Department of Neurobiology
Fengyu Liu
Liu Fengyu, Ph.D., Associate Professor
Neuroscience Research Institute Peking University
38 Xueyuan Road Beijing 100191, China
Contact Information
Tel: + 86(0)10 8280 1067
Email: liufyu@bjmu.edu.cn
Education
Sep, 2002-Jun, 2005 |
Ph.D., Neuroscience Research Institute, Peking University |
Sep, 1999-Jun, 2002 |
M.S., Department of Physiology, Shandong University |
Sep, 1994-Jun, 1999 |
B.M., Nursing School, Shandong Medical University |
Work Experience
Aug, 2013-present |
Associate Professor Neuroscience Research Institute, Peking University |
Aug, 2018-Aug, 2020 |
Visiting Scholar The Solomon H. Snyder Department of Neuroscience Johns Hopkins University, School of Medicine Advisor: Prof. Dong Xingzhong |
Aug, 2005-Jul, 2013 |
Assistant Professor Neuroscience Research Institute, Peking University |
Sep, 2010-Nov, 2011 |
Visiting Scholar Department of Physiology, University of Hong Kong Advisor: Prof. Chen Yingcheng |
Research Interest
With combinative application of opto- and chemo-genetics, two-photon calcium imaging, in vivo and in vitro electrophysiology, my study focuses on neuronal and circuitry basis of chronic pain and Learning and memory disorders.
Grants
1. 01/2022-12/2025, Synchronized activity of primary sensory neurons in dorsal root ganglion contributes to neuropathic pain. National Natural Science Foundation of China (NSFC). Principal Investigator: Feng-Yu Liu
2. 01/2024-12/2026, Development of multifunctional brain-computer interface platform based on transparent cranial window and its application on cerebral engram cells in chronic pain. Beijing Natural Science Foundation. Principal Investigator: Feng-Yu Liu
3. 05/2018-04/2023, Transmission of information from the optic nervous system. National Key R&D Program of China. Core Instructor: Feng-Yu Liu
4. 01/2018-12/2018, Investigation on the pathogenesis and diagnostic significance of Ubiquitin Carboxyl Hydrolase L1 and its autoantibody in neuropsychiatric systemic lupus erythematosus. The Interdisciplinary Medicine Seed Fund of Peking University. Co-Principal Investigator: Feng-Yu Liu
5. 01/2014-12/2014, Molecular mechanisms of Cav3.2 T-type calcium channels in peripheral injured and uninjured neurons and nerve fibers in neuropathic pain. National Natural Science Foundation of China (NSFC), Exploration Program. Principal Investigator: Feng-Yu Liu
6. 01/2009-12/2011, Endogenous formaldehyde induces bone cancer pain through the transient receptor potential vanilloid 1 receptor (TRPV1). the Key Project of Chinese Ministry of Education. Principal Investigator: Feng-Yu Liu
7. 01/2007-12/2009, Activation of satellite glial cells in dorsal root ganglia after spinal nerve ligation and their possible role in neuropathic pain. National Natural Science Foundation of China (NSFC), Young Scientist Fund. Principal Investigator: Feng-Yu Liu
8. 06/2006-07/2008, Activation of satellite glial cells in dorsal root ganglia after spinal nerve ligation and their possible role in neuropathic pain. The Research Fund of 985 for the Young talents of School of Basic Medical Sciences in Peking University. Principal investigator: Feng-Yu Liu
Representative publications
1. Jia-Xin Wang, Shuai-Xin Gao, Su Fu, Ya-Wei Li, Li Su, Xiao-Man Li, Guang-Hao Wu, Jian-Kuo Jiang, Zi-Fang Zhao, Chao-Juan Yang, Xiao-Yi Wang, Kun Cui, Xiao-Yan Sun, Xue-Tao Qi, Cheng Wang, Hao-Jie Sun, Shan Shao, Yue Tian, Ting-Ting Gong, Jian-Yuan Luo, Jie Zheng, Shuang Cui, Fei-Fei Liao, Feng-Yu LiuCA, Dong-Xin WangCA, Catherine C.L. WongCA, Ming YiCA, You WanCA. Irisin reprograms microglia through activation of STAT6 and prevents cognitive dysfunction after surgery in mice. Brain behavior and immunity. 2025; 125:68-91.
