Yun Wang, MD, PhD

Yun Wang is a Boya Distinguished Professor & principal investigator at the McGovern Institute for Brain Research at Peking University, and a recipient of the National Distinguished Young Scholars award. She is also a Chang Jiang Distinguished Professor (Ministry of Education) and currently serves as Vice Dean of Peking University’s Advanced Institute of Clinical Medicine and Deputy Director of the Institute of Neuroscience

Contact information

Address: 38 XueYuan Road, Haidian District, Beijing, China

Phone: 8610-82801119 (O)

Email: wangy66@bjmu.edu.cn

Research Directions

Pain coding, neural development and injury, and molecular and circuit mechanisms of major brain disorders

The research group primarily studies cell signaling in the nervous system. Using an integrated, multidisciplinary approach, we combine molecular biology, biochemistry, genetics, electrophysiology, morphology, and behavioral methods to carry out the following two main lines of work:

1. Cell signaling pathways of pain and pain modulation

We use chronic pathological pain models to investigate plastic changes occurring in peripheral and central neurons within pain transmission pathways. Focusing on protein kinases as central molecules in cellular signal transduction, we examine the specific signaling pathways that underlie chronic pain, pain-related negative affect, and pain memory formation. The goal is to identify novel analgesic targets or analgesic compounds and to provide new strategies for addressing clinical pain management.

2. Neural development, injury repair, and mechanisms of major brain diseases

Using both in vitro cell culture and in vivo animal models, we investigate key molecules involved in neural developmental processes—such as neuronal polarity establishment, migration, dendritic development, synapse formation, and synaptic pruning—as well as molecular mechanisms shared with peripheral nerve repair after injury. We also study critical molecules in neuronal ischemic injury and neuroprotection. The aim is to elucidate the pathological mechanisms of congenital neurodevelopmental disorders, neurodegenerative diseases, and acquired neural injuries (e.g., mechanical or ischemic damage), identify key molecular players, and design potential intervention strategies to suggest new therapeutic approaches for common clinical neuropsychiatric disorders.

Personal Profile

Yun Wang is a Boya Distinguished Professor at Peking University, a Principal Investigator at the McGovern Institute for Brain Research (Peking University), a recipient of the National Science Fund for Distinguished Young Scholars, and a Chang Jiang Distinguished Professor appointed by the Ministry of Education. She currently serves as Vice Dean of the Advanced Institute of Clinical Medicine at Peking University and Deputy Director of the Institute of Neuroscience.

She also holds multiple academic appointments: President of the Chinese Association for Physiological Sciences; First Vice President of the Asia-Pacific Association for Physiological Sciences; Vice Chair of the Teaching Guidance Committee for Basic Medical Sciences, Ministry of Education; Secretary General of the Chinese Branch of the International Neuropeptide Society; and Executive Committee Member of the Chinese Society for Neuroscience.

Her long-term research interests focus on pain coding, neural development, injury and repair, and the mechanisms of neurodevelopmental and other major brain disorders. Her laboratory employs multidisciplinary approaches to study cellular signal transduction in the nervous system, integrating molecular biology, biochemistry, genetics, electrophysiology, morphology, and behavioral analysis.

As principal investigator, she has led over 30 national grants, including major projects under the National Key Research and Development Program (e.g., the Brain Science and Brain-Inspired Intelligence project of the Innovation 2030 Initiative), key and major international cooperation projects of the National Natural Science Foundation of China, and subprojects of the Ministry of Science and Technology’s 973 Program. She has published nearly 80 SCI-indexed papers in high-impact international journals such as Advanced Science, Nature Communications, Molecular Psychiatry, Science Signaling, and The Journal of Neuroscience; several of her articles have been highlighted or recommended by Pain Research Forum, Faculty of 1000, and Nature China. She has filed nine Chinese invention patent applications, seven of which have been granted.

Education

1984-1989	Bachelor's Degree, Jiangxi Medical College,
1989-1992	Master's Degree Program, Beijing Medical University
1993-1996	Doctoral Program in Neuroscience, Beijing Medical University

Professional Experience

2023- now   Associate dean of the Institute of Advanced Clinical Medicine, Peking University

2013-2023  Associate dean of the School of Basic Medical Sciences and vice director of Neuroscience Research Institute, Peking University

2004-present	Professor and vice director of Neuroscience Research Institute, Peking University
1999-2004	Associate professor, Neuroscience Research Institute, Peking University
2000-2002	NCI, NIH, USA. Visiting scientist
1992-1999	Lecturer, Neuroscience Research Institute, Beijing Medical University

