Xu Zhang, PhD

Assistant Professor | Principal Investigator (PI) | PhD Supervisor

Department of Biophysics, School of Basic Medical Sciences, Peking University Health Science Center; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University

Contact Information

Address: No. 38, Xueyuan Road, Haidian District, Beijing, China

Zip Code: 100191

E-mail: xuzhang@bjmu.edu.cn

Research Interests

l Elucidate the molecular mechanisms by which bioactive lipids drive the development of cardiovascular and metabolic diseases.

l Identify the diagnostic and prognostic value of bioactive lipids using clinical sample–based studies.

l Explore the translational significance of bioactive lipids for therapeutic intervention.

l Develop new methodologies in metabolomics and lipidomics.

Educational experience

2006-2011: Doctor of Science

Institute of Biophysics, Chinese Academy of Sciences, Cell Biology

2002-2006: Bachelor's degree

Wuhan University, Biological Sciences

Research and academic work experience

2025-present: Assistant Professor

Department of Biophysics, College of Basic Medical Sciences, Peking University

2019-2025: Research Professor

Tianjin Medical University, Basic Medical Research Center

2013-2019: Associate Researcher

Tianjin Medical University, Basic Medical Research Center

2011-2013: Postdoctoral Fellow/Assistant Researcher

Department of Physiology and Pathophysiology, Faculty of Medicine, Peking University

Academic Service / Professional Appointments

2023–Present

Biophysical Society of China, Division of Redox Biology and Medicine

Council Member; Chair, Youth Committee

2021–Present

Biophysical Society of China, Division of Metabolic Biology

Youth Committee Member

2019–Present

Biophysical Society of China, Division of Metabolomics

Committee Member

2016–Present

Chinese Society of Pathophysiology, Cardiovascular Committee

Secretary; Committee Member

2014–Present

Chinese Society of Biochemistry and Molecular Biology, Committee on Lipids and Lipoproteins

Youth Committee Member

Selected Publications (Past Five Years)

1. Talabieke S, Yang X, Yang J, Wan Q, Zhu D, Rao H, Wu Y, Chen Z, Li H, Xu P, Chen H, Liu DP, Zhang X*, FitzGerald GA^* and Wang M^*. Arachidonic acid synergizes with aspirin preventing myocardial ischemia-reperfusion injury and mitigates bleeding risk.  Cardiovascular research . 2025.

2. Zhang Y, Yuan M, Cai W, Sun W, Shi X, Liu D, Song W, Yan Y, Chen T, Bao Q, Zhang B, Liu T, Zhu Y, Zhang X* and Li G^*. Prostaglandin I(2) signaling prevents angiotensin II-induced atrial remodeling and vulnerability to atrial fibrillation in mice.  Cell Mol Life Sci . 2024;81:264.

3. Aili A, Wang Y, Shang Y, Zhang L, Liu H, Li Z, Xue L, Chen Y, Sun Y, Zhang X^*, Jin R^* and Chang C^*. LPG 18:0 is a general biomarker of asthma and inhibits the differentiation and function of regulatory T-cells.  Eur Respir J . 2024;64.

4. Peng L, Song Z, Zhao C, Abuduwufuer K, Wang Y, Wen Z, Ni L, Li C, Yu Y, Zhu Y, Jiang H, Shen J, Jiang X, Chen C, Zhang X* and Wang DW^*. Increased Soluble Epoxide Hydrolase Activity Positively Correlates with Mortality in Heart Failure Patients with Preserved Ejection Fraction: Evidence from Metabolomics.  Phenomics (Cham, Switzerland) . 2023;3:34-49.

5. Duan J, Dong W, Wang G, Xiu W, Pu G, Xu J, Ye C, Zhang X*, Zhu Y^* and Wang C^*. Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity.  Nature communications . 2023;14:8151.

6. 13. Cai W, Liu L, Shi X, Liu Y, Wang J, Fang X, Chen Z, Ai D, Zhu Y and Zhang X*. Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting Cardiomyocyte Ferroptosis.  Circulation . 2023;147:1444-1460.

7. Wang H, Shi X, Gao Y, Zhang X, Zhao H, Wang L, Zhang X* and Chen R^*. Polystyrene nanoplastics induce profound metabolic shift in human cells as revealed by integrated proteomic and metabolomic analysis.  Environment international . 2022;166:107349.

8. Ma K, Yang J, Shao Y, Li P, Guo H, Wu J, Zhu Y, Zhang H, Zhang X*, Du J^* and Li Y^*. Therapeutic and Prognostic Significance of Arachidonic Acid in Heart Failure.  Circulation research . 2022;130:1056-1071.

9. Yuan M, Zhang Y, Hua T, Liu XL, Liu T, Yuan RY, Li GP^*, Zhu Y^* and Zhang X*. Omega-3 polyunsaturated fatty acid supplementation improves lipid metabolism and endothelial function by providing a beneficial eicosanoid-pattern in patients with acute myocardial infarction: A randomized, controlled trial.  Clinical nutrition (Edinburgh, Scotland) . 2021;40:445-459.

10. Wang H, Li Q, Zhu Y^* and Zhang X*. Omega-3 Polyunsaturated Fatty Acids: Versatile Roles in Blood Pressure Regulation.  Antioxidants & redox signaling . 2021;34:800-810.

11. Wang C^*, Yang J^* and Zhang X*. Editorial: The Role of Bioactive Lipids in Homeostasis and Pathology.  Frontiers in physiology . 2021;12:773632.

12. Cui Z, Li B, Zhang Y, He J, Shi X, Wang H, Zhao Y, Yao L, Ai D, Zhang X* and Zhu Y^*. Inhibition of Soluble Epoxide Hydrolase Attenuates Bosutinib-Induced Blood Pressure Elevation.  Hypertension (Dallas, Tex : 1979) . 2021;78:1527-1540.

13.  Cai WB, Zhao YJ, Liu L, Cheng Q, Wang J, Shi XL, Yao L, Qiao XH, Zhu Y, Chen C^* and Zhang X^*. Redox environment metabolomic evaluation (REME) of the heart after myocardial ischemia/reperfusion injury.  Free radical biology & medicine . 2021;173:7-18.