导师介绍
冼勋德 研究员
冼勋德博士，研究员
北京大学心血管研究所研究员/助理教授
分子心血管教育部重点实验室PI
脂代谢紊乱与代谢性疾病实验室主任
主要学历、科研工作经历和学术任职：
1999/9-2003/7 北京大学药学院 学士
2003/9-2008/7 北京大学生理学专业 博士
2008/11-2012/7，美国德克萨斯州西南医学中心分子遗传学系，博士后
2012/8-2015/6，美国德克萨斯州西南医学中心分子遗传学系，讲师
2015/7-2019/8，美国德克萨斯州西南医学中心分子遗传学系，助理教授
2019/11-2022/03，北京大学，北京大学心血管研究所副研究员
2022/04-至今，北京大学，北京大学心血管研究所研究员
冼勋德博士目前任北京大学心血管研究所研究员，博士生导师，血管稳态与重构全国重点实验室PI，脂代谢紊乱与代谢性心血管疾病实验室主任，国家级海外高层次人才青年项目获得者，北京大学博雅青年学者。冼勋德于2008年至2019年在1985年诺贝尔生理与医学奖获得者Michael Brown/Joseph Goldstein领导的美国德克萨斯州西南医学中心分子遗传学系进行博士后，讲师和助理教授工作，于2019年入职北京大学心血管研究所。主要从事脂质代谢调控与代谢性心血管疾病的研究，建立了一系列拥有我国自主知识产权的脂代谢紊乱的基因工程仓鼠模型，相关研究成果发表在European Heart Journal，Journal of Hepatology, Nature Communications，Military Medical Research, Circulation Research，ATVB，PNAS，Theranostics，Science Signaling，EBioMedicine，Metabolism等国际著名期刊。荣获2020年中国实验动物学会优秀青年人才奖，获得2022年度北京市医学会科技奖一等奖、北京市科协自然科技奖二等奖，获批国际和国家专利12项。目前担任中国病理生理学会动脉粥样硬化委员会常务委员和国际动脉粥样硬化学会中国分会副主席，国际动脉粥样硬化杂志Atherosclerosis和Scientific Reports编委，同时为Nature Cell Biology，Nature Communications，Journal of Clinical Investigation，PNAS等特邀审稿人。
近五年作为第一作者/责任作者发表论文
1. Yitong Xu, Jingxuan Chen, Yiran Liu, Ge Zhang, Guolin Miao, Jingdong Wu, Kaikai Lu, Yinqi Zhao, Wenxi Zhang, Liwen Zheng, Lianxin Zhang, Jinxuan Chen, Zihao Zhou, Yufei Han, Pingping Lai, Jiabao Guo, Donghui Wu, Si Mei, Ling Zhang, Yang Zhao, Wei Huang, Yuhui Wang, Junnan Tang, Dongyu Zhao, Xunde Xian #(责任作者). The macrophage-derived motor protein KIF13B enhances MERTK-mediated efferocytosis and prevents atherosclerosis in mice. European Heart Journal, 2025. (In press)
2. Kaikai Lu, Yitong Xu, Lei He, Yinqi Zhao, Xunde Xian #(责任作者). Revisiting the Role of CBL in Liver Fibrosis: Unveiling the Antifibrotic Potential of CBLB inhibitor NX-1607. J Hepatol. 2025 Mar 25:S0168-8278(25)00211-9. doi: 10.1016/j.jhep.2025.03.023. Epub ahead of print. PMID: 40139509.
3. Pingping Lai, Guolin Miao, Yinqi Zhao, Yufei Han, Yanwei Li, Yiran Liu, Jiabao Guo, Wenxi Zhang, Xin Guo，Yitong Xu，Lianxin Zhang，Gonglie Chen, Zihao Zhou, Si Mei, Jingxuan Chen, Jinxuan Chen，Luzheng Xu, Chong Zhang, Yang Ding，Xiaoguang Dou, Shengmei Wen, Sin Man Lam, Guanghou Shui，Yuhui Wang，Wei Huang, Dongyu Zhao，Xunde Xian #(责任作者). SR-A3 suppresses AKT activation to protect against MAFLD by inhibiting XIAP-mediated PTEN degradation. Nature communications. 2025. doi:10.1038/s41467-025-57585-0.
