赵东宇 博士

研究员 博士生导师 

实验室网站：https://www.labxing.com/med.bio_zhao

Email: zhaodongyu@bjmu.edu.cn

研究方向：

1）建立精准的疾病基因识别方法和开发相关生物信息学分析工具；

2）结合多组学数据研究疾病（主要是肿瘤、心血管）基因组变异和转录调控；

3）开发基于第三代纳米孔测序数据的分析软件。

个人简介：

北京大学基础医学院医学生物信息学系主任、党支书。国家级高层次青年人才计划入选者，北京大学博雅青年学者，血管稳态与重构全国重点实验室PI。2013年于中国科学院北京基因组研究所获得博士学位，先后在美国康奈尔大学休斯敦Methodist研究所、哈佛大学医学院从事博士后研究。2021年回国加入北京大学基础医学院，主要研究生物信息学、疾病基因挖掘和机制探索。发表学术论文50余篇，其中以通讯作者（含共同）在European Heart Journal, Nucleic Acids Research, Military Medical Research, Small Methods, Genome Research, The Lancet Infectious Diseases(Review), eBioMedicine(Review)等国际高水平期刊发表10余篇论文。获得软件著作权6项。主持国家自然科学基金和北京市自然科学基金等项目。获北京大学医学部教学优秀奖、基础医学院青年教师奖励基金、基础医学院优秀教学奖等奖励。现为中国运筹学会计算系统生物学分会理事、中国生物信息学会表观遗传信息学专委会/系统生物学专委会委员等。

代表性论文：（^ 通讯作者）

1． Yitong Xu, Jingxuan Chen, Yiran Liu, Ge Zhang, Guolin Miao, Jingdong Wu, Kaikai Lu, Yinqi Zhao, Wenxi Zhang, Liwen Zheng, Lianxin Zhang, Jinxuan Chen, Zihao Zhou, Yufei Han, Pingping Lai, Jiabao Guo, Donghui Wu, Si Mei, Ling Zhang, Yang Zhao, Wei Huang, Yuhui Wang, Junnan Tang^, Dongyu Zhao^, Xunde Xian^. The macrophage-derived motor protein KIF13B enhances MERTK-mediated efferocytosis and prevents atherosclerosis in mice. European Heart Journal, 2025. (in press)

2． Shaodong Huang, Yulong Han, Yiran Liu, Lina Bu, Chenyang Wu, Ziyan Rao, Chuan Ye, Hansen Cheng, Yunxi Liao, Yunan Sun, Yushu Zou, Zixu Wang, Bryan-Yu Sun, Shu Meng^, Dongyu Zhao^. Super-enhancer-mediated circRNAs exhibit high splicing circularization diversity and transcriptional activity. Nucleic Acids Research, 2025, 53(11): gkaf505.

3． Ziyan Rao, Chenyang Wu, Yunxi Liao, Chuan Ye, Shaodong Huang, Dongyu Zhao^. POCALI: Prediction and Insight on CAncer LncRNAs by Integrating Multi-Omics Data with Machine Learning. Small Methods, 2025, 23: e2401987.

4． Ziyan Rao, Min Zhang^, Shaodong Huang, Chenyang Wu, Yuheng Zhou, Weijie Zhang, Xia Lin, Dongyu Zhao^. Cancer Driver Topologically Associated Domains identify oncogenic and tumor suppressive lncRNAs. Genome Research, 2025, doi: 10.1101/gr.280235.124.

5． Guolin Miao, Wenxi Zhang, Yitong Xu, Yiran Liu, Pingping Lai, Jiabao Guo, Gonglie Chen, Jingxuan Chen, Zihao Zhou, Yanwei Li, Chong Zhang, Yang Ding, Lianxin Zhang, Yufei Han, Jinxuan Chen, Jingdong Wu, Yinqi Zhao, Si Mei, Yang Zhao, Yuanwu Ma, Ling Zhang, Wei Huang, Dongyu Zhao^, Erdan Dong^, Yuhui Wang^, Xunde Xian^. Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease. Military Medical Research, 2025, 12(1):11.

6． Xuyuan Liu, Siqi Wang, Yunan Sun, Yunxi Liao, Guangzhen Jiang, Bryan-Yu Sun, Jingyou Yu^, Dongyu Zhao^. Unlocking the potential of circular RNA vaccines: a bioinformatics and computational biology perspective. EBioMedicine (Review), 2025, 114:105638.

7． Guangzhen Jiang, Yushu Zou, Dongyu Zhao^, Jingyou Yu^. Optimising vaccine immunogenicity in ageing populations: key strategies. The Lancet Infectious Diseases (Review), 2024, 25(1):e23-e33.

8． Lina Bu, Shaodong Huang, Ziyan Rao, Chenyang Wu, Bryan-Yu Sun, Yanhua Liu, Lin He, Dongyu Zhao^. CHD6 eviction of promoter nucleosomes maintains housekeeping transcriptional program in prostate cancer. Molecular Therapy Nucleic Acids, 2024, 35(4):102397.

9． Yunxi Liao, Ziyan Rao, Shaodong Huang, Dongyu Zhao^. Protocol to analyze immune cells in the tumor microenvironment by transcriptome using machine learning. STAR Protocols, 2024, 5(1):102684.

10． Chuan Ye, Xuemei Wang, Jun Lin, Chenyang Wu, Yuhua Gao, Chenghao Guo, Yunxi Liao, Ziyan Rao, Shaodong Huang, Weixuan Chen, Ying Huang, Jinpeng Sun, Dongyu Zhao^, Changtao Jiang^. Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis. Science China Life Sciences, 2024. 68(4): 1057-1072.

11． Yun Lv, Ziyan Rao, Lulu Liu, Jun Jia, Chenyang Wu, Jun Xu, Yuanyuan Du, Yinan Liu, Bei Liu, Jihang Shi, Guangya Li, Dongyu Zhao^, Hongkui Deng^. The efficient generation of functional human hepatocytes from chemically induced pluripotent stem cells. Cell proliferation, 2024. 57(2): e13540.

12． Senpeng Zhang, Dongyu Zhao^, Qinghua Cui^. Gap-Δenergy, a New Metric of the Bond Energy State, Assisting to Predict Molecular Toxicity. ACS Omega. 2024. 9(16):17839-17847.

13． Chenhao Zhang, Yang Yang, Qinghua Cui^, Dongyu Zhao^, Chunmei Cui^. Identification and Analysis of Sex-Biased Copy Number Alterations. Health Data Sci. 2024. 11:4:0121.

14． Yunxi Liao, Chenyang Wu, Yang Li, Jinhua Wen^, Dongyu Zhao^. MIF is a critical regulator of mononuclear phagocytic infiltration in hepatocellular carcinoma. iScience, 2023. 26(8): 107273.