Current funding

2025.01-2029.12	The mechanisms of neural plasticity in psychiatric diseases	Key International Cooperation program of the National Natural Science Foundation of China(Grant NO. W2411014)	PI	RMB: 2,400,000
2021.11-2026.11	Regulatory Mechanisms and Intervention Strategies for Pain-Emotion Interaction in Physiological and Pathological States	Scientific and Technological Innovation 2030 - "Brain Science and Brain-Inspired Research" Major Project (Grant NO2021ZD0203200)	PI	RMB: 35,000,000
2021.1-2025.12	The neural circuit mechanisms of allodynia	State Key Program of National Natural Science of China (Grant NO. 32030052)	PI	RMB: 2,980,000

Awards and honors

2024 — Peking University Teaching Achievement Award

2024 — Boya Distinguished Professor for Curriculum/Textbook Development, Peking University

2023 — Principal Instructor, First-Class Offline Course (Ministry of Education)

2022 — Principal Instructor, High‑Quality Undergraduate Course (Beijing Higher Education)

2020 — Leader, Outstanding Undergraduate Education Team (Beijing Higher Education)

2017 — Five Continents Women’s Science & Technology Award, Chinese Female Physicians Association

2016 — Recipient of the Special Government Allowance from the State Council

2013 — Chang Jiang (Yangtze River) Distinguished Professor, Ministry of Education’s Chang Jiang Scholars Program

2013 — Beijing Higher Education Teaching Master Award

2013 — First Prize, Beijing Municipal Education and Teaching Achievement Award, for “Construction and Practice of an Innovative Talent‑Training System for Undergraduate Basic Medical Education”

2012 — One of Peking University’s Top Ten Teachers

2011 — “Education Pioneer — Outstanding Individual in Teaching and Moral Education,” Beijing Education Trade Union

2011 — Zhang Xiangtong Young Neuroscientist Award (2011)

2010 — National Science Fund for Distinguished Young Scholars (National Distinguished Young Scholar Award)

2010 — National Honorary Title: Outstanding Science and Technology Worker (National)

2001 — Excellent Young Teacher Award, Ministry of Education (Higher Education Institutions)

Representative research paper (CA responsible author)

1. Xiang-Sha Yin, Bai-Rong Chen, Xi-Chun Ye, Yun Wang^CA. Modulating the Pronociceptive Effect of Sleep Deprivation: A Possible Role for Cholinergic Neurons in the Medial Habenula.  Neurosci Bull.  2024 Dec;40(12):1811-1825. doi: 10.1007/s12264-024-01281-4. Epub 2024 Aug 19.

2. Yaming Yang, Bai-Rong Chen Xi-Chun Ye, Liang-Yu Ni, Xi-Yin Zhang, Yun-Ze Liu, Tian-Jie Lyu, Yue Tian, Yun-Jie Fu, Yun Wang^CA. Chromodomain protein CDYL confers forebrain identity to human cortical organoids by inhibiting neuronatin.  Cell Reports  Cell Rep. 2024 Oct 22;43(10):114814. doi: 10.1016/j.celrep.2024.114814. Epub 2024 Oct 7.

3. Chen BR, Wu T, Chen TH, Wang Y^CA. Neuroimmune interactions and their roles in neurodegenerative diseases.  Fundamental Research . 2024 March 251-261. doi: 10.1016/j.fmre.2023.04.002 (invited review).

4. Lyu TJ, Ma J, Zhang XY, Xie GG, Liu C, Du J, Xu YN, Yang DC, Cen C, Wang MY, Lyu NY, Wang Y^CA, Zhang HQ^CA. Deficiency of FRMD5 results in neurodevelopmental dysfunction and autistic-like behavior in mice.  Mol Psychiatry . 2024, 29:1253–1264. Jan 16. doi: 10.1038/s41380-024-02407-w. Epub ahead of print. PMID: 38228891.

5. Huan-Yu Zheng, Yu-Meng Chen, Yao Xu, Cheng Cen^CA, Yun Wang^CA. Excitatory neurons in the lateral parabrachial nucleus mediate the interruptive effect of inflammatory pain on a sustained attention task.  J Transl Med.  2023 Dec 10;21(1):897. doi: 10.1186/s12967-023-04778-0.

6. Chen Q, Zhang XY, Wang YP, Fu YJ, Cao F, Xu YN, Kong JG, Tian NX, Xu Y, Wang Y^CA. Unveiling adcyap1 as a protective factor linking pain and nerve regeneration through single-cell RNA sequencing of rat dorsal root ganglion neurons.  BMC Biol.  2023 Oct 25;21(1):235.

