导师介绍
邢国刚 教授
邢国刚，博士、教授、博士生导师
北京大学神经科学研究所副所长
北京大学基础医学院神经生物学系副主任
教育部/卫健委神经科学重点实验室副主任
联系方式
地址：北京市海淀区学院路38号 北京大学神经科学研究所
邮编：北京100191
电话：(010)-82805842
E-mail: ggxing@bjmu.edu.cn
研究方向
慢性痛/干细胞与神经发育障碍性疾病/营养与脑发育
个人简介
2001年于西安交通大学获得博士学位，同年在北京大学神经科学研究所做博士后研究，2003年8月任北京大学神经科学研究所讲师，2004年晋升副教授。2004年至2006年先后在美国Sanford Burnham Prebys(SBP)医学研究所和威斯康星大学神经科学系做高级访学。2013年至今任北京大学神经科学研究所教授。主要从事慢性痛、干细胞与神经发育障碍性疾病及营养与脑发育机制研究。主持和承担包括国家自然科学基金、北京市自然科学基金、国家重点研发计划项目、国家重点基础研究发展计划(科技部“973”计划)课题、国家重大科研仪器研制项目、国家卫健委行业专项基金、科技创新特区项目等多项国家级与省部级课题，在Advanced Materials, Molecular Psychiatry, Cell Communication and Signaling, Brain Behavior and Immunity, Journalof Neuroinflammation,The Journal of Neuroscience, Pain, Science Signaling等国内外学术期刊上发表研究论著100余篇。参加编写《神经科学》、国家卫健委“十三五”、“十四五”规划教材《生理学》（第9版、第10版），以及《康复生理学》（第2版、第3版）（人民卫生出版社）等教材和专著10部。获得北京市自然科学奖二等奖、北京市科学技术奖二等奖、中国针灸学会科学技术奖二等奖等奖项。
社会兼职
中国神经科学学会神经内稳态与内分泌分会副主任委员，中国针灸学会针刺麻醉分会副主任委员，中国神经科学学会感觉和运动分会常务委员，北京神经科学学会神经痛微创治疗专业委员会副主任委员。Brain Sciences, Journal of Pain Research, Frontiers in Pain Research, Nature Cell and Science, Annals of Biomedical Research,中国疼痛医学杂志等学术期刊编委。
研究兴趣
(1)疼痛与记忆、认知和情绪机制研究：采用分子生物学、细胞生物学、行为药理学、基因组学、代谢组学和单细胞测序的方法，结合神经示踪、活体钙成像、电生理学、光遗传学、化学遗传学和表观遗传学技术，从分子、细胞水平，突触水平，以及神经网络水平来研究离子通道与慢性痛的感觉、认知和负性情绪机制，包括疼痛记忆、认知障碍、焦虑、抑郁及其共病的中枢神经网络机制。
(2)干细胞与神经发育障碍性疾病研究：采用细胞重编程技术，利用化学小分子诱导人尿源性和血源性诱导多能干细胞（iPSCs），定向分化神经细胞、体外培养脑类器官，建立神经发育障碍性疾病的细胞模型及脑类器官模型；结合上述各种神经生物学技术和组学方法，研究神经发育障碍性疾病的发病机制；结合基因编辑技术进行疾病的干预措施研究。
(3)营养与脑发育机制研究：运用线虫、人脑类器官和小鼠模型，采用基因组学、代谢组学、结合神经示踪、活体钙成像、电生理学、光遗传学、化学遗传学和表观遗传学技术，研究多种营养成分在早期脑发育中的作用及机制。
科研基金
(1)国家自然科学基金面上项目，82371227，组蛋白去乙酰化酶HDAC2对Kv7(KCNQ)/M钾离子通道的转录抑制调控及其在大鼠骨癌痛中的作用研究，2024/01-2027/12
(2)国家自然科学基金面上项目，82171226，神经病理痛共病抑郁症的杏仁核内部微环路及分子机制研究，2022/01-2025/12
(3)北京市自然科学基金面上项目，7222105，杏仁核调控神经病理痛共病抑郁症的内部微环路及分子机制，2022/01-2024/12
(4)XXX创新**项目，22-TQ***-02，神经元培养功能XXX，2022/12-2024/12
(5)国家自然科学基金面上项目，81974169，杏仁核在慢性应激加重神经病理痛中的作用及神经调控环路机制研究，2020/01-2023/12
(6)国家重点研发计划项目，2019YFC1712104，循经配穴治疗坐骨神经痛的躯体感觉传入机制研究，2019/12-2022/06
