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博士生导师

朱薛辰 副研究员

发布日期：2023-04-15



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手  机: 18810718992

E - mail: zhuxc@bjmu.edu.cn


个人履历：

2008年 9月 - 2012年 6月  四川大学  学士

2012年 9月 - 2017年10月   清华大学  博士

2017年12月 - 2019年12月  清华大学   博士后

2020年 1月 - 2023年3月  西湖大学   博士后

2023年4月 至今  北京大学 基础医学院  副研究员、博士生导师


主要研究方向：

  1. 胚胎早期发育过程中卵母细胞成熟、极性建立、组织分化、神经诱导过程的分子机制。

  2. 出生缺陷疾病动物模型的构建和发病机理研究。

科研论文 (* co-first author)

  1. Zhu X*, Huang G*, Zeng C*, Zhan X*, Liang K*, Zhao Y, Wang P, Wang Q, Zhou Q, Tao Q, Liu M, Lei J, Yan C, Shi Y. Near-atomic Structure of the Cytoplasmic Ring of the Xenopus laevis Nuclear Pore Complex. Science. 2022 Jun 10;376(6598): eabl8280 (* co-first author)

  2. Huang G*, Zhan X*, Zeng C*, Zhu X*, Liang K*, Zhao Y, Wang P, Wang Q, Zhou Q, Tao Q, Liu M, Lei J, Yan C, Shi Y. Cryo-EM structure of the nuclear ring from Xenopus laevis nuclear pore complex. Cell Research. 2022 Apr;32(4):349-358 (* co-first author)

  3. Huang G*, Zhan X*, Zeng C*, Liang K*, Zhu X*, Zhao Y, Wang P, Wang Q, Zhou Q, Tao Q, Liu M, Lei J, Yan C, Shi Y. Cryo-EM structure of the Inner Ring from Xenopus laevis Nuclear Pore Complex. Cell Research. 2022 Mar;32(5):451-460. (* co-first author)

  4. Zhu X*, Wang P*, Wei J, Li Y, Zhai J, Zheng T, Tao Q. Lysosomal degradation of the maternal dorsal determinant Hwa safeguards dorsal body axis formation. EMBO Reports. 2021 Dec 6;22(12):e53185.

  5. Zhang F*, Zhu X*, Wang P*, He Q, Huang H, Zheng T, Li Y, Jia H, Xu L, Zhao H, Colozza G, Tao Q, De Robertis EM, Ding Y. The cytokine FAM3B/PANDER is an FGFR ligand that promotes posterior development in Xenopus. Proc Natl Acad Sci USA. 2021 May 18;118(20):e2100342118.

  6. Nong J, Kang K, Shi Q, Zhu X, Tao Q, Chen YG. Phase separation of Axin organizes the β-catenin destruction complex. Journal of Cell Biology. 2021 Apr 5;220(4):e202012112.

  7. Huang G*, Zhang Y*, Zhu X*, Zeng C*, Wang Q, Zhou Q, Tao Q, Liu M, Lei J, Yan C, Shi Y. Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis. Cell Research. 2020 Jun;30(6):520-531.

  8. Zhang Y*, Li S*, Zeng C*, Huang G*, Zhu X*, Wang Q, Wang K, Zhou Q, Yan C, Zhang W, Yang G, Liu M, Tao Q, Lei J, Shi Y. Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex. Cell Research. 2020 Jun;30(6):532-540.

  9. Yan L*, Chen J*, Zhu X*, Sun J, Wu X, Shen W, Zhang W, Tao Q, Meng A. Maternal Huluwa dictates the embryonic body axis through β-catenin in vertebrates. Science. 2018 Nov 23;362(6417).

  10. Pan X, Li Z, Zhou Q, Shen H, Wu K, Huang X, Chen J, Zhang J, Zhu X, Lei J, Xiong W, Gong H, Xiao B, Yan N. Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1. Science. 2018 Oct 19;362(6412).

  11. Lin H*, Zhu X*, Chen G, Song L, Gao L, Khand AA, Chen Y, Lin G, Tao Q. KDM3A-mediated demethylation of histone H3 lysine 9 facilitates the chromatin binding of Neurog2 during neurogenesis. Development. 2017 Oct 15;144(20):3674-3685.

  12. Zhu X, Xing R, Tan R, Dai R, Tao Q. The RNF146 E3 ubiquitin ligase is required for the control of Wnt signaling and body pattern formation in Xenopus. Mechanisms of Development. 2017 Oct; 147:28-36.

  13. Min Z, Lin H, Zhu X, Gao L, Khand AA, Tao Q. Ascl1 represses the mesendoderm induction in Xenopus. Acta Biochimica et Biophysica Sinica. 2016 Nov;48(11):1006-1015.

  14. Gao L*, Zhu X*, Chen G, Ma X, Zhang Y, Khand AA, Shi H, Gu F, Lin H, Chen Y, Zhang H, He L, Tao Q. A novel role for Ascl1 in the regulation of mesendoderm formation via HDAC-dependent antagonism of VegT. Development. 2016 Feb 1;143(3):492-503.

  15. Zhu X, Min Z, Tan R, Tao Q. NF2/Merlin is required for the axial pattern formation in the Xenopus laevis embryo. Mechanisms of Development 138 Pt 3, 305-312.

  16. Shi S, Zhu X, Guo Q, Wang Y, Zuo T, Luo F, Qian Z. Self-assembled mPEG-PCL-g-PEI micelles for simultaneous codelivery of chemotherapeutic drugs and DNA: synthesis and characterization in vitro. International Journal of Nanomedicine. 2012; 7:1749-59.

  17. Wu QJ*, Zhu X*, Xiao X, Wang P, Xiong da K, Gong CY, Wang YS, Yang L, Wei YQ. A novel vaccine delivery system: biodegradable nanoparticles in thermosensitive hydrogel. Growth Factors. 2011 Dec; 29(6):290-7.