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导师介绍

冼勋德 研究员

发布日期：2021-10-11

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冼勋德博士，研究员

北京大学心血管研究所研究员/助理教授

分子心血管教育部重点实验室PI

脂代谢紊乱与代谢性疾病实验室主任

主要学历、科研工作经历和学术任职：

1999/9-2003/7 北京大学药学院 学士

2003/9-2008/7 北京大学生理学专业 博士

2008/11-2012/7，美国德克萨斯州西南医学中心分子遗传学系，博士后

2012/8-2015/6，美国德克萨斯州西南医学中心分子遗传学系，讲师

2015/7-2019/8，美国德克萨斯州西南医学中心分子遗传学系，助理教授

2019/11-至今，北京大学，北京大学心血管研究所助理教授/PI


冼勋德博士目前是任北京大学心血管研究所研究员，博士生导师，分子心血管教育部重点实验室PI。冼勋德于2008年至2019年在1985年诺贝尔生理与医学奖获得者Michael Brown/Joseph Goldstein领导的美国德克萨斯州西南医学中心分子遗传学系进行博士后，讲师和助理教授工作，长期致力于脂蛋白受体对多种代谢性疾病影响的研究，包括动脉粥样硬化，糖尿病，肥胖以及神经退行性疾病。通过与北京大学刘国庆教授长期合作，冼勋德领导的课题组并率先在世界范围内创建了基因工程仓鼠技术平台，建立了一系列拥有我国自主知识产权的脂代谢紊乱的基因工程仓鼠模型并系统阐明了利用拟人化仓鼠模型研究脂代谢紊乱与动脉粥样硬化的优势，发表了一些列代表性论文，获得同行的高度认可。相关研究成果发表在Circulation Research，ATVB，Journal of Neuroscience，PNAS，eLife，Science Signaling，EBioMedicine，Metabolism等国际著名期刊。荣获2020年中国实验动物学会优秀青年人才奖并入选2021年国家级海外高层次人才青年项目。主持国家自然科学基金委面上项目2项，申请专利9项，获批5项。目前担任中国病理生理学会动脉粥样硬化委员会常务委员，国际动脉粥样硬化学会中国分会副主席和教育部学位论文评审专家，国际动脉粥样硬化杂志（Atherosclerosis）和Animal Modes and Experimental Medicine编委，同时为Nature Cell Biology，Nature Communication，Journal of Clinical Investigation，Atherosclerosis，Journal of Clinical Endocrinology and Metabolism，Journal of Lipid Research等国际著名期刊的特邀审稿人。


近五年作为第一作者/责任作者发表论文

  1. Shi H*, Guo J*, Yu Q, Hou X, Liu L, Gao M, Wei L, Zhang L, Huang W, Wang Y, Liu G, Tontonoz P, Xian X# (责任作者). CRISPR/Cas9 based blockade of IL-10 signaling impairs lipid and tissue homeostasis to accelerate atherosclerosis. Front Immunology. 2022 Aug 30;13:999470. doi: 10.3389/fimmu.2022.999470. eCollection 2022.

  2. Xu Y*, Guo J*, Zhang L*, Miao G, Lai P, Zhang W, Liu L, Hou X, Wang Y, Huang W, Liu G, Gao M#, Xian X#(责任作者). Targeting ApoC3 Paradoxically Aggravates Atherosclerosis in Hamsters With Severe Refractory Hypercholesterolemia. Front. Cardiovasc. Med., 02 February 2022 | https://doi.org/10.3389/fcvm.2022.840358.

  3. Liang C, Wang X, Peng K, Lai P, Liu Z, Ma J, Chen X, Liu G, Zheng M, Wang Y, Yang H, Liu G, Xian X#（并列责任作者）, Gao M#. Idol Depletion Protects against Spontaneous Atherosclerosis in a Hamster Model of Familial Hypercholesterolemia. Oxid Med Cell Longev. 2022 May 24;2022:1889632. doi: 10.1155/2022/1889632. eCollection 2022.

  4. Xian X*(第一作者), Wang Y, Liu G. Genetically Engineered Hamster Models of Dyslipidemia and Atherosclerosis. Methods Mol Biol. 2022;2419:433-459. doi: 10.1007/978-1-0716-1924-7_26.

