Dr. Tianyun Wang

Assistant Professor, School of Basic Medical Sciences, Peking University

Investigator, Institute of Neuroscience, Peking University

Secretary General, Autism Research Center, Peking University Health Science Center

Contact Information

E-mail：tianyun.wang@pku.edu.cn

Office：B402E Health Science and Technology Building Peking University,

38 Xueyuan Road, Haidian District, Beijing 100191, China

Zip code：100191

E-mail：tianyun.wang@pku.edu.cn

Research Direction

Genetics of neurodevelopmental disorders

Personal Profile

Dr. Tianyun Wang is assistant professor in the Department of Medical Genetics at School of Basic Medical Sciences, investigator in the Neuroscience Research Institute at Peking University, and Secretary General of Autism Research Center at Peking University Health Science Center. His research is focus on investigating the genetic basis and mechanisms for neurodevelopmental disorders, and has published over 40 papers including  Nature Genetics, Nature Communications, PNAS, Annals of Neurology , etc. He is now hosting multiple national grants, and severing as deputy director of the Pediatric Neurodevelopmental and Related Disease Research Professional Committee of the Beijing Neuroscience Society, etc. He was also been named as one of the Global “40 under 40” young researcher by Simons Foundation in 2022.

Experience

2022-             Assistant professor, Medical Genetics, Peking University, Beijing, China

2017-2022  Postdoc fellow, Genome Sciences (Mentor: Evan E. Eichler), University of Washington, Seattle, US

2014-2016 Visiting scholar, Genome Sciences (Mentor: Evan E. Eichler), University of Washington, Seattle, US

2011-2016  Ph.D., Genetics (Mentor: Kun Xia), Central South University, Changsha, China

2007-2011 B.S., Biology, Central South University, Changsha, China

Courses

Medical Genetics、Integrated Experiments in Medical Genetics、Advances in Neuroscience、Autism Spectrum Disorders、Problem-based Learning (PBL)

Grants

1) National Major Science and Technology Project Young Scientist Program, Analysis of Neurobiological Mechanisms of Autism Caused by Genetic Factors and Research on Precision Diagnosis and Treatment Strategies, 2025ZD0218000, 2025-09 to 2030-08, 3,000,000 RMB.

2) National Natural Science Foundation of China (NSFC) General Fund, Identification of mutation hotspots in neurodevelopmental disorders and study of their pathogenic mechanisms, 82471194, 2025-01 to 2028-12, 490,000 RMB.

3) NSFC Excellent Young Scientists Fund Program (Overseas), Genetic Basis and Regulatory Mechanisms of Autism Spectrum Disorders, HY-2023-01, 2024-01 to 2026-12, 2,000,000 RMB.

4) NSFC Young Scientists Fund, The mechanism study of CUL3 and its loss-of-function mutations in autism spectrum disorders, 82201314, 2023-01 to 2025-12, 300,000 RMB.

Representing publications (^#co-first author; ^*Correspondence author)

1) Blackburn, P. R.^#*; Ebstein, F.^#; Hsieh, T. C.^#; Motta, M.; Radio, F. C.; Herkert, J. C.; Rinne, T.; Thiffault, I.; Rapp, M.; Alders, M.; Maas, S.; Gerard, B.; Smol, T.; Vincent-Delorme, C.; Cogne, B.; Isidor, B.; Vincent, M.; Bachmann-Gagescu, R.; Rauch, A.; Joset, P.; Ferrero, G. B.; Ciolfi, A.; Husson, T.; Guerrot, A. M.; Bacino, C.; Macmurdo, C.; Thompson, S. S.; Rosenfeld, J. A.; Faivre, L.; Mau-Them, F. T.; Deb, W.; Vignard, V.; Agrawal, P. B.; Madden, J. A.; Goldenberg, A.; Lecoquierre, F.; Zech, M.; Prokisch, H.; Necpal, J.; Jech, R.; Winkelmann, J.; Koprusakova, M. T.; Konstantopoulou, V.; Younce, J. R.; Shinawi, M.; Mighton, C.; Fung, C.; Morel, C. F.; Lerner-Ellis, J.; DiTroia, S.; Barth, M.; Bonneau, D.; Krapels, I.; Stegmann, A. P. A.; van der Schoot, V.; Brunet, T.; Bussmann, C.; Mignot, C.; Zampino, G.; Wortmann, S. B.; Mayr, J. A.; Feichtinger, R. G.; Courtin, T.; Ravelli, C.; Keren, B.; Ziegler, A.; Hasadsri, L.; Pichurin, P. N.; Klee, E. W.; Grand, K.; Sanchez-Lara, P. A.; Kruger, E.; Bezieau, S.; Klinkhammer, H.; Krawitz, P. M.; Eichler, E. E.; Tartaglia, M.; Kury, S.; Wang, T^*. Loss-of-Function Variants in CUL3 Cause a Syndromic Neurodevelopmental Disorder.  Annals of Neurology  2024. DOI: 10.1002/ana.27077

2) Gao, S.; Shan, C.; Zhang, R.; Wang, T^*. Genetic advances in neurodevelopmental disorders.  Medical Review  2024. DOI: 10.1515/mr-2024-0040

3) Tian, P.; Xu, Y.; Zhang, Y.; Wang, T^*. Genetic diseases are not necessarily inherited: suggestion on its Chinese translation.  Hereditas 2024 . DOI: 10.16288/j.yczz.24-199

4) Ding, Z.^#;  Huang, G.^#;  Wang, T.^#;  Duan, W.;  Li, H.;  Wang, Y.;  Jia, H.;  Yang, Z.;  Wang, K.;  Chu, X.;  Kurtz-Nelson, E. C.;  Ahlers, K.;  Earl, R. K.;  Han, Y.;  Feliciano, P.;  Chung, W. K.;  Eichler, E. E.;  Jiang, M.; Xiong, B., Genetic ablation of GIGYF1, associated with autism, causes behavioral and neurodevelopmental defects in zebrafish and mice.  Biological Psychiatry  2023 .02.993

5) Wang, T.^*; Kim, C. N.; Bakken, T. E.; Gillentine, M. A.; Henning, B.; Mao, Y.; Gilissen, C.; Consortium, S.; Nowakowski, T. J.; Eichler, E. E.^*, Integrated gene analyses of de novo variants from 46,612 trios with autism and developmental disorders.  Proceedings of the National Academy of Sciences  2022 , 119 (46), e2203491119.

6) Zhou, X.^#;  Feliciano, P.^#;  Shu, C.^#;  Wang, T.^#;  Astrovskaya, I.^#;  Hall, J. B.;  Obiajulu, J. U.;  Wright, J. R.;  Murali, S. C.;  Xu, S. X.;  Brueggeman, L.;  Thomas, T. R.;  Marchenko, O.;  Fleisch, C.;  Barns, S. D.;  Snyder, L. G.;  Han, B.;  Chang, T. S.;  Turner, T. N.;  Harvey, W. T.;  Nishida, A.;  O’Roak, B. J.;  Geschwind, D. H.;  The, S. C.;  Michaelson, J. J.;  Volfovsky, N.;  Eichler, E. E.;  Shen, Y.; Chung, W. K., Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes.  Nature Genetics  2022 , 54, 1305–1319.

7) Wang, T.; Zhao, P. A.; Eichler, E. E.^*, Rare variants and the oligogenic architecture of autism.  Trends in Genetics 2022 .03.009

See complete publication list here: https://scholar.google.com/citations?user="vKWiy_EAAAAJ&hl=en