个人简介

      孙露洋，教授，博士生导师，国家自然科学基金优秀青年科学基金获得者，入选中组部青年拔尖人才和教育部新世纪优秀人才支持计划。实验室长期聚焦病理生理状态下的表观遗传调控机制，关注细胞如何将复杂多变的微环境信号“编译”为具有时空特异性的基因转录程序。围绕这一科学问题，系统开展代谢信号、应激适应及疾病脆性节点的机制研究，相关成果发表于Cell Metabolism、Molecular Cell 等国际学术期刊。主持国家自然科学基金原创探索计划项目、科技部国家重点研发计划子课题、北京市重点专项等多项科研项目。“乳腺癌发生发展的表观遗传机制”获国家自然科学二等奖（第四完成人）。以第一发明人申请国际PCT专利2项（授权1项）、中国发明专利5项（授权3项）。

研究领域

高等真核生物的基因组DNA缠绕组蛋白八聚体形成核小体，并进一步折叠为具有层级结构的染色质。染色质并非静态支架，而是承载调控信息、整合细胞内外信号并塑造转录程序的动态平台。其可塑性不仅决定基因转录、DNA复制和损伤修复等基本生命过程；其失调也常与肿瘤等重大疾病的发生发展密切相关，因此成为理解疾病机制和发展精准干预策略的重要切入点。

实验室重点关注细胞如何感知复杂多变的微环境信号，并在染色质层面完成信息的存储、读取与转译，从而编译出具有特异性和时效性的基因转录程序。尤其关注代谢波动、应激压力等内外源信号如何被表观修饰系统整合，并进一步塑造细胞命运、功能状态及疾病演进。围绕这一主线，实验室从快速表观响应、长期表观记忆和可干预脆性节点三个层面展开研究，形成了“快感知、长记忆、靶脆性”的研究框架，致力于揭示细胞微环境信号表观编译的基本规律及其在重大疾病中的干预策略。

研究方向

1. 组蛋白化学修饰的动态变化及功能调控

2. 非编码序列的功能鉴定及三维基因组学

主要代表作：（*为第一作者，#为通讯作者）

Ø Kenan Zhang*, Lin He*#, Yizhou Wang, Sen Qin, Chunyu Yu, Enrun Zheng, Zedan Zhang, Yawei Xu, Xiaolin Chen, Yanhua Liu, Xiaoya Liu, Sudun Guan, Lu Xia, Feiya Suo, Fei Pei, Juan Du, Yiran Su, Yanze Li, Yu Wu, Xuehong Zhou, Jingcheng Zhou, Lin Cai, Xinjing Tang, Zheng Zhang, Yongfeng Shang, Qing Zhang#, Kan Gong#, Luyang Sun# (2026). Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2a inhibitors by suppressing H4K12 lactylation. Signal Transduction and Targeted Therapy (2026)11:117

Ø Lu Xia*, Jichuan Wang*, Hui Xue, Haimeng Li, Qinghua Li, Sen Qin, Chunyu Yu, Yanhua Liu, Yu Gao, Lingyun Li, Sudun Guan, Enrun Zheng, Feiya Suo, Lin He, Yongsheng Wang, Wenling Han#, Yongfeng Shang#, Yong Geng#, and Luyang Sun# (2025). A CMTM6 Nanobody Overcomes EGFR-TKI Resistance in Non-small Cell Lung Cancer. Advanced Science 12(27):e2410945Ø Jianze Wang*, Qianrui Guo*, Lin He*, Rui Song, Jinhong Du, Haoyi Zhou, Yameng Hao, Xiujie Yang, Feng Wang, Kui Li, Mo Li, Zhi Yang, Luyang Sun#, Zhaofei Liu# (2025). A Nano-Radiosensitizer Potentiates Tumor Radiotherapy through JFK Inhibition and Hypoxia Alleviation. Nano Letters 25(13):5435-5443

