruan, Yue-mao Shen, Xiao Yu, Jin-Peng Sun^# and Jiangyun Wang^#. Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin.  Nature Chemical Biology . 2018 Sep;14(9):876-886.

24. Yuan Zheng, Dan Jiang, Yan Lu, Chao Zhang, Shen-Ming Huang, Haocheng Lin, Daolai Zhang, Shengchao Guo, Jifei Han, Jun Chen, Yaxuan He, Mingxiang Zhang, Yanhui Gao, Yongyuan Guo, Ran Wei, Ming Xia, Yingying Qin, Zhaoqian Liu, Fan Yang, Shaohua Ge, Fan Yi, Xiao Yu^#, Hui Lin^#, Peng Xiao^#, Jin-Peng Sun^# & Shiqing Feng^#. Development of an allosteric adhesion GPCR nanobody with therapeutic potential.  Nature Chemical Biology . 2025. https://doi.org/10.1038/ s41589-025-01896-2.

25. Lulu Guo, Kongkai Zhu, Ya-Ni Zhong, Mingxin Gao, Junyan Liu, Zhimin Qi, Zili Liu, Naikang Rong, Minghui Zhang, Dongfang Li, Qiyue Zhang, Gongming Yang, Xinxin Zhang, Mingyue Zhang, Ning Ding, Yu-qi Ping, Zhao Yang, Peng Xiao, Ming Xia^#, Xiao Yu^#, Alatan Gaole^#, Jin-Peng Sun^#, and Fan Yang^#. Structural basis and biased signaling of proton sensation by GPCRs mediated by extracellular histidine rearrangement.  Molecular Cell . 2025 Apr 17;85(8):1658-1673.e7.

26. Chunyou Mao, Ru-Jia Zhao, Ying-Jun Dong, Mingxin Gao, Li-Nan Chen, Chao Zhang, Peng Xiao, Jia Guo, Jiao Qin, Dan-Dan Shen, Su-Yu Ji, Shao-Kun Zang, Huibing Zhang, Wei-Wei Wang, Qingya Shen, Jin-Peng Sun^#, and Yan Zhang^#. Conformational transitions and activation of the adhesion receptor CD97.  Molecular Cell . 2024 Feb 1;84(3):570-583.e7.

27. Zhao Yang, Shu-Hua Zhou, Qi-Yue Zhang, Zhi-Chen Song, Wen-Wen Liu, Yu Sun, Ming-Wei Wang, Xiao-Long Fu, Kong-Kai Zhu, Ying Guan, Jie-Yu Qi, Xiao-Hui Wang, Yu-Nan Sun, Yan Lu, Yu-Qi Ping, Yue-Tong Xi, Zhen-Xiao Teng, Lei Xu, Peng Xiao, Zhi-Gang Xu, Wei Xiong, Wei Qin, Wei Yang^#, Fan Yi^#, Ren-Jie Chai^#, Xiao Yu^#, Jin-Peng Sun^#. A force-sensitive adhesion GPCR is required for equilibrioception.  Cell Research . 2025 Apr;35(4):243-264.

28. Yi Fu, Yaqian Huang, Zhao Yang, Yufei Chen, Jingang Zheng, Chenfeng Mao, Zhiqing Li, Zhixin Liu, Bing Yu, Tuoyi Li, Meili Wang, Chanjuan Xu, Yiwei Zhou, Guizhen Zhao, Yiting Jia, Wei Guo, Xin Jia, Tao Zhang, Li Li, Ziyi Liu, Shengchao Guo, Mingliang Ma, Heng Zhang, Bo Liu, Junbao Du, Wengong Wang, Chaoshu Tang, Pei Gao, Qingbo Xu, Xian Wang, Jianfeng Liu, Jinpeng Sun^# and Wei Kong^#. Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury.  Cell Research . 2021 Jul;31(7):773-790.

29. Hong-Mei Wang, Yun-Fei Xu, Shang-Lei Ning, Du-Xiao Yang, Yi Li, Yu-Jie Du, Fan Yang, Ya Zhang, Nan Liang, Wei Yao, Ling-Li Zhang, Li-Chuan Gu, Cheng-Jiang Gao, Qi Pang, Yu-Xin Chen, Kun-Hong Xiao, Rong Ma, Xiao Yu^#, Jin-Peng Sun^#. The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes.  Cell Research . 2014 Sep;24(9):1067-90.

30. Yufei Chen, Chenfeng Mao, Rui Gu, Rujia Zhao, Weihao Li, Zihan Ma, Yiting Jia, Fang Yu, Jian Luo, Yi Fu, Jinpeng Sun^#, Wei Kong^#. Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification.  Circulation Research . 2022 Dec 2;131(12):1037-1054.

