王杰 医学博士

北京大学基础医学院病原生物学系，副研究员，博士生导师

联系方式

Email: wangjie2015@hsc.pku.edu.cn

主要研究方向

乙型肝炎病毒和病毒感染相关肿瘤

1. 乙型肝炎病毒感染的诊疗及与宿主因子的相互作用

2. 病毒感染相关肿瘤的发生机制及靶向治疗

个人简介

2000-2005年，天津医科大学医学检验学系，医学学士；2005-2008年，北京大学基础医学院病原生物学系，医学硕士；2008-2010年，美国田纳西大学医学院分子科学系，访问学者；2012-2015年，北京大学基础医学院病原生物学系，医学博士；2015年至今，北京大学基础医学院病原生物学系，讲师、副研究员。目前已发表中英文文章90余篇，其中以第一或通讯作者（含并列）在Gut、Journal of Hepatology、Advanced Science、Autophagy、Small、Cell Death & Disease、Oncogene、Journal of Virology、Emerging Microbes & Infections等杂志上发表30余篇SCI论文，获得国家授权发明专利10余项。主持国家自然科学基金原创探索项目、面上项目、北京市自然科学基金、部委融合重点项目（子课题）、科技部“传染病防治”重大专项（任务）等多项科研课题。现任中华医学会肝病学分会青年学组委员及肝炎学组、肝癌学组和肝病基础医学与实验诊断协作组委员，北京医学会肝病学分会常务委员，中华预防医学会促进消除病毒性肝炎工作委员会委员，中国研究型医院学会病毒肿瘤学专业委员会委员等。

代表性论文（#第一作者，*通讯作者）

1.Yang X#, Sun H, Luo Z, Zhang Q, Song Y, Li J, Liu X, Wang J*. Anticodon engineered transfer RNA (tRNASUAG) inhibits hepatitis B virus replication by promoting the degradation of core protein. Advanced Science. 2025; e03534.

2.Li Z#, Song Y#, Huang H#, Chen R, Liu M, Yang X, Luo Z, Liu BM, Wang J*. Highly stable Cas9 promotesHBV genome destruction by antagonizing HSC70-mediated degradation. Emerging Microbes & Infections. 2025, Sep 4:2556728. doi: 10.1080/22221751.2025.2556728. Online ahead of print.

3.Song Y#, Feng Y#, Jiang Feng#, Xu X#, Yang P#, Liu M, Li L, Du C, Li H, Li Q, Qiao J, Shi J, Yang L, Yao T, Zhang G, Wang J*, Li J*. The HBV seroprevalence and immune responses to hepatitis B vaccination among college students from four universities in China. Vaccine. 2025; 61:127408.

4.Huang H#, Shi W#, Yan H#, Fan L, Lu J, Long Z, Li X, Li J, Wang J*, Liu L*, Qian J*. Dual roles of CXCR4 (C-X-C motif chemokine receptor 4) in promoting entry of ebolavirus and targeting excessive glycoprotein of reticulophagic degradation to facilitate viral fitness. Autophagy. 2025;Apr 20:1-20. doi: 10.1080/15548627.2025.2492877. Online ahead of print.

5.Li Y#, Song Y, Xiao Y, Wang T, Li L, Liu M, Li J*, Wang J*. The characteristic of HBV quasispecies is related to occult HBV infection of infants born to highly viremic mothers. Viruses. 2024; 16(7): 1104.

6.Zheng H#, Liu M#, Shi S#, Huang H, Yang X, Luo Z, Song Y, Xu Q, Li T, Xue L, Lu F, Wang J*. MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2–TGFb2–Smad2/3 signaling pathway in cervical cancer. Mol Oncol. 2024; 18(5):1327-1346.

7.Liu M#, Song Y#, Li Y, Yang X, Zhuang H, Li J*, Wang J*.C2729T mutation associated with HBV mother-to-child transmission reduces HBV production via suppressing LHBs expression. Virulence. 2023; 14(1):2189676.

8.Song Y#, Lu Y, Li Y, Liu M, Zhuang H, Li J*, Wang J*. HBx 128-133 deletion affecting HBV mother-to-child transmission weakens HBV replication via reducing HBx level and CP/ENII transcriptional activity. Viruses. 2022; 14(9):1887.

