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博士生导师

吴华君 研究员

吴华君 博士

北京大学医学部精准医疗多组学研究中心

北京大学医学部基础医学院

北京大学肿瘤医院

研究员 博士生导师

研究方向:多组学数据的统计方法开发及其在癌症研究中的应用

电子邮件:hjwu@bjmu.edu.cn

实验室主页:https://multiomics-bjmu.github.io

科研经历

2001-2005 北京师范大学 学士

2007-2012 中科院遗传与发育生物学研究所 博士

2013-2015 Dana-Farber Cancer Institute 博士

2015-2020 Dana-Farber Cancer Institute 助理研究员(Research Associate)

2020-2021 Dana-Farber Cancer Institute 数据科学家(Scientist)

2021- 北京大学医学部精准医疗多组学研究中心 研究员

代表论文 (* Equal contribution. + Co-corresponding authors.)

  1. Wu HJ*, Landshammer A*, Stamenova E, Bolondi A, Kretzmer H, Meissner A+, Michor F+ (2021) Topological isolation of developmental regulators in mammalian genomes. Nature Communications, 12(1):4897.

  2. Wu HJ*, Michor F+ (2016) A computational strategy to adjust for copy number in tumor Hi-C data. Bioinformatics 32, 3695-3701.

  3. Hinohara K*, Wu HJ*, Vigneau S, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales SC, Lal-Nag M, Rai G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrandt AA, Michor F+, Polyak K+ (2018) KDM5 histone demethylase activity links cellular transcriptomic heterogeneity to therapeutic resistance. Cancer Cell 34, 939-953.

  4. Shu S*, Wu HJ*, Ge JY, Zeid R, Harris IS, Jovanovic B, Murphy K, Wang B, Qiu X, Endress JE, Reyes J, Lim K, Font-Tello A, Syamala S, Xiao T, Chilamakuri CSR, Papachristou EK, D'Santos C, Anand J, Hinohara K, Li W, McDonald TO, Luoma A, Modiste RJ, Nguyen Q-D, Michel B, Cejas P, Kadoch C, Jaffe JD, Wucherpfennig KW, Qi J, Liu XS, Long H, Brown M, Carroll JS, Brugge JS, Bradner J, Michor F+, Polyak K+ (2020) Synthetic lethal and resistance interactions with BET bromodomain inhibitors in tripe-negative breast cancer. Molecular Cell 78, 1096-1113.

  5. Jun HJ*, Appleman VA*, Wu HJ*, Rose CM, Pineda JJ, Yeo AT, Delcuze B, Lee C, Gyuris A, Zhu H, Woolfenden S, Bronisz A, Nakano I, Chiocca EA, Bronson RT, Ligon KL, Sarkaria JN, Gygi SP, Michor F, Mitchison TJ, Charest A (2018) A PDGFRalpha-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine. Nature Communications 9, 3116, 1-13.