31. Qingqing Chu, Yujia Li, Jichao Wu, Yanjiao Gao, Xiangyun Guo, Jing Li, Hang Lv, Min Liu, Wei Tang, Peng Zhan, Tao Zhang, Huili Hu, Hong Liu, Jinpeng Sun^#, Xiaojie Wang^#, Fan Yi^#. Oxysterol Sensing Through GPR183 Triggers Endothelial Senescence in Hypertension.  Circulation Research . 2024 Sep 13;135(7):708-721.

32. Lin-Qi Zhang, Chang-Xiao Che, Ya-Qin Du, Lu-lu Han, Jia-le Wang, Chen-Yu Zhang, Shen-Ming Huang, Zhong-Yuan Zheng, Qing-Tao He, Zhao Yang, Long Zhang, Nan Chen, Fan Yang, Ying-Li Jia, Shi-Min Zhao, De-min Zhou, Chu Wang, Xian Wang, Jin-Peng Sun^#, Lu Tie^#. N-homocysteinylation of β-arrestins biases GPCR signaling and promotes platelet activation.  Blood . 2025 May 15;145(20):2374-2389.

33. Jun-Hong Dong, Yi-Jing Wang, Min Cui, Xiao-Jing Wang, Wen-Shuai Zheng, Ming-Liang Ma, Fan Yang, Dong-Fang He, Qiao-Xia Hu, Dao-Lai Zhang, Shang-Lei Ning, Chun-Hua Liu, Chuan Wang, Yue Wang, Xiang-Yao Li, Fan Yi, Amy Lin, Alem W. Kahsai, Thomas Joseph Cahill Ⅲ, Zhe-Yu Chen, Xiao Yu, and Jin-Peng Sun^#. Adaptive activation of a stress response pathway improves learning and memory through Gs and β-arrestin-1-regulated lactate metabolism.  Biological Psychiatry . 2017 Apr 15;81(8):654-670.

34. Wentao An, Hui Lin, Lijuan Ma, Chao Zhang, Yuan Zheng, Qiuxia Cheng, Chuanshun Ma, Xiang Wu, Zihao Zhang, Yani Zhong, Menghui Wang, Dongfang He, Zhao Yang, Lutao Du, Shiqing Feng, Chuanxin Wang, Fan Yang, Peng Xiao^#, Pengju Zhang^#, Xiao Yu^#, and Jin-Peng Sun^#. Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.  Proceedings of the National Academy of Sciences of the United States of America . 2022 Apr 12;119(15):e2117004119.

35. Shen-Ming Huang, Meng-Yao Xiong, Lei Liu, Jianqiang Mu, Ming-Wei Wang, Ying-Li Jia, Kui Cai, Lu Tie, Chao Zhang, Sheng Cao, Xin Wen, Jia-Le Wang, Sheng-Chao Guo, Yu Li, Chang-Xiu Qu, Qing-Tao He, Bo-Yang Cai, Chenyang Xue, Shiyi Gan, Yihe Xie, Xin Cong, Zhao Yang, Wei Kong, Shuo Li, Zijian Li, Peng Xiao, Fan Yang, Xiao Yu, You-Fei Guan, Xiaoyan Zhang^#, Zhongmin Liu^#, Bao-Xue Yang^#, Yang Du^#, Jin-Peng Sun^#. Single hormone or synthetic agonist induces Gs/Gi coupling selectivity of EP receptors via distinct binding modes and propagating paths.  Proceedings of the National Academy of Sciences of the United States of America . 2023 Jul 25;120(30):e2216329120.

36. Ming-Wei Wang, Zhao Yang, Xu Chen, Shu-Hua Zhou, Ge-Lin Huang, Jian-Ning Sun, Hui Jiang, Wen-Ming Xu^#, Hao-Cheng Lin^#, Xiao Yu^#, Jin-Peng Sun^#. Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways.  Proceedings of the National Academy of Sciences of the United States of America . 2021 Nov 9;118(45):e2107363118.

37. Changxiu Qu, Ji Young Park, Min Woo Yun, Qing-tao He, Fan Yang, Kiae Kim, Donghee Ham, Rui-rui Li, T. M. Iverson, Vsevolod V. Gurevich, Jin-Peng Sun^#, and Ka Young Chung^#. Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade.  Proceedings of the National Academy of Sciences of the United States of America . 2021 Sep 14;118(37):e2026491118.