2. Bo Cao*, Qi-Xuan Xu*, Ya-Jiao Shi*, Rui-Yang Zhao*, Hang-Hang Li*, Jie Zheng, Feng-Yu LiuCA, You WanCA, Bo WeiCA. Pathology of pain and its implications for therapeutic interventions. Signal Transduction and Targeted Therapy. 2024; 9(1):155.
3. Su Fu*, Hao-Jie Sun*, Jia-Xin Wang, Shuai-Xin Gao, Liu Zhu, Kun Cui, Shi-Meng Liu, Xue-Tao Qi, Rui Guan, Xiao-Cen Fan, Qing-Ying Liu, Wen Chen, Li Su, Shuang Cui, Fei-Fei Liao, Feng-Yu LiuCA, Catherine C L WongCA, Ming YiCA, You WanCA. Impaired neuronal macroautophagy in the prelimbic cortex contributes to comorbid anxiety-like behaviors in rats with chronic neuropathic pain. Autophagy. 2024; 20(7):1559-1576.
4. Na-Na Yang, Feng-Yu LiuCA, Xin-Yue Zhang, Chen-Ni Chen, Zhi-Yuan Xia, Su Fu, Jia-Xin Wang, Jing-Jing Xu, Shuang Cui, Yong Zhang, Ming Yi, You Wan, Qing Li, Sheng-Yong XuCA. A hybrid titanium-softmaterial, high-strength, transparent cranial window for transcranial injection and neuroimaging. Biosensors (Basel) 2022; 12(2):129.
5. Na-Na Yang, Qing LiCA, Xin-Yue Zhang, Jing-Jing Xu, Sheng-Yong Xu, Feng-Yu LiuCA. From transparent cranial windows to multifunctional smart cranial platforms. Electronics 2022; 11: 2559.
6. Qing-Ying Liu*, Wen Chen*, Xiao-Cen Fan, Jia-Xin Wang, Su Fu, Shuang Cui, Fei-Fei Liao, Jie Cai, Xin-Hong Wang, Yan-Hua Huang, Li Su, Li-Jun Zhong, Ming Yi, Feng-Yu LiuCA, You WanCA. Upregulation of interleukin-6 on Cav3.2 T-type calcium channels in dorsal root ganglion neurons contributes to neuropathic pain in rats with spinal nerve ligation. Experimental Neurology. 2019; 317:226-243.
7. Wen Chen*, Ye-Nan Chi*, Xue-Jing Kang, Qing-Ying Liu, Hao-Lin Zhang, Zhi-Hua Li, Zi-Fang Zhao, Yin Yang, Li Su, Jie Cai, Fei-Fei Liao, Ming Yi, You WanCA, Feng-Yu LiuCA. Accumulation of Cav3.2 T-type calcium channels in the uninjured sural nerve contributes to neuropathic pain in rats with spared nerve injury. Frontiers in Molecular Neuroscience. 2018; 11:24.
8. Qing-Ying Liu, Wen Chen, Shuang Cui, Fei-Fei Liao, Ming Yi, Feng-Yu LiuCA, You WanCA. Upregulation of Cav3.2 T-type calcium channels in adjacent intact L4 dorsal root ganglion neurons in neuropathic pain rats with L5 spinal nerve ligation. Neuroscience Research. 2019; 142:30-37.
9. Jia Liu*, Feng-Yu Liu*, Zhi-Qian Tong, Zhi-Hua Li, Wen Chen, Wen-Hong Luo, Hui Li, Hong-Jun Luo, Yan Tang, Jun-Min Tang, Jie Cai, Fei-Fei Liao, You WanCA. Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats. Plos One. 2013; 8(3):e58957.