7. Kong JG, Mei Z, Zhang Y, Xu LZ, Zhang J^CA, Wang Y^CA. CDYL knockdown reduces glioma development through an antitumor immune response in the tumor microenvironment.  Cancer Lett.  2023 Jul 28;567:216265. doi: 10.1016/j.canlet.2023.216265. Epub 2023 Jun 9.PMID: 37302564.

8. Sun ZW, Waybright JM, Beldar S, Chen L, Foley CA, Norris-Drouin JL, Lyu TJ, Dong A, Min J, Wang YP, James LI^CA, Wang Y^CA. Cdyl deficiency brakes neuronal excitability and nociception through promoting Kcnb1 transcription in peripheral sensory neurons.  Adv Sci  (Weinh). 2022 Feb 4:e2104317. doi: 10.1002/advs.202104317. Online ahead of print.PMID: 35119221.

9. Wang F, Yin XS, Lu J, Cen C^CA and Wang Y^CA. Phosphorylation-dependent positive feedback on the oxytocin receptor through the kinase PKD1 contributes to long-term social memory.  Sci Signal.  2022 Feb;15(719):eabd0033. doi: 10.1126/scisignal.abd0033. Epub 2022 Feb 1.

10. Liu L, Liu TT, Xie GG, Zhu XQ, Wang Y^CA.  Ubiquitin ligase TRIM32 promotes dendrite arborization by mediating degradation of the epigenetic factor CDYL.  FASEB J.  2022 Jan;36(1):e22087. doi: 10.1096/fj.202100031RR.PMID: 34888944

11. Dong C, Liu Y, Lyu TJ, Beldar S, Lamb KN, Tempel W, Li Y, Li Z, James LI, Qin S^CA, Wang Y^CA, Min J^CA. Structural Basis for the Binding Selectivity of Human CDY Chromodomains.  Cell Chem Biol.  2020 Jul 16;27(7):827-838.e7. doi: 10.1016/j.chembiol.2020.05.007. Epub 2020 May 28.

12. Liu H, Su D, Liu L, Chen L, Zhao Y, Chan SO, Zhang W, Wang Y^CA, Wang J^CA. Identification of a new functional domain of Nogo-A that promotes inflammatory pain and inhibits neurite growth through binding to NgR1.  FASEB J.  2020 Jun 29. doi: 10.1096/fj.202000377R. Online ahead of print.

13. Huang S, Zheng C, Xie G, Song Z, Wang P, Bai Y, Chen D, Zhang Y, Lv P, Liang W, She S, Li Q, Liu Z, Wang Y, Xing GG^CA, Wang Y^CA. FAM19A5/TAFA5, a novel neurokine, plays a crucial role in depressive-like and spatial memory-related behaviors in mice.  Mol Psychiatry.  2020 Apr 21. doi: 10.1038/s41380-020-0720-x. Online ahead of print.

14. Yin XS, Yang JY, Cao S, Wang Y^CA. Failure of Placebo Analgesia Model in Rats with Inflammatory Pain.  Neurosci Bull.  2020 Feb;36(2):121-133. doi: 10.1007/s12264-019-00420-6. Epub 2019 Aug 21.

15. Li WQ, Luo LD, Hu ZW, Lyu TJ, Cen C, Wang Y^CA. PLD1 promotes dendritic spine morphogenesis via activating PKD1.  Mol Cell Neurosci.  2019 Sep;99:103394. doi: 10.1016/j.mcn.2019.103394. Epub 2019 Jul 26.

16. Liu J, Du J, Wang Y^CA. CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2μ2.  Sci Signal.  2019 Jun 11;12(585). pii: eaaw2040. doi: 10.1126/scisignal.aaw2040.

17. Xu Y, Tian NX, Bai QY, Chen Q, Sun XH, Wang Y^CA. Gait Assessment of Pain and Analgesics: Comparison of the DigiGait™ and CatWalk™ Gait Imaging Systems.  Neurosci Bull.  2019 Jun;35(3):401-418. doi: 10.1007/s12264-018-00331-y. Epub 2019 Jan 18.

18. Hu F, Liu HC, Su DQ, Chen HJ, Chan SO, Wang Y^CA, Wang J^CA. Nogo-A promotes inflammatory heat hyperalgesia by maintaining TRPV-1 function in the rat dorsal root ganglion neuron.  FASEB J . 2019 Jan;33(1):668-682. doi: 10.1096/fj.201800382RR. Epub 2018 Jul 19. PMID:30024789

19. Guo YP, Zhi YR, Liu TT, Wang Y, Zhang Y^CA. Global Gene Knockout of Kcnip3 Enhances Pain Sensitivity and Exacerbates Negative Emotions in Rats.  Front Mol Neurosci.  2019 Jan 25;12:5. doi: 10.3389/fnmol.2019.00005. eCollection 2019. PMID: 30740043

20. Duo L, Hu L, Tian N, Cheng G, Wang H, Lin Z, Wang Y^CA, Yang Y^CA. TRPV1 gain-of-function mutation impairs pain and itch sensations in mice. Mol Pain. 2018 Jan-Dec;14:1744806918762031. doi: 10.1177/1744806918762031. Epub 2018 Feb 9.