Ø Yazi Yang*, Sen Qin*, Mengyu Yang, Ting Wang, Ru Feng, Chunli Zhang, Enrun Zheng, Qinghua Li, Pengyu Xiang, Shangyong Ning, Xiaodong Xu, Xin Zuo, Shuai Zhang, Xiaoya Yun, Xuehong Zhou, Yue Wang, Lin He, Yongfeng Shang^#, Luyang Sun^#, Hui Liu^# (2024). Reconstitution of the Multiple Myeloma Microenvironment Following Lymphodepletion with BCMA CAR-T Therapy. Clinical Cancer Research 30:4201-14

Ø Sen Qin*, Yawei Xu*, Shimiao Yu, Wencong Han, Shiheng Fan, Wenxiang Ai, Kenan Zhang, Yizhou Wang, Xuehong Zhou, Qi Shen, Kan Gong#, Luyang Sun#, Zheng Zhang# (2024). Molecular Classification and Tumor Microenvironment Characteristics in Pheochromocytomas. eLife 12:RP87586.

Ø Lin He#, Yiping Cao, Luyang Sun# (2024). NSD Family Proteins: Rising Stars as Therapeutic Targets. Cell Insight 3 (2): 100151

Ø Lin He, Chunyu Yu, Sen Qin, Enrun Zheng, Xinhua Liu, Yanhua Liu, Shimiao Yu, Yang Liu, Xuelin Dou, Zesen Shang, Yizhou Wang, Yue Wang, Xuehong Zhou, Boning Liu, Yuping Zhong, Zhiqiang Liu, Jin Lu, and Luyang Sun# (2023). The Proteasome Component PSMD14 Drives Myelomagenesis through a Histone Deubiquitinase Activity. Molecular Cell 83(22):4000-4016

Ø Rui-Yuan Pan*, Lin He*, Jing Zhang, Xinhua Liu, Yajin Liao, Ju Gao, Yang Liao, Yuhan Yan, Qianqian Li, Xuehong Zhou, Jinbo Cheng, Qu Xing, Fangxia Guan, Xinglong Wang, Jie Zhang, Luyang Sun#, Zengqiang Yuan# (2022). Positive Feedback Regulation of Microglial Glucose Metabolism by Histone H4 Lysine 12 Lactylation in Alzheimer’s Disease. Cell Metabolism 34(4):634-648.e6 (ESI Highly Cited Papers)

        Highlighted by Yiyun Song# (2022). A vicious cycle. Nature Chemical Biology 18, 434

        Highlighted by Yingjun Zhao, and Huaxi Xu# (2022). Microglial lactate metabolism as a potential therapeutic target for Alzheimer’s disease. Molecular Neurodegeneration 17, 36

Ø Xujun Liu*, Wenzhe Si*, Lin He, Jianguo Yang, Yani Peng, Jie Ren, Xiaoping Liu, Tong Jin, Huajing Yu, Zihan Zhang, Xiao Cheng, Wenting Zhang, Lu Xia, Yunchao Huang, Yue Wang, Shumeng Liu, Lin Shan, Yu Zhang, Xiaohan Yang, Haixia Li, Jing Liang, Luyang Sun# and Yongfeng Shang# (2021). The Existence of a Nonclassical TCA Cycle in the Nucleus that Wires the Metabolic-Epigenetic Circuitry. Signal Transduction and Targeted Therapy (2021)6:375

Ø Lin He*, Ruorong Yan*, Ziran Yang, Yue Zhang, Xinhua Liu, Jianguo Yang, Xujun Liu, Xiaoping Liu, Lu Xia, Yue Wang, Jiajing Wu, Xiaodi Wu, Lin Shan, Xiaohan Yang, Jing Liang, Yongfeng Shang, and Luyang Sun# (2021). SCF^JFK Is Functionally Linked to Obesity and Metabolic Syndrome. EMBO Reports 22(7):e52036

Ø Xia Ting, Lu Xia, Jianguo Yang, Lin He, Wenzhe Si, Yongfeng Shang, and Luyang Sun# (2019). USP11 Acts as a Histone Deubiquitinase Functioning in Chromatin Reorganization during DNA Repair. Nucleic Acids Research 47(18):9721-9740 (Recommended by F1000)

       Recommended by F1000: By Prof. Vitaly Citovsky and Prof. Ido Keren. https://connect.h1.co/article/736581402

