孙琳琳博士，助理教授，博士生导师

联系方式

北京大学医学部医学科技楼北楼502B

电话：010-82801120;

邮箱：linlin.sun@pku.edu.cn

研究方向

疼痛与镇痛、药物成瘾的神经机制

研究方向

1) 体感、内脏感觉异常的神经机制

2) 药物成瘾中社交、记忆、情绪等行为障碍的神经基础

个人简介

孙琳琳，博士，北京大学神经科学研究所特聘研究员，博士生导师。2005-2013年就读北京大学基础医学本博连读八年制专业，获博士学位；2013-2020年先后于美国罗格斯大学，纽约大学，哥伦比亚大学进行博士后研究。2021年初加入北京大学基础医学院，主要研究领域为疼痛与镇痛、药物成瘾的神经机制。已发表论著20余篇篇，成果发表在包括Neuron、Nature Communications、PNAS等生物医学领域主流期刊上。担任《中华疼痛医学杂志》通讯编委，北京神经科学学会头痛与感觉障碍专业委员会委员，CADAPT 成瘾和脑科学小组委员会成员，Pain Medicine 等杂志审稿顾问。获得北京大学海外人才引进专项基金、国家自然科学基金、北京市自然科学基金资助。

科研成果（基金、论文等）

1.Huo, Y. #, Wang, X. #, Lin, X., Yu, J., Li, BL., Liu, Z., Guo, S., Wang, YT., Tang, R., Li, BF., Zhang, S., Zhang, Y., Jiang, Z., Fan, X., Ye, X., Li, YF., Zhang, X., Yao, Y., Song, S., Xu, M., Jiang, H., Xing, G., Wan, Y., Cui, C., Li, YJ.,Sun, L. (2025). "Corticotropin-Releasing Hormone Signaling from Piriform Cortex to Amygdala Mediates Social Homophily in Opioid Addiction" Neuron.10.1016/j.neuron.2025.08.012.# co-first author

2.Sun, L.#*, C. Chen, X.# Xiang, S. Guo and G. Yang* (2024). "Generalized modality responses in primary sensory neurons of awake mice during the development of neuropathic pain."Frontiers in Neuroscience 18: 1368507. # co-first author; * co-corresponding author.

3.Chen, C#; Sun, L#; Adler, A; Zhou, H; Zhang, LC; Zhang, LH; Deng, J; Bai, Y; Zhang, J; Yang, G; Gan, WB; Tang, P. (2023). Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain. Nature Communications 1 14(1): 689. # co-first author.

4.Sun, L.#, Tong, CK. #, Morgenstern, TJ. #, Zhou, H., Yang, G., Colecraft, HM. (2022) Targeted ubiquitination of sensory neuron calcium channels reduces development of neuropathic pain. Proceedings of the National Academy of Sciences, e2118129119. # co-first author.

5.Li, Y. #, Guo, X. #, Sun, L.#, Xiao, J. #, Su, S. #, Du, S. #, Li, Z., Wu, S., Liu, W., Mo, K., Xia, S., Chang, Y., Denis, D., Tao, YX. (2020) N6-methyladenosine demethylase FTO contributes to neuropathic pain by stabilizing G9a expression in primary sensory neurons. Advanced Science, 375(1799): 234. # co-first author.

6.Chen, C. #, Zhang, J. #, Sun, L. #, Y. Zhang, W. Gan, P. Tang, G. Yang. (2019) "Long-term imaging of dorsal root ganglia in awake behaving mice." Nature Communications 10(1):3087. # co-first author.

7.Sun, L., Zhou, H., Cichon, J., Yang, G. (2019) Experience and sleep-dependent synaptic plasticity: from structure to activity. Philosophical Transactions B375(1799): 20190234.

8.Sun, L. #, Gu, X. #, Z. Pan, X. Guo, J. Liu, F. E. Atianjoh, S. Wu, K. Mo, B. Xu, L. Liang, A. Bekker and Y. X. Tao. (2019) "Contribution of DNMT1 to neuropathic pain genesis partially through epigenetically repressing Kcna2 in primary afferent neurons." The Journal of Neuroscience 39(33): 6595– 6607. # co-first author.

9.Sun, L. #, J. Y. Zhao#, X. Gu#, L. Liang, S. Wu, K. Mo, J. Feng, W. Guo, J. Zhang, A. Bekker, X. Zhao, E. J. Nestler and Y. X. Tao. (2017). "Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons." Pain 158(6): 1153-1165. # co-first author.

10.Sun, L., B. M. Lutz and Y. X. Tao (2016). "The CRISPR/Cas9 system for gene editing and its potential application in pain research." Translational Perioperative and Pain Medicine 1(3): 22-33.

11.Sun, L. #, Hu, L. #, Li, Y. # and Cui, C. (2013). "Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal." Brain Structure and Function 219(5): 1755-1771. # co-first author.

12.Li, Z. #, Gu, X. #, Sun, L. #, S. Wu, L. Liang, J. Cao, B. M. Lutz, A. Bekker, W. Zhang and Y. X. Tao. (2015). "Dorsal root ganglion myeloid zinc finger protein 1 contributes to neuropathic pain after peripheral nerve trauma." Pain 156(4): 711-721. # co-first authors

13.Li, J., X. Kong, L. Sun, X. Chen, G. Ouyang, X. Li and S. Chen (2024). "Identification of autism spectrum disorder based on electroencephalography: A systematic review." Computers in Biology and Medicine 170: 108075.