21. Tian NX, Xu Y, Yang JY, Li L, Sun XH, Wang Y^CA and Zhang Y^CA. KChIP3 N-terminal 31-50 fragment mediates its association with TRPV1 and alleviates inflammatory hyperalgesia in rats.  J Neurosci.  2018 Jan 15. pii: 2242-17. doi: 10.1523/JNEUROSCI.2242-17.2018. [Epub ahead of print] PMID: 29335353.

22. Cen C, Luo LD, Li WQ, Li G, Tian NX, Zheng G, Yin DM, Zou YM, Wang Y^CA. PKD1 promotes functional synapse formation coordinated with N-cadherin in hippocampus.  J Neurosci.  2018 Jan 3; 38(1):183-199.

23. Luo LD, Li G, Wang Y^CA. PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage.  Scientific Reports.  2017 Jul 20; 7(1):6035. doi: 10.1038/s41598-017-06121-2.

24. Huang M, Cheng G, Tan H, Qin R, Zou Y, Wang Y^CA, Zhang Y^CA. Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors.  Exp Neurol.  2017 Sep;295:66-76. doi: 10.1016/j.expneurol.2017.05.001. Epub 2017 May 4.

25. Qin R, Cao S, Lyu T, Qi C, Zhang W, Wang Y^CA. CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy.  Cell Rep.  2017 Jan 10;18(2):380-390. doi: 10.1016/j.celrep.2016.12.043.

26. Zhang C, Lu J, Liu B, Cui Q^CA, Wang Y^CA. Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease.  Aging  (Albany NY). 2016 Feb;8(2):272-90.

27. Liu J, Du J, Yang Y, Wang Y^CA. Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia.  Exp Neurol  .  2015 Nov;273:253-62. doi: 10.1016/j.expneurol.2015.09.005. Epub 2015 Sep 12.

28. Wang Y. FXYD2: a promising drug target for inflammatory mechanical pain therapy.  Science Bulletin  2015, 60(9):896-898. (Research Highlight )

29. Wang GQ, Cen C, Cao S, Li C, Wang N, Zhou Z, Liu XM, Xu Y, Tian NX, Zhang Y, Wang J, Wang LP^CA and Wang Y^CA. Deactivation of excitatory neurons in the contralateral prelimbic cortex via Cdk5 promotes pain sensation and anxiety. Nat Commun.  2015, Jul 16; 6: 7660. doi: 10.1038/ncomms8660.

30. Zhang Y, Wang N, Su P, Lu J, Wang Y^CA. Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice.  Neurosci Bull.  2014, 30(6):1025-35.

31. Li Y, Hu F, Chen HJ, Du YJ, Xie ZY, Zhang Y, Wang J^CA, Wang Y^CA. LIMK-dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats.  Sci Signal.  2014 Jun 24;7(331):ra61. doi: 10.1126/scisignal.2005353.

32. Wang N, Su P, Zhang Y, Lu J, Xing BM, Kang K, Li WQ, Wang Y^CA. Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses.  Neuropsychopharmacol.  2014, 39(5):1290-301.

33. Qi C, Liu SM, Qin R, Zhang Y, Wang GQ, Shang, YF, Wang Y^CA and Liang J^CA. Coordinated Regulation of Dendrite Arborization by Epigenetic Factors CDYL and EZH2.  J Neurosci.  2014 March 26;34(13):4494-508.

34. Li G, Wang Y^CA. Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system.  Neurosci Bull.  2014 Jun;30(3):497-504. doi: 10.1007/s12264-013-1403-2. Epub 2014 Feb 13.

35. Xing BM, Yang YR, Du JX, Chen HJ, Qi C, Huang ZH, Zhang Y^CA and Wang Y^CA. Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B.  J Neurosci.  2012 Oct 17;32(42):14709-21.

36. Zhu YB, Kang K, Zhang Y, Qi C, Li G, Yin DM^CA and Wang Y^CA. PLD1 negatively regulates dendritic branching. J Neurosci.  2012 Jun 6;32 (23):7960-9.

37. Wang KW^CA, Wang Y^CA. Negative modulation of NMDA receptor channel function by DREAM/calsenilin/KChIP3 provides neuroprotection?  Front Mol Neurosci.  (Invited review) 2012 Mar 15;5:39.