Ø Lin He, Xinhua Liu, Jianguo Yang, Wanjin Li, Shumeng Liu, Xujun Liu, Ziran Yang, Jie Ren, Yue Wang, Lin Shan,Chengjian Guan, Fei Pei, Liandi Lei, Yu Zhang, Xia Yi, Xiaohan Yang, Jing Liang, Rong Liu, Luyang Sun# and Yongfeng Shang# (2018). Imbalance of the reciprocally inhibitory loop between theubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis. Cell Research 28(9):934-951

Ø Xujun Liu, Wenzhe Si, Xinhua Liu, Lin He, Jie Ren, Ziran Yang, Jianguo Yang, Wanjin Li, Shumeng Liu, Fei Pei, Xiaohan Yang, Luyang Sun# (2017). JMJD6 Promotes Melanoma Carcinogenesis through Regulation of the Alternative Splicing of PAK1, a Key MAPK Signaling Component. Molecular Cancer 2017 16:175

Ø Lifang Li, Xinhua Liu, Lin He, Jianguo Yang, Fei Pei, Wanjin Li, Shumeng Liu, Zhe Chen, Guojia Xie, Bosen Xu, Xia Ting, Zihan Zhang, Tong Jin, Xujun Liu, Wenting Zhang, Shuai Yuan, Ziran Yang, Chongyang Wu, Yu Zhang, Xiaohan Yang, Xia Yi, Jing Liang, Yongfeng Shang, and Luyang Sun# (2017). ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin. Nature Communications 8(1):691

Ø Ruorong Yan, Lin He, Zhongwu Li, Xiao Han, Jing Liang, Wenzhe Si, Zhe Chen, Lei Li, Guojia Xie, Wanjin Li, Peiyan Wang, Liandi Lei, Hongquan Zhang, Fei Pei, Dengfeng Cao, Luyang Sun#, and Yongfeng Shang# (2015). SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer. Genes &Development 29(6):672-85

Ø Feng Wang, Lin He, Peiwei Huangyang, Jing Liang, Wenzhe Si, Ruorong Yan, Xiao Han, Shumeng Liu, Bin Gui, Wanjin Li, Di Miao, Chao Jing, Zhihua Liu, Fei Pei, Luyang Sun#, and Yongfeng Shang# (2014). JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation. PLOS Biology 12(3):e1001819 (Recommended as Editor’s Picks)

Ø Na Yu, Peiwei Huangyang, Xiaohan Yang, Xiao Han, Ruorong Yan, Hongti Jia, Yongfeng Shang, and Luyang Sun# (2013). MicroRNA-7 Suppresses EMT and Invasion of Breast Cancer Cells and Sensitizes Cells to DNA Damages by Targeting Lysine Methyltransferase SET8. Journal of Biological Chemistry 288(27): 19633-42

Ø Lei Shi*, Luyang Sun*, Qian Li, Jing Liang, Wenhua Yu, Xia Yi, Xiaohan Yang, Yanyan Li, Xiao Han, Yu Zhang, Chenghao Xuan, Zhi Yao, Yongfeng Shang (2011). JMJD2B Coordinates H3K4/H3K9 Methylation and Promotes Hormonally Responsive Breast Carcinogenesis. PNAS 108(18):7541-6 

Ø Luyang Sun, Lei Shi, Feng Wang, Peiwei Huangyang, Wenzhe Si, Jie Yang, Zhi Yao, and Yongfeng Shang (2011). Substrate Phosphorylation and Feedback Regulation in JFK-promoted p53 Destabilization. Journal of Biological Chemistry 286(6):4226-35

Ø Luyang Sun*, Lei Shi*, Wenqian Li, Wenhua Yu, Jing Liang, Hua Zhang, Xiaohan Yang, Yan Wang, Ruifang Li, Xingrong Yao, Xia Yi, and Yongfeng Shang (2009). JFK, a Kelch Domain-containing F-box Protein, Links the SCF Complex to p53 Regulation. PNAS 106(25): 10195-10200 (Recommended by F1000)

Recommended by F1000: By Prof. Anindya Dutta. https://connect.h1.co/article/1162802

联系方式

Email: Luyang_sun@hsc.pku.edu.cn