导师介绍
亓超 研究员
亓超 研究员 博士生导师
北京大学基础医学院生物物理系，北京大学神经科学研究所
地址：北京市海淀区学院路38号中心实验楼816
Email: chaoqi@bjmu.edu.cn
简介：亓超，研究员，北京大学基础医学院生物物理系博士生导师，北京大学神经科学研究所双聘PI。入选国家海外高层次人才计划，北京大学博雅青年学者。长期从事细胞信号转导， 神经退行性疾病及结构生物学等领域研究，围绕细胞信号转导中关键蛋白的信号传递与工作机理，tau疾病中tau纤维结构等取得了一系列具有重要意义的原创性科研成果。1)系统性研究cAMP信号转导通路中关键蛋白腺苷酸环化酶9的催化机制，揭示了AC9的自抑制机制，并开发特异性结合AC9的DARPin工具，全面阐述了AC9的激活机理。2）阐述了Hedgehog信号通路中PTCH1与其配体hedgehog相互作用并激活Hedgehog信号通路的机制。3)阐述了间隙连接蛋白Connexin32，Connexin43的“开放”与“关闭”机制，揭示了脂类分子在调节Connexin功能中的重要作用。4）解析tau突变体及地方性tau疾病中tau纤维结构，丰富了基于结构的tau疾病分类。
迄今为止，以第一作者（含共同第一作者）在Science (2019)，Nature Structural & Molecular Biology (2025)，Science Advances (2019,2023)，Nature Communications (2022)，PNAS (2023), eLife (2023), Acta Neuropathologica(2024) 等杂志发表一系列重要论文，多次受邀在国际会议进行报告，为eLife, Science Advances, Nature杂志审稿人。
亓超实验室聚焦于跨膜信号转导，神经退行性疾病等领域，并开发原位结构生物学冷冻断层显微成像方法，为进一步的药物研发和临床转化奠定理论基础。
教育及工作经历
2025 研究员 北京大学基础医学院
2022-2025 博士后 英国医学理事会分子生物学研究所（MRC-LMB）
Mentor Sjors Scheres 院士, Michel Goedert院士
Advisor Chris Tate院士
2019-2021 博士后 瑞士苏黎世联邦理工大学（ETH Zurich）及保罗谢尔研究所(PSI)
Mentor Prof. Volodymyr Korkhov
2015-2019 博士 瑞士苏黎世联邦理工大学（ETH Zurich）及保罗谢尔研究所(PSI)
Mentor Prof .Volodymyr Korkhov
2012-2015 硕士 中国科学院生物物理研究所
导师 王大成院士
2007-2012 本科 吉林大学白求恩医学部药学院生物工程（五年制）
2008.2-2008.6 中山大学中山医学院临床医学
奖励与资助:
eLife杂志early-career reviewer pool
国家优秀自费留学生奖学金
EMBO short-term fellowship
国家自然科学基金优秀青年科学基金（海外）
发表文章
第一作者文章:
1. Chao Qi, Sofia Lovestam, Alexey G Murzin, Sew Peak-Chew, Catarina Franco, Marika Bogdani, Caitlin Latimer, Jill R Murrell, Patrick W Cullinane, Zane Jaunmuktane, Thomas D Bird, Bernardino Ghetti, Sjors HW Scheres, Michel Goedert. Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W. Nat Struct Mol Biol, doi:10.1038/s41594-025-01498-5 (2025).
2. Chao Qi, Ryota Kobayashi, Shinobu Kawakatsu, Fuyuki Kametani, Sjors HW Scheres, Michel Goedert, Masato Hasegawa. Tau filaments with the chronic traumatic encephalopathy fold in a case of Vacuolar Tauopathy with VCP mutation D395G. Acta Neuropathol 147,86 (2024).
3. Chao Qi*, Bert M Verheijen*, Yasumasa Kokubo*, Yang Shi*, Stephan Tetter, Alexey G Murzin, Asa Nakahara, Satoru Morimoto, Marc Vermulst, Ryogen Sasaki, Eleonora Aronica, Yoshifumi Hirokawa, Kiyomitsu Oyanagi, Akiyoshi Kakita, Benjamin Ryskeldi-Falcon, Mari Yoshida, Masato Hasegawa, Sjors HW Scheres, Michel Goedert. Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) adopt the CTE Fold. Proceedings of the National Academy of Sciences 120, e2306767120 (2023).
4. Chao Qi*, Masato Hasegawa*, Masaki Takao, Motoko Sakai, Mayasuki Sasaki, Masashi Mizutani, Akio Akagi, Yasushi Iwasaki, Hiroaki Miyahara, Mari Yoshida, Sjors HW Scheres, Michel Goedert. Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy. Acta Neuropathol Commun 11(1): 74. (2023).