38. Chen HJ, Xie WY, Hu F, Zhang Y, Wang J, Wang Y^CA. Disruption of δ-opioid receptor phosphorylation at Threonine 161 attenuates morphine tolerance in rats with CFA-induced inflammatory hypersensitivity.  Neurosci Bull.  April 1, 2012, 28(2): 182-192.

39. Zhang Y, Su P, Liang P, Liu T, Liu X, Liu XY, Zhang B, Han T, Zhu YB, Yin DM, Li JF, Zhou Z, Wang KW, Wang Y^CA. The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit.  J Neurosci.  2010 Jun 2;30(22):7575-86.

40. Xie WY, He Y, Yang YR, Li YF, Kang K, Xing BM, Wang Y^CA. Disruption of cdk5- associated phosphorylation of residue threonine-161 of the delta opioid receptor: impaired receptor function and attenuated morphine antinociceptive tolerance.  J Neurosci.  2009 Mar 18;29(11):3551-64.

41. Yin DM, Huang YH, Zhu YB, Wang Y^CA. Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus.  J Neurosci.  2008 Aug 27;28(35):8832-43.

42. Zhu HH, Yang YR, Zhang H, Han Y, Li YF, Zhang Y, Yin DM, He QH, Zhao ZQ, Blumberg PM, Han JS, Wang Y^CA. Interaction between protein kinase D1 and transient receptor potential V1 in primary sensory neurons is involved in heat hypersensitivity.  Pain.  2008 Jul 31;137(3):574-88.

43. He Y, Li HL, Xie WY, Yang CZ, Yu AC, Wang Y^CA. The presence of active Cdk5 associated with p35 in astrocytes and its important role in process elongation of scratched astrocyte.  Glia  .  2007 Apr 15;55(6):573-83.

44. Yang YR, He Y, Zhang Y, Li Y, Li YF, Han Y, Zhu HH, Wang Y^CA. Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia. Pain . 2007 Jan; 127(1-2):109-20. Full-text

45. Wang Y^CA, Kedei N, Wang M, Wang QJ, Huppler AR, Toth A, Tran R, Blumberg PM. The interaction between PKCmu and vanilloid receptor type 1.  J Biol Chem.  2004 Dec 17;279(51):53674-82.

46. Wang Y, Xie WY, He Y, Wang M, Yang YR, Zhang Y, Yin DM, Jordan-Sciutto KL, Han JS, Wang Y ^CA. Role of CDK5 in neuroprotection from serum deprivation by mu-opioid receptor agonist.  Exp Neurol.  2006 Dec;202(2):313-23.

47. Wang Y^CA, Zhang Y, Wang W, Cao Y, Han JS. Effects of synchronous or asynchronous electroacupuncture stimulation with low versus high frequency on spinal opioid release and tail flick nociception. Exp Neurol. 2005 Mar; 192 (1):156-62.

48. Sun RH, Wang HC, Wan Y, Jing Z, Luo F, Han JS, and Wang Y^CA. Suppression of neuropathic pain by peripheral electrical stimulation in rats: mu-opioid receptor and NMDA receptor implicated.  Exp Neurol.  2004 May;187(1):23-9.

49. Wang Y^CA. The functional regulation of TRPV1 and its role in pain sensitization.  Neurochem Res  .  2008 Oct;33(10):2008-12. (review)

50. Li Y, Zhang Y, Han JS, Wang Y^CA. Distinct responses of DREAM to electroacupuncture stimulation with different frequency under physiological and inflammatory conditions in rats.  Neurochem Res.  2008 Oct;33(10):2070-7.

51. Zhang Y, Li Y, Yang YR, Zhu HH, Han JS, Wang Y^CA. Distribution of downstream regulatory element antagonist modulator (DREAM) in rat spinal cord and upregulation of its expression during inflammatory pain.  Neurochem Res . 2007, 32(9):1592-9. Full-text

52. Lazar J, Braun DC, Toth A, Wang Y, Pearce LV, Pavlyukovets VA, Blumberg PM, Garfield SH, Wincovitch S, Choi HK, Lee J. Kinetics of penetration influence the apparent potency of vanilloids on TRPV1. Mol Pharmacol.  2006 Apr;69(4):1166-73.

53. Zhang Y, Xiang B, Li YM, Wang Y, Wang X, Wang YN, Wu LL, Yu GY. Expression and characteristics of vanilloid receptor 1 in the rabbit submandibular gland.  Biochem Biophys Res Commun . 2006 Jun 23;345(1):467-73.