4. GuoLin Miao, WenXi Zhang, YiTong Xu, YiRan Liu, PingPing Lai, JiaBao Guo, GongLie Chen, JingXuan Chen, ZiHao Zhou, YanWei Li, Chong Zhang, Yang Ding, LianXin Zhang, YuFei Han, JinXuan Chen, JingDong Wu, YinQi Zhao, Si Mei, Yang Zhao, YuanWu Ma, Ling Zhang, Wei Huang, DongYu Zhao, ErDan Dong, YuHui Wang and Xunde Xian #(责任作者). Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction‑associated fatty liver disease. Mil Med Res. 2025. doi: 10.1186/s40779-025-00594-3.
5. Zhidan Zhang, Meijie Chen, Yitong Xu, Zhihua Wang, Zhenghong Liu, Chenyang He, Fanshun Zhang, Xiaojun Feng, Xiayun Ni, Yuanli Chen, Jixia Wang, Xinmiao Liang, Zhifu Xie, Jingya Li, Maciej Banach, Jaroslav Pelisek, Yuqing Huo, Yunhui Hu, Paul C Evans, Li Wang, Xiao-Yu Tian, Jianbo Xiao, Yuhua Shang, Yijun Zheng , Xunde Xian #(责任作者), Jianping Weng#，Suowen Xu#，Theranostics. 2025 Mar 18;15(10):4325-4344.
6. Jiabao Guo, Guolin Miao, Wenxi Zhang, Haozhe Shi, Pingping Lai, Yitong Xu, Lianxin Zhang, Gonglie Chen, Yufei Han, Ying Zhao, George Liu, Ling Zhang, Yuhui Wang, Wei Huang, Xunde Xian #(责任作者). Depletion of ApoA5 aggravates spontaneous and diet-induced nonalcoholic fatty liver disease by reducing hepatic NR1D1 in hamsters. Theranostics. 2024. doi:10.7150/thno.91084.
7. Guolin Miao; Jiabao Guo; Pingping Lai; Wenxi Zhang; Yitong Xu; Jingxuan Chen; Lianxin Zhang; Zihao Zhou; Yufei Han; Gonglie Chen; Jinxuan Chen; Yijun Tao; Lemin Zheng; Ling Zhang; Wei Huang; Yuhui Wang; Xunde Xian #(责任作者). Remodeling Intestinal Microbiota Alleviates Severe Combined Hyperlipidemia-Induced Non-Alcoholic Steatohepatitis and Atherosclerosis in LDLR-/- Hamsters, Research. 2024. doi: 10.34133/research.0363.
8. Wenxi Zhang, Jiabao Guo, Guolin Miao, Jingxuan Chen, Yitong Xu, Pingping Lai, Lianxin Zhang, Yufei Han, Sin Man Lam, Guanghou Shui, Yuhui Wang, Wei Huang, Xunde Xian #(责任作者). Fat-1 ameliorates MAFLD and atherosclerosis through promoting the nuclear localization of PPARα in hamsters. Research. 2025. doi:10.34133/research.0577.
9. Meijie Chen, Yitong Xu, Lu Sun, Zhi-hua Wang, Peter J. Little, Li Wang, Xunde Xian #(责任作者), Jian-ping Weng, Suo-wen Xu. A Novel Mouse Model of Familial Combined Hyperlipidemia and Atherosclerosis. Acta Pharmacologica Sinica 2024. doi:10.1038/s41401-024-01241-8.
10. Yitong Xu, Wenxi Zhang, Jiabao Guo, Jinxuan Chen, Guolin Miao, Lianxin Zhang, Yufei Han, Jingxuan Chen, Ying Zhao, Xunde Xian #(责任作者). ApoL1 risk allele accelerates high-fat diet-induced atherosclerosis in LDLR−/− hamsters. Genes & Diseases. 2024. doi: 10.1016/j.gendis.2024.101379.
11. Xiao Lin; Wei Zhang; Chun Yang; Ping Ma; Kunxiang He; Gonglie Chen; Yijun Tao; Haizhao Yan; Zhao Yang; Ling Zhang; Jianglin Fan; Qinghua Cui; Wei Huang; George Liu; Xunde Xian #(共同责任作者); Yuhui Wang#. Depleting LCAT Aggravates Atherosclerosis in LDLR-deficient Hamster with Reduced LDL-Cholesterol Level. J Adv Res. 2023. doi: 10.1016/j.jare.2023.10.016.