  5. Liu G, Lai P, Guo J, Wang Y, Xian X#(责任作者). Genetically-engineered Hamster Models: Applications and Perspective in Dyslipidemia and Atherosclerosis-related Cardiovascular Disease. Medical Review. 2021 (In press).

  6. Pohlkamp T*, Xian, X*(并列一作), Wong C*, Durakoglugil M, Werthmann C, Saido, Evers B, White C, Connor J, Hammer R, Herz J. NHE6-Depletion Corrects ApoE4-Mediated Synaptic Impairments and Reduces Amyloid Plaque Load. eLife. 2021 (In press).

  7. Guo M, Ma S, Xu Y, Huang W, Gao M, Wu X, Dong X, Wang Y, Liu G, Xian X#(责任作者). Correction of Familial LCAT Deficiency by AAV-hLCAT Prevents Renal Injury and Atherosclerosis in Hamsters-Brief Report. Arterioscler Thromb Vasc Biol.2021. Jul;41(7):2141-2148.

  8. Guo M, Liu Z, Xu Y, Ma P, Huang W, Gao M, Wang Y, Liu G, Xian X#(责任作者). Spontaneous Atherosclerosis in Aged LCAT-Deficient Hamsters With Enhanced Oxidative Stress. Arterioscler Thromb Vasc Biol. 2020 Dec 40(12):2829-2836.

  9. Guo M, Xu Y, Dong Z, Zhou Z, Cong NX, Gao M, Huang W, Wang Y, Liu G, Xian X#(责任作者). Inactivation of Apoc3 by CRISPR/Cas9 Protects Against Atherosclerosis in Hamsters. Circ Res. 2020 Sep 21. doi: 10.1161/CIRCRESAHA.120.317686. Online ahead of print.

  10. Yu Q, Ma X, Wang Y, Shi H, An J, Wang Y, Dong Z, Lu Y, Ge J, Liu G#, Xian X#1, Sun A#1 (责任作者，1Lead contact). Dietary Cholesterol Exacerbates Statin-Induced Hepatic Toxicity in Syrian Golden Hamsters and in Patients in an Observational Cohort Study. Cardiovasc Drugs Ther. 2020 Aug 29. doi:10.1007/s10557-020-07060-3. Online ahead of print.

  11. Chun Yang, Wenhong Tian, Sisi Ma, Mengmeng Guo, Xiao Lin, Fengying Gao, Xiaoyan Dong, Mingming Gao, Yuhui Wang, George Liu#, Xunde Xian#1 (责任作者，1Lead contact). AAV-mediated ApoC2 gene therapy: reversal of severe hypertriglyceridemia and rescue of neonatal death in ApoC2 deficient hamsters. Molecular Therapy Methods & Clinical Development. 2020 Jul 15;18:692-701. doi: 10.1016/j.omtm.2020.07.011.

  12. Gao M, Yang C, Wang X, Guo M, Yang L, Gao S, Zhang X, Ruan G, Li X, Tian W, Lu G, Dong X, Ma S, Li W, Wang Y, Zhu H, He J, Yang H, Liu G#, Xian X#1（责任作者，1Lead contact）. ApoC2 Deficiency Elicits Severe Hypertriglyceridemia and Spontaneous Atherosclerosis: A Rodent Model Rescued From Neonatal Death. Metabolism: Clinical and Experimental. 2020 Jun 17;154296. doi:10.1016/j.metabol.2020.154296.

  13. Lili Wei, Haozhe Shi, Xiao Lin, Xin Zhang, Yuhui Wang, George Liu#, Xunde Xian#1(责任作者). Impact of Cholesterol on Ischemic Stroke in Different Human-Like Hamster Models: A New Animal Model for Ischemic Stroke Study. Cells. 2019 Sep; 8(9): 1028.

