Yiting Jia   Tenure-Track Assistant Professor, Associate Research Fellow

Contact Information

Email: yitingjia@bjmu.edu.cn

Mobile: +86 15201278161

Landline: +86-10-82801473

Research Direction

Metabolic Reprogramming and Lysosomal Homeostasis Imbalance in Major Vascular Diseases

Personal profile

Jia Yiting, Research Fellow and Doctoral Supervisor at the Department of Pharmacology, Peking University School of Basic Medical Sciences. Over the past five years, his research has focused on metabolic reprogramming and lysosomal homeostasis imbalance in the pathogenesis of major vascular diseases (such as atherosclerosis, restenosis, aneurysms, and vascular calcification), conducting target exploration and drug discovery. He has presided over projects including the General Program and Youth Program of the National Natural Science Foundation of China, as well as Non-communicable Chronic Diseases-National Science and Technology Major Project. In the past five years, he has published more than 20 SCI papers, with first-author (including co-first author) and corresponding-author (including co-corresponding author) works appearing in leading cardiovascular journals such as  Circulation, Circulation Research, Cell Discovery, ATVB,  and  JACC: Basic to Translational Science . He has received awards including the 17^th Zhang Xijun Foundation National Outstanding Youth Physiology Academic Award (First Prize, the sole recipient), the Gong Lansheng Young Investigator Award, and the First Prize of Hubei Provincial Science and Technology Progress Award. Currently, he serves as a peer reviewer for academic journals such as Advanced Science, Acta Pharmacologica Sinica B, Cell Reports, and American Journal of Physiology-Cell Physiology, and holds memberships in professional committees including the Youth Committee of the Cardiovascular Pharmacology Professional Committee of the Chinese Pharmacological Society, the Biochemistry and Pharmacology Professional Committee, the Youth Committee of the Teaching and Popularization Professional Committee, and the Ion Channels and Receptors Branch of the Chinese Society for Neuroscience.

Education

B.S.     Basic Medical Science    2010.09-2015.07  

Peking University Health Science Center

Ph.D.    Physiology      2015.09-2018.07

Department of Physiology and Pathophysiology,  Peking University

Research Experience

Postdoc.    Biophysics      2018.09-2023.03

Department of Biophysics,  Peking University

PI     Cardiovascular Pharmacology  2023.04-present

Department of Pharmacology,  Peking University

Courses

Pharmacology, Clinical Application and Therapeutics of Drugs, PBL (Problem-Based Learning), Molecular Pharmacology

Grants

2025 Non-communicable Chronic Diseases-National Science and Technology Major Project

2023 General Program of the National Natural Science Foundation of China

2021 Young Scientists Fund of the National Natural Science Foundation of China

2024, 2025 Internal Grant for Independent Projects of National Key Laboratory of Vascular Homeostasis and Remodeling

Publications

(1) Li Z, Gong Z, Li W, Chen Y, Dai R, Yang S, Chen Y, Yu F, Fu Y, Li W, Wang DW*, Jia Y*, Kong W. The Reduction of COMP Serves as a Predictor for Warning of Aortic Dissection Progression.  JACC Basic Transl Sci . 2025 Aug;10(8):101329.

(2) Jia Y†*, Mao C†, Ma Z, Huang J, Li W, Ma X, Zhang S, Li M, Yu F, Sun Y, Chen J, Feng J, Zhou Y, Xu Q, Zhao L, Fu Y, Kong W*. PHB2 Maintains the Contractile Phenotype of VSMCs by Counteracting PKM2 Splicing.  Circ Res  .  2022 Oct 28;131(10):807-824.

(3) Jia Y†, Zhang †L, Liu Z†, Mao C, Ma Z, Li W, Yu F, Wang Y, Huang Y, Zhang W, Zheng J, Wang X, Xu Q, Zhang J, Feng W, Yun C, Liu C, Sun J, Fu Y, Cui Q*, Kong W*. Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm.  Cell Discov . 2022; 8(1):21.

(4) Mao C†, Ma Z†, Jia Y†, Li W, Xie N, Zhao G, Ma B, Yu F, Sun J, Zhou Y, Cui Q, Fu Y, Kong W*. Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling.  C  ircula  tion . 2021 ; 144(15):1244-1261.

(5) Jia Y†, Wang M†, Mao C, Yu F, Wang Y, Xiao R, Jiang C, Zheng L, Xu Q, Zheng M, Fu Y, Hu Q, Kong W*. COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity.  Cell Death Dis . 2018 ; 9(6):676.

(6) Jia Y, Kong W*. ADAM17: A Molecular Switch to Control TNFR2 During Atherogenesis In Vivo.  Arterioscler Thromb Vasc Biol . 2017; 37(2):176-178.

(7) Ma Z†, Mao C†, Chen X, Yang S, Qiu Z, Yu B, Jia Y, Wu C, Wang Y, Wang Y, Gu R, Yu F, Yin Y, Wang X, Xu Q, Liu C, Liao Y*, Zheng J*, Fu Y, * Kong W*. Peptide Vaccine Against ADAMTS-7 Ameliorates Atherosclerosis and Postinjury Neointima Hyperplasia.  Circulation . 2023 Feb 28;147(9):728-742.

(8) Ma Z†, Mao C†, Jia Y, Yu F, Xu P, Tan Y, Zou QH, Zhou XJ, Kong W*, Fu Y*. ADAMTS7-Mediated Complement Factor H Degradation Potentiates Complement Activation to Contributing to Renal Injuries.  J Am Soc Nephrol . 2023 Feb 1;34(2):291-308.

(9) Chen Y†, Mao C†*, Gu R, Zhao R, Li W, Ma Z, Jia Y, Yu F, Luo J, Fu Y, Sun J*, Kong W*. Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification.  Circ Res . 2022 Dec 2;131(12):1037-1054.

(10) Tang Y, Jia Y, Fan L, Liu H, Zhou Y, Wang M, Liu Y, Zhu J, Pang W*, Zhou J*. MFN2 Prevents Neointimal Hyperplasia in Vein Grafts via Destabilizing PFK1.  Circ Res . 2022;130(11): e26-e43.

(11) Yang L, Dai R, Wu H, Cai Z, Xie N, Zhang X, Shen Y, Gong Z, Jia Y, Yu F, Zhao Y, Lin P, Ye C, Hu Y, Fu Y, Xu Q*, Li Z*, Kong W*. Unspliced XBP1 Counteracts β-Catenin to Inhibit Vascular Calcification.  Circ Res . 2022;130(2):213-229.

(12) Fu Y†, Huang Y†, Yang Z, Chen Y, Zheng J, Mao C, Li Z, Liu Z, Yu B, Li T, Wang M, Xu C, Zhou Y, Zhao G, Jia Y, Guo W, Jia X, Zhang T, Li L, Liu Z, Guo S, Ma M, Zhang H, Liu B, Du J, Wang W, Tang C, Gao P, Xu Q, Wang X, Liu J, Sun J*, Kong W*. Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury.  Cell Res . 2021;31(7):773-790.

(13) Li H, Guo J, Jia Y, Kong W, Li W*. LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice.  Genes (Basel) . 2021;12(4).

(14) Ma Z, Mao C, Jia Y, Fu Y*, Kong W*. Extracellular matrix dynamics in vascular remodeling.  Am J Physiol Cell Physiol . 2020;319(3):C481-C499.

(15) Wang M, Fu Y, Gao C, Jia Y, Huang Y, Liu L, Wang X, Wang W, Kong W*. Cartilage oligomeric matrix protein prevents vascular aging and vascular smooth muscle cells senescence.  Biochem Biophys Res Commun . 2016;478(2):1006-13.

(16) Fu Y†, Gao C†, Liang Y, Wang M, Huang Y, Ma W, Li T, Jia Y, Yu F, Zhu W, Cui Q, Li Y, Xu Q, Wang X*, Kong W*. Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification.  Circ Res . 2016;119(2):261-76.

Complete List of Published Work in My Bibliography:

https://www.ncbi.nlm.nih.gov/myncbi/yiting.jia.1/bibliography/public/