赵东宇 博士

研究员 博士生导师 

医学生物信息学系主任

实验室网站：https://www.labxing.com/med.bio_zhao

Email: zhaodongyu@bjmu.edu.cn

研究方向：

1）建立精准的疾病基因识别方法和开发相关生物信息学分析工具；

2）结合多组学数据研究疾病（主要是肿瘤、心血管）基因组变异和转录调控；

3）开发基于第三代纳米孔测序数据的分析软件。

个人简介：

国家级高层次青年人才计划入选者，北京大学博雅青年学者。北京大学基础医学院医学生物信息学系PI，血管稳态与重构全国重点实验室PI。中国生物信息学学会表观遗传信息学专委会委员、中国抗癌协会肿瘤测序及大数据分析专委会委员，中国运筹学会计算系统生物学分会青年理事，北京生物信息学研究会会员， Frontiers in Genetics期刊责任编辑。2013年获得中国科学院北京基因组研究所博士学位，曾在美国康奈尔大学休斯敦Methodist研究所、哈佛大学医学院波士顿儿童医院等机构从事博士后研究。2021年初回国加入北京大学基础医学院，现带领团队主要致力于疾病基因的遗传和表观遗传机制的计算模型研究。至今在Molecular Cell、Nature Communications（3篇）、Oncogene、Nucleic Acids Research、iScience等国际著名学术期刊上发表学术论文30余篇。获得美国Moran Foundation学术奖励、2021年北京大学基础医学院教学基本功比赛二等奖、2021年北京大学（医学类）青教赛三等奖、2022年北京大学基础医学院优秀教师奖和优秀论文奖等奖励。

代表性论文：（# 并列第一作者，^ 并列通讯作者）

1.  Yunxi Liao, Chenyang Wu, Yang Li, Jinhua Wen^, Dongyu Zhao^. MIF is a critical regulator of mononuclear phagocytic infiltration in hepatocellular carcinoma. iScience, 2023. DOI:https://doi.org/10.1016/j.isci.2023.107273.

2.  Dongyu Zhao#, Min Zhang#, Shaodong Huang, Qi Liu, Sen Zhu, Yanqiang Li, Weihua Jiang, Daniel L. Kiss, Qi Cao, Lili Zhang, Kaifu Chen. CHD6 Promotes Broad Nucleosome Eviction for Transcriptional Activation in Prostate Cancer Cells. Nucleic Acids Research, 2022,50(21):12186-12201.

3． Dongyu Zhao^#, Lili Zhang^#, Min Zhang, Bo Xia, Jie Lv, Xinlei Gao, Guangyu Wang, Qingshu Meng, Yang Yi, Sen Zhu, Alin S. Tomoiaga, John P. Cooke, Qi Cao^, Kaifu Chen^. Broad Genic Repression Domains Signify Enhanced Silencing of Oncogenes.  Nature Communications , 2020, 11(1): 1-14.

4． Bo Xia^#, Dongyu Zhao^#, Guangyu Wang^#, Jie Lv, Alin S. Tomoiaga, Min Zhang, Yanqiang Li, Xin Wang, Shu Meng, John Cooke, Qi Cao^, Lili Zhang^, Kaifu Chen^. Machine Learning uncovers cell identity regulator by histone code.  Nature Communications , 2020, 11: 2696-2708.

5． Sen Zhu^#, Dongyu Zhao^#, Chao Li^#, Qiaqia Li, Weihua Jiang, Qipeng Liu, Rui Wang, Ladan Fazli, Yinan Li, Lili Zhang, Yang Yi, Qingshu Meng, Wanyi Wang, Xiongbing Zu, Wei Zhao, Tuo Deng, Jindan Yu, Xuesen Dong, Kaifu Chen^, Qi Cao^. BMI1 is directly regulated by androgen receptor to promote castration resistance in prostate cancer.  Oncogene , 2019, 39: 17-29.

6． Shilpa S. Dhar^#, Dongyu Zhao^#, Tao Lin, Bingnan Gu, Khusboo Pal, Hunain Alam, Jie Lv, Vidya Gopalakrishnan, Wei Li, Ali Shilatifard, Roy V. Sillitoe, Kaifu Chen^, Min Gyu Lee^. MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes.  Molecular Cell , 2018, 70(5): 825-841.

7． Sen Zhu^#, Dongyu Zhao^#, Lin Yan^#, Weihua Jiang, Jung-Sun Kim, Bingnan Gu, Qipeng Liu, Rui Wang, Bo Xia, Jonathan C Zhao, Gang Song, Wenyi Mi, Rong-Fu Wang, Xiaobing Shi, Hung-Ming Lam, Xuesen Dong, Jindan Yu, Kaifu Chen^, Qi Cao^. BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1.  Nature Communications , 2018, 9(1): 1-13.

8． Yongbing Zhao^#, Chen Sun^#, Dongyu Zhao^#, Yadong Zhang, Yang You, Xinmiao Jia, Junhui Yang, Lingping Wang, Jinyue Wang, Haohuan Fu, Yu Kang, Fei Chen, Jun Yu, Jiayan Wu^ and Jingfa Xiao^. PGAP-X: Extension on pan-genome analysis pipeline.  BMC Genomics , 2018, 19(36): 115-124.

9． Dongyu Zhao^#, Jiayan Wu^#, Yuanyuan Zhou, Wei Gong, Jingfa Xiao^, and Jun Yu^. WikiCell: A Unified Resource Platform for Human Transcriptomics Research.  OMICS: A Journal of Integrative Biology , 2012, 16(6): 357-362.

10． Dongyu Zhao, Yan Wang, Di Luo, Xiaohu Shi, Liupu Wang, Dong Xu, Chunguang Zhou, Jun Yu， Yanchun Liang. PMirP: A pre-microRNA prediction method based on structure-sequence hybrid features.  Artificial Intelligence in Medicine , 2010, 49: 127-132.