李婷婷  博士

教授、博士生导师、PI

北京大学基础医学院医学信息学系

联系方式

邮箱：litt@hsc.pku.edu.cn

电话：010-82801585

研究方向

1) 生物信息学

2) 生物大分子相分离与相变

3) 蛋白质翻译后修饰

简介

主要研究方向为生物大分子凝聚体组成及动态调控的计算解析。在PNAS、Genome Biology、Nucleic Acids Research等期刊发表SCI论文40余篇。作为课题负责人承担国家重点研发计划蛋白质专项，作为负责人承担国家自然科学基金4项，作为骨干参加973计划等国家级课题3项。担任中国人工智能学会生物信息学与人工生命专委会委员、中国自动化学会智能健康与生物信息专委会委员、中国计算机学会生物信息学专委会委员、生物物理学会生物大分子相分离与相变分会委员。

教育背景及研究经历

2024.2 - 至今    博雅特聘教授、长聘正教授

2022.8 - 2024.1    北京大学基础医学院医学信息学系 研究员、长聘副教授 博士生导师 

2012.8-2022.7  北京大学基础医学院医学信息学系 副教授

2009.8-2012.7  北京大学基础医学院医学信息学系 讲师

2003.9-2009.1  清华大学 生物信息学专业博士导师张学工教授

1999.9-2003.7   西安交通大学自动化专业 学士

近期主要研究论文

1. Zhaoming Chen#, Chao Hou#, Liang Wang#, Chunyu Yu, Taoyu Chen, Boyan Shen, Yaoyao Hou, Pilong Li*, Tingting Li*; Screening Membraneless Organelle Participants with Machine Learning Models that Integrate Multimodal Features; PNAS, 2022;119:e2115369119.

2. Fugang Duan#, Yifan Wang#, Taoyu Chen#, Zhu Zhu#, Meng Yu, Hui Dai, Shangen Zheng, Yinying Lu*, Tingting Li*, Xiaoyan Qiu*; A novel strategy for identifying biomarker in serum of patient with COVID-19 using immune complex; Signal Transduction and Targeted Therapy, 2022;7:63.

3. Minglei Shi#*, Kaiqiang You#, Taoyu Chen, Chao Hou, Zhengyu Liang, Mingwei Liu, Jifeng Wang, Taotao Wei, Jun Qin, Yang Chen*, Michael Q Zhang*, Tingting Li*; Quantifying the phase separation property of chromatin-associated proteins under physiological conditions using an anti-1,6-hexanediol index; Genome Biology, 2021;22(1):229.

4. Chunyu Yu#, Yunzhi Lang#, Chao Hou, Ence Yang, Xianwen Ren*, Tingting Li*; Distinctive Network Topology of Phase-Separated Proteins in Human Interactome; Journal of Molecular Biology, 2021;167292.

5. Boyan Shen#, Zhaoming Chen#, Chunyu Yu, Taoyu Chen, Minglei Shi, Tingting Li*; Computational Screening of Biological Phase-separating Proteins; Genomics, Proteomics & Bioinformatics; 2021 Feb;19(1):13-24

6. Kaiqiang You#, Qi Huang#, Chunyu Yu#, Boyan Shen, Cristoffer Sevilla, Minglei Shi, Henning Hermjakob*, Yang Chen*, Tingting Li*; PhaSepDB: a database of liquid–liquid phase separation related proteins; Nucleic Acids Research, 2020;48(D1):D354-D359.

7. Chunyu Yu, Boyan Shen, Kaiqiang You, Qi Huang, Minglei Shi, Congying Wu, Yang Chen, Chaolin Zhang, Tingting Li*; Proteome-scale analysis of phase-separated proteins in immunofluorescence images; Briefings in Bioinformatics, 2020;bbaa187.

8. Chao Hou#, Haotai Xie#, Yang Fu#, Yao Ma#, Tingting Li *; MloDisDB: a manually curated database of the relations between membraneless organelles and diseases; Briefings in Bioinformatics, 2020;bbaa271.

9. Rongting Huang#, Yuanhua Huang#, Yubin Guo#, Shangwei Ji, Ming Lu, Tingting Li*; Systematic Characterization and Prediction of Post-Translational Modification Cross-Talk between proteins; Bioinformatics; 2019,35(15):2626-2633.

10. Mengsha Tong#, Chunyu Yu#, Dongdong Zhan, Ming Zhang, Bei Zhen, Weimin Zhu, Yi Wang, Congying Wu, Fuchu He*, Jun Qin*, Tingting Li*; Molecular subtyping of cancer and nomination of kinase candidates for inhibition with phosphoproteomics: reanalysis of CPTAC ovarian cancer; EBioMedicine; 2019,40:305-317.

11. Yipeng Du*#, Hao Hu#, Saisi Qu#, Jifeng Wang, Chaoju Hua, Jialing Zhang, Peng Wei, Xiaolong He, Junfeng Hao, Pingsheng Liu, Fuquan Yang, Tingting Li *, Taotao Wei*. SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice, EBioMedicine, 2018.

12. Ying Li, Xueya Zhou, Zichao Zhai, Tingting Li*. Co-occurring protein phosphorylation are functionally associated, PLoS Computational Biology, 2017;13(5):e1005502.

13. Yipeng Du, Zichao Zhai, Ying Li, Ming Lu, Tanxi Cai, Bo Zhou, Lei Huang, Taotao Wei*, Tingting Li*. Prediction of lysine acylation by integrating multiple protein functional features, Journal of Proteome Research, 2016;15(12):4234-4244.

14. Kaili Gu#, Qiang Zhang#, Ying Yan#, Tingting Li#, Feifei Duan, Jing Hao, Xiwen Wang, Ming Shi, Daren Wu, Wenting Guo, Yangming Wang*. Pluripotency associated miR-290/302 family of microRNAs promote the dismantling of naive pluripotency. Cell Research, 2016;3:350-366.

15. Yuanhua Huang, Bosen Xu, Xueya Zhou, Ying Li, Ming Lu, Rui Jiang, Tingting Li*. Systematic characterization and prediction of post-translational modification cross-talk, Mol Cell Proteomics, 2015;14:761-770.