王维斌   副研究员，预聘制助理教授，博士生导师

联系方式

电子邮箱：weibinwang@bjmu.edu.cn

教育与科研经历

(1) 2004-2008：学士，首都医科大学，医学实验学系

(2) 2008-2011：硕士，北京大学医学部，生物化学与分子生物学系

(3) 2011-2014：博士，北京大学医学部，生物化学与分子生物学系

(4) 2014-2019：博士后，耶鲁大学，分子生物物理与生物化学系

(5) 2019-至今：助理教授，北京大学医学部，放射医学系

主要研究方向

DNA损伤/DNA放射损伤的修复机制与肿瘤等疾病

具体研究内容：

该实验室主要利用生物化学、分子生物学、细胞生物学和模式动物等研究方法，着重研究各种类型DNA损伤（DNA放射损伤）的修复机制，及其与基因组不稳定性和肿瘤等疾病的相关性。该实验室正在开展中的研究课题具体包括：

(1) DNA双链断裂损伤（DNA放射损伤）的修复机制与肿瘤发生、肿瘤放化疗

(2) RNA-DNA杂合体/R-loop的调控机制与基因组不稳定性

(3) DNA交联损伤的修复机制与范可尼贫血综合征

(4) 新的DNA损伤修复因子的鉴别及其干预策略的建立

科研基金

(1) 2019：新引进人才类科研启动经费

(2) 2020：国家自然科学基金面上项目

(3) 2022：国家自然科学基金面上项目

(4) 2024：国家自然科学基金面上项目

以通讯作者发表的论文

(1) Zhang T, Yang H, Zhou Z, Bai Y, Wang J, Wang W. Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin.  Nature Communications . 2022, 13(1): 5133

(2) Xu Z, Nie C, Liao J, Ma Y, Zhou XA, Li X, Li S, Lin H, Luo Y, Cheng K, Mao Z, Zhang L, Pan Y, Chen Y, Wang W, Wang J. DDX39A resolves replication fork-associated RNA-DNA hybrids to balance fork protection and cleavage for genomic stability maintenance.  Molecular Cell . 2025, 85(3): 490-505

(3) Zhou Z, Yang H, Liang X, Zhou T, Zhang T, Yang Y, Wang J, Wang W. C1orf112 teams up with FIGNL1 to facilitate RAD51 filament disassembly and DNA interstrand cross-link repair.  Cell Reports . 2023, 42(8): 112907

(4) Zhou Z, Yang H, Liang X, Zhou T, Liu Q, Wang J, Wang W. Reconstitution of the antagonistic effect between C1orf112/FIRRM-FIGNL1 and BRCA2 on RAD51 filament stabilization.  STAR Protocols . 2024, 5(1): 102791

(5) Xu Z, Li X, Li H, Nie C, Liu W, Li S, Liu Z, Wang W, Wang J. Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA.  Oncogene . 2020, 39(47): 7051-7062

(6) Yu G, Xiong Y, Xu Z, Zhang L, Zhou XA, Nie C, Li S, Wang W, Li X, Wang J. MBD1 protects replication fork stability by recruiting PARP1 and controlling transcription-replication conflicts.  Cancer Gene Therapy . 2024, 31(1): 94-107

受邀以通讯作者发表的综述

(1) Zhang T, Zhou Z, Yang H, Wang W. MRE11-RAD50-NBS1-CtIP: one key nuclease ensemble functions in the maintenance of genome stability.  Genome Instability & Disease . 2022, 3: 123-135

(2) Bai Y, Wang W, Wang J. Targeting DNA repair pathways: mechanisms and potential applications in cancer therapy.  Genome Instability & Disease . 2020, 1(6): 318-338

以第一作者发表的论文

(1) Wang W, Daley JM, Kwon Y, Krasner DS, Sung P. Plasticity of the Mre11-Rad50-Xrs2-Sae2 nuclease ensemble in the processing of DNA-bound obstacles.  Genes & Development . 2017, 31(23-24): 2331-2336

(2) Bai Y, Wang W, Li S, Zhan J, Li H, Zhao M, Zhou XA, Li S, Li X, Huo Y, Shen Q, Zhou M, Zhang H, Luo J, Sung P, Zhu WG, Xu X, Wang J. C1QBP promotes homologous recombination by stabilizing MRE11 and controlling the assembly and activation of MRE11/RAD50/NBS1 complex.  Molecular Cell . 2019, 75(6): 1299-1314

(3) Wang W, Pan K, Chen Y, Huang C, Zhang X. The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression.  Nucleic Acids Research . 2012, 40(3): 981-995

(4) Li H, Wang W, Liu X, Paulson KE, Yee AS, Zhang X. Transcriptional factor HBP1 targets p16INK4A, upregulating its expression and consequently is involved in Ras-induced premature senescence.  Oncogene . 2010, 29(36): 5083-5094

(5) Wang W, Daley JM, Kwon Y, Xue X, Krasner DS, Miller AS, Nguyen KA, Williamson EA, Shim EY, Lee SE, Hromas R, Sung P. A DNA nick at Ku-blocked double-strand break ends serves as an entry site for exonuclease 1 (Exo1) or Sgs1-Dna2 in long-range DNA end resection.  Journal of Biological Chemistry . 2018, 293(44): 17061-17069

(6) Wang W, Chen Y, Wang S, Hu N, Cao Z, Wang W, Tong T, Zhang X. PIASxalpha ligase enhances SUMO1 modification of PTEN protein as a SUMO E3 ligase.  Journal of Biological Chemistry . 2014, 289(6): 3217-3230