38. Lijuan Ma, Fan Yang, Xiang Wu, Chunyou Mao, Lulu Guo, Tianshu Miao, Shao-Kun Zang, Xiaoyu Jiang, Dan-Dan Shen, Tianhui Wei, Hengxing Zhou, Qin Wei, Shiyang Li, Qiang Shu, Shiqing Feng, Changtao Jiang, Bo Chu, Lutao Du^#, Jin-Peng Sun^#, Xiao Yu^#, Yan Zhang^#, and Pengju Zhang^#. Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity.  Proceedings of the National Academy of Sciences of the United States of America . 2022 Jul 19;119(29):e2117054119.

39. Lulu Guo, Yumu Zhang, Guoxing Fang, Lu Tie, Yuming Zhuang, Chenyang Xue, Qi Liu, Minghui Zhang, Kongkai Zhu, Chongzhao You, Peiyu Xu, Qingning Yuan, Chao Zhang, Lei Liu, Naikang Rong, Shengxuan Peng, Yuan Liu, Chuanzheng Wang, Xin Luo, Zongyao Lv, Dongwei Kang, Xiao Yu, Cheng Zhang, Yi Jiang, Xinzhong Dong, Jiuyao Zhou^#, Zhongmin Liu^#, Fan Yang^#, H. Eric Xu^#, Jin-Peng Sun^#. Ligand recognition and G protein coupling of the human itch receptor MRGPRX1.  Nature Communications . 2023 Aug 17;14(1):5004.

40. Fan Yang, Xiao Yu, Chuan Liu, Chang-Xiu Qu, Zheng Gong, Hong-Da Liu, Fa-Hui Li, Hong-Mei Wang, Dong-Fang He, Fan Yi, Chen Song, Chang-Lin Tian, Kun-Hong Xiao, Jiang-Yun Wang^# & Jin-Peng Sun^#. Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and ¹⁹F-NMR.  Nature Communications . 2015 Sep 8;6:8202.

41. Chun-Hua Liu, Zheng Gong , Zong-Lai Liang , Zhi-Xin Liu , Fan Yang , Yu-Jing Sun , Ming-Liang Ma , Yi-Jing Wang , Chao-Ran Ji , Yu-Hong Wang , Mei-Jie Wang , Fu-Ai Cui , Amy Lin , Wen-Shuai Zheng , Dong-Fang He, Chang-xiu Qu, Peng Xiao, Chuan-Yong Liu, Alex R.B. Thomsen, Thomas Joseph Cahill III , Alem W Kahsai, Fan Yi, Kun-Hong Xiao, Tian Xue, Zhuan Zhou, Xiao Yu, Jin-Peng Sun^#. Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.  Nature Communications . 2017 Feb 9:8:14335.

42. Qi Liu, Qing-tao He, Xiaoxuan Lyu, Fan Yang, Zhong-liang Zhu, Peng Xiao, Zhao Yang, Feng Zhang, Zhao-ya Yang, Xiao-yan Wang, Peng Sun, Qian-wen Wang, Chang-xiu Qu, Zheng Gong, Jing-yu Lin, Zhen Xu, Shao-le Song, Shen-ming Huang, Sheng-chao Guo, Ming-jie Han, Kong-kai Zhu, Xin Chen, Alem W. Kahsai, Kun-Hong Xiao, Wei Kong, Fa-hui Li, Ke Ruan, Zi-jian Li, Xiao Yu, Xiao-gang Niu, Chang-wen Jin, Jiangyun Wang^# & Jin-peng Sun^#. DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl ¹H-NMR probe.  Nature Communications . 2020 Sep 25;11(1):4857.

43. Shaoyong Lu^#, Xinheng He, Zhao Yang, Zongtao Chai, Shuhua Zhou, Junyan Wang, Ashfaq Ur Rehman, Duan Ni, Jun Pu, Jinpeng Sun^#, Jian Zhang^#. Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design.  Nature communications . 2021 Aug 5;12(1):4721.

44. Qing-Tao He, Peng Xiao, Shen-Ming Huang, Ying-Li Jia, Zhong-Liang Zhu, Jing-Yu Lin, Fan Yang, Xiao-Na Tao, Ru-Jia Zhao, Feng-Yuan Gao, Xiao-Gang Niu, Kun-Hong Xiao, Jiangyun Wang^#, Changwen Jin^#, Jin-Peng Sun^#, Xiao Yu^#. Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2.  Nature communications . 2021 Apr 22;12(1):2396.

