孙琳琳

博士，特聘研究员，博士生导师

北京大学医学部中心楼10楼1011房间

联系方式: linlin.sun@ pku.edu.cn

主要经历

2005.9-2013.7 北京大学基础医学本博连读八年制 （导师：崔彩莲教授）

2013.8-2016.7 美国罗格斯大学麻醉系 （导师：Yuanxiang Tao, PhD）

2016.7-2018.4 美国纽约大学麻醉系 （导师：Guang Yang, PhD）

2018.5-2020.11 美国哥伦比亚大学麻醉系 （导师：Guang Yang, PhD）

2021.1至今 北京大学基础医学院神经生物学系 特聘研究员

研究方向

1. 慢性神经病理痛发生发展的外周及中枢机制。

2. 药物成瘾记忆形成、消退和唤起过程中的神经元突触可塑性及其分子机制。

3. 孤独症的感觉异常及认知障碍的神经机制。

研究特长

在外周神经系统进行清醒小动物双光子成像，在中枢神经系统进行活体双光子、光纤光度法记录，脑电及离体脑片及细胞电生理记录。同时实验室具有成熟的环路示踪、光遗传、化学遗传学调控技术，可实现对清醒小动物进行实时行为学观察，对神经元、胶质细胞甚至是亚细胞结构进行活体观察，并对小动物进行光化学调控观察细胞及行为水平改变。同时，实验室也具有成熟的分子生物学尤其是表观遗传学相关研究手段及技术。实验室长期致力于探究感觉障碍及药物成瘾过程中神经可塑性的关键改变，以期寻找良好的临床药物靶点。

代表性论文

1.  Li, Y. #, Guo, X. #, Sun, L. #, Xiao, J. #, Su, S. #, Du, S. #, Li, Z., Wu, S., Liu, W., Mo, K., Xia, S., Chang, Y., Denis, D., Tao, YX. (2020) N6-methyladenosine demethylase FTO contributes to neuropathic pain by stabilizing G9a expression in primary sensory neurons. Advanced Science, 375(1799): 234. # co-first author.

2.  Chen, C. #, Zhang, J. #, Sun, L. #, Y. Zhang, W. Gan, P. Tang, G. Yang. (2019) "Long-term imaging of dorsal root ganglia in awake behaving mice." Nature Communications 10(1):3087. # co-first author.

3.  Sun, L., Zhou, H., Cichon, J., Yang, G. (2019) Experience and sleep-dependent synaptic plasticity: from structure to activity. Philosophical Transactions B 375(1799): 20190234.

4.  Sun, L. #, Gu, X. #, Z. Pan, X. Guo, J. Liu, F. E. Atianjoh, S. Wu, K. Mo, B. Xu, L. Liang, A. Bekker and Y. X. Tao. (2019) "Contribution of DNMT1 to neuropathic pain genesis partially through epigenetically repressing Kcna2 in primary afferent neurons." The Journal of Neuroscience 39(33): 6595– 6607. # co-first author.

5.  Sun, L.#, J. Y. Zhao#, X. Gu#, L. Liang, S. Wu, K. Mo, J. Feng, W. Guo, J. Zhang, A. Bekker, X. Zhao, E. J. Nestler and Y. X. Tao. (2017). "Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons." Pain 158(6): 1153-1165. # co-first author.

6.  Sun, L., B. M. Lutz and Y. X. Tao (2016). "The CRISPR/Cas9 system for gene editing and its potential application in pain research." Translational Perioperative and Pain Medicine 1(3): 22-33. (Review)

7.  Sun, L.#, Hu, L. #, Li, Y. # and Cui, C. (2013). "Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal." Brain Structure and Function 219(5): 1755-1771. # co-first author.

8.  Li, Z.#, Gu, X. #, Sun, L. #, S. Wu, L. Liang, J. Cao, B. M. Lutz, A. Bekker, W. Zhang and Y. X. Tao. (2015). "Dorsal root ganglion myeloid zinc finger protein 1 contributes to neuropathic pain after peripheral nerve trauma." Pain 156(4): 711-721. # co-first authors

9. Cichon, J., J. Magrane, E. Shtridler, C. Chen, Sun. L, G. Yang and W. B. Gan (2020). "Imaging neuronal activity in the central and peripheral nervous systems using new Thy1.2-GCaMP6 transgenic mouse lines."Journal of Neuroscience Methods 334: 108535.

