Juan Feng, Associate Researcher, Doctoral Supervisor

Independent PI of the Department of Integrated Traditional Chinese and Western Medicine and the National Key Laboratory of Vascular Homeostasis and Remodeling, Peking University Health Science Center

Contact Information

Email: juanfeng@bjmu.edu.cn

Research direction

Integrated traditional Chinese and Western medicine for improving vascular injury and remodeling

Personal Profile

Graduated from the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University in 2009, with a Doctoral degree in "Human Physiology". The research field mainly focuses on the mechanisms and intervention strategies of metabolic vascular injury and repair. In combination with clinical patient and related animal disease model samples of metabolic vascular injury-related diseases, as well as cell experiments, her studies explore new perspectives such as epigenetic modifications of RNA and proteins, remodeling of cellular glucose and lipid metabolism, and regulation of organelle functions. By using methods including single-cell sequencing, cell lineage tracking, targeted intervention with nanomaterials, and multi-omics integration analysis, her studies have revealed the pathological mechanisms of metabolic vascular injury mediated by exosomes, cytokines, active metabolic small molecules and pathogenic antibodies in the immune inflammatory microenvironment for vascular injury repair, and provided potential precise intervention targets and experimental basis for the early warning, diagnosis and treatment of related clinical diseases. So far, 34 SCI research papers have been published, among which 24 are first or corresponding author (including co-authors). Two English reviews are published in SCI journals. As the first or corresponding author (including co-authors), she published 14 Chinese reviews. And she has presided over 11 national and provincial-level funds.

Representative papers (# First Author; * Corresponding Author) 

1. Song Y,^# Yang J, ^# Li T, ^# Sun X, Lin R, He Y, Sun K, Han J, Yang G, Li X, Liu B, Yang D, Dang G, Ma X, Du X, Zhang B, Hu Y, Kong W, Wang X, Zhang H^*,Xu Q^*, Feng J*. CD34⁺ cell-derived fibroblast–macrophage crosstalk drives limb ischemia recovery through the OSM–ANGPTL signaling axis.  Sci Adv.  2023; 9(15): eadd2632.

2. DuX, Ma X, Tan Y, Shao F, Li C, Zhao Y, Miao Y, Han L, Dang G, Song Y, Yang D, Deng Z, Wang Y, Jiang C, Kong W, Feng J*, Wang X^*. B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis.  Signal Transduct Target Ther.  2023; 8:103.

3. Dang G^#, Li T^#, Yang D, Yang G, Du X, Yang J, Miao Y, Han L, Ma X, Song Y, Liu B, Li X, Wang X, Feng J*. T lymphocyte-derived extracellular vesicles aggravate abdominal aortic a 1 neurysm by promoting macrophage lipid peroxidation and migration via pyruvate kinase muscle isozyme 2.  Redox Biol. 2022;50:102257.

4. Luo Y^#, Feng J^#, Xu Q, Wang W*, Wang X*. NSun2 deficiency protects endothelium from inflammation via mRNA methylation of ICAM-1.  Circ Res . 2016;118:944-956.

5. Feng J, Lü S, Ding Y, Zheng M*, Wang X*. Homocysteine activates T cells by enhancing endoplasmic reticulum-mitochondria coupling and increasing mitochondrial respiration.  Protein & Cell.  2016; 7: 391-402. Cover Story