10. Feng-Yu Liu*, Yan-Ni Sun*, Fa-Tian Wang*, Qian Li, Li Su, Zi-Fang Zhao, Xiang-Ling Meng, Hong Zhao, Xi Wu, Qian Sun, Guo-Gang XingCA, You WanCA. Activation of satellite glial cells in lumbar dorsal root ganglia contributes to neuropathic pain after spinal nerve ligation. Brain Research. 2012; 1427:65-77.
11. Feng-Yu Liu, Xiao-Xiu Qu, Jie Cai, Fa-Tian Wang, Guo-Gang Xing, You WanCA. Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation. Neuroscience Bulletin. 2011; 27(1):1-8.
12. Feng-Yu Liu*, Xiao-Xiu Qu*, Xu Ding*, Jie Cai, Hong Jiang, You Wan, Ji-Sheng Han, Guo-Gang XingCA. Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation. Brain Research. 2010; 1330:45-60.
13. Feng-Yu Liu*, Guo-Gang Xing*, Xiao-Xiu Qu, Isabella Shi Xu, Ji-Sheng Han, You WanCA. Roles of 5-HT receptor subtypes in the inhibitory effects of 5-HT on the C-fiber responses of the spinal wide dynamic range neurons in rats. Journal of Pharmacology and Experimental Therapeutics. 2007; 321(3):1046-1053.
14. Feng-Yu Liu, Chuan-Yong LiuCA, Jing-Zhang Liu, Dong-Ping Xie. The caudal ventrolateral medulla participates in the regulation of gallbladder motility in rabbits. Chinese Journal of Physiology. 2004; 47(1):1-6.
15. Long-Yu Ma*, Lu-Peng Yue*, Shu-Ting Liu, Shi Xu, Ji-Fu Tong, Xiao-Yan Sun, Li Su, Shuang Cui, Feng-Yu Liu, You WanCA, Ming YiCA. A distinct neuronal ensemble of prelimbic cortex mediates spontaneous pain in rats with peripheral inflammation. Nature Communications. 2024; 15(1):7922.
16. Kun Cui, Xue-Tao Qi, Zi-Long Liu, Wei-Qi Sun, Pei-Jie Jiao, Chang Liu, Ji-Fu Tong, Xiao-Yan Sun, Hao-Jie Sun, Su Fu, Jia-Xin Wang, Ya-Wen Zheng, Tian-Yu Liu, Shuang Cui, Feng-Yu Liu, Jian Mao, Jie Zheng, You WanCA, Ming YiCA. Dominant activities of fear engram cells in the dorsal dentate gyrus underlie fear generalization in mice. PLoS Biol. 2024; 22(7):e3002679.
17. Zhi-Ling Zhang, Zi-Yang Wu, Feng-Yu Liu, Hang-Yu Chen, Suo-Di ZhaiCA. Tetrandrine alleviates oxaliplatin-induced mechanical allodynia via modulation of inflammation-related genes. Frontiers in Molecular Neuroscience. 2024; 17:1333842.
18. Yu-Xin Wan, Cai-Yi Wang, Bin-Gao Zhang, Yi-Xuan Liu, Hai-Long Yang, Feng-Yu Liu, Jing-Jing Xu, Sheng-Yong XuCA. Biocompatible electrical and optical interfaces for implantable sensors and devices. Sensors (Basel). 2024; 24(12):3799.
19. Long-Yu Ma, Lu-Peng Yue, Shu-Ting Liu, Yu Zhang, Meng Zhang, Shuang Cui, Feng-Yu Liu, Ming YiCA, You WanCA. Dynamic changes of the infralimbic cortex and its regulation of the prelimbic cortex in rats with chronic inflammatory pain. 2024. Neuroscience Bulletin. 2024; 40(7):872-886.
20. Xue-Tao Qi*, Shu-Lu Yuan*, Jiu-Yang Ding*, Wei-Qi Sun, Ya-Jiao Shi, Yuan-Wei Xing, Zi-Long Liu, Yun Yao, Su Fu, Bao-Fei Sun, Xiao-Lan Qi, Bing Xia, Feng-Yu Liu, Ming Yi, Jian Mao, You WanCA, Jie ZhengCA. Emerging signs of Alzheimer-like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID-19. Aging Cell. 2024; e14352.