10.  Griffiths, K. K., A. Wang, L. Wang, M. Tracey, G. Kleiner, C. M. Quinzii, Sun. L, G. Yang, J. F. Perez-Zoghbi, P. Licznerski, M. Yang, E. A. Jonas and R. J. Levy (2020). "Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndrome." The FASEB Journal 10.1096/fj.202000283RR.

11.  Ruan, C., Sun, L., Kroshilina, A., Beckers, L., De Jager, P., Bradshaw, E., Hasson, L., Yang, G., Elyaman, W. (2020) A Novel Tmem119-tdTomato Reporter Mouse Model for Studying Microglia in the Central Nervous System. Brain Behavior and Immunity 83(180)-191.

12.  Mao, Q., S. Wu, X. Gu, S. Du, K. Mo, Sun, L., J. Cao, A. Bekker, L. Chen and Y. X. Tao. (2019). "DNMT3a-triggered downregulation of K2p 1.1 gene in primary sensory neurons contributes to paclitaxel-induced neuropathic pain." International Journal of Cancer 145(8):2122-34.

13.  Cichon, J., Sun, L. and Yang, G. (2018). Spared Nerve Injury Model of Neuropathic Pain in Mice. Bio-protocol 8(6): e2777.

14.  Sun, X., Wang, N., Wang, X., Sun, L., Li, Y., Cui, C. (2019). AMPA Receptor in Ventromedial Prefrontal Cortex Plays Different Roles in the Recent and Remote Retrieval of Morphine-Associated Memory. Neurochemical Research 44(8):1939-1949.

15.  Wang, N., F. Ge, C. Cui, Y. Li, X. Sun, L. Sun, X. Wang, S. Liu, H. Zhang, Y. Liu, M. Jia and M. Yang. (2018). "Role of Glutamatergic Projections from the Ventral CA1 to Infralimbic Cortex in Context-Induced Reinstatement of Heroin Seeking." Neuropsychopharmacology 43(6):1373-1384. doi: 10.1038/npp.2017.279. Epub 2017 Nov 14.

16.  Zhao, J. Y., L. Liang, X. Gu, Z. Li, S. Wu, L. Sun, F. E. Atianjoh, J. Feng, K. Mo, S. Jia, B. M. Lutz, A. Bekker, E. J. Nestler and Y. X. Tao. (2017). "DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons." Nature Communications 8: 14712.

17.  Xu, J. T., L. Sun, B. M. Lutz, A. Bekker and Y. X. Tao. (2016) "Intrathecal rapamycin attenuates morphine-induced analgesic tolerance and hyperalgesia in rats with neuropathic pain." Translational Perioperative and Pain Medicine 2(2): 27-34.

18.  Li, Y. J., X. J. Ping, C. Qi, F. Shen, L. L. Sun, X. W. Sun, F. F. Ge, G. G. Xing and C. L. Cui. (2015). "Re-exposure to morphine-associated context facilitated long-term potentiation in the vSUB-NAc glutamatergic pathway via GluN2B-containing receptor activation." Addiction Biology 22(2): 435-445.

19.  Lv, X. F., L.L. Sun, C. L. Cui and J. S. Han. (2015). "NAc Shell Arc/Arg3.1 Protein Mediates Reconsolidation of Morphine CPP by Increased GluR1 Cell Surface Expression: Activation of ERK-Coupled CREB is Required." International Journal of Neuropsychopharmacology 18(9): pyv030. Published online 2015 Apr 15. doi: 10.1093/ijnp/pyv030

20.  Hu, L., N. N. Chu, L. L. Sun, R. Zhang, J. S. Han and C. L. Cui. (2009). "Electroacupuncture treatment reverses morphine-induced physiological changes in dopaminergic neurons within the ventral tegmental area." Addiction Biology 14(4): 431-437.

Book Chapter

Sun, L., B. M. Lutz and Y. X. Tao (2016). "Contribution of Spinal Cord mTORC1 to Chronic Opioid Tolerance and Hyperalgesia." Book: Neuropathology of Drug Addictions and Substance Misuse (Vol. 3, pp. 482-489). Publisher:Elsevier Inc.