Department of Microbiology
Jie Wang
Jie Wang M.D.
Associate Professor, Doctoral Supervisor
Department of Microbiology & Infectious Disease Center
School of Basic Medical Sciences
Contact Information
Email: wangjie2015@hsc.pku.edu.cn
Main research direction
Hepatitis B virus and virus-associated tumors
1. Diagnosis and treatment of hepatitis B virus infection and its interaction with host factors
2. The mechanism of virus-associated tumors and targeted therapy
Personal Profile
From 2000 to 2005, Bachelor's degree from the Department of Medical Laboratory Science at Tianjin Medical University; From 2005 to 2008, Master's degree from the Department of Microbiology at Peking University; From 2008 to 2010, Visiting scholar from the Department of Molecular Science at University of Tennessee; From 2012 to 2015, Doctor's degree from the Department of Microbiology at Peking University; Since 2015, Lecturer and subsequent Associate Professor in the Department of Microbiology at Peking University. At present, more than 30 SCI papers, including Gut, Journal of Hepatology, Advanced Science, Autophagy, Small, Cell Death & Disease, Oncogene, Journal of Virology, and Emerging Microbes & Infections, have been published as the first or corresponding author, and more than 10 authorized national invention patents have been obtained. Hosted multiple scientific research projects, including the National Natural Science Foundation of China, Natural Science Foundation of Beijing Municipality, Key project (sub project) for departmental integration, and the Ministry of Science and Technology's major special project (task) for infectious disease prevention and control. Currently serving as a member of the Youth Study Group, Hepatitis Study Group, Liver Cancer Study Group, and Liver Disease Basic Medicine and Experimental Diagnosis Collaboration Group of the Hepatology Branch of the Chinese Medical Association, an executive member of the Hepatology Branch of the Beijing Medical Association, a member of the Working Committee for Promoting the Elimination of Viral Hepatitis of the Chinese Preventive Medicine Association, and a member of the Viral Oncology Professional Committee of the Chinese Research Hospital Association.
Representative paper (#First author, * Corresponding author)
1. Yang X # , Sun H, Luo Z, Zhang Q, Song Y, Li J, Liu X, Wang J*. Anticodon engineered transfer RNA (tRNASUAG) inhibits hepatitis B virus replication by promoting the degradation of core protein. Advanced Science. 2025; e03534.
2. Li Z # , Song Y # , Huang H # , Chen R, Liu M, Yang X, Luo Z, Liu BM, Wang J*. Highly stable Cas9 promotes HBV genome destruction by antagonizing HSC70-mediated degradation. Emerging Microbes & Infections. 2025, Sep 4:2556728. doi: 10.1080/22221751.2025.2556728. Online ahead of print.
3. Song Y # , Feng Y # , Jiang Feng # , Xu X # , Yang P # , Liu M, Li L, Du C, Li H, Li Q, Qiao J, Shi J, Yang L, Yao T, Zhang G, Wang J*, Li J*. The HBV seroprevalence and immune responses to hepatitis B vaccination among college students from four universities in China. Vaccine. 2025; 61:127408.
4. Huang H # , Shi W # , Yan H # , Fan L, Lu J, Long Z, Li X, Li J, Wang J*, Liu L*, Qian J*. Dual roles of CXCR4 (C-X-C motif chemokine receptor 4) in promoting entry of ebolavirus and targeting excessive glycoprotein of reticulophagic degradation to facilitate viral fitness. Autophagy. 2025; Apr 20:1-20. doi: 10.1080/15548627.2025.2492877. Online ahead of print.
5. Li Y # , Song Y, Xiao Y, Wang T, Li L, Liu M, Li J*, Wang J*. The characteristic of HBV quasispecies is related to occult HBV infection of infants born to highly viremic mothers. Viruses. 2024; 16(7): 1104.
6. Zheng H#, Liu M#, Shi S#, Huang H, Yang X, Luo Z, Song Y, Xu Q, Li T, Xue L, Lu F, Wang J*. MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2–TGFb2–Smad2/3 signaling pathway in cervical cancer. Mol Oncol. 2024; 18(5):1327-1346.
7. Liu M # , Song Y # , Li Y, Yang X, Zhuang H, Li J*, Wang J*. C2729T mutation associated with HBV mother-to-child transmission reduces HBV production via suppressing LHBs expression. Virulence. 2023; 14(1):2189676.
8. Song Y # , Lu Y, Li Y, Liu M, Zhuang H, Li J*, Wang J*. HBx 128-133 deletion affecting HBV mother-to-child transmission weakens HBV replication via reducing HBx level and CP/ENII transcriptional activity. Viruses. 2022; 14(9):1887.
