导师介绍
王凯 研究员
王凯 研究员 博士生导师
联系方式
kai.wang88@pku.edu.cn
研究方向
干细胞与心血管类器官
个人简介
王凯博士,北京大学基础医学院生理学与病理生理学系,研究员,血管稳态与重构全国重点实验室PI。王凯在北京大学获得博士学位(2016),在哈佛医学院/波士顿儿童医院、康奈尔大学(2016-2021)接受博士后训练。他的实验室长期致力于干细胞、类器官和组织工程的学科交叉研究, 试图从疾病模型、基因和细胞治疗的角度为包括心血管病和糖尿病等疾病的治疗提供解决方案。相关研究成果以通讯作者(含共同)发表在Cell Stem Cell (2025a, 2025b封面), Nat Commun (2024), Adv Sci (2024)等国际期刊。先后承担NSFC(青B、面上、培育),北京市(杰青、科技新星)和四大慢病重大项目课题等。担任Cell Organoid共同主编,Cell Transplantation 和Microvascular Research副主编。担任细胞生物学学会类器官研究与应用分会委员、生理学会青年工作委员会委员等。获奖包括中国细胞生物学学会干细胞卓越青年研究员(2025), 林松年杰出青年学者奖(2025)和龚兰生青年学者奖(2025)。
学习经历/工作经历
2006-2010 东南大学 本科
2010-2016 北京大学 博士
2016-2021 哈佛医学院 博士后
2021-现在 北京大学 研究员
科研成果
Liyan Gong, Yadong Zhang, Yonglin Zhu, Umji Lee, Allen Chilun Luo, Xiang Li, Xi Wang, Danyang Chen, William T. Pu, Ruei-Zeng Lin, Minglin Ma, Miao Cui, Kaifu Chen, Kai Wang*, Juan M. Melero-Martin*. Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages. Cell Stem Cell , 2025 Jun 10:S1934-5909(25)00221-8.(Previews & Cover)
Yun Zhao#, Mengze Sun#, Zihang Pan#, Weijing Kong, Zixuan Hong, Wei Zhang, Bingbing Sun, Jingjing Zhang*, Xi Wang*, Kai Wang*. A novel quantitative angiogenesis assay based on visualized vascular organoid. Angiogenesis , 2025 Jan 3;28(1):10. doi: 10.1007/s10456-024-09967-z
Zihang Pan#, Qiyang Yao#, Weijing Kong, Xiaojing Ma, Liangliang Tian, Yun Zhao, Shuntian Zhu, Sheng Chen, Mengze Sun, Jiao Liu, Simin Jiang, Jianxun Ma, Qijia Liu, Xiaohong Peng, Xiaoxia Li, Zixuan Hong, Yi Hong, Xue Wang, Jiarui Liu, Jingjing Zhang, Wei Zhang, Bingbing Sun, Sara Pahlavan,Youchen Xia, Weimin Shen, Yuyong Liu, Wenjian Jiang, Zhengwei Xie*, Wei Kong,* Xi Wang,* Kai Wang*. Generation of iPSC-derived venous endothelial cells for the modeling of vascular malformation and drug discovery. Cell Stem Cell , 2025,32(2),227-245. Doi: 10.1016/j.stem.2024.10.015 (Previews)
Umji Lee#, Yadong Zhang#, Yonglin Zhu, Allen Chilun Luo, Liyan Gong, Daniel M. Tremmel, Yunhye Kim, Victoria Sofia Villarreal, Xi Wang, Ruei-Zeng Lin, Miao Cui, Minglin Ma, Ke Yuan, Kai Wang*, Kaifu Chen*, Juan M. Melero-Martin*. Robust differentiation of human pluripotent stem cells into mural progenitor cells via transient activation of NKX3.1. Nature Communications , 2024, 15 (1), 8392. doi:10.1038/s41467-024-52678-8
Xuanyu Liu#, Qingyi Zeng#, Hang Yang, Wenke Li, Qianlong Chen, Kunlun Yin, Zihang Pan, Kai Wang*, Mingyao Luo*, Chang Shu*, Zhou Zhou*. Single-nucleus Multiomic Analyses Identifies Gene Regulatory Dynamics of Phenotypic Modulation in Human Aneurysmal Aortic Root. Advanced Science , 2024, 11(22), e2400444. doi:10.1002/advs.202400444
Kai Wang, Ruei-Zeng Lin, Alex H. Ng, Xuechong Hong, Chin Nien Lee, Joseph Neumeyer, Gang Wang, Xi Wang, Minglin Ma, William T. Pu, George M. Church, Juan M. Melero-Martin*, Robust Differentiation of Human Pluripotent Stem Cells into Endothelial Cells via Temporal Activation of ETV2 with Modified mRNA. Science Advances 2020; 6(30): eaba7606. Doi: 10.1126/sciadv.aba7606
指导学生情况
已毕业学生:2017级八年制博士研究生 潘子航 田亮亮