Jiawen Feng | Assistant Professor

Contact Information

Email：jiawen_feng@hsc.pku.edu.cn or jiawen_feng@bjmu.edu.cn

Research

Genome Instability and Transcriptional Reprogramming in Cancer.

Goals and Approaches

By profiling the genetic, epigenetic and transcriptomic characteristics of cancer cells and tissues at bulk or single-cell resolution, using approaches such as massively parallel reporter assay (MPRA) and high-throughput screening by CRISPR-based genetic/epigenetic editing or prime editing, and capturing the 3D genome architecture by CAPTURE-3C or HiChIP, we are decoding transcriptional reprogramming in cancer and developing strategies for therapy.

Education

2007-2012 B.S., School of Basic Medical Sciences, Peking University Health Science Center.

2012-2015 M.D., Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center.

Experience

2015-2020 Instructor, Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center.

2020-Present Assistant Professor, Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center.

Teaching courses: Pharmacology, Experiments of Pharmacology, Integrated Experiments of Organ Systems, Comprehension and Communication in Scientific Literature.

Funding

Talented Doctor of Peking University Health Science Center (BMU20150503)

National Natural Science Foundation of China Grant (31600618, 81972662)

The Fundamental Research Funds for the Central Universities (BMU2021RCZX015)

Clinical Medicine Plus X - Young Scholars Project, Peking University, the Fundamental Research Funds for the Central Universities (PKU2023LCXQ018)

The Young Elite Scientist Sponsorship Program by BAST (BYESS2023022).

Selected Publications

1. Li K.#,*, Wei GH*, Yin Y.*, Feng J. #,* Targeting Noncoding cis-Regulatory Elements for Cancer Therapy in the Context of the 3D Genome.  Cancer Discovery . 2024 Nov 1;14(11):2061-2065. (IF: 30.6，co-corresponding author，co-first author)

2. Feng J.#, Dang Y.#, Zhang W., Zhao X., Zhang C., Hou Z., Jin Y., Mcnutt M., Marks, A.* and Yin Y.* PTEN arginine methylation by PRMT6 suppresses PI3K-AKT signaling and modulates pre-mRNA splicing.  PNAS . 2019 Apr 2; 116(14):6868-6877. (IF: 9.412，co-first author)

3. Liang L.#,*, Feng J.#, Zuo P., Yang J., Lv Y., Yin Y.* Molecular basis for assembly of the shieldin complex and its implications for NHEJ.  Nature Communications , 2020, Apr 24; 11(1):1972. (IF: 14.919，co-first author)

4. Feng, J.#, Liang, J.#, Li, J., Li, Y., Liang, H. Zhao, X., Mcnutt, M., and Yin, Y.* PTEN Ensures Accuracy of DNA Replication and Maintains Genomic Stability.  Cell Reports , 2015, Nov 17;13(7):1295-1303.（IF：8.032，co-first author）

5. Liu S.#,*, Wang Y.#, Feng J.#, Liu Z.*, Zhou S.* Building an Organ-Wide Macroscopic View of Cancer Hallmarks.  Cancer Discovery . 2024 Nov 1;14(11):2041-2046. (IF: 30.6，co-first author)