9. Huang H # , Han Q # , Zheng H, Liu M, Shi S, Zhang T, Yang X, Li Z, Xu Q, Guo H*, Lu F, Wang J*. MAP4K4 mediates the SOX6-induced autophagy and reduces the chemosensitivity of cervical cancer. Cell Death & Disease. 2022; 13(1):13.
10. Yu G # , Chen R, Zheng S, Liu Y, Zou J, Gu Z, Jiang B, Gao Q, Dai L*, Peng J*, Wang J*, Lu F*. A standardized assay for the quantitative detection of serum HBV RNA in chronic hepatitis B patients. Emerging Microbes & Infections. 2022; 11(1):775-785.
11. Li Y # , Xiao Y, Li L, Song Y, Zhai X, Liu J, Duan Z, Yan L, Ding F, Liu J, Zhu L, Jiang J, Zou H, Li L, Liang C, Wang J*, Li J*. The dynamic changes of HBV quasispecies diversity in infancy after immunoprophylaxis failure: a prospective cohort study. Virology Journal. 2021; 18:236.
12. Lu Y # , Song Y # , Zhai X, Zhu F, Liu J, Chang Z, Li Y, Xiao Y, Li L, Liu M, Liu J, Duan Z, Zou H, Zhuang H, Wang J*, Li J*. Maternal Hepatitis B e Antigen can be an Indicator for Antiviral Prophylaxis of Perinatal Transmission of Hepatitis B Virus. Emerging Microbes & Infections. 2021; 10(1):555-564.
13. Xiao Y # , Sun K # , Duan Z, Liu Z, Li Y, Yan L, Song Y, Zou H, Liu J, Zhuang H*, Wang J*, Li J*. Quasispecies characteristic in “a” determinant region is a potential predictor for the risk of immunoprophylaxis failure of mother-to-child-transmission of sub-genotype C2 hepatitis B virus: a prospective nested case-control study. Gut. 2020; 69(5):933-941.
14. Li Y # , Liu Z # , Song Y, Xiao Y, Jiang J, Li L, Zhai X, Liu J, Duan Z, Ding F, Liu J, Zhuang H, Zhu L, Jiang J, Zou H, Wang J*, Li J*. Reduction of the occurrence of occult HBV infection in infants by increasing the dose of hepatitis B vaccine: A large prospective cohort study. Emerging Microbes & Infections. 2020; 9(1):1881-1891.
15. Shi S # , Liu M, Xi J, Liu H, Guan G, Shen C, Guo Z, Zhang T, Xu Q, Kudereti D, Chen X, Wang J*, Lu F*. Sex-determining region Y box 4 (SOX4) suppresses hepatitis B virus replication by inhibiting hepatocyte nuclear factor 4α expression. Antiviral Research. 2020; 176: 104745.
16. Chen R # , Huang H # , Liu H, Xi J, Ning J, Zeng W, Shen C, Zhang T, Yu G, Xu Q, Chen X, Wang J*, Lu F*. Friend or Foe? Evidences Indicate Endogenous Exosomes Can Deliver Functional gRNA and Cas9 Protein. Small . 2019; 15(38): e1902686.
17. Wang J#, Chen R#, Zhang R#, Ding S, Zhang T, Yuan Q, Guan G, Chen X, Zhang T, Zhuang H, Nunes F, Block T, Liu S, Duan Z, Xia N*, Xu Z*, Lu F*. The gRNA-miRNA-gRNA ternary cassette combining CRISPR/Cas9 with RNAi approach strongly inhibits hepatitis B virus replication. Theranostics. 2017; 7(12):3090-3105.
18. Wang J#, Shen T#, Huang X#, Kumar GR#, Chen X, Zeng Z, Zhang R, Chen R, Li T, Zhang T, Yuan Q, Li PC, Huang Q, Colonno R, Jia J, Hou J, McCrae MA, Gao Z*, Ren H*, Xia N*, Zhuang H, Lu F*. Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound. Journal of Hepatology. 2016; 65(4):700-710.
19. Wang J, Ding S, Duan Z, Xie Q, Zhang T, Zhang X, Wang Y, Chen X*, Zhuang H, Lu F*. The role of p14ARF-HDM2-p53 in SOX6-mediated tumor suppression. Oncogene. 2016; 35(13):1692-1702.
20. Wang J, Liu B, Wang N, Lee YM, Liu C, Li K*. TRIM 56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection. Journal of Virology. 2011; 85(8):3733-3745.