博士生导师
杜晓娟 教授
联系方式：
电话：010-82801547（实验室）
Email: duxiaojuan100@bjmu.edu.cn
主要工作简历：
2011.08-今：北京大学基础医学院，细胞生物学系，教授，博士生导师
2001.10-2011.07：北京大学基础医学院，细胞生物学系，副教授
1995.10-1998.06：首都儿科研究所，生化与免疫，副研究员
1993.10-1995.09：首都儿科研究所，生化与免疫，助理研究员
1991.09-1993.09：首都儿科研究所，生化与免疫，实习研究员
教育经历：
1998.07-2001.07：德国Freiburg大学，生物学，博士
1988.09-1991.07：首都儿科研究所，生化与免疫，硕士
1982.09-1988.07：北京医科大学，临床医学，本科
研究方向：
肿瘤相关蛋白的作用机制及功能研究
主要研究内容：
对肿瘤相关蛋白在肿瘤发生、细胞有丝分裂、肿瘤代谢、肿瘤耐药和转移中的作用进行研究。主要研究内容包括：1.核仁蛋白在核糖体RNA的转录以及加工过程中的作用机制；2.肿瘤相关蛋白促进p53和RB的降解、以及稳定c-Myc的作用机制；3.在DNA损伤时，肿瘤抑制蛋白通过乙酰化p53、稳定MDM2发挥抑癌作用；4.在细胞处于能量应激时，核仁蛋白调控核糖体发生与细胞自噬之间的转换；5.肿瘤蛋白通过调节微管骨架的马达蛋白功能在有丝分裂过程中发挥作用。同时，对肿瘤相关蛋白在细胞处于各种应激条件下的作用以及耐药的机制进行研究。
承担的研究项目：
主持国家自然科学基金共9项、国家863计划项目1项、北京市教育委员会科技成果转化与产业化项目1项；参与973项目2项、创新团体3项。
近期主要发表文章：（*责任作者）
1. Yang Yang, Pengwei Ren, Xiaofeng Liu, Xiaoyan Sun, Chunfeng Zhang, Xiaojuan Du*, Baocai Xing*. PPP1R26 drives hepatocellular carcinoma progression by controlling glycolysis and epithelial-mesenchymal transition. J Exp. Clin. Cancer Res. 2022, 41 （1）:101. DOI : 10.1186/s13046-022-02302-8.
2. Jiaojiao Zheng#, Yuqin Tan#, Xiaofeng Liu, Chunfeng Zhang, Kunqi Su, Yang Jiang, Jianyuan Luo, Li Li* and Xiaojuan Du*. NAT10 regulates mitotic cell fate by acetylating Eg5 to control bipolar spindle assembly and chromosome segregation. Cell Death Differ. 2022，29 :836-860. doi: 10.1038/s41418-021-00899-5.
3. Xiaofeng Liu*, Kunqi Su, Xiaoyan Sun, Yang Jiang, Lijun Wang, Chenyu Hu, Chunfeng Zhang, Min Lu, Xiaojuan Du* and Baocai Xing*. Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway. J Exp. Clin. Cancer Res. 2021, 40(1):132.
4. Jiaojiao Zheng, Chunfeng Zhang, Yuan Li, Yang Jiang, Baocai Xing*, and Xiaojuan Du*. p21-activated kinase 6 controls mitosis and hepatocellular carcinoma progression by regulating Eg5. BBA Mol Cell Res., 2021;1868(2):118888. doi: 10.1016/j.bbamcr.2020.118888.
5. Yuan Li#, Ling Wang#, Xiaofeng Liu, Chunfeng Zhang, Xiaojuan Du*, Baocai Xing*. NIR promotes progression of colorectal cancer through regulating RB. BBA Mol. Cell Res. 2021; 1868(1):118856. doi: 10.1016/j.bbamcr.2020.118856. (#First authors)
6. Zhenzhen Liu, Xiaofeng Liu, Yuan Li, Pengwei Ren, Chunfeng Zhang, Lijun Wang, Xiaojuan Du*, Baocai Xing*. MiR-6716-5p promotes metastasis of colorectal cancer through downregulating NAT10 expression. Cancer Management and Research. 2019, 11:5317-5332.
7. Ren P, Sun X, Zhang C, Wang L, Xing B, Du X*. Human UTP14a promotes angiogenesis through upregulating PDGFA expression in colorectal cancer. Biochem. Biophys. Res. Commun. 2019, 512(4):871-876.
8. Jingyi Zhang#, Pengwei Ren#, Da Xu#, Xiaofeng Liu, Zhenzhen Liu, Chunfeng Zhang, Yuan Lia, Lijun Wanga, Xiaojuan Du* and Baocai Xing*. Human UTP14a promotes colorectal cancer progression by forming a positive regulation loop with c-Myc. Cancer Letters. 2019, 440-441 :106-115.
