导师介绍
曾克武 研究员
个人简介：曾克武，北京大学博雅特聘教授，研究员，博导，中西医结合教研室主任，天然药物及仿生药物全国重点实验室PI，国家杰青，教育部高层次青年人才计划入选者。聚焦天然药物的直接靶标发现及靶标驱动的药物分子机制解码和创新药物转化。获中华中医药学会科学技术奖中青年创新人才奖，中国药理学会青年药理学家奖。在PNAS，Science Advances，Advanced Science，ACS Nano 等发表系列研究论文，授权发明专利10项。成果入选2022年度中医药十大学术进展，2017年度中国十大医学进展。
联系方式：ZKW@bjmu.edu.cn
研究方向：基于化学生物学策略的天然药物靶标鉴定新方法及细胞分子机制
授课课程：《中药化学生物学》、《天然药物化学》、《天然药物化学实验》、《天然药物前沿概论》、《分子药理学》等。
科研成果:累计承担国家自然科学基金杰出青年项目（青A）、面上项目、区域联合项目、青年项目、科技部重点研发计划子课题、北京市自然科学基金面上项目、联合基金重点专项等科研课题20项。获中华民族医药学会科学技术奖一等奖，华夏医学科技奖二等奖，中国中西医结合科学技术二等奖，教育部高等学校科学研究优秀成果奖二等奖。
指导学生情况：目前指导在读研究生14人。共培养了博士研究生15人、硕士研究生14人。培养学生中3人获国家奖学金，2人获北京大学优秀博士学位论文，多人获北京市优秀毕业生、北京大学优秀毕业生、北京大学三好学生标兵等奖励和称号。毕业学生中迄今7人获得了国家基金委青年基金项目资助。
代表性论文：
1.Xin-Yu Xiao, Qian-Wei Luo, Wang-Shu Li, Ze-Kun Chen, ZhuoYang, Ya-Xuan Zhu, Mu-Rong Lei, Fang-Fang Zhuo, Ming Yu, Tian-Tian Wei, Hong-Wei Jin, Zhong-Yao Li, Zhi-Yuan Lu, Zhu-Qing Zhang, Hua Wang, Yong-Cheng Wang, Qing Xia, Wei Yu, Bo Han, Peng-Fei Tu*, Ke-WuZeng*.Nanoparticles induce protein corona conformational change to reshape intracellular interactome for microglial polarization.ACS Nano19(2025)32920-32942.
2. Mei-Mei Zhao#, Ting-Ting Ren#, Jing-Kang Wang, Lu Yao, Ting-Ting Liu, Ji-Chao Zhang, Yang Liu, Lan Yuan, Dan Liu, Jiu-Hui Xu, Peng-Fei Tu, Xiao-Dong Tang*,Ke-Wu Zeng*.Endoplasmic reticulum membrane remodeling by targeting reticulon-4 induces pyroptosis to facilitate antitumor immune.Protein Cell16(2025)121-135.
3.Zhuo Yang, Xiao-Wen Zhang, Fang-Fang Zhuo, Ting-Ting Liu, Qian-Wei Luo, Yong-Zhe Zheng, Li L, Heng Yang, Yi-Chi Zhang, Yan-Hang Wang, Dan Liu, Peng-Fei Tu, Ke-Wu Zeng*. Allosteric activation of transglutaminase 2 via inducing an "open" conformation for osteoblast differentiation. Advanced Science10(2023)2206533.
4. Xiao-Wen Zhang#, Na Feng#, Yan-Chen Liu, Qiang Guo, Jing-Kang Wang, Yi-Zhen Bai, Xiao-Ming Ye, Zhuo Yang, Heng Yang, Yang Liu, Mi-Mi Yang, Yan-Hang Wang, Xiao-Meng Shi, Dan Liu, Peng-Fei Tu*, Ke-Wu Zeng*. Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy.Science Advances8(2022)eabo0789.
5. Lu Yao, Mei-Mei Zhao, Qian-Wei Luo, Yi-Chi Zhang, Ting-Ting Liu, Zhuo Yang, Min Liao, Peng-Fei Tu*, Ke-Wu Zeng*. Carbon quantum dots-based nanozyme from coffee induces cancer cell ferroptosis to activate antitumor immunity. ACS Nano 16(2022)9228-9239.
6. Li-Xi Liao#, Xiao-Min Song#, Li-Chao Wang#, Hai-Ning Lv, Jin-Feng Chen, Dan Liu, Ge Fu, Ming-Bo Zhao, Yong Jiang, Ke-Wu Zeng*, Peng-Fei Tu*. Highly selective inhibition of IMPDH2 provides the basis of antineuroinflammation therapy. PNAS114(2017)E5986-E5994.
7. Yang Liu, Qiang Guo, Heng Yang, Xiao-Wen Zhang, Na Feng, Jing-Kang Wang, Ting-Ting Liu, Ke-Wu Zeng*, Peng-Fei Tu*. Allosteric regulation of IGF2BP1 as a novel strategy for the activation of tumor immune microenvironment. ACS Central Science8(2022)1102-1115.
8. Qiang Guo, Yi-Chi Zhang, Wei Wang, Yu-Qi Wang, Yang Liu, Zhuo Yang, Mei-Mei Zhao, Na Feng, Yan-Hang Wang, Xiao-Wen Zhang, Heng Yang, Ting-Ting Liu, Lun-Yong Shi, Xiao-Meng Shi, Dan Liu, Peng-Fei Tu*, Ke-Wu Zeng*. Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification.Pharmacological Research176(2022)106046.
9.Ting-Ting Liu#, Heng Yang#, Fang-Fang Zhuo, Zhuo Yang, Mei-Mei Zhao, Qiang Guo, Yang Liu, Dan Liu, Ke-Wu Zeng*, Peng-Fei Tu*. Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy. EBioMedicine 86(2022)104353.
10. Xiaoqing Zhou#, Shaoyang Zhao#, Tingting Liu#, Lu Yao, Meimei Zhao, Xiaoming Ye, Xiaowen Zhang, Qiang Guo, Pengfei Tu, Kewu Zeng*. Schisandrol A protects AGEs-induced neuronal cells death by allosterically targeting ATP6V0d1 subunit of V-ATPase. Acta Pharmaceutica Sinica B12(2022)3843-3860.