12. Chenxi Liang; Xiaowei Wang; Kenan Peng; PingPing Lai; Ziwei Liu; Jiaao Ma; Xin Chen; Gang Liu; Mingqi Zheng; Yuhui Wang; Hongyuan Yang; George Liu; Xunde Xian #(责任作者); Mingming Gao ; Idol Depletion Protects against Spontaneous Atherosclerosis in a Hamster Model of Familial Hypercholesterolemia, Oxid Med Cell Longev. 2022. doi:10.1155/2022/1889632.
13. Haozhe Shi; Jiabao Guo; Qiongyang Yu; Xinlin Hou; Lili Liu; Mingming Gao; Lili Wei; Ling Zhang; Wei Huang; Yuhui Wang; George Liu; Peter Tontonoz; Xunde Xian #(责任作者). CRISPR/CAS9 based blockade of IL-10 signaling impairs lipid and tissue homeostasis to accelerate atherosclerosis. Front Immunol. 2022. doi: 10.3389/fimmu.2022.999470.
14. Pohlkamp T*, Xunde Xian*(共同第一作者), Wong C*, Durakoglugil M, Werthmann C, Saido, Evers B, White C, Connor J, Hammer R, Herz J. NHE6-Depletion Corrects ApoE4-Mediated Synaptic Impairments and Reduces Amyloid Plaque Load. eLife. 2021.
15. Guo M, Ma S, Xu Y, Huang W, Gao M, Wu X, Dong X, Wang Y, Liu G, Xunde Xian #(责任作者). Correction of Familial LCAT Deficiency by AAV-hLCAT Prevents Renal Injury and Atherosclerosis in Hamsters-Brief Report. Arterioscler Thromb Vasc Biol.2021. Jul;41(7):2141-2148.
16. Guo M, Liu Z, Xu Y, Ma P, Huang W, Gao M, Wang Y, Liu G, Xunde Xian #(责任作者). Spontaneous Atherosclerosis in Aged LCAT-Deficient Hamsters With Enhanced Oxidative Stress. Arterioscler Thromb Vasc Biol. 2020 Dec 40(12):2829-2836.
17. Guo M, Xu Y, Dong Z, Zhou Z, Cong NX, Gao M, Huang W, Wang Y, Liu G, Xunde Xian #(责任作者). Inactivation of Apoc3 by CRISPR/Cas9 Protects Against Atherosclerosis in Hamsters. Circ Res. 2020 Sep 21. doi: 10.1161/CIRCRESAHA.120.317686.
18. Gao M, Yang C, Wang X, Guo M, Yang L, Gao S, Zhang X, Ruan G, Li X, Tian W, Lu G, Dong X, Ma S, Li W, Wang Y, Zhu H, He J, Yang H, Liu G#, Xunde Xian #(责任作者). ApoC2 Deficiency Elicits Severe Hypertriglyceridemia and Spontaneous Atherosclerosis: A Rodent Model Rescued From Neonatal Death. Metabolism. 2020 Jun 17;154296. doi:10.1016/j.metabol.2020.154296.
在研基金
1. 国家自然科学基金(NSFC)面上项目（2023/1 - 2026/12）
2. 北京市自然科学基金（2024/1 - 2026/12）
近五年作为第一完成人获得专利
1. CBL抑制剂NX1607在制备治疗动脉粥样硬化药物中的应用，2025-06-02，中国，CN 119868356 A
2. A类清道夫受体3或提高A类清道夫受体3表达量的试剂在制备降血糖的产品中的应用，2024-08-27，中国，CN 118161596B
3. SCARA3基因敲除仓鼠模型的构建方法, 2023-05-26, 中国, CN202210545169.X
4. 构建ABCA1基因敲除模型的试剂盒和方法, 2021-9-24, 中国，CN201811376682.0
5. 构建ApoC2基因敲除仓鼠模型的试剂盒和方法, 2020-7-7, 中国, CN201811179674.7
6. 构建LCAT基因敲除模型的系统和方法, 2020-5-26, 中国, CN201810201435.0
7. A CONSTRUCTION METHOD OF APOC3 GENE NON-EXPRESSION HAMSTER MODEL，2024-03-27，南非，C12N.202308300
8. CONSTRUCTION METHOD OF APOA5 GENE KNOCKOUT HAMSTER MODEL，2024-03-22，尼日利亚，CRP: 010781
9. A CONSTRUCTION METHOD OF IL-10 GENE NON-EXPRESSION HAMSTER MODEL，2024-03-27，南非，C12N.202308299