14.Zhou H, Li M, Zhao R, Sun L, Yang G (2023). A sleep-active basalocortical pathway crucial for generation and maintenance of chronic pain. Nature Neuroscience, 26(3):458-469.

15.Cichon, J., J. Magrane, E. Shtridler, C. Chen, Sun. L, G. Yang and W. B. Gan (2020). "Imaging neuronal activity in the central and peripheral nervous systems using new Thy1.2-GCaMP6 transgenic mouse lines." Journal of Neuroscience Methods 334: 108535.

16.Griffiths, K. K., A. Wang, L. Wang, M. Tracey, G. Kleiner, C. M. Quinzii, Sun. L, G. Yang, J. F. Perez-Zoghbi, P. Licznerski, M. Yang, E. A. Jonas and R. J. Levy (2020). "Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndrome." The FASEB Journal 10.1096/fj.202000283RR.

17.Ruan, C., Sun, L., Kroshilina, A., Beckers, L., De Jager, P., Bradshaw, E., Hasson, L., Yang, G., Elyaman, W. (2020) A Novel Tmem119-tdTomato Reporter Mouse Model for Studying Microglia in the Central Nervous System. Brain Behavior and Immunity 83(180)-191.

18.Mao, Q., S. Wu, X. Gu, S. Du, K. Mo, Sun, L., J. Cao, A. Bekker, L. Chen and Y. X. Tao. (2019). "DNMT3a-triggered downregulation of K2p 1.1 gene in primary sensory neurons contributes to paclitaxel-induced neuropathic pain." International Journal of Cancer 145(8):2122-34.

19.Cichon, J., Sun, L. and Yang, G. (2018). Spared Nerve Injury Model of Neuropathic Pain in Mice. Bio-protocol 8(6): e2777.

20.Sun, X., Wang, N., Wang, X., Sun, L., Li, Y., Cui, C. (2019). AMPA Receptor in Ventromedial Prefrontal Cortex Plays Different Roles in the Recent and Remote Retrieval of Morphine-Associated Memory. Neurochemical Research 44(8):1939-1949.

21.Wang, N., F. Ge, C. Cui, Y. Li, X. Sun, L. Sun, X. Wang, S. Liu, H. Zhang, Y. Liu, M. Jia and M. Yang. (2018). "Role of Glutamatergic Projections from the Ventral CA1 to Infralimbic Cortex in Context-Induced Reinstatement of Heroin Seeking." Neuropsychopharmacology 43(6):1373-1384. doi: 10.1038/npp.2017.279. Epub 2017 Nov 14.

22.Zhao, J. Y., L. Liang, X. Gu, Z. Li, S. Wu, Sun, L., F. E. Atianjoh, J. Feng, K. Mo, S. Jia, B. M. Lutz, A. Bekker, E. J. Nestler and Y. X. Tao. (2017). "DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons." Nature Communications 8: 14712.

23.Xu, J. T., Sun, L., B. M. Lutz, A. Bekker and Y. X. Tao. (2016) "Intrathecal rapamycin attenuates morphine-induced analgesic tolerance and hyperalgesia in rats with neuropathic pain." Translational Perioperative and Pain Medicine 2(2): 27-34.

24.Li, Y. J., X. J. Ping, C. Qi, F. Shen, L. Sun, L., X. W. Sun, F. F. Ge, G. G. Xing and C. L. Cui. (2015). "Re-exposure to morphine-associated context facilitated long-term potentiation in the vSUB-NAc glutamatergic pathway via GluN2B-containing receptor activation." Addiction Biology 22(2): 435-445.

25.Lv, X. F., L. Sun, L., C. L. Cui and J. S. Han. (2015). "NAc Shell Arc/Arg3.1 Protein Mediates Reconsolidation of Morphine CPP by Increased GluR1 Cell Surface Expression: Activation of ERK-Coupled CREB is Required." International Journal ofNeuropsychopharmacology 18(9): pyv030. Published online 2015 Apr 15. doi: 10.1093/ijnp/pyv030

26.Hu, L., N. N. Chu, L. Sun, L., R. Zhang, J. S. Han and C. L. Cui. (2009). "Electroacupuncture treatment reverses morphine-induced physiological changes in dopaminergic neurons within the ventral tegmental area." Addiction Biology 14(4): 431-437.

27.林晓瑞，霍昱，樊响，孙琳琳*，李亦婧* (2022). "微小RNA132在突触可塑性以及药物成瘾中的作用." 中国药物滥用防治杂志28(7): 22. * co-corresponding author.

科研论著

1.Sun, L., B. M. Lutz and Y. X. Tao (2016). "Contribution of Spinal Cord mTORC1 to Chronic Opioid Tolerance and Hyperalgesia." Book: Neuropathology of Drug Addictions and Substance Misuse (Vol. 3, pp. 482-489). Publisher:Elsevier Inc.

2.Guo, S., Sun, L. (2024). "Chapter 3: Mechanisms of pain." Book: Pain Surgery (Vol. 1, pp. 35-45). Publisher: Peking University Medical Press.