何林 博士

新体制助理教授，副研究员，博士生导师

北京大学基础医学院中西医结合教研室

Email: linhe@bjmu.edu.cn

研究方向：

肿瘤表观遗传调控及干预策略。揭示肿瘤等疾病发生发展的表观遗传及基因转录调控机制，阐释中药及其活性成分发挥抗肿瘤等作用的分子机制，探索临床相关疾病治疗的中西医干预策略。

个人简介：

2022.10至今 北京大学，中西医结合基础，新体制助理教授，副研究员，博士生导师

2018.10—2022.09 北京大学，药学， 博士后

2013.09—2018.09 北京大学，医学生物化学与分子生物学， 博士

2009.09—2013.08 中央民族大学，生物科学，学士

以第一或通讯作者（含共同）身份在Cell Metabolism、Cell Research及EMBO Reports等期刊发表研究成果。承担国家自然科学基金面上项目、青年项目、北京市自然科学基金面上项目及中国博士后基金面上项目等6项。

获奖情况：

2022年，北京大学基础医学院青年岗位能手

2021年，北京大学“拜耳”博士后

2021年，北京大学医学部优秀博士后

2019年，北京大学优秀博士学位论文

2018年，北京大学博雅博士后

2018年，北京大学优秀毕业生及三好学生

2017年，北京大学医学研究生特等（精勤厚道医学生）奖学金

2014年，国家奖学金

主要代表作：（*为第一作者，#为通讯作者）

1. Rui-Yuan Pan*, Lin He*, Jing Zhang, Xinhua Liu, Yajin Liao, Yuhan Yan, Ju Gao, Qianqian Li, Yang Liao, Jinbo Cheng, Qu Xing, Fangxia Guan, Xinglong Wang, Jie Zhang, Luyang Sun#, and Zengqiang Yuan# (2022). Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease. Cell Metabolism 34(4):634-648.

2. Lin He, Xinhua Liu, Jianguo Yang, Wanjin Li, Shumeng Liu, Xujun Liu, Ziran Yang, Jie Ren, Yue Wang, Lin Shan, Fei Pei, Liandi Lei, Yu Zhang, Xia Yi, Xiaohan Yang, Jing Liang, Luyang Sun#, and Yongfeng Shang# (2018). Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis. Cell Research 28:934-951.

3. Lin He*, Ruorong Yan*, Ziran Yang, Yue Zhang, Xinhua Liu, Jianguo Yang, Xujun Liu, Xiaoping Liu, Lu Xia, Yue Wang, Jiajing Wu, Xiaodi Wu, Lin Shan, Xiaohan Yang, Jing Liang, Yongfeng Shang, and Luyang Sun# (2021). SCFJFK Is Functionally Linked to Obesity and Metabolic Syndrome. EMBO Reports 22(7): e52036.

4. Ziran Yang*, Xuehong Zhou*, Enrun Zheng, Yizhou Wang, Xinhua Liu, Yue Wang Yanpu Wang, Zhaofei Liu, Fei Pei, Yue Zhang, Jie Ren, Yunchao Huang, Lu Xia, Sudun Guan, Sen Qin, Feiya Suo, Jie Shi, Lijing Wang, Lin He#, and Luyang Sun# (2021). JFK Is a Hypoxia-inducible Gene that Functions to Promote Breast Carcinogenesis. Frontiers in Cell and Developmental Biology 9: 686737.

5. Xujun Liu, Wenzhe Si, Lin He, Jianguo Yang, Yani Peng, Jie Ren, Xiaoping Liu, Tong Jin, Huajing Yu, Zihan Zhang, Xiao Chen, Wenting Zhang, Lu Xia, Yunchao Huang, Yue Wang, Shumeng Liu, Lin Shan, Yu Zhang, Xiaohan Yang, Haixia Li, Jing Liang, Luyang Sun#, and Yongfeng Shang# (2021). The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry. Signal Transduction and Targeted Therapy 6(1): 375.

6. Xiaoping Liu*, Bosen Xu*, Jianguo Yang, Lin He, Zihan Zhang, Xiao Cheng, Huajing Yu, Xujun Liu, Tong Jin, Yani Peng, Yunchao Huang, Lu Xia, Yue Wang, Jiajing Wu, Xiaodi Wu, Shumeng Liu, Lin Shan, Xiaohan Yang, Luyang Sun, Jing Liang, Yu Zhang#, and Yongfeng Shang# (2021). UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1. Molecular Cell 81(14):2960-2974.

7. Jianguo Yang, Xiaoping Liu, Yunchao Huang, Lin He, Wenting Zhang, Jie Ren, Yue Wang, Jiajing Wu, Xiaodi Wu, Lin Shan, Xiaohan Yang, Luyang Sun, Jing Liang, Yu Zhang#, and Yongfeng Shang# (2021). TRPS1 drives heterochromatic origin refiring and cancer genome evolution. Cell Reports 34(10):108814.

