孔炜  教授

北京大学医学部生理与病理生理系主任。教育部长江学者；基金委杰出青年基金获得者

“万人计划领军人才”入选者，基金委创新群体带头人

 

主要研究方向

血管微环境与重大心血管疾病。在Circulation，Blood, Circ Res等权威期刊发表SCI论文110余篇；主持基金委创新群体、重点、国际合作及科技部多项基金。获得“中国青年科技奖”，“教育部高等学校科学研究优秀成果一等奖”，“国家科技部•比尔盖茨基金会创新大挑战-青年科学家奖”等奖励。担任国际基质生物学会常务理事，担任Am J Physiology-Cell Physiology 副主编及Circ Res, Matrix Biology; Cardiovasc Res.等杂志编委。

部分代表性工作

1. Yang L, Dai R, Wu H, Cai Z, Xie N, Zhang X, Shen Y, Gong Z, Jia Y, Yu F, Zhao Y, Lin P, Ye C, Hu Y, Fu Y, Xu Q, Li Z, Kong W. Unspliced XBP1 Counteracts β-catenin to Inhibit Vascular Calcification. Circ Res. 2022 Jan 21;130(2):213-229.

2. Fu Y, Huang Y, Yang Z, Chen Y, Zheng J, Mao C, Li Z, Liu Z, Yu B, Li T, Wang M, Xu C, Zhou Y, Zhao G, Jia Y, Guo W, Jia X, Zhang T, Li L, Liu Z, Guo S, Ma M, Zhang H, Liu B, Du J, Wang W, Tang C, Gao P, Xu Q, Wang X, Liu J, Sun J, Kong W. Cartilage oligomeric matrix protein is an endogenous beta-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury. Cell Res. 2021 Jul;31(7):773-790.

3. Mao C, Ma Z, Jia Y, Li W, Xie N, Zhao G, Ma B, Yu F, Sun J, Zhou Y, Cui Q, Fu Y, Kong W.Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling. Circulation. 2021 Oct 12;144(15):1244-1261.

4.  Wang Y, Chen D, Zhang Y, Wang P, Zheng C, Zhang S, Yu B, Zhang L, Zhao G, Ma B, Cai Z, Xie N, Huang S, Liu Z, Mo X, Guan Y, Wang X, Fu Y, Ma D, Wang Y, and Kong W. A Novel Adipokine, FAM19A5, Inhibits Postinjury Neointima Formation through Sphingosine-1-Phosphate Receptor 2. Circulation 2018 Jul 3;138(1):48-63.

5. Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun J, Kong W. Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury. Nat Commun 2018 Jan 2;9(1):11

Selected Publication in past 5 years (* corresponding author)

1. Li Z, Zhao Z, Cai Z, Sun Y, Li L, Yao F, Yang L, Zhou Y, Zhu H, Fu Y, Wang L, Fang W, Chen Y, Kong W*. Runx2 (Runt-Related Transcription Factor 2)-Mediated Microcalcification Is a Novel Pathological Characteristic and Potential Mediator of Abdominal Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1352-1369.

2. Wang Y, Chen D, Zhang Y, Wang P, Zheng C, Zhang S, Yu B, Zhang L, Zhao G, Ma B, Cai Z, Xie N, Huang S, Liu Z, Mo X, Guan Y, Wang X, Fu Y, Ma D, Wang Y, and Kong W*. A Novel Adipokine, FAM19A5, Inhibits Postinjury Neointima Formation through Sphingosine-1-Phosphate Receptor 2. Circulation 2018 Feb 16. [Epub ahead of print]

3. Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun J, Kong W*. Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury. Nat Commun 2017 2018 Jan 2;9(1):11

4. Zhao G, Fu Y, Cai Z, Yu F, Gong Z, Dai R, Hu Y, Zeng L, Xu Q, Kong W*. Unspliced XBP1 Confers VSMC Homeostasis and Prevents Aortic Aneurysm Formation via FoxO4 Interaction. Circ Res. 2017 Dec 8;121(12):1331-1345

5. Yu B, Liu Z, Fu Y, Wang Y, Zhang L, Cai Z, Yu F, Wang X, Zhou J, Kong W*. CYLD Deubiquitinates Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Contributing to Adventitial Remodeling. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1698-1709.

6. Kong W, Du J, Zhu Y, Dong E. Basic and Translational Vascular Research in China: Past, Present, and Future. Circ Res. 2017 Aug 4;121(4):335-337.

7. Fu Y, Gao C, Liang Y, Wang M, Huang Y，Ma W，Li T，Jia Y，Yu F，Zhu W，Cui Q，Li Y，Xu Q，Wang X, Kong W*. Shift of Macrophage Phenotype due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification Circ. Res. 2016 Jul 8;119(2):261-76 (Cover story with editorial comment)

8. Gao C, Fu Y, Li Y, Zhang X, Zhang L, Yu F, Xu S, Xu Q, Zhu Y, Guan Y, Wang X, Kong W* Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification. Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):108-21

9. Liang Y, Fu Y, Qi R, Wang M, Yang N, He L, Yu F, Zhang J, Yun CH, Wang X, Liu J, Kong W*. Cartilage oligomeric matrix protein is a natural inhibitor of thrombin. Blood. 2015 Aug 13;126(7):905-14 （with editorial comment）

10. Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M, Ge Q, Xu Q, Zhu Y, Wang X, Schmidt K, de Wit C, Erdmann J, Schunkert H, Aherrahrou Z, Kong W*. ADAMTS-7 Inhibits Re-Endothelialization of Injured Arteries and Promotes Vascular Remodeling Via Cleavage of Thrombospondin-1. Circulation. 2015 Mar 31;131(13):1191-201（with editor）