郑杰

博士，助理教授，副研究员，博士生导师

北京大学神经科学研究所，北京大学基础医学院神经生物系

联系地址：北京市海淀区学院路38号北京大学医学部医学科技楼北楼502D

Email: zhengjiie@hsc.pku.edu.cn

课题组网页：https://www.x-mol.com/groups/zhengjiie

研究方向

课题组主要围绕阿尔茨海默病（AD）及相关神经退行性疾病的预防、诊断和治疗开展研究工作：（1）从分子-细胞-神经环路-整体水平，研究AD病理机制，针对其中关键靶点开发治疗药物。目前主要以tau蛋白病变为关注重点。（2）探讨通过诱导神经再生治疗AD的相关问题。（3）AD诊断生物标志物发现、风险因素解析。

个人简介

2012年毕业于华中科技大学生物医学工程专业，获工学学士学位，2017年于北京大学获医学神经生物学博士学位，2017-2020年于华中科技大学同济医学院王建枝教授实验室从事博士后研究工作，后于遵义医科大学任教两年，2022年入职北京大学医学部神经生物学系，建立实验室。

代表性成果

(# co-first author, * correspondence)

 Qi X#, Yuan S#, Ding J#, Sun W, Shi Y, Xing Y, Liu Z, Yao Y, Fu S, Sun B, Qi X, Xia B, Liu F, Yi M, Mao J, Wan Y*, Zheng J*. Emerging signs of Alzheimer-like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID-19. Aging Cell. 2024 Sep 29:e14352. doi: 10.1111/acel.14352

 Xiao Y#, Wei L#, Su J#, Lei H, Sun F, Li M, Li S, Wang X*, Zheng J*, Wang JZ*. A tau dephosphorylation-targeting chimera selectively recruits protein phosphatase-1 to ameliorate Alzheimer's disease and tauopathies. Cell Chem Biol. 2024. 31(10):1787-1799.e6

 Su J#, Xiao Y#, Wei L, Lei H, Sun F, Wang W, Li S, Wang X*, Zheng J*, Wang JZ*. A new tau dephosphorylation-targeting chimera for the treatment of tauopathies. Acta Pharmacol Sin. 2024. 45(11):2267-2276

 Su J#, Xiao Y#, Wei L, Lei H, Sun F, Wang W, Yin J, Xiong R, Li S, Zhang P, Zhou Y, Wang X*, Zheng J*, Wang JZ*. Generation of tau dephosphorylation-targeting chimeras for the treatment of Alzheimer's disease and related tauopathies. Sci Bull. 2024. 69(8):1137-1152.

 Gao Y#*, Wang YY#, Lei HY, Xu ZD, Li SH, Yu HT, Xie JZ, Zhang ZT, Liu GP, Zhang Y*, Zheng J*, Wang JZ*. A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau. Transl Neurodegener. 2023. 12(1), 51.

 Gao Y#, Yu H#, Liu Y, Xu Z, He B, Liu H, Wang Y, Zhang Y, Liang Y, Yang Y, Zheng J*, Wang JZ*. GSK-3β activation mediates apolipoprotein E4-associated cognitive impairment in type 2 diabetes mellitus: A multicenter, cross-sectional study. J Diabetes. 2023. 16(1):e13470.

 Shi Y, Wan Y, Zheng J*. Waking up neural stem cells through inhibition of mitochondrial pyruvate import. Brain‐X. 2023. 1(2).e13. Commentary

 Zheng J. Hippocampal neurogenesis and pro-neurogenic therapies for Alzheimer's disease. Animal Model Exp Med. 2022. 5(1):3-14. Review (Cover story)

 Zheng J#*, Tian N#, Liu F, Zhang Y, Su J, Gao Y, Deng M, Wei L, Ye J, Li H, Wang JZ*. A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies. Signal Transduct Target Ther. 2021. 6(1):269. (Cover story)

 Zheng J*, Li Y. Compensation for Neurodegeneration by Hippocampal Neurogenesis in Alzheimer's Disease: Where is the Way? Neurosci Bull. 2021. 37(6):885-888. Insight

 Zheng J#*, Li HL#, Tian N, Liu F, Wang L, Yin YL, Yue LP, Ma LY, Wan Y, Wang JZ*. Interneuron accumulation of phosphorylated tau impairs adult hippocampal neurogenesis by suppressing GABAergic transmission. Cell Stem Cell. 2020. 26(3):331-345.e6.

 Liu F, Tian Na, Zhang HQ, Li SH, Zhou QZ, Zheng J*, Wang JZ*. GSK-3β activation accelerates early-stage consumption of hippocampal neurogenesis in senescent mice. Theranostics. 2020. 10(21):9674-9685.

 Zheng J, Jiang YY, Ma LY, Liu FY, Cui S, Cai J, Liao FF, Wan Y*, Yi M*. Adult hippocampal neurogenesis along the dorsoventral axis contributes differentially to environmental enrichment combined with voluntary exercise in alleviating chronic inflammatory pain in mice. J Neurosci. 2017. 37(15):4145-4157.

 Zheng J, Yi M, Wan Y*. Hippocampal neurogenesis: does it relieve or worsen chronic pain? Pain. 2016. 157(2):506-507. Letter to editor