陈扬，副研究员，博士生导师

北京大学临床医学高等研究院精准医疗多组学研究中心

北京大学医学部基础医学院生物化学与分子生物学系

联系方式

Email: chenyang1816185048@bjmu.edu.cn

研究方向及领域

主要研究方向为细胞器生物学发生和基于质谱的蛋白组学方法开发和应用。主要关注外泌体、新细胞结构迁移体等结构发生、物质分选运输等分子细胞生物学机制。应用蛋白质谱技术大规模地发掘基于疾病问题和临床队列的生物标志物，探索疾病发生规律。

主要代表作

1. Peiyao Fan*, Rui Ji1, Yiling Wen, Yaping Dang, Yong Li, Xiaojie Yan, Murong Li, Qiaoxia Zheng, Yifan Ge, Pengli Zheng, Yang Chen#. Contact-Dependent Incorporation of Endoplasmic Reticulum into Retraction Fiber and Migrasomes: Transfer Hub at Cell Far End.  Journal of Cell Biology ,  Formal Acceptance.

2. Yiling Wen*, Yong Li*, Jiayi Chen*, Dianxing Liu, Yuan Chao Li, Ying Li, Haohao Tang, Peