郑 铭 研究员

联系方式

zhengm@bjmu.edu.cn

研究方向

心肌及骨骼肌线粒体稳态调控的病理生理机制

个人简介

2001年博士毕业于北京大学，病理生理学专业。近30年来，专注于心脏疾病的病理生理机制研究，在Circ Res、PNAS、Hypertension等领域权威杂志发表论文70余篇，并先后主持国家自然科学基金、科技部国家重点基础研究发展规划项目子课题多项。

近年代表论文

1.Huang X, Sun L, Ji S, Zhao T, Zhang W, Xu J, Zhang J, Wang Y, Wang X, Franzini-Armstrong C, Zheng M*, Cheng H.Kissing and nanotunneling mediate intermitochondrial communication in the heart. Proc Natl Acad Sci U S A. 2013; 110(8):2846-2851. (*correspondence author)

2.Zhao T, Huang X, Han L, Wang X, ChengH, Zhao Y, Chen Q, Chen J, Cheng H, Xiao R, Zheng M*. Central Role of Mitofusin 2 in Autophagosome-Lysosome Fusion in Cardiomyocytes. J Biol Chem . 2012; 287(28):23615-25   (*correspondence author)

3.Ma Q, Fang H, Shang W, Liu L, Xu Z, Ye T, Wang X, Zheng M*, Chen Q, Cheng H. Superoxide flashes: early mitochondrial signals for oxidative stress-induced apoptosis. J Biol Chem . 2011; 286:27573-81(*correspondence author) 

4.Cheng H*, Zheng M*,Peter AK, Kimura K, Li X, Ouyang K, Shen T, Cui L, Frank D, Dalton ND, Gu Y, Frey N, Peterson KL, Evans SM, Knowlton KU, Sheikh F, Chen J. Selective Deletion of Long but not Short Cypher Isoforms Leads to LateOnset Dilated Cardiomyopathy. Hum Mol Genet. 2011; 20:1751-62.  (Co-first author)

5.Zheng M, Xiao RP. Role of mitofusin 2 in cardiovascular oxidative injury. J Mol Med . 2010; 88:987-91

6.Zheng M, Cheng H, Banerjee I, Chen J. ALP/Enigma PDZ-LIM domain proteins in the heart. J Mol Cell Biol . 2010; 2: 96-102

7.Zheng M, Cheng H, Li X, Zhang J, Cui L, Ouyang K, Han L, Zhao T, Gu Y, Dalton ND, Bang ML, Peterson KL, Chen J. Cardiac-specific ablation of cypher leads to a severe form of dilated cardiomyopathy with premature death. Hum Mol Genet . 2009; 18:701-13

8.Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JP.Y, Lakatta EG, Sheu S-S, Ouyang K, Chen J, Dirksen RT, Cheng H. Superoxide Flashes in Single Mitochondria. Cell. 2008; 134:279-290

9.Shen T*, Zheng M*, Cao C, Chen C, Tang J, Zhang R, Cheng P, Chen KH, Xiao RP. Mitofusin 2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis.   J.Biol.Chem .2007; 282:23354-61 (*Co-first author)