54. Toth A, Wang Y, Kedei N, Tran R, Pearce LV, Kang SU, Jin MK, Choi HK, Lee J, Blumberg PM. Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1.  Life Sci  .  2005 May 6; 76(25):2921-32.

55. Lee J, Jin MK, Kang SU, Kim SY, Lee J, Shin M, Hwang J, Cho S, Choi YS, Choi HK, Kim SE, Suh YG, Lee YS, Kim YH, Ha HJ, Toth A, Pearce LV, Tran R, Szabo T, Welter JD, Lundberg DJ, Wang Y, Lazar J, Pavlyukovets VA, Morgan MA, Blumberg PM. Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists.  Bioorg Med Chem Lett .  2005 Sep 15;15(18):4143-50.

56. Lee J, Kang SU, Kil MJ, Shin M, Lim JO, Choi HK, Jin MK, Kim SY, Kim SE, Lee YS, Min KH, Kim YH, Ha HJ, Tran R, Welter JD, Wang Y, Szabo T, Pearce LV, Lundberg DJ, Toth A, Pavlyukovets VA, Morgan MA, Blumberg PM. Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists.  Bioorg Med Chem L ett.  2005 Sep 15;15(18):4136-42.

57. Lee J, Kang SU, Lim JO, Choi HK, Jin MK, Toth A, Pearce LV, Tran R, Wang Y, Szabo T, Blumberg PM. N-[4-(Methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: analysis of structure–activity relationships for the ‘C-Region’.  Bioorg Med Chem.  2004 Jan 15;12(2):371-85.

58. Lee J, Kim SY, Lee J, Kang M, Kil MJ, Choi HK, Jin MK, Wang Y, Toth A, Pearce LV, Lundberg DJ, Tran R, Blumberg PM. Analysis of structure-activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism.  Bioorg Med Chem  .  2004 Jul 1;12(13):3411-20.

59. Lee J, Kang SU, Choi HK, Lee J, Lim JO, Kil MJ, Jin MK, Kim KP, Sung JH, Chung SJ, Ha HJ, Kim YH, Pearce LV, Tran R, Lundberg DJ, Wang Y, Toth A, Blumberg PM. Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity.  Bioorg Med Chem Lett.  2004 May 3;14(9):2291-7.

60. Tang XQ, Wang Y, Huang ZH, Han JS, Wan Y. Adenovirus-mediated GDNF ameliorates corticospinal neuronal atrophy and motor function deficits in rats with spinal cord injury.  NeuroReport.  2004 Mar 1;15(3):425-9.

61. Wang Y, Toth A, Tran R, Szabo T, Welter JD, Blumberg PM, Lee J, Kang SU, Lim JO, Lee J.  High affinity partial agonists of vanilloid receptor.  Mol Pharmacol.  2003 Aug;64(2):325-33. Full-text

62. Wang Y, Szabo T, Welter JD, Toth A, Tran R, Lee J, Kang SU, Suh YG, Blumberg PM, Lee J.  High affinity antagonists of the vanilloid receptor.  Mol Pharmacol.  2002 Oct;62(4):947-56. Full-text

63. Fang M, Wang Y, He QH, Sun YX, Deng LB, Wang XM, Han JS. Glial cell line-derived neurotrophic factor contributes to delayed inflammatory hyperalgesia in adjuvant rat pain model.  Neuroscience.  2003;117(3):503-12.

64. Tóth A, Kedei N, Wang Y, Blumberg PM. Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat.  Life Sci.  2003 Jun 13;73(4):487-98.

65. Lee J, Lee J, Kang M, Shin M, Kim JM, Kang SU, Lim JO, Choi HK, Suh YG, Park HG, Oh U, Kim HD, Park YH, Ha HJ, Kim YH, Toth A, Wang Y, Tran R, Pearce LV, Lundberg DJ, Blumberg PM. N-(3-Acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl] thiourea Analogues: Novel Potent and High Affinity Antagonists and Partial Antagonists of the Vanilloid Receptor.  J Med Chem. 2003 Jul 3;46(14):3116-26.

66. Tóth A, Kedei N, Szabó T, Wang Y, Blumberg PM. Thapsigargin binds to and inhibits the cloned vanilloid receptor-1.  Biochem Biophys Res Commun.  2002 May 3;293(2):777-82.

67.  Huang C, Wang Y, Han JS, Wan Y. Characteristics of electroacupuncture-induced analgesia in mice: variation with strain, frequency, intensity and opioid involvement.  Brain Res.  2002 Jul 26;945(1):20-5.