5. Chao Qi*, Pia Lavriha*, Erva Bayraktar*, Anand Vaithia, Dina Schuster, Micaela Pannella, Valentina Sala, Paola Picotti, Mario Bortolozzi, Volodymyr M Korkhov. Structures of wild-type and selected CMT1X mutant connexin 32 gap junction channels and hemichannels. Science Advances. (2023).
6. Chao Qi*, Silvia Acosta-Gutierrez*, Pia Lavriha, Alaa Othman, Diego Lopez-Pigozzi, Erva Bayraktar, Dina Schuster, Paola Picotti, Nicola Zamboni, Mario Bortolozzi, Francesco L Gervasio, and Volodymyr M. Korkhov. Structure of the connexin-43 gap junction channel reveals a closed sieve-like molecular gate. eLife 12:RP87616. (2023).
7. Chao Qi, Pia Lavriha, Ved Mehta, Basavraj Khannpnavar, Inayathulla Mohammed, Yong Li, Michalis Lazaratos, Jonas V. Schaefer, Birgit Dreier, Andreas Plückthun, Ana-Nicoleta Bondar, Carmen W. Dessauer, Volodymyr M. Korkhov. Structural basis of adenylyl cyclase 9 activation. Nature Communications 13, 1045 (2022).
8. Chao Qi, Simona Sorrentino, Ohad Medalia, Volodymyr M. Korkhov. The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein. Science 364, 389-394, (2019).
9. Chao Qi, Giulio Di Minin, Irene Vercellino, Anton Wutz, Volodymyr M. Korkhov. Structural basis of sterol recognition by human hedgehog receptor PTCH1. Science Advances 5, eaaw6490 (2019).
10. Na Feng*, Chao Qi*, Yan-jie Hou, Ying Zhang, Da-Cheng Wang, De-Feng Li. The C2'- and C3'-endo equilibrium for AMP molecules bound in the cystathionine-beta-synthase domain. Biochem Biophys Res Commun 497, 646-651.(2018). (*co-first author)
11. Chao Qi*, De-Feng Li*, Lei Feng, Yanjie Hou, Hui Sun, Da-Cheng Wang, Wei Liu . Biochemical and structural characterization of a novel ubiquitin-conjugating enzyme E2 from Agrocybe aegeria reveals Ube2w family-specific properties. Sci Rep 5, 16056. (2015).
综述文章:
12. B. Khannpnavar*, V. Mehta*, Chao Qi*, V. Korkhov, Structure and function of adenylyl cyclases, key enzymes in cellular signaling. Curr Opin Struct Biol 63, 34-41 (2020). (*co-first author)
共同作者文章:
13. Basavraj Khanppnavar, Julian Maier, Freja Herborg, Ralph Gradisch, Erika Lazzarin, Dino Luethi, Jae-Won Yang, Chao Qi, Marion Holy, Kathrin Jaentsch, Oliver Kudlacek, Klaus Schicker, Thomas Werge, Ulrik Gether, Thomas Stockner, Volodymyr Korkhov, Harald H Sitte. Structural basis of organic cation transporter-3 inhibition. Nature Communications. (2022).
14. Xuefeng Zhang, Alejandro Pizzoni, Kyoungja Hong, Nyla Naim, Chao Qi, Volodymyr Korkhov, Daniel L Altschuler. CAP1 binds and activates adenylyl cyclase in mammalian cells. Proc Natl Acad Sci U S A 118(24).(2021).
15. F. Cannac, Chao Qi, J Falschlunger, G Hausmann, K Basler, VM Korkhov. Cryo-EM structure of the Hedgehog release protein Dispatched. Sci Adv 6, eaay7928 (2020).
16. X. Q. Xie, X-L Zhang, Chao Qi, D-F Li, Joy Fleming, D-C Wang, L-J Bi. Crystallographic observation of the movement of the membrane-distal domain of the T7SS core component EccB1 from Mycobacterium tuberculosis. Acta Crystallogr F Struct Biol Commun 72, 139-144 (2016).
17. Li-Li Miao, Yan-Jie Hou, Hong-Xia Fan, Jie Qu, Chao Qi, Ying Liu, De-Feng Li, Zhi-Pei Liu. Molecular Structural Basis for the Cold Adaptedness of the Psychrophilic beta-Glucosidase BglU in Micrococcus antarcticus. Appl Environ Microbiol 82, 2021-2030 (2016).
* co-first author
