魏国超 博士

研究员、助理教授、博士生导师

地址：海淀区学院路38号北京大学基础医学院 邮编：100191

E-mail: weiguochao@hsc.pku.edu.cn

入选国家海外高层次人才项目，科技部国家重点研发计划课题负责人。长期致力于HIV与宿主互作机制及新型长效抗HIV药物的研究，代表性论文发表在Science、Nature Microbiology、Nature Communications等国际一流期刊。

研究方向

1. 揭示HIV与宿主相互作用的分子机制（结合病毒学、生物化学、细胞生物学及结构生物学等手段）；

2. 设计并筛选新型长效抗HIV药物；

3. 建立HIV合并其他重大传染病病毒感染的模型并探究其免疫调控机制。

学习/工作经历

2023年6月—至今：助理教授/研究员，北京大学

2018年4月—2023年2月：博士后，美国科罗拉多大学安舒茨校区

2013年12月—2018年01月：博士，病毒学，德国海德堡大学

2012年7月—2013年12月：助教，哈尔滨医科大学医学检验与技术学院

2005年9月—2012年7月：本科+硕士（七年制），基础医学，哈尔滨医科大学

发表论文（*共同第一作者，#通讯作者）

1. Bester, S.M.*, Wei, G.*, Zhao, H.*, Adu-Ampratwum, D., Iqbal, N., Courouble, V.V., Francis, A.C., Annamalai, A.S., Singh, P.K., Shkriabai, N., Van Blerkom, P., Morrison, J., Poeschla, E.M., Engelman, A.N., Melikyan, G.B., Griffin, P.R., Fuchs, J.R., Asturias, F.J. #, Kvaratskhelia, M#., (2020). Structural and mechanistic bases for a potent HIV-1 capsid inhibitor. Science 370, 360-364.

2. Rebensburg, S.V.*, Wei, G.*, Larue, R.C., Lindenberger, J., Francis, A.C., Annamalai, A.S., Morrison, J., Shkriabai, N., Huang, S.W., KewalRamani, V., Poeschla, E.M., Melikyan, G.B., Kvaratskhelia, M#., (2021). Sec24C is an HIV-1 host dependency factor crucial for virus replication. Nature Microbiology 6, 435-444

3. Wei, G., Iqbal, N., Courouble, V.V., Francis, A.C., Annamalai, A.S., Bester, S.M., Singh, P.K Huang, S.W., Shkriabai, N., Haney R., KewalRamani, V., Engelman, A.N, Melikyan, G.B., Griffin, P.R., Asturias, F.J, Kvaratskhelia, M. #, (2022). Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection. Nature Communications, 13(1):5879.

4. Wei, G., Kehl, T., Bao, Q., Benner, A., Lei, J., Lochelt, M. #, (2018). The chromatin binding domain, including the QPQRYG motif, of feline foamy virus Gag is required for viral DNA integration and nuclear accumulation of Gag and the viral genome. Virology 524, 56-68.

5. Bester, S.M., Adu-Ampratwum, D., Annamalai, A.S., Wei, G., Haney R., Fuchs, J.R., Kvaratskhelia, M. #, (2022). Structural basis of viral resistance to HIV-1 capsid inhibitor lenacapavir. mBio, Oct 3;e0180422.

6. Lindemann, D., Hutter, S., Wei, G., Lochelt, M. #, (2021). The Unique, the Known, and the Unknown of Spumaretrovirus Assembly. Viruses 13.

7. Ledesma-Feliciano, C., Hagen, S., Troyer, R., Zheng, X., Musselman, E., Slavkovic Lukic, D., Franke, A.M., Maeda, D., Zielonka, J., Munk, C., Wei, G., VandeWoude, S., Lochelt, M. #, (2018). Replacement of feline foamy virus bet by feline immunodeficiency virus vif yields replicative virus with novel vaccine candidate potential. Retrovirology 15, 38.

8. Liu Y, Betts MJ, Lei J, Wei G, Bao Q, Kehl T, Russell RB, Lochelt M#: Mutagenesis of N-terminal residues of feline foamy virus Gag reveals entirely distinct functions during capsid formation, particle assembly, Gag processing and budding. Retrovirology 2016, 13:57.

9. Lei J, Osen W, Gardyan A, Hotz-Wagenblatt A, Wei G, Gissmann L, Eichmuller S, Lochelt M#: Replication-Competent Foamy Virus Vaccine Vectors as Novel Epitope Scaffolds for Immunotherapy. PLoS One 2015, 10:e0138458.

10. Wei G, Chen J, Liu A-Y, Zhang M, Liu X-J, Liu D, Xu J, Liu B-R, Ling H, Wu H-X#: Prevalence of Helicobacter pylori vacA, cagA and iceA genotypes and correlation with clinical outcome. Experimental and therapeutic medicine 2012, 4:1039-1044.