68. Wang Y, Wang XM, Han JS. Discrimination between peptide and non-peptide opioid agonists on the transcription of opioid receptors in two cell lines.  Life Sci  .  2001 May 4;68(24):2731-40.

69. Chen ZW, Yang K, Wang Y^CA, Han JS. The metabolic evidence of synergistic interaction between DAMGO and DPDPE on undifferentiated SH-SY5Y cells.  NeuroReport.  2001 Mar 26;12(4):845-9.

70. Chen ZW, Yang K, Wang Y^CA, Han JS. The metabolic evidence of synergistic effect between ohmefentanyl and [D-Pen2, D-Pen5] enkephalin on differentiated SH-SY5Y cells in humans.  Neurosci Lett.  2001 Feb 9;298(3):199-202.

71. Sun R, Wang Y^CA, Zhao CS, Chang JK, Han JS. Changes in Brain content of   nocicepin/orphanin FQ and endomorphin 2 in a rat model of neuropathic pain.  Neurosci Lett. 2001 Sep 21;311(1):13-6.

72. Tang XQ, Wang Y, Han JS, Wan Y. Adenovirus-mediated GDNF protects cultured motoneurons from glutamate injury.  Neuroreport.  2001 Oct 8;12(14):3073-6.

73. Sun RQ, Zhao CS, Wang HJ, Jing Z, Wang W, Yang K, Wang Y, Chang JK, Han JS. Nocistatin, a peptide reversing acute and chronic morphine tolerance.  Neuroreport.  2001 Jun 13;12(8):1789-92.

74. Huang C, Wang Y^CA, Chang JK, Han JS. Endomorphin and mu-opioid receptors in mouse brain mediate the analgesic effect induced by 2 Hz but not 100 Hz electroacupuncture stimulation.  Neurosci Lett  .  2000 Nov 24;294(3):159-62.

75. Wang Y, Huang C, Cao Y, Han JS. Repeated administration of low dose ketamine for the treatment of monoarthritic pain in rat.  Life Sci . 2000 Jun 8;67(3):261-7.

76. Fang M, Wang Y, Liu HX, Liu XS, Han JS. Decreased GDNF expression in dorsal spinal cord of unilateral arthritic rat.  NeuroReport.  2000 Mar 20;11(4):737-41.

77. Zhao CS, Li BS, Zhao GY, Liu HX, Luo F, Wang Y, Tian JH, Chang JK, Han JS. Nocistatin reverses the effect of orphanin FQ/nociceptin in antagonizing morphine analgesia .   NeuroReport.  1999 Feb 5;10(2):297-9.

78. Han Z, Jiang YH, Wan Y, Wang Y, Chang JK, Han JS. Endomorphin-1 mediates 2 Hz but not 100 Hz electroacupuncture analgesia in the rat.  Neurosci Lett.  1999 Oct 22;274(2):75-8.

Editor, chief translator and contributor

1. 《神经系统》。樊东升，王韵 主编，北京大学医学出版社，北京，2025年1月，ISBN：978-7-5659-3096-6.

2. 《人体形态与功能总论》（教育部基础医学“101计划”核心教材）。王韵，闫剑群 主编，北京大学医学出版社，北京，2024年07月，ISBN：978-7-5659-3171-0.

3. 《神经系统》（教育部基础医学“101计划”核心教材）。王韵，鲁友明 主编，北京大学医学出版社，北京，2024年07月，ISBN：978-7-5659-3213-7.

4. 《神经科学》（第四版）韩济生 主编，北京大学医学出版社，北京，2022年11月，ISBN：978-7-5659-2735-6。王韵，第四篇第9章，神经肽II：阿片肽及其受体，p595-614。

5. 《神经与精神疾病》（第二版）（国家卫生健康委员会“十四五”规划教材及全国高等学校器官系统整合教材）. 闫剑群等主编。人民卫生出版社，北京，2021年10月，ISBN 978-7-117-31507-4. 王韵，第三章，神经生理。

6. 《疾病学基础》. 副主编，第二章疾病的神经内分泌机制及第十六章神经退行性疾病（国家卫生健康委员会“十三五”规划教材，专科医生核心能力提升导引丛书，供专业学位研究生及专科医生用）. 人民卫生出版社，北京，2021年11月第一版，ISBN：978-7-117-31569-2.

7. “以器官系统为中心”翻译教材，神经系统—基础与临床（第二版），主译，北京大学医学出版社，北京，2019年7月第一版，ISBN：978-7-5659-2002-8。

8. Y Xu and Wang Y*. Cocaine, Protein Kinase, and Phosphorylation of Neuronal Receptors. In: Victor R. Preedy, editors, The Neuroscience of Cocaine. Academic Press, 2017, pp. 183-194. ISBN: 978-0-12-803750-8. Copyright. 2017 Elsevier Inc. Academic Press.