45. Tuoyi Li, Bing Yu, Zhixin Liu, Jingyuan Li, Mingliang Ma, Yingbao Wang, Mingjiang Zhu, Huiyong Yin, Xiaofeng Wang, Yi Fu, Fang Yu, Xian Wang, Xiaohong Fang, Jinpeng Sun^#, Wei Kong^#. Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury.  Nature Communications . 2018 Jan 2;9(1):11.

46. Xuan Zhang, Guibing Liu, Ya-Ni Zhong, Ru Zhang, Chuan-Cheng Yang, Canyang Niu, Xuanyu Pu, Jingjing Sun, Tianyao Zhang, Lejin Yang, Chao Zhang, Xiu Li, Xinyuan Shen, Peng Xiao^#, Jin-Peng Sun^#, Weimin Gong^#. Structural basis of ligand recognition and activation of the histamine receptor family.  Nature Communications . 2024 Sep 27;15(1):8296.

47. Shen-Ming Huang, Zhi-Zhen Huang, Lei Liu, Meng-Yao Xiong, Chao Zhang, Bo-Yang Cai, Ming-Wei Wang, Kui Cai, Ying-Li Jia, Jia-Le Wang, Ming-Hui Zhang, Yi-He Xie, Min Li, Hang Zhang, Cheng-Hao Weng, Xin Wen, Zhi Li, Ying Sun, Fan Yi, Zhao Yang, Peng Xiao, Fan Yang, Xiao Yu, Lu Tie^#, Bao-Xue Yang^# & Jin-Peng Sun^#. Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters.  Nature Communications . 2024 Nov 26;15(1):10226.

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49. Changxiu Qu, Chunyou Mao, Peng Xiao, Qingya Shen, Ya-Ni Zhong, Fan Yang, Dan-Dan Shen, Xiaona Tao, Huibing Zhang, Xu Yan, Ru-Jia Zhao, Junyan He, Ying Guan, Chao Zhang, Guihua Hou, Peng-Ju Zhang, Guige Hou, Zijian Li, Xiao Yu, Ren-Jie Chai^#, You-Fei Guan, Jin-Peng Sun^#, Yan Zhang^#. Ligand recognition, unconventional activation and G protein coupling of the prostaglandin E₂ receptor 2 EP2 subtype.  Science Advances . 2021 Apr 2;7(14):eabf1268.

50. Yujia Li, Yiqi Duan, Qingqing Chu, Hang Lv, Jing Li, Xiangyun Guo, Yanjiao Gao, Min Liu, Wei Tang, Huili Hu, Hong Liu, Jinpeng Sun^#, Xiaojie Wang^# and Fan Yi^#. G-protein coupled receptor GPR124 protects against podocyte senescence and injury in diabetic kidney disease.  Kidney Int . 2025 Apr;107(4):652-665.

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52. Juliane Lehmann, Hui Lin, Zihao Zhang, Maren Wiermann, Albert M Ricken, Franziska Brinkmann, Jana Brendler, Christian Ullmann, Luisa Bayer, Sandra Berndt, Anja Penk, Nadine Winkler, Franz Wolfgang Hirsch, Thomas Fuhs, Josef Käs, Peng Xiao, Torsten Schöneberg, Martina Rauner, Jin-Peng Sun^#, Ines Liebscher^#. The mechanosensitive adhesion G protein-coupled receptor 133 (GPR133/ADGRD1) enhances bone formation.  Signal Transduction and Targeted Therapy . 2025 Jun 30;10(1):199.

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55. Xiu Li, Xuan Zhang^#, Xin Wen, Daolai Zhang, Changxiu Qu, Xinyi Miao, Wenkai Zhang, Ru Zhang, Guibing Liu, Peng Xiao^#, Jin-Peng Sun^#, Weimin Gong^#. Structural basis for ligand recognition and activation of the prostanoid receptors.  Cell Reports . 2024 Mar 26;43(3):113893.

56. Songbo Zhao, Rongkun Li, Yuan Xia, Xiaojie Wang, Zhiyong Liu, Qingqing Chu, Jiman He, Jiaying Zhang, Yixuan Guo, Youzhao Wang, Jichao Wu, Yan Zhang, Ziying Wang, Zhiyue Zhang, Rui Zeng, Chun Zhang, Jicheng Lv, Jinpeng Sun^#, Wei Tang^#, Fan Yi^#. Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic kidney disease.  Cell Stem Cell . 2025 Sep 4;32(9):1390-1402.e9.

