Lin Wang, Assistant Professor, PI, Excellent Youth of NSFC

Room 326, Pathology Building, No.38 Xueyuan Road, Beijing

Contact Information

Email: lin_wang@pku.edu.cn

Personal profile

My lab is dedicated to the development of small animal models for Hepatitis E Virus (HEV) and the study of viral pathogenesis and cross-species transmission mechanisms. The following original achievements have been made: ① Established an immunocompetent acute HEV-1 infection  gerbil model, updating the understanding of HEV-1 susceptible host range, and utilized the model to reveal HEV release mechanisms and refine the viral life cycle; ② Developed an immunosuppressed chronic HEV-3 infection rabbit model, using the model to uncover chronic infection mechanisms and identify potential predictive indicator, aiding in the development and application of diagnostic, preventive, and therapeutic strategies; ③ Proposed a new paradigm for constructing animal models of hepatitis virus infection based on a lipid nanoparticle delivery system. I have published research papers as the first or corresponding author (including co-authorship) in  PNAS  (2025),  Gastroenterology  (2024),  Gut  (2017, 2020, 2025),  Hepatology  (2022a, 2022b, 2023), and  Journal of Virology  (2019, 2024). I am the PI of several grants, including National Key R&D Program and the General Program of the National Natural Science Foundation of China, and has been selected for the Excellent Youth of NSFC, Young Elite Scientists Sponsorship Program by the China Association for Science and Technology. Building on previous work, my current interests are: elucidate the key mechanisms determining the host range of HEV; the establishment of an immunocompetent HEV infection mouse model; the establishment of mouse infection models of other major human-pathogenic viruses.

Selected Publications (#co-first author; *corresponding author)

1) Liu T, He Q, Yang X, Li Y, Yuan D, Lu Q, Tang T, Guan G, Zheng L, Zhang H, Xia C, Yin X, Wei G, Chen X, Lu F, Wang Lin*. An Immunocompetent Mongolian Gerbil Model for Hepatitis E Virus Genotype 1 Infection.  Gastroenterology . 2024;167(4):750-763.e10. (With  Editorials )

2) Liu T#, Yang X#, Zhang H, Yin X, Wang Lin*. Prior HEV genotype 1 infection is not protective against rat HEV infection in Mongolian gerbils.  J Hepatol . 2025:S0168-8278(25)02254-8.

3) He Q, Zhang F, Shu J, Li S, Liang Z, Du M, Liu X, Liu T, Li M, Yin X, Pan Q, Lu F*, Wang L*, Wang Lin*. Immunocompromised rabbit model of chronic HEV reveals liver fibrosis and distinct efficacy of different vaccination strategies.  Hepatology . 2022;76(3):788-802. doi:10.1002/hep.32455. (Featured Article)

4) Liu X#, Liu T#, Shao Z, Xiong X, Qi S, Guan J, Wang M, Tang YD, Feng Z, Wang Lin*, Yin X*. Palmitoylation-dependent association with Annexin II directs hepatitis E virus ORF3 sorting into vesicles and quasi-enveloped virions.  PNAS . 2025;122(1):e2418751122.

5) Liu T#, Li J#, Yin X, Lu F, Zhao H, Wang Lin*, Qin CF*. Establishment of enterically transmitted hepatitis virus animal models using lipid nanoparticle-based full-length viral genome RNA delivery system.  Gut . 2025;74(3):467-476. (Featured Video)

6) Chen Z#, Wang L#, Zhang Y#, Li G#, Yin J, Fan J, Liu T, Wu H, Huang Y, Huang W, Liu D, Zheng X, Zang X, Huang X, Song L, Wen S, Li J, Ying D, Fang M, Wang Y, Wu T, Sridhar S, Zhang J, Xia N*, Wang Lin*, Lu Y*, Zheng Z*. Substantial spillover burden of rat hepatitis E virus in humans.  Nat Commun . 2025;16(1):4038.

7) He Q, Liu T, Yang X, Yuan D, Lu Q, Li Y, Zhang H, Liu X, Xia C, Sridhar S, Tian L, Liu X, Meng L, Ning J, Lu F, Wang L, Yin X, Wang Lin*. Optimization of immunosuppression strategies for the establishment of chronic hepatitis E virus infection in rabbits.  J Virol . 2024;98(7):e0084624.

8) Ying D#, He Q#, Tian W#, Chen Y#, Zhang X, Wang S, Liu C, Chen Z, Liu Y, Fu L, Yan L, Wang L, Tang Z*, Wang Lin*, Zheng Z*, Xia N*. Urine is a viral antigen reservoir in hepatitis E virus infection.  Hepatology . 2023;77(5):1722-1734. doi:10.1002/hep.32745. (With  Editorials )