9. Xiaofeng Liu, Shiying Cai, Chunfeng Zhang, Zhenzhen Liu, Jianyuan Luo, Baocai Xing* and Xiaojuan Du*. Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress. Nucl Acids Res., 2018 Oct 12;46(18):9601-9616.
10. Tong Zheng, Min Lu, Ting Wang, Chunfeng Zhang, Xiaojuan Du*. NRBE3 promotes metastasis of breast cancer by down-regulating E-cadherin expression. BBA Mol Cell Res. 2018, 12(1865) : 1869-1877.
11. Huijiao Liu#, Jiangnan Wang#, Yun Liu, Min Lu, Lelin Hu, Chunfeng Zhang, Baocai Xing and Xiaojuan Du*. Human U3 protein14a is a novel type ubiquitin ligase that binds RB and promotes RB degradation depending on a Leucine-rich region. BBA Mol Cell Res., 2018, 1865 :1611-1620.
12. Yuqin Tan, Jiaojiao Zheng, Xiaofeng Liu, Min Lu, Chunfeng Zhang, Baocai Xing, Xiaojuan Du*, Loss of nucleolar localization of NAT10 promotes cell migration and invasion in hepatocellular carcinoma, Biochem. Biophys. Res. Commun. 2018, 499: 1032-1038.
13. Ma T, Lu C, Guo Y, Zhang C, Du X*. Human U3 protein 14a plays an anti-apoptotic role in cancer cells. Biol. Chem. 2017, 398(11):1247-1257.
14. Cai S, Liu X, Zhang C, Xing B, Du X*. Autoacetylation of NAT10 is critical for its function in rRNA transcription activation. Biochem. Biophys. Res. Commun. 2017, 483: 624-629.
15. Liu X, Tan Y, Zhang C, Zhang Y, Zhang L, Ren P, Deng H, Luo J, Ke Y, Du X*. NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2. EMBO Rep. 2016, 17(3): 349-366.
16. Wang Y, Zheng Z, Zhang J, Wang Y, Kong R, Liu J, Zhang Y, Deng H, Du X*, Ke Y*. A novel retinoblastoma protein (RB) E3 ubiquitin Ligase (NRBE3) Promotes RB degradation and is transcriptionally regulated by E2F1 transcription factor. J Biol Chem. 2015, 290(47): 28200-13.
17. Jin K, Liu F, Gu J, Du X* and Xing B*. N-WASP is highly expressed in hepatocellular carcinoma and associated with poor prognosis. Surgery. 2013, 153: 518-25.
18. Song J, Lu M, Liu F, Du X* and Xing B*. AIB1 as an independent prognostic marker in hepatocellular carcinoma after Hepatic Resection. J Gastrointest Surg. 2012, 16: 356-360.
19. Kong R, Zhang L, Hu L, Peng Q, Han W, Du X* and Ke Y*. hALP, A novel t-UTP, activates polymerase I transcription by binding and acetylating the upstream binding factor. J Biol Chem. 2011, 286(9): 7139-48.
20. Hu L, Wang J, Zhang L, Kong R, Zheng Z, Han W, Du X* and Ke Y*. A small ribosomal subunit (SSU) processome component, the human U three protein 14a binds p53 and promotes p53 degradation. J Biol Chem. 2011, 286(4): 3119-28.
Non-corresponding author publications:
1. Song S, Yang Y, Liu M, Liu B, Yang X, Yu M, Qi H, Ren M, Wang Z, Zou J, Li F, Du X, Zhang H, Luo J. MiR-125b attenuates human hepatocellular carcinoma malignancy through targeting SIRT6. Am J Cancer Res. 2018, 8(6):993-1007.
2. Qijiong Li, Xiaofeng Liu, Kemin Jin, Min Lu, Chunfeng Zhang, Xiaojuan Du and Baocai Xing*. NAT10 is upregulated in hepatocellular carcinoma and enhances mutant p53 activity. BMC Cancer. 2017, 17:605-614.
3. Abulaiti X, Zhang H, Wang A, Li N, Li Y, Wang C, Du X, Li L. Phosphorylation of Threonine343 Is Crucial for OCT4 Interaction with SOX2 in the Maintenance of Mouse Embryonic Stem Cell Pluripotency. Stem Cell Reports. 2017, 9(5):1630-1641.
4. Chen M, Zhang C, Liu W, Du X, Liu X*, Xing B*, Long noncoding RNA LINC01234 promotes hepatocellular carcinoma progression through orchestrating aspartate metabolic reprogramming. Mol Therapy. 2022, S1525-0016(22)00104-6. doi: 10.1016/j.ymthe.2022.02.020.