9.Huang H#, Han Q#, Zheng H, Liu M, Shi S, Zhang T, Yang X, Li Z, Xu Q, Guo H*,Lu F, Wang J*. MAP4K4 mediates the SOX6-induced autophagy and reduces the chemosensitivity of cervical cancer. Cell Death & Disease. 2022; 13(1):13.

10.Yu G#, Chen R, Zheng S, Liu Y, Zou J, Gu Z, Jiang B, Gao Q, Dai L*, Peng J*, Wang J*, Lu F*. A standardized assay for the quantitative detection of serum HBV RNA in chronic hepatitis B patients. Emerging Microbes & Infections. 2022; 11(1):775-785.

11.Li Y#, Xiao Y, Li L, Song Y, Zhai X, Liu J, Duan Z, Yan L, Ding F, Liu J, Zhu L, Jiang J, Zou H, Li L, Liang C, Wang J*, Li J*.The dynamic changes of HBV quasispecies diversity in infancy after immunoprophylaxis failure: a prospective cohort study. Virology Journal. 2021; 18:236.

12.Lu Y#, Song Y#, Zhai X, Zhu F, Liu J, Chang Z, Li Y, Xiao Y, Li L, Liu M, Liu J, Duan Z, Zou H, Zhuang H, Wang J*, Li J*. Maternal Hepatitis B e Antigen can be an Indicator for Antiviral Prophylaxis of Perinatal Transmission of Hepatitis B Virus. Emerging Microbes & Infections. 2021; 10(1):555-564.

13.Xiao Y#, Sun K#, Duan Z, Liu Z, Li Y, Yan L, Song Y, Zou H, Liu J, Zhuang H*, Wang J*, Li J*. Quasispecies characteristic in “a” determinant region is a potential predictor for the risk of immunoprophylaxis failure of mother-to-child-transmission of sub-genotype C2 hepatitis B virus: a prospective nested case-control study.Gut. 2020; 69(5):933-941.

14.Li Y#, Liu Z#, Song Y, Xiao Y, Jiang J, Li L, Zhai X, Liu J, Duan Z, Ding F, Liu J, Zhuang H, Zhu L, Jiang J, Zou H, Wang J*, Li J*. Reduction of the occurrence of occult HBV infection in infants by increasing the dose of hepatitis B vaccine: A large prospective cohort study. Emerging Microbes & Infections. 2020; 9(1):1881-1891.

15.Shi S#, Liu M, Xi J, Liu H, Guan G, Shen C, Guo Z, Zhang T, Xu Q, Kudereti D, Chen X, Wang J*, Lu F*. Sex-determining region Y box 4 (SOX4) suppresses hepatitis B virus replication by inhibiting hepatocyte nuclear factor 4α expression. Antiviral Research. 2020; 176: 104745.

16.Chen R#, Huang H#, Liu H, Xi J, Ning J, Zeng W, Shen C, Zhang T, Yu G, Xu Q, Chen X, Wang J*, Lu F*. Friend or Foe? Evidences Indicate Endogenous Exosomes Can Deliver Functional gRNA and Cas9 Protein. Small. 2019;15(38): e1902686.

17.Wang J#, Chen R#, Zhang R#, Ding S, Zhang T, Yuan Q, Guan G, Chen X, Zhang T, Zhuang H, Nunes F, Block T, Liu S, Duan Z, Xia N*, Xu Z*, Lu F*. The gRNA-miRNA-gRNA ternary cassette combining CRISPR/Cas9 with RNAi approach strongly inhibits hepatitis B virus replication. Theranostics. 2017; 7(12):3090-3105.

18.Wang J#, Shen T#, Huang X#, Kumar GR#,Chen X,Zeng Z,Zhang R,Chen R,Li T,Zhang T,Yuan Q,Li PC,Huang Q,Colonno R,Jia J,Hou J,McCrae MA,Gao Z*,Ren H*,Xia N*,Zhuang H,Lu F*. Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound. Journal of Hepatology. 2016; 65(4):700-710.

19.Wang J, Ding S, Duan Z, Xie Q, Zhang T, Zhang X, Wang Y, Chen X*, Zhuang H, Lu F*. The role of p14ARF-HDM2-p53 in SOX6-mediated tumor suppression. Oncogene. 2016; 35(13):1692-1702.

20.Wang J, Liu B, Wang N, Lee YM, Liu C, Li K*. TRIM 56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection. Journal of Virology. 2011; 85(8):3733-3745.