吴聪颖 研究员

北京大学医学部 系统生物医学研究所

联系方式

电话：+86 15010838990

邮箱：congyingwu@hsc.pku.edu.cn

教育经历

2008-2013	理学博士，北卡罗来纳大学教堂山分校
2012	暑期课程“生理学：细胞与分子生物学”，伍兹霍尔（Woods Hole）海洋生物实验室（MBL），导师：Clare Waterman与Dyche Mullins
2004-2008	理学学士，清华大学

科研经历

2015至今	助理教授，北京大学系统生物医学研究所
2013-2015	博士后，北卡罗莱纳大学教堂山分校莱恩贝格尔综合癌症中心
2008-2013	博士，北卡罗莱纳大学教堂山分校细胞与发育生物学系
2007-2008	毕业设计，清华大学生物科学与生物技术系

研究方向

主要研究细胞骨架对细胞迁移和肿瘤转移的影响。

课题组关注细胞骨架、细胞黏附结构对机械力信号的响应以及对细胞迁移和肿瘤转移的影响。应用原子力显微镜（AFM）、微流控体系、相分离体外重构、高时空分辨率活细胞成像、图像分析和多组学平台，并进行深入的临床合作，开展机械力信号—蛋白质相分离—细胞黏附结构组成和功能—细胞迁移和能量代谢—肿瘤发生发展等多层次、跨学科的研究。

期刊论文（#表示作者贡献相同）

1. Wang Y#, Shi P, Liu G, Chen W, Wang YJ, Hu Y, Yang A, Wei T, Chen YC, Liang L, Liu Z, Liu YJ, Wu C*. Espin enhances confined cell migration by promoting filopodia formation and contributes to cancer metastasis. EMBO Rep. 2025 May;26(10):2574-2596. doi: 10.1038/s44319-025-00437-1. Epub 2025 Apr 4. PMID: 40185977; PMCID: PMC12117036.

2. Yang W#, Wang Y, Liu G, Wang Y, Wu C* TPM4 condensates glycolytic enzymes and facilitates actin reorganization under hyperosmotic stress. Cell Discov. 2024 Dec 3;10(1):120. doi: 10.1038/s41421-024-00744-2. PMID: 39622827; PMCID: PMC11612400.

3. Kang C#, Chen P, Yi X, Li D, Hu Y, Yang Y, Cai H, Li B, Wu C*. Amoeboid cells undergo durotaxis with soft end polarized NMIIA. Elife. 2024 Dec 13;13:RP96821. doi: 10.7554/eLife.96821. PMID: 39671466; PMCID: PMC11643633.

4. Ren X#, Shi P#, Su J, Wei T, Li J, Hu Y, Wu C*. Loss of Myo19 increases metastasis by enhancing microenvironmental ROS gradient and chemotaxis. EMBO Rep. 2024 Jan 26. doi: 10.1038/s44319-023-00052-y. Epub ahead of print. PMID: 38279020.

5. Zhang C#, Wang Y#, Zhen Z, Li J, Su J, Wu C*. mTORC1 Mediates Biphasic Mechano-Response to Orchestrate Adhesion-Dependent Cell Growth and Anoikis Resistance. Adv Sci (Weinh). 2024 Feb;11(6):e2307206. doi: 10.1002/advs.202307206. Epub 2023 Dec 2. PMID: 38041494; PMCID: PMC10853740.

6. Shi P#, Ren X#, Meng J, Kang C, Wu Y*, Rong Y, Zhao S, Jiang Z, Liang L, He W, Yin Y, Li X, Liu Y, Huang X, Sun Y, Li B, Wu C. Mechanical instability generated by Myosin 19 contributes to mitochondria cristae architecture and OXPHOS. Nat Commun. 2022 May 13;13(1):2673. doi: 10.1038/s41467-022-30431-3. PMID: 35562374; PMCID: PMC9106661.

7. Huang Y, Su J, Liu J, Yi X, Zhou F, Zhang J, Wang J, Meng X, Si L, Wu C*. YAP Activation in Promoting Negative Durotaxis and Acral Melanoma Progression. Cells. 2022 Nov 9;11(22):3543. doi: 10.3390/cells11223543. PMID: 36428972; PMCID: PMC9688430.

8. Rong Y.#, Yang W.#, Hao H., Wang W., Lin S., Shi P., Huang Y., Li B., Sun Y., Liu Z., and Wu C.*, The Golgi microtubules regulate single cell durotaxis. EMBO Rep, 2021. 22(3): p. e51094..

