魏潇凡 博士，副教授

研究方向

肿瘤侵袭转移的分子机制；蛋白质翻译后修饰与肿瘤进展

联系方式

Email: weixiaofan@bjmu.edu.cn

电话：010-82801392

个人简介

魏潇凡博士，副教授，博士生导师，北京大学基础医学院人体解剖与组织胚胎学系副主任。主持包括4项国家自然科学基金、2项北京市自然科学基金等13项科学基金。已发表研究论文20篇，近年来以第一作者/通讯作者（含共同）在Nat Commun, J Cell Biol（2篇）, J Am Soc Nephrol等经典期刊发表论文。副主编/参编14部教材。主持5项教学项目包括教育部产学研项目、企业产学研横向项目等。作为负责人开设包括《组织学与胚胎学》AI课程等多门课程。曾获广东省科技进步奖一等奖、黄庭芳/信和青年杰出学者奖、北京高校第十届青年教师教学基本功比赛二等奖和最受学生欢迎奖、中国肿瘤学大会（CCO）全国优秀论文二等奖、中国解剖学会第三届“李继硕优秀青年论文奖”等奖项。兼任中国解剖学会组织学与胚胎学分会委员、中国解剖学会青年委员会常务委员/副秘书长、中国生理学会基质生物学专业委员会委员、中国病理生理学会蛋白质修饰与疾病专委会青年委员、北京解剖学会常务理事、《中国组织化学与细胞化学》编委、《解剖学报》青年编委等。

代表性论文

1. Liu Tong, Liu Cheng, Yan Meisi, Zhang Lei, Zhang Jing, Xiao Min, Li Zhigao, Wei Xiaofan*, Zhang Hongquan*; Single cell profiling of primary and paired metastatic lymph node tumors in breast cancer patients; Nature Communications; 2022 Nov 10;13(1):6823.

2. Dai Xiaoyan，Xin Yanli，Xu Weizhi，Tian Xinxia*，Wei Xiaofan*，Zhang Hongquan*; CBP-mediated Slug acetylation stabilizes Slug and promotes EMT and migration of breast cancer cells; SCIENCE CHINA Life Sciences; 2021 Apr;64(4):563-574IF:6.038.

3. Wei Xiaofan, Zhang Hongquan; Four and a half LIM domains protein 1 can be as a double-edged sword in cancer progression;Cancer Biol Med; 2020 May 15;17(2):270-281.

4. Wang Xiang#, Wei Xiaofan#, Yuan Yang, Sun Qingrui, Zhan Jun, Zhang Jing, Tang Yan, Li Feng, Ding Lihua, Ye Qinong, Zhang Hongquan; Src-mediated phosphorylation converts FHL1 from tumor suppressor to tumor promoter; J Cell Biol；2018 217(4):1335-1351.

5. Wei Xiaofan#, Wang Xiang#, Zhan Jun, Chen Yuan, Fang Weigang, Fang Lingqiang, Zhang Hongquan; E3 ubiquitin liagse Smurf1 regulates integrin activation by modulating Kindlin-2 ubiquitination and degradation; J Cell Biol; 2017 216(5):1455-1471.

6. Liu Yuqing#, Wei Xiaofan#, Guan Lizhao, Xu Sidi, Yuan Yang, LvDanyu, He Xiaokun, Zhan Jun, Kong Yan, Guo Jun and Zhang Hongquan; Unconventional myosin VIIA promotes melanoma progression; J Cell Sci（IF：4.831）; 2018 22;131(4).

7.Li Sixuan; Zhang Hongquan, Wei Xiaofan*; Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery; Life (Basel);2021 Sep 14;11(9):965.

8. Xiaofan Wei, Yang Xia, Feng Li, Yan Tang, Jing Nie, Youhua Liu, Zhanmei Zhou, Hongquan Zhang, Fan Fan Hou; Kindlin-2 mediates activation of TGF-β/Smad signaling and renal fibrosis; J Am Soc Nephrol. 2013 Sep;24(9):1387-98.