21. Ya-Wen Zheng*, Shan Sha*, Yu Zhang, Shu-Lu Yuan, Yuan-Wei Xing, Jia-Xin Wang, Xue-Tao Qi, Kun Cui, Ji-Fu Tong, Feng-Yu Liu, Shuang Cui, You Wan, Ming YiCA. HCN2 channels in the ventral hippocampal CA1 regulate nociceptive hypersensitivity in mice. International Journal of Molecular Sciences. 2023; 24(18):13823.
22. Yue Wang, Nai-Zheng Liu, Long-Yu Ma, Lu-Peng Yue, Shuang Cui, Feng‑Yu Liu, Ming Yi, You WanCA. Ventral hippocampal CA1 pyramidal neurons encode nociceptive information. Neuroscience Bulletin. 2024 Feb;40(2):201-217.
23. Yu-Qi Zhang, Long-Yu Ma, Xue-Ying Zhang, Lu-Peng Yue, Jia-Xin Wang, Jie Zheng, Shuang Cui, Feng-Yu Liu, Zhi-Yan WangCA, You WanCA, Ming YiCA. Deep brain stimulation in the lateral habenula reverses local neuronal hyperactivity and ameliorates depression-like behaviors in rats. Neurobiology of Disease. 2023; 180:106069.
24. Xue-Tao Qi, Kun Cui, Yu Zhang, Lin-Shu Wang, Ji-Fu Tong, Wei-Qi Sun, Shan Shao, Jia-Xin Wang, Cheng Wang, Xiao-Yan Sun, Li-Ming Xiao, Ke Xi, Shuang Cui, Feng-Yu Liu, Long-Yu Ma, Jie Zheng, Ming YiCA, You WanCA. A nociceptive neuronal ensemble in the dorsomedial prefrontal cortex underlies pain chronicity. Cell Reports. 2022; 41(11):111833.
25. Bin-Xuan Han, Shuang Cui, Feng-Yu Liu, You Wan, Yan ShiCA, Ming YiCA. Suppression of ventral hippocampal CA1 pyramidal neuronal activities enhances water intake. Am J Physiol Cell Physiol. 2021; 321(6):C992-C999.
26. Hao-Jie Sun, Su Fu, Shuang Cui, Xiang-Sha Yin, Xiao-Yan Sun, Xue-Tao Qi, Kun Cui, Jia-Xin Wang, Long-Yu Ma, Feng-Yu Liu, Fei-Fei Liao, Xin-Hong Wang, Ming YiCA, You WanCA. Development of a CRISPR-SaCas9 system for projection- and function-specific gene editing in the rat brain. Science Advances. 2020; 6(12):eaay6687.
27. Ran Huo*, Song-Ping Han*, Feng-Yu Liu, Xiao-Jing Shou, Ling-Yu Liu, Tian-Jia Song, Fu-Jun Zhai, Rong Zhang, Guo-Gang XingCA, Ji-Sheng HanCA. Responses of primary afferent fibers to acupuncture-like peripheral stimulation at different frequencies: characterization by single-unit recording in rats. Neuroscience Bulletin. 2020; 36(8):907-918.
28. Jun Ma*, Zi-Fang Zhao*, Shuang Cui, Feng-Yu Liu, Ming Yi, You WanCA. A novel 3D-printed multi-drive system for synchronous electrophysiological recording in multiple brain regions. Frontiers in Neuroscience. 2019; 13:1322.
29. Long-Yu Ma*, Lu-Peng Yue*, Yu-Qi Zhang, Yue Wang, Bing-Xuan Han, Shuang Cui, Feng-Yu Liu, You WanCA, Ming YiCA. Spontaneous pain disrupts ventral hippocampal CA1-infralimbic cortex connectivity and modulates pain progression in rats with peripheral inflammation. Cell Reports. 2019; 29(6):1579-1593.
30. Guo-Gang XingCA, Feng-Yu Liu, Xiao-Xiu Qu, Ji-Sheng Han, You WanCA. Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain. Experimental Neurology. 2007; 208(2):323-332.