57. Ying Guan, Hai-Bo Du, Zhao Yang, Yu-Zhu Wang, Rui Ren, Wen-Wen Liu, Chao Zhang, Jia-Hai Zhang, Wen-Tao An, Na-Na Li, Xiao-Xue Zeng, Jie Li, Yi-Xiao Sun, Yan-Fei Wang, Fan Yang, Jun Yang, Wei Xiong, Xiao Yu, Ren-Jie Chai, Xiao-Ming Tu^#, Jin-Peng Sun^#, and Zhi-Gang Xu^#. Deafness-Associated ADGRV1 Mutation Impairs USH2A Stability through Improper Phosphorylation of WHRN and WDSUB1 Recruitment.  Advanced Science . 2023 Jun;10(16):e2205993.

58. Qing-Ya Shen, Xin-Yan Tang, Xin Wen, Shi-Zhuo Cheng, Peng Xiao, Shao-Kun Zang, Dan-Dan Shen, Lei Jiang, Yanrong Zheng, Huibing Zhang, Haomang Xu, Chunyou Mao, Min Zhang^#, We-Wei Hu^#, Jin-Peng Sun^#, Yan Zhang^# and Zhong Chen^#. Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.  Advanced Science  (Weinh) . 2024 Jun;11(23):e2310120.

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65. Zhenzhen Zhou, Weifeng Zhang, Fabao Zhao, Yanying Sun, Na Wang, Jie Cheng, Peng Zhan, Fan Yang^#, Jin-Peng Sun^#, Xinyong Liu^# and Dongwei Kang^#. Structure-Based Design of Novel G-Protein-Coupled Receptor TAAR1 Agonists as Potential Antipsychotic Drug Candidates.  Journal of Medicinal Chemistry . 2024 Mar 14;67(5):4234-4249.

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69. Zhao Yang, Fan Yang, Daolai Zhang, Zhixin Liu, Amy Lin, Chuan Liu, Peng Xiao, Xiao Yu, Jin-Peng Sun^#. Phosphorylation of G Protein-Coupled Receptors: From the Barcode Hypothesis to the Flute Model.  Molecular Pharmacology.  2017 Sep;92(3):201-210.

70. Hong-Da Liu, Wen-bo Wang, Zhi-gang Xu^#, Chang-hong Liu, Dong-fang He, Lv-Pei Du, Min-Yong Li, Xiao Yu^#, Jin-peng Sun^#. FFA4 receptor (GPR120): A hot target for the development of anti-diabetic therapies.  European Journal of Pharmacology . 2015 Sep 15;763(Pt B):160-8.

71. Dao-Lai Zhang, Yu-Jing Sun, Ming-Liang Ma, Yi-jing Wang, Hui Lin, Rui-Rui Li, Zong-Lai Liang, Yuan Gao, Zhao Yang, Dong-Fang He, Amy Lin, Hui Mo, Yu-Jing Lu, Meng-Jing Li, Wei Kong, Ka Young Chung, Fan Yi, Jian-Yuan Li, Ying-Ying Qin, Jingxin Li, Alex R B Thomsen, Alem W Kahsai, Zi-Jiang Chen, Zhi-Gang Xu, Mingyao Liu, Dali Li^#, Xiao Yu^#, Jin-Peng Sun ^#. Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.  Elife . 2018 Feb 2;7:e33432.

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73. Yujing Sun, Daolai Zhang, Ming-Liang Ma, Hui Lin, Youchen Song, Junyan Wang, Chuanshun Ma, Ke Yu, Wentao An, Shengchao Guo, Dongfang He, Zhao Yang, Peng Xiao, Guige Hou, Xiao Yu^#, and Jin-Peng Sun^#. Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology.  Journal of Biological Chemistry . 2021 Jan-Jun;296:100174.

74. Jing-Yu Lin, Zhao Yang, Chan Yang, Ji-Xiang Du, Fan Yang, Jie Cheng, Wei Pan, Shi-Jie Zhang, Xu Yan, Jia Wang, Jin Wang, Lu Tie, Xiao Yu^#, Xin Chen^#, and Jin-Peng Sun^#. An ionic lock and a hydrophobic zipper mediate the coupling between an insect pheromone receptor BmOR3 and downstream effectors.  Journal of Biological Chemistry . 2021 Oct;297(4):101160.

75. Duxiao Yang, Peng Xiao, Qing Li, Xiaolei Fu, Chang Pan, Di Lu, Shishuai Wen, Wanying Xia, Dongfang He, Hui Li, Hao Fang, Yuemao Shen, Zhigang Xu, Amy Lin, Chuan Wang, Xiao Yu, Jiawei Wu^#, and Jin-Peng Sun ^#. Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot auto-inhibition and activation.  Journal of Biological Chemistry . 2018 Oct 19;293(42):16226-16241.

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