  14. Jinjie Wang, Kunxiang He, Chun Yang, Xiao Lin, Xin Zhang, Yuhui Wang, George Liu#, Xunde Xian#(责任作者). Dietary Cholesterol Is Highly Associated with Severity of Hyperlipidemia and Atherosclerotic Lesions in Heterozygous LDLR-Deficient Hamsters. Int J Mol Sci. 2019 Jul 18;20(14). pii: E3515. doi: 10.3390/ijms20143515

  15. Kunxiang He, Jinjie Wang, Haozhe Shi, Qiongyang Yu, Xin Zhang, Mengmeng Guo, Yuhui Wang, Xunde Xian# (责任作者) and George Liu#. An interspecies study of lipid profile and atherosclerosis in familial hypercholesterolemia animal models with low density lipoprotein receptor deficiency. Am J Transl Res. 2019 May 15;11(5):3116-3127. eCollection 2019

  16. Xunde Xian*#(*第一作者#责任作者), Theresa Pohlkamp*, Murat S. Durakoglugil, Connie Wong, JÜrgen K. Beck, Courtney Lane-Donovan, Joachim Herz#: Reversal of ApoE4 Induced Recycling Block as a Novel Prevention Approach for Alzheimer's Disease. eLife. 2018 Oct 30;7. pii: e40048. (Featured and Cover Article封面杂志)

  17. Zhao Dong, Haozhe Shi, Mingming Zhao, Xin Zhang, Wei Huang, Yuhui Wang, Lemin Zheng, Xunde Xian#(责任作者) and George Liu#. Loss of LCAT Activity in the Golden Syrian Hamster Elicits Pro-atherogenic Dyslipidemia and Enhanced Atherosclerosis. Metabolism: Clinical and Experimental. 2018 Mar 8. pii: S0026-0495(18)30069-6.

  18. Xin Guo, Mingming Gao, Yunan Wang, Xiao Lin, Liu Yang, Nathan Cong, Xiangbo An, Feng Wang, Kai Qu, Liqing Yu, Yuhui Wang, Jinjie Wang, Haibo Zhu, Xunde Xian#(责任作者) and George Liu#: LDL receptor gene targeted hamsters: a familial hypercholesterolemic rodent model with dominant inheritance characteristics. EBioMedicine 2018 Jan;27:214-224. doi: 10.1016/j.ebiom.2017.12.013 (期刊重点文章并受邀请加拿大脂代谢专家Dr Adeli撰写同刊评论An article with journal highlights and a commentary by Khosrow Adeli et al.).

  19. Xunde Xian*#(*第一作者#责任作者), Yinyuan Ding*, Marco Dieckmann*, Li Zhou, Mingxia Liu, John Parks, Robert E Hammer, Philippe Boucher, Shirling Tsai, Joachim Herz#: LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis. eLife 2017 Nov 16;6. pii: e29292. doi: 10.7554/eLife.29292

  20. Yinyuan Ding*, Xunde Xian*#(*#(*第一作者#责任作者), William Holland, Shirling Tsai, Joachim Herz#: Low-Density Lipoprotein Receptor-Related Protein-1 Protects Against Hepatic Insulin Resistance and Hepatic Steatosis. EbioMedicine. 2016;7:135-145. (期刊重点文章并受邀请美国脂代谢专家Dr Tontonoz撰写同刊评论An article with the accompanying commentary by Peter Tontonoz et al.)

  21. Yinyuan Ding1, Linzhang Huang1, Xunde Xian1(第一作者), Ivan S. Yuhanna, Catherine R. Wasser, Michael Frostcher, Chieko Mineo, Philip W. Shaul. Joachim Herz: Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial adhesion and lesion macrophage accumulationd atherosclerosis. Science Signaling. 2016; 9(419):ra29.

在研基金

  1. 2021年国家级海外高层次人才青年项目

  2. 国家自然科学基金(NSFC)：82070460和82270479.

  3. 北京大学专项经费：BMU2020XY011.

  4. 北京大学医学-X项目：BMU2020MX001.

专利

  1. Promoting Cycling of ApoE4 Isoform (Pub. No.: US 2011/0136832 A1)

  2. Methods and compositions for treatment of atherosclerosis (Patent No.: WO2017053734A1)

  3. 构建LCAT基因敲除仓鼠模型的系统和方法 (CN201810201435.0）

  4. 构建ApoC2基因敲除仓鼠模型的试剂盒和方法 (CN201811179674.7）

  5. 构建ABCA1基因敲除仓鼠模型的试剂盒和方法 (CN 201811376682.0）

  6. 一种基于IL10基因敲除仓鼠模型的构建（202210619290.2）

  7. 一种ApoC3基因敲除仓鼠的构建方法（202210619286.6）

  8. SCARA3基因敲除仓鼠模型的构建方法（202210545169.X）

  9. ApoA5基因敲除仓鼠模型的构建方法（202210545600.0）