王丽超，新体制助理教授，副研究员，博士生导师

北京大学基础医学院中西医结合教研室

E-mail: wanglichao@bjmu.edu.cn

  王丽超博士主要从事细胞衰老所致机体衰老及老年性疾病的机制和药物干预研究，以第一（含共同第一）作者在Cell Metabolism (x 2)、Nature Aging、PNAS、EbioMedicine等杂志发表多篇论文，构建了可体内追踪和调控衰老细胞的新型p21-cre工具小鼠并发现了肥胖和衰老相关的p21high衰老细胞群；建立了靶向p21high细胞群改善机体代谢功能紊乱、减轻衰老组织功能退化以及延长健康寿命的策略；应用天然产物有效延缓了机体衰老并显著改善了衰老相关疾病如代谢功能紊乱、骨质疏松症等。课题组长期招收研究生和博士后，欢迎加入！

研究方向：

1. 细胞衰老发生及致病机制

2. 抗衰老中药药效物质及作用机制

学习/工作经历:

2025.03-今 北京大学基础医学院中西医结合教研室，副研究员

2018.11-2025.02 康涅狄格大学医学院衰老研究中心，博士后  

2015.09- 2018.06 中国药科大学/北京大学（联合培养），生药学，博士  

2012.09- 2015.06 中国药科大学，生药学，硕士  

2008.09- 2012.06 中国药科大学，中药资源与开发，学士

主持科研项目：

(1) Gut microbiome changes associated with p21high cell clearance in aging

Glenn Foundation for Medical Research Postdoctoral Fellowships in Aging Research by American Federation for Aging Research, 7/1/2023-6/30/2024, $75000, PI. (https://www.afar.org/2023-grant-recipients)

(2) Proteomic mechanisms of lifespan and healthspan extension by targeting p21high cell in vivo

San Diego Nathan Shock Center Pilot Grant Program, 10/24/2022-05/31/2023, $19200, PI. (https://www.salk.edu/science/research-centers/san-diego-nathan-shock-center/funding-and-workshops/)

代表性论文：

1. Wang L#, Wang B#, Gasek NS, Zhou Y, Cohn RL, Martin DE, Zuo W, Flynn WF, Guo C, Jellison ER, Kim T, Prata LGPL, Palmer AK, Li M, Inman CL, Barber LS, Al-Naggar IMA, Zhou Y, Du W, Kshitiz, Kuchel GA, Meves A, Tchkonia T, Kirkland JL, Robson P, Xu M. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity. Cell Metab. 2022 Jan 4;34(1):75-89.e8. (#, co-1st author, a peer pre-reviewed paper)

2. Wang B#, Wang L#, Gasek NS, Kuo CL, Nie J, Kim T, Yan P, Zhu J, Torrance BL, Zhou Y, Flores LC, Allen C, Andrade AM, Guo C, Cohn RL, Jellison ER, Bartley JM, Kuchel GA, Li S, Pirtskhalava T, Tchkonia T, Yadav S, Haynes L, Kirkland JL, Ikeno Y, Xu M. Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function. Cell Metab. 2024 Aug 6;36(8):1795-1805.e6. (#, co-1st author)

3. Wang B#, Wang L#, Gasek NS#, Zhou Y, Kim T, Guo C, Jellison ER, Haynes L, Yadav S, Tchkonia T, Kuchel GA, Kirkland JL, Xu M. An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo. Nat Aging. 2021 Oct;1(10):962-973. (#, co-1st author, F1000 recommendation)

4. Liao LX#, Song XM#, Wang LC#, Lv HN, Chen JF, Liu D, Fu G, Zhao MB, Jiang Y, Zeng KW, Tu PF. Highly selective inhibition of IMPDH2 provides the basis of antineuroinflammation therapy. Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5986-E5994. (#, co-1st author)

5. Wang LC, Liao LX, Lv HN, Liu D, Dong W, Zhu J, Chen JF, Shi ML, Fu G, Song XM, Jiang Y, Zeng KW, Tu PF. Highly Selective Activation of Heat Shock Protein 70 by Allosteric Regulation Provides an Insight into Efficient Neuroinflammation Inhibition. EBioMedicine. 2017 Sep;23:160-172.