(8)国家自然科学基金面上项目，81671085，P2X3嘌呤能受体的转录调控及其在大鼠骨癌痛中的作用研究，2017/01-2020/12
(9)国家自然科学基金(国家重大科研仪器研制项目)，61527815，多层次调控与高通量神经信号同步检测仪器，2016/01-2020/12
(10)国家自然科学基金面上项目，81371237，KCNQ/M(Kv7)钾通道的转录抑制调控及其在大鼠骨癌痛中的作用研究，2014/01-2017/12
(11)国家重点基础研究发展计划(973计划)课题，2013CB531905，针药复合麻醉镇痛机制研究，2013/01-2017/12
(12)国家卫生健康委员会行业专项基金，201302013-01，经皮穴位电刺激技术在生殖医学中的应用研究，2013/01-2017/12
(13)国家自然科学基金面上项目，31171063，KCNQ/M电压门控钾通道在骨癌痛中的作用及机制研究，2012/01-2015/12
(14)国家自然科学基金预探索项目，81072951，生精散激活精子特异性钙通道蛋白CatSper治疗弱精子症的临床与基础研究，2011/01-2011/12
(15)国家自然科学基金(仪器专项)，61027001，高通量神经信息检测分析仪器研制，2011/01-2013/12
(16)北京市自然科学基金面上项目，7112079，BDNF激活NMDA受体2B亚基磷酸化在神经病理痛中的作用，2011/01-2013/12
(17)国家重点基础研究发展计划(973计划)课题，2009CB522003，阿片类物质精神依赖的神经生物学机制，2009/01-2013/12
(18)教育部留学回国人员科研启动基金，2008890，背根神经节神经元超极化激活电流(Ih)参与大鼠神经病理痛的分子机制，2008/06-2011/06
(19)国家重点基础研究发展计划(973计划)课题，2007CB512501，针麻镇痛中高级中枢痛觉信息调制回路的作用，2007/07-2011/08
(20)国家自然科学基金面上项目，30370470，脊髓背角突触传递的长时程抑制在电针治疗神经病理痛中的作用及其机理研究，2004/01-2006/12
代表性研究论文(*通讯作者; #第一作者)
(1)Ye Jiang, Jing Yang, Min Wei, Jiayin Shou, Shixiong Shen, Zhuoying Yu, Zixian Zhang, Jie Cai, Yanhan Lyu, Dongsheng Yang, Yongzheng Han, Jinpiao Zhu, Zhigang Liu, Daqing Ma*, Guo-Gang Xing*and Min Li*. Probiotics alleviate painful diabetic neuropathy by modulating the microbiota-gut-nerve axis in rats. Journal of Neuroinflammation. 2025 Feb 2;22(1):30.
(2)Zi-Xian Zhang#, Yue Tian#, Song Li, Hong-Bo Jing, Jie Cai, Min Li*, Guo-Gang Xing*.Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription repression activated by EREG/EGFR-ERK-Runx1 signaling in bone cancer pain.Cell Communication and Signaling2024 Aug 27;22(1):416.
(3)Wen-Ge Shi, Yao Yao, Ya-Jing Liang, Jie Lei, Shi-Yang Feng, Zi-Xian Zhang, Yue Tian, Jie Cai, Guo-Gang Xing*, Kai-Yuan Fu*. Activation of TGR5 in the injured nerve site according to a prevention protocol mitigates partial sciatic nerve ligation-induced neuropathic pain by alleviating neuroinflammation. Pain. 2025 Jun 1;166(6):1296-1313.
