梅帆

助理教授  副研究员 博士生导师

北京大学基础医学院

办公地址：医学部科技北楼

Email: meifan@hsc.pku.edu.cn

个人简介

梅帆，预聘制助理教授，副研究员，博士生导师。2008年获北京大学学士学位，2011年获北京大学博士学位（基础医学八年制，导师：柯杨、鲁白）。2007-2010年美国国立卫生研究院（NIH）访问学者。长期致力于神经系统疾病的遗传易感性和致病机制研究。基于临床队列的组学数据，进行高通量功能性筛选；结合人源性类脑器官疾病模型和动物模型，鉴定疾病易感基因和非编码区功能性变异，解析致病机制，发现疾病干预新靶点。近五年，以第一作者或通讯作者（含并列）在Cell Research, Nature Communications, Cell Reports, EMBO Reports等期刊发表论文。主持国家自然科学基金面上项目、青年项目，北京市自然科学基金面上项目等。获华夏医学科学技术三等奖、北京大学教学优秀团队奖等。

研究方向

（1） 阿尔茨海默病遗传易感性和致病机制

（2） 阿尔茨海默病认知减退的胆碱能神经调控机制

（3） 神经发育性疾病的基因型-表型关联以及致病机制研究

研究成果

1. Mei F, Zhao C, Li S, Xue Z, Zhao Y, Xu Y, Ye R, You H, Yu P, Han X, Carr G, Weinberger D, Yang F*, Lu B*. Ngfr+ cholinergic projection from SI/nBM to mPFC selectively regulates temporal order recognition memory. Nature Communications. 2024 Aug 26;15(1):7342. doi: 10.1038/s41467-024-51707-w.

2. Liu H#, Mei F#, *, Ye R, Han X, Wang S, Ding Y, Zhi Y, Pang K, Guo W, Lu B*. APOE3ch alleviates Aβ and tau pathology and neurodegeneration in the human APPNL-G-F cerebral organoid model of Alzheimer's disease.Cell Research. 2024 Jun;34(6):451-454. doi: 10.1038/s41422-024-00957-w. Epub 2024 Apr 12.

3. Wu Z#, Mei F#, Gan Y, Liu A, Hu J, Jin Y, Yin Y*.FAM69C functions as a kinase for eIF2α and promotes stress granule assembly.EMBO Reports. 2023 May 4;24(5): e55641. doi: 10.15252/embr.202255641. Epub 2023 Mar 16.

4. Mei F#, Hu J#, Wu Z, Zhang G, Liu A, Li X, Zhu M, Gan Y, Liang L, Zhao X, Yuan Y, Meng X, Li Y, Jin Y, Jia J* and Yin Y*. FAM69C, a kinase critical for synaptic function and memory, is defective in neurodegenerative dementia. Cell Reports. 2022 Jul 19;40(3):111101. doi: 10.1016/j.celrep.2022.111101.

5. Wang P#, Mei F#, Hu J, Zhu M, Qi H, Chen X, Li R, McNutt MA, Yin Y*. PTENα modulates CaMKII signaling and controls contextual fear memory and spatial learning. Cell Reports. 2017 Jun 20;19(12):2627-2641. doi: 10.1016/j.celrep.2017.05.088.

6. Li W#, Pang Y#, Wang Y#, Mei F, Guo M, Wei Y, Li X, Qin W, Wang W, Jia L, Jia J*. Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer's disease. BMC Medicine. 2023 Jun 26;21(1):223. doi: 10.1186/s12916-023-02930-7.

7. Zhang S, Li X, Zhang L, Meng X, Ma L, Zhang G, Wu H, Liang L, Cao M, Mei F*. Identification of a Rare PSEN1 mutation (Thr119Ile) in late-onset Alzheimer’s Disease with early presentation of behavioral disturbance. Frontiers in Psychiatry. 2020 May 14;11:347. doi: 10.3389/fpsyt.2020.00347. eCollection 2020.

8. Yuan Y, Zhao X, Wang P, Mei F, Zhou J, Jin Y, McNutt MA, Yin Y*. PTENα regulates endocytosis and modulates olfactory function. FASEB Journal. 2019 Oct;33(10):11148-11162. doi: 10.1096/fj.201900588RR. Epub 2019 Jul 10.

9. Zhang T, Li S, Mei F, You H, Chen Y, Yang F, Lu B*. A protocol for establishing a male G×E schizophrenia mouse model. STAR Protocols. 2022 Dec 16;3(4):101856. doi: 10.1016/j.xpro.2022.101856. Epub 2022 Nov 19.

10. Zhang S*, Wang Y, Liu L, Zhang L, Ma L, Wu H, He X, Zhu M, Wang L, Mei F.Case report of a pathologically confirmed vascular parkinsonism with early cognitive impairment and behavioral disturbance. BMC Neurology. 2021 Jan 11;21(1):15. doi: 10.1186/s12883-020-02038-y.

11. Wu H, Mei F, Liu L, Zhang L, Hao H, Zhang S*. Rare case of anti-LGI1 limbic encephalitis with rapidly progressive dementia, psychiatric symptoms, and frequently seizures: A case report. Medicine (Baltimore). 2021 Jul 23;100(29):e26654. doi: 10.1097/MD.0000000000026654.

（#第一作者，*通讯作者）