8. Chengjian Guan, Lin He, Zhenyu Chang, Xinjin Gu, Jing Liang, and Rong Liu# (2020). ZNF774 is a potent suppressor of hepatocarcinogenesis through dampening the NOTCH2 signaling. Oncogene 39(8):1665-1680.

9. Huajing Yu, Chen Bu, Yuncheng Liu, Tianyu Gong, Xiaoping Liu, Shumeng Liu, Xiaojun Peng, Wenting Zhang, Yani Peng, Jianguo Yang, Lin He, Yu Zhang, Xia Yi, Xiaohan Yang, Luyang Sun, Yongfeng Shang, Zhongyi Cheng, and Jing Liang# (2020). Global crotonylome reveals CDYL-regulated RPA1 crotonylation in homologous recombination–mediated DNA repair. Science Advances 6(11): eaay4697.

10. Xia Ting, Lu Xia, Jianguo Yang, Lin He, Wenzhe Si, Yongfeng Shang, and Luyang Sun# (2019). USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair. Nucleic Acids Research 47(18):9721-9740.

11. Zhe Chen, Zhe Chen, Bin Gui, Yu Zhang, Guojia Xie, Wanjin Li, Shumeng Liu, Bosen Xu, Chongyang Wu, Lin He, Jianguo Yang, Xia Yi, Xiaohan Yang, Luyang Sun, Jing Liang, and Yongfeng Shang# (2017). Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly. Journal of Biological Chemistry 292(44):18113-18128.

12. Lifang Li, Xinhua Liu, Lin He, Jianguo Yang, Fei Pei, Wanjin Li, Shumeng Liu, Zhe Chen, Guojia Xie, Bosen Xu, Xia Ting, Zihan Zhang, Tong Jin, Xujun Liu, Wenting Zhang, Shuai Yuan, Ziran Yang, Chongyang Wu, Yu Zhang, Xiaohan Yang, Xia Yi, Jing Liang, Yongfeng Shang, and Luyang Sun# (2017). ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin. Nature Communications 8: 691-707.

13. Shumeng Liu, Huajing Yu, Yongqing Liu, Xinhua Liu, Yu Zhang, Chen Bu, Shuai Yuan, Zhe Chen, Guojia Xie, Wanjin Li, Bosen Xu, Jianguo Yang, Lin He, Tong Jin, Yundong Xiong, Luyang Sun, Xiaohui Liu, Chunsheng Han, Zhongyi Cheng, Jing Liang#, and Yongfeng Shang# (2017). Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis. Molecular Cell 67: 853-866 e855.

14. Wanjin Li, Zihan Zhang, Xinhua Liu, Xiao Cheng, Yu Zhang, Xiao Han, Shumeng Liu, Jianguo Yang, Bosen Xu, Lin He, Luyang Sun, Jing Liang, and Yongfeng Shang# (2017). The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer. Journal of Clinical Investigation 27: 3421-3440.

15. Lei Li, Lan Shi, Shangda Yang, Ruorong Yan, Di Zhang, Jianguo Yang, Lin He, Wanjin Li, Xia Yi, Luyang Sun, Jing Liang, Zhe Chen, Lei Shi, Yongfeng Shang#, and Wenhua Yu# (2016). SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability. Nature Communications 7: 12235.

16. Yu Zhang*, Di Zhang*, Qian Li, Jing Liang, Luyang Sun, Xia Yi, Zhe Chen, Ruorong Yan, Guojia Xie, Wanjin Li, Shumeng Liu, Bosen Xu, Lei Li, Jianguo Yang, Lin He, and Yongfeng Shang# (2016). Nucleation of DNA repair factors by FOXA1 links DNA demethylation to transcriptional pioneering. Nature Genetics 48: 1003-1013.

17. Wenzhe Si, Wei Huang, Yu Zheng, Yang Yang, Xujun Liu, Lin Shan, Xing Zhou, Yue Wang, Dongxue Su, Jie Gao, Ruorong Yan, Xiao Han, Wanjin Li, Lin He, Lei Shi, Chenghao Xuan, Jing Liang, Luyang Sun, Yan Wang#, and Yongfeng Shang# (2015). Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis. Cancer Cell 27(6):822-36.

18. Ruorong Yan, Lin He, Zhongwu Li, Xiao Han, Jing Liang, Wenzhe Si, Zhe Chen, Lei Li, Guojia Xie, Wanjin Li, Peiyan Wang, Liandi Lei, Hongquan Zhang, Fei Pei, Dengfeng Cao, Luyang Sun#, and Yongfeng Shang# (2015). SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer. Genes & Development 29: 672-685.

19. Feng Wang, Lin He, Peiwei Huangyang, Jing Liang, Wenzhe Si, Ruorong Yan, Xiao Han, Shumeng Liu, Bin Gui, Wanjin Li, Di Miao, Chao Jing, Zhihua Liu, Fei Pei, Luyang Sun#, and Yongfeng Shang# (2014). JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. Plos Biology 12(3): e1001819.