(4)Yue Tian#, Xue-Wei Yang#, Lin Chen, Ke Xi, Si-Qing Cai, Jie Cai, Xiao-Mei Yang, Zhi-Yong Wang, Min Li*, Guo-Gang Xing*. Activation of CRF/CRFR1 signaling in the central nucleus of the amygdala contributes to chronic stress-induced exacerbation of neuropathic pain by enhancing GluN2B-NMDA receptor-mediated synaptic plasticityinadult male rats. Journal of Pain 2024 Aug;25(8):104495.
(5)Jing Yang, Zhuoying Yu, Ye Jiang, Zixian Zhang, Yue Tian, Jie Cai, Min Wei, Yanhan Lyu, Dongsheng Yang, Shixiong Shen, Guo-Gang Xing*, and Min Li*.SIRT3 alleviates painful diabetic neuropathy by mediating the FoxO3a-PINK1-Parkin signaling pathway to activate mitophagy.CNS Neuroscience & Therapeutics 2024Apr;30(4):e14703.
(6)Tongling Liufu,Haiyan Yu,Jiaxi Yu,Meng Yu,Yue Tian,Yichun Ou,Jianwen Deng,Guo-Gang Xing*,Zhaoxia Wang*. Complex I deficiency in m.3243A>G fibroblasts is alleviated by reducing NADH accumulation. Frontiers inPhysiology.2023 Aug 15;14:1164287.
(7)Ke Xi#, Si-Qing Cai#, Hui-Fang Yan, Yue Tian, Jie Cai,Xiao-Mei Yang*, Jing‑MinWang*, Guo-Gang Xing*. CSMD3 deficiency leads to motor impairments and autism-like behaviors via dysfunction of cerebellar Purkinje cells in mice. The Journal of Neuroscience 2023 May 24;43(21):3949-3969.
(8)Zhu-Lin Yuan#, Xiao-Dan Liu#, Zi-Xian Zhang#, Song Li, Yue Tian, Ke Xi, Jie Cai,Xiao-Mei Yang, Min Liu, Guo-Gang Xing*.Activation of GDNF-ERK-Runx1 signaling contributes to P2X3R gene transcription and bone cancer pain. iScience 2022 Aug 13; 25(9): 104936.
(9)Fan Xu#, Xian-wei Zou#, Li-qiong Yang#, Shi-cong Mo#, Quan-hao Guo, Jing Zhang, Xiechuan Weng* and Guo-Gang Xing*. Facial muscle movements in patients with Parkinson’s disease undergoing phonation tests. Frontiers in Neurology 2022 Oct 31; 13:1018362.
(10)Wang Wang#, Wei-Zhen Liu, Zi-Liang Wang, Dong-Xiao Duan, Xue-Yun Wang, Shi-Jin Liu, Zhi-Ju Wang, Guo-Gang Xing*, Ying Xing*. Spinal microglial activation promotes perioperative social defeat stress-induced prolonged postoperative pain in a sex-dependent manner. Brain, Behavior, and Immunity 2022Feb;100:88-104.
(11)Min Hao#, Zixian Zhang, Chao Liu, Yue Tian, Jiazhi Duan, Jianlong He, Zhaoyang Sun, He Xia, Shan Zhang, Shuhua Wang, Yuanhua Sang*,Guo-Gang Xing*, Hong Liu*. Hydroxyapatite Nanorods Function as Safe and Effective Growth Factors Regulating Neural Differentiation and Neuron Development. Advanced Materials 2021 Aug;33(33):e2100895.
(12)Hong Jiang#, Jiang-Ping Liu#, Ke Xi#, Ling-Yu Liu, Ling-Yu Kong, Jie Cai,Si-Qing Cai, Xi-Yuan Han, Jing-Gui Song, Xiao-Mei Yang, You Wan, Guo-Gang Xing*. Contribution of AMPA receptor-mediated LTD in LA/BLA-CeA pathway to comorbid aversive and depressive symptoms in neuropathic pain. TheJournal of Neuroscience2021 Aug 25;41(34):7278-7299.