9. Wang Y.#, Zhang C.#, Yang W., Shao S., Xu X., Sun Y., Li P., Liang L.*, and Wu C.*, LIMD1 phase separation contributes to cellular mechanics and durotaxis by regulating focal adhesion dynamics in response to force. Dev Cell, 2021. 56(9): p. 1313-1325 e7. y .

10. Dandan Wang, Congying Wu*, Congying Liu*. Loss of 4.1N in Epithelial Ovarian Cancer Results in EMT and Matrix-detached Cell Death Resistance.  Protein and Cell  2020.

11. Huiwen Hao, Jiahao Niu, Boxin Xue, Qian Peter Su, Menghan Liu, Jinshan Qin, Shujuan Zhao, Congying Wu*, Yujie Sun*. Golgi-associated microtubules are fast cargo tracks and required for persistent cell migration.  EMBO reports  2020.

12. Yuxing Huang, Xin Yi, Chenlu Kang, Congying Wu. Arp2/3-branched actin maintains an active pool of GTP-RhoA and controls RhoA abundance.  Cells  2019.

13. Jing Du, Fan Y, Guo Z, Wang Y, Zheng X, Huang C, Liang B, Gao L, Cao Y, Chen Y, Zhang X, Li L, Xu L, Congying Wu, Weitz DA, Xiqiao Feng. Compression Generated by a 3D Supracellular Actomyosin Cortex Promotes Embryonic Stem Cell Colony Growth and Expression of Nanog and Oct4.  Cell Systems  2019

14. Peng Shi^#, Yuan Wang^#, Yuxing Huang, Chunlei Zhang, Ying Li, Yaoping Liu, Tingting Li, Wei Wang, Xin Liang, Congying Wu. Arp2/3-branched actin regulates microtubule acetylation level and affects mitochondrial distribution.  Journal of Cell Science  2019 .

15. Jian Gao, Yingxue Rong, Yuxing Huang, Peng Shi, Xitao Wang, Xuan Meng, Jiahong dong, Congying Wu. Cirrhotic stiffness affects the migration of hepatocellular carcinoma cells and induces sorafenib resistance through YAP,  Journal of Cellular Physiology  2018 .

16. Dan He, Mingming Zhao, Congying Wu, Wenjing Zhang, Chenguang Niu, Baoqi Yu, Jingru Jin, Liang Ji, Belinda Willard, Anna V. Mathew, Y. Eugene Chen, Subramaniam Pennathure, Huiyong Yin, Yuan He, Bing Pan, Lemin Zheng. Apolipoprotein A-1 mimetic peptide 4F promotes endothelial repairing and compromises reendothelialization impaired by oxidized HDL through SR-B1,  Redox Biology  2018.

17. David S. Paul^#, Caterina Casari^#, Congying Wu, Raymond Piatt, Swetha Pasala, Robert A. Campbell, Kathryn O. Poe, Dorsaf Ghalloussi, Robert H. Lee, Jeremy D. Rotty, Brian C. Cooley, Kellie R. Machlus, Joseph E. Italiano, Jr, Andrew S. Weyrich, James E. Bear, and Wolfgang Bergmeier. Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice,  Blood Advance  2017 .

18. Xuan Meng^#, Nicole R. Tackmann^#, Shijie Liu, Jing Yang, Jiahong Dong, Congying Wu, Adrienne D. Cox, and Yanping Zhang. RPL23 Links Oncogenic RAS Signaling to p53-Mediated Tumor Suppression,  Cancer Research  2016 .

19. Jeremy D. Rotty^#, Congying Wu^#, Elizabeth M. Haynes, Cristian Suarez, Jonathan D. Winkelman, Heath E. Johnson, Jason M. Haugh, David R. Kovar, and James E. Bear. Profilin-1 Serves as a Gatekeeper for Actin Assembly by Arp2/3-Dependent and -Independent Pathways,  Developmental Cell  2015 .

20. Congying Wu, Elizabeth M. Haynes, Sreeja B. Asokan, Jeremy M. Simon, Norman E. Sharpless, Albert S. Baldwin, Ian J. Davis, Gary L. Johnson, and James E. Bear. Loss of Arp2/3 induces an NF-κB–dependent, nonautonomous effect on chemotactic signaling,  Journal of Cell Biology  2013 .

21. Jeremy D. Rotty, Congying Wu and James E. Bear. New insights into the regulation and cellular functions of the ARP2/3 complex,  Nature Reviews Molecular Cell Biology  2013 .

22. Congying Wu^#, Sreeja B. Asokan^#, Matthew E. Berginski, Elizabeth M. Haynes, Norman E. Sharpless, Jack D. Griffith, Shawn M. Gomez, and James E. Bear (2012). Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis,  Cell  2012 .