9. 《疼痛学》（第一版），韩济生 主编，北京大学医学出版社，北京，2012年2月第1版，ISBN：978-7-5659-0198-0。王韵，第9章，阿片及阿片受体系统，p78-89。国家“十一五”重点图书。

10. 《神经生物学》（第一版），于龙川 主编，北京大学出版社，北京，2012年8月第1版，ISBN：978-7-301-21113-7。张瑛，王韵，第3篇第12章，神经系统的感觉功能，p287-329。适用于综合性大学本科生和研究生教材。

11. 《神经科学》第三版，韩济生 主编，北京大学医学出版社，北京，2009年1月第3版， ISBN：978-7-81116-605-7。王韵，第24章，神经肽II：阿片肽及其受体，p438-455。

12. 《镇痛药研究方法学》（第一版），洪庚辛 主编，人民卫生出版社，北京，2009年4月第1版，ISBN：978-7-117-11072-3。王韵，第3章，神经递质、调质与疼痛，p37-49。

Editing and Writing experience

1. Nervous System. Edited by Dongsheng Fan and Yun Wang, Peking University Medical Press, Beijing, January 2025, ISBN: 978-7-5659-3096-6.

2. General Introduction to Human Morphology and Function (Core Textbook of the "101 Plan" for Basic Medicine by the Ministry of Education). Edited by Yun Wang and Jianqun Yan, Peking University Medical Press, Beijing, July 2024, ISBN: 978-7-5659-3171-0.

3. Nervous System (Core Textbook of the "101 Plan" for Basic Medicine by the Ministry of Education). Edited by Yun Wang and Youming Lu, Peking University Medical Press, Beijing, July 2024, ISBN: 978-7-5659-3213-7.

4. Neuroscience (4th Edition). Edited by Jisheng Han, Peking University Medical Press, Beijing, November 2022, ISBN: 978-7-5659-2735-6. Yun Wang, Chapter 9 of Part IV: Neuropeptides II: Opioid Peptides and Their Receptors, pp. 595–614.

5. Neurological and Mental Diseases (Second Edition) (Textbook of the 14th five year plan of the National Health Commission and textbook of organ system integration in national colleges and universities) Jianqun Yan and other editors. People's Health Publishing House, Beijing, October 2021, ISBN 978-7-117-31507-4. Yun Wang, Chapter 3, neurophysiology.

6. The Deputy editor in chief of Fundamentals of Disease., Chapter 2 neuroendocrine mechanism of diseases and Chapter 16 neurodegenerative diseases (Textbook of the 13th five year plan of the National Health Commission, guidance series for the improvement of core competence of specialists, for postgraduates with professional degrees and specialists) People's Health Publishing House, Beijing, November 2021, first edition, ISBN: 978-7-117-31569-2

7. The Chief Editor of "Organ system centered" translation textbook, nervous system - basic and clinical (Second Edition), main translation, Peking University Medical Press, Beijing, first edition in July 2019, ISBN: 978-7-5659-2002-8.

8. Y Xu and Yun Wang *. Cocaine, Protein Kinase, and Phosphorylation of Neuronal Receptors. In: Victor R. Preedy, editors, The Neuroscience of Cocaine. Academic Press, 2017, pp. 183-194. ISBN: 978-0-12-803750-8. Copyright. 2017 Elsevier Inc. Academic Press.

9. Pain Science (First Edition), edited by Jisheng Han, Peking University Medical Press, Beijing, February 2012, first edition, ISBN: 978-7-5659-0198-0. Yun Wang, Chapter 9, opioids and opioid receptor system, p78-89. National key books in the Eleventh Five Year Plan。

10. Neurobiology (First Edition), edited by Longchuan Yu, Peking University Press, Beijing, 1st edition, August 2012, ISBN: 978-7-301-21113-7. Ying Zhang, Yun Wang. Chapter 12, Chapter 3, sensory function of nervous system, p287-329. It is suitable for undergraduate and graduate teaching materials in comprehensive universities.

11. Neuroscience, 3rd Edition, edited by Jisheng Han, Peking University Medical Press, Beijing, January 2009, 3rd Edition, ISBN: 978-7-81116-605-7. Yun Wang, Chapter 24, neuropeptide II: opioid peptides and their receptors, p438-455.

12. Research methodology of analgesics (First Edition), edited by Gengxin Hong, people's Health Publishing House, Beijing, April 2009, first edition, ISBN: 978-7-117-11072-3. Yun Wang, Chapter 3, neurotransmitters, modulation and pain, p37-49.