(13)Jiang-Ping Liu#, Hong-Bo Jing#, Ke Xi, Zi-Xian Zhang, Zi-Run Jin, Si-Qing Cai, Yue Tian, Jie Cai and Guo-Gang Xing*. Contribution of TRESK two-pore domain potassium channel to bone cancer-induced spontaneous pain and evoked cutaneous pain in rats. Molecular Pain 2021 Jun-Dec;17(1-8):17448069211023230.
(14)Zi-Run Jin#, Dong Fang, Bo-Heng Liu, Jie Cai, Wen-Hao Tang, Hui Jiang, Guo-Gang Xing*. Roles of CatSper channels in the pathogenesis of asthenozoospermia and the therapeutic effects of acupuncture-like treatment on asthenozoospermia.Theranostics2021 Jan 1;11(6):2822-2844.
(15)Shiyang Huang#, Can Zheng#, Guoguang Xie#, Zhanming Song, Pingzhang Wang, Yun Bai, Dixin Chen, Yan Zhang, Ping Lv, Weiwei Liang, Shaoping She, Qingqing Li, Zhongtian Liu, Yun Wang, Guo-Gang Xing*, Ying Wang*. FAM19A5/TAFA5, a novel neurokine, plays a crucial role in depressive-like and spatial memory-related behaviors in mice.Molecular Psychiatry2021 Jun;26(6):2363-2379.
(16)Ran Huo#, Song-Ping Han#, Feng-Yu Liu, Xiao-Jing Shou, Ling-Yu Liu, Tian-Jia Song, Fu-Jun Zhai, Rong Zhang, Guo-Gang Xing*, Ji-Sheng Han*. Responses of Primary Afferent Fibers to Acupuncture-Like Peripheral Stimulation at Different Frequencies: Characterization by Single-Unit Recording in Rats.Neuroscience Bulletin2020Aug;36(8):907-918.
(17)Meng Xue#,Ya-Lan Sun, Yang-Yang Xia, Zhi-Hua Huang,Cheng Huang*andGuo-Gang Xing*. Electroacupuncture modulates spinal BDNF/TrkB signaling pathway and ameliorates the sensitization of dorsal horn WDR neurons in spared nerve injury rats. International Journal of Molecular Sciences2020 Sep 7;21(18):E6524.
(18)Ya-Jing Liang#, Shi-Yang Feng, Ya-Ping Qi, Kai Li, Zi-Run Jin, Hong-Bo Jing, Ling-Yu Liu, Jie Cai, Guo-Gang Xing*, Kai-Yuan Fu*. Contribution of microglial reaction to increased nociceptive responses in high-fat-diet (HFD)-induced obesity in male mice.Brain, Behavior, and Immunity2019 Aug; 80:777-792.
(19)Ling-Yu Liu#, Rui-Ling Zhang, Lin Chen, Hong-Yan Zhao, Jie Cai, Jia-Kang Wang, Da-Qing Guo, Yan-Jun Cui*, Guo-Gang Xing*. Chronic stress increases pain sensitivity via activation of the rACC–BLA pathway in rats.Experimental Neurology2019 Mar;313:109-123.
(20)Yue Yang#, Song Li#, Zi-Run Jin#, Hong-Bo Jing#, Hong-Yan Zhao, Bo-Heng Liu, Ya-Jing Liang, Ling-Yu Liu, Jie Cai,You Wan, Guo-Gang Xing*. Decreased abundance of TRESK two-pore domain potassium channels in sensory neurons underlies the pain associated with bone metastasis.Science Signaling2018 Oct 16; 11(552):eaao5150.
(21)Hong-Yan Zhao#, Ling-Yu Liu, Jie Cai, Yan-Jun Cui*, Guo-Gang Xing*.Electroacupuncture Treatment Alleviates the Remifentanil-induced Hyperalgesia by Regulating the Activities of Ventral Posterior Lateral Nucleus of the Thalamus Neurons in Rats.Neural Plasticity2018 Nov 11; 2018:6109723.
