梁令 博士

副研究员、博士生导师

北京大学基础医学院生物物理学系

Email: liangling@bjmu.edu.cn

梁令，北京大学基础医学院助理教授、博士生导师。主要从事重要蛋白复合物的工作机制研究，特别关注蛋白质降解机器。利用冷冻电镜、X射线晶体学、分子动力学模拟等实验及计算方法研究与疾病相关的蛋白质功能调节及生物大分子复合物的组装，并进行基于人工智能的蛋白质设计，靶向肿瘤治疗。主持国家自然科学基金青年科学基金项目及面上项目。近五年以第一或通讯作者身份（含共同）在Nature Communications （2020, 2024, 2025a, 2025b）、Developmental Cell （2021）、EMBO Journal （2024）、Chemical Engineering Journal （2024a, 2024b）等国际知名期刊发表SCI论文多篇。

学习和工作经历：

2008.09-2013.07，北京大学基础医学院，基础医学，医学学士

2013.09-2016.07，北京大学基础医学院，病理学，医学博士

2016.08-2021.07，北京大学基础医学院，生物化学与生物物理学系，讲师

2021.08-至今，北京大学基础医学院，生物物理学系，助理教授

代表性论文(#共同第一作者，*共同通讯作者)

(1) Shang Yu#, Jin-hui Ding#, Jia-le Wang#, Weize Wang, Peng Zuo, Ao Yang, Zonglin Dai, Yuxin Yin, Jin-peng Sun* and LingLiang*, Structural insights into cholesterol sensing by the LYCHOS-mTORC1 pathway, Nature Communications, 2025, Accepted In Principle.

(2) Peng Zuo, Weize Wang, Zonglin Dai, Jiye Zheng, Shang Yu, Guangxi Wang, Yue Yin, Ling Liang*, Yuxin Yin*, Synergistic activation of the human phosphate exporter XPR1 by KIDINS220 and inositol pyrophosphate, Nature Communications, 2025, 16:2879.

(3) Weize Wang#, Ling Liang#*, Zonglin Dai#, Peng Zuo, Shang Yu, Yishuo Lu, Dian Ding, Hongyi Chen, Hui Shan, Yan Jin, Youdong Mao, Yuxin Yin*, A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3KLHL22, Nature Communications, 2024, 15: 3789

(4) Ling Liang#*, Jiawen Feng#, Peng Zuo, Juan Yang, Yishuo Lu, Yuxin Yin*, Molecular basis for assembly of the shieldin complex and its implications for NHEJ, Nature Communications, 2020, 11: 1972

(5) Yuan Wang#, Chunlei Zhang#, Wenzhong Yang, ShiPeng Shao, Xinmin Xu, Yujie Sun, Pilong Li, Ling Liang*, Congying Wu*, LIMD1 phase separation contributes to cellular mechanics and durotaxis by regulating focal adhesion dynamics in response to force, Developmental Cell, 2021, 56(9): 1-13

(6) Zonglin Dai#, Ling Liang#, Weize Wang#, Peng Zuo, Shang Yu, Yaqi Liu, Xuyang Zhao, Yishuo Lu, Yan Jin, Fangting Zhang, Dian Ding, Weiwei Deng, Yuxin Yin, Structural insights into the ubiquitylation strategy of the oligomeric CRL2FEM1B E3 ubiquitin ligase, EMBO Journal, 2024, 43(6): 1089-1109

(7) Chuanda Zhu, ZongLin Dai, Lu Qin, Jing Wang, Ling Liang*. Efficient cytosolic delivery of proteins enabled by modular fusion protein. Chemical Engineering Journal, 2024; 497(1):154619

(8) Chuanda Zhu#; Xi Chen#; Jingjing Gong; Jiao Liu; Lidong Gong; Zeliang Yang; Zhenyu Zhu; Qiang Zhang; Tiancheng Li*; Ling Liang*; Zhiqiang Lin*; An elastase nanocomplex with metal cofactors for enhancement of target protein cleavage activity and synergistic antitumor effect, Chemical Engineering Journal, 2024, 485: 149902

(9) Chang Song#, Ling Liang#, Yan Jin, Yunqiao Li, Yang Liu, Limei Guo, Congying Wu, Cai-Hong Yun*, Yuxin Yin*, RCC2 is a novel p53 target in suppressing metastasis, Oncogene, 2018, 37(1): 8~17

(10) Ling Liang#, Yuhua Li#, Xing Tian, Juntuo Zhou*, Lijun Zhong*, Comprehensive lipidomic, metabolomic and proteomic profiling reveals the role of immune system in vitiligo，Clinical and Experimental Dermatology, 2019, 44(7): e216-e223

(11) Ling Liang, Xiao-E Yan, Yuxin Yin*, Cai-Hong Yun*, Structural and biochemical studies of the PDGFRA kinase domain, Biochem Biophys Res Commun, 2016, 477(4): 667~672

(12) Xiao-E Yan#, Pelin. Ayaz#, Su-Jie Zhu#, Peng Zhao#, Ling Liang, Casey H. Zhang, Ya-Chuang Wu, Je-Luen Li, Hwan Geun Choi, Xin. Huang, Yibing Shan*, David E. Shaw*, Cai-Hong Yun*, Structural basis of AZD9291 selectivity for EGFR T790M, Journal of Medicinal Chemistry, 2020, 63(15): 8502-8511