(22)Lin Chen#, Song Li#, Jie Cai, Tian-Jiao Wei, Ling-Yu Liu, Hong-Yan Zhao, Bo-Heng Liu, Hong-Bo Jing, Zi-Run Jin, Min Liu, You Wan, Guo-Gang Xing*. Activation of CRF/CRFR1 signaling in the basolateral nucleus of the amygdala contributes to chronic forced swim-induced depressive-like behaviors in rats.Behavioural Brain Research 2018 Feb 15; 338:134-142.
(23)Xu Ding#, Ya-Jing Liang, Li Su, Fei-Fei Liao, Dong Fang, Jun Tai, Guo-Gang Xing*. BDNF contributes to the neonatal incision-induced facilitation of spinal long-term potentiation and the exacerbation of incisional pain in adult rats.Neuropharmacology 2018 Jul 15; 137:114-132.
(24)Ming-Jia Li#, Ling-Yu Liu#, Lin Chen#, Jie Cai, You Wan, Guo-Gang Xing*. Chronic stress exacerbates neuropathic pain via the integration of stress-affect related information and nociceptive information in the central nucleus of the amygdala.Pain2017 Apr;158(4):717-739.
(25)Song Li#, Jie Cai, Zhi-Bo Feng, Zi-Run Jin, Bo-Heng Liu, Hong-Yan Zhao, Hong-Bo Jing, Tian-Jiao Wei, Guan-Nan Yang, Ling-Yu Liu, Yan-Jun Cui*, Guo-Gang Xing*. BDNF contributes to spinal long-term potentiation and mechanical hypersensitivity via Fyn-mediated phosphorylation of NMDA receptor GluN2B subunit at tyrosine 1472 in rats following spinal nerve ligation.Neurochemical Research 2017 Oct;42(10): 2712-2729.
(26)Dong Fang#, Ling-Yu Kong#, Jie Cai#, Song Li, Xiao-Dan Liu, Ji-Sheng Han, Guo-Gang Xing*. Interleukin-6-mediated functional upregulation of TRPV1 receptors in dorsal root ganglion neurons through the activation of JAK/PI3K signaling pathway: roles in the development of bone cancer pain in a rat model.Pain 2015 Jun;156(6):1124-1144.
(27)Jie Cai#, Dong Fang, Xiao-Dan Liu, Song Li, Juan Ren* and Guo-Gang Xing*. Suppression of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to the sensitization of dorsal horn WDR neurons and pain hypersensitivity in a rat model of bone cancer pain. Oncology Reports 2015 Mar; 33(3): 1540-1550.
(28)Xu Ding#, Jie Cai, Song Li, Xiao-Dan Liu, You Wan, Guo-Gang Xing*. BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation. Neurobiology of Disease2015 Jan; 73:428-451.
(29)Xiao-Dan Liu#, Jing-Jing Yang#, Dong Fang, Jie Cai, You Wan*, Guo-Gang Xing*. Functional Upregulation of Nav1.8 Sodium Channels on the Membrane of Dorsal Root Ganglia Neurons Contributes to the Development of Cancer-Induced Bone Pain. PLoS One 2014Dec 11;9(12): e114623.
(30)Hong Jiang#, Dong Fang#, Ling-Yu Kong, Zi-Run Jin, Jie Cai, Xue-Jing Kang, You Wan* and Guo-Gang Xing*. Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats. Molecular Brain 2014 Oct 4; 7:72.
(31)Lei Ding#, Jie Cai#, Xiang-Yang Guo, Xiu-Li Meng*, Guo-Gang Xing*. The anti-allodynic action of pregabalin may depend on the suppression of spinal neuronal hyperexcitability via decreasing the dorsal horn N-methyl-D-aspartate receptors in rats with spared nerve injury. Pain Research & Management 2014Jul-Aug;19(4):205-211.
(32)Min Liu#, Huan Yang, Dong Fang, Jing-Jing Yang, Jie Cai, You Wan, De-Hua Chui, Ji-Sheng Han, Guo-Gang Xing*. Up-regulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglion contributes to the bone cancer pain. Pain2013Sep;154(9):1551-1568.
(33)Qin Zheng#, Dong Fang, Ming Liu, Jie Cai, You Wan, Ji-Sheng Han,Guo-Gang Xing*. Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model. Pain 2013Mar;154(3):434-448.
(34)Qin Zheng#, Dong Fang, Jie Cai, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Enhanced excitability of small dorsal root ganglion neurons in rats with bone cancer pain. Molecular Pain 2012Apr 3;8:24.
(35)Feng-Yu Liu#, Yan-Ni Sun#, Fa-Tian Wang#, Qian Li, Li Su, Zi-Fang Zhao, Xiang-Ling Meng, Hong Zhao, Xi Wu, Qian Sun, Guo-Gang Xing*, You Wan*. Activation of satellite glial cells in lumbar dorsal root ganglia contributes to neuropathic pain after spinal nerve ligation. Brain Research2012Jan 3;1427:65-77.
(36)Ying-Ying Wang#, Jiong Qin*, Ying Han, Jie Cai, Guo-Gang Xing*. Hyperthermia induces epileptiform discharges in cultured rat cortical neurons. Brain Research 2011Oct 12;1417:87-102.
(37)Shan-Jing Geng#, Fei-Fei Liao#, Wen-Hao Dang, Xu Ding, Xiao-Dan Liu, Jie Cai, Ji-Sheng Han, You Wan, Guo-Gang Xing*. Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation. Experimental Neurology2010Apr;222(2):256-266.
(38)Feng-Yu Liu#, Xiao-Xiu Qu#, Xu Ding#, Jie Cai, Hong Jiang, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation. Brain Research. 2010May 12;1330:45-60.
(39)Tianran Song#, Yue Wang, Guian Chen* and Guogang Xing*. Tyrosine hydroxylase-positive cells and dopaminergic neuronal function in human embryonic stem cells: An electrophysiological validation.Neural Regeneration Research 2010; 5(3):185-190.
(40)Xiao-Xiu Qu#, Jie Cai#, Ming-Jia Li, Ye-Nan Chi, Fei-Fei Liao, Feng-Yu Liu, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain. Experimental Neurology 2009 Feb; 215(2):298-307.
(41)Lu Yu#, Fei Yang, Hao Luo, Feng-Yu Liu, Ji-Sheng Han, Guo-Gang Xing* and You Wan*. The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant. Molecular Pain 2008Dec 4;4:61.
(42)Guo-Gang Xing*, Feng-Yu Liu, Xiao-Xiu Qu, Ji-Sheng Han, You Wan*. Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain. Experimental Neurology2007 Dec;208(2):323-332.
(43)Feng-Yu Liu#, Guo-Gang Xing#, Xiao-Xiu Qu, Isabella S. Xu, Ji-Sheng Han, You Wan*. Roles of 5-HT receptor subtypes in the inhibitory effects of 5-HT on C-fiber responses of spinal wide dynamic range neurons in rats. The Journal of Pharmacology and Experimental Therapeutics2007 Jun;321(3):1046-1053.
(44)Guo-Gang Xing#,Rengang Wang#, Bo Yang, Dongxian Zhang*. Postnatal switching of NMDA receptor subunits from NR2B to NR2A in rat facial motor neurons. European Journal of Neuroscience 2006 Dec; 24(11):2987-2992.
(45)Qian Sun#, Guo-Gang Xing#, Huiyin Tu, Ji-Sheng Han, You Wan*. Inhibition of hyperpolarization- activated current by ZD7288 suppresses ectopic discharges of injured dorsal root ganglion neurons in a rat model of neuropathic pain. Brain Research 2005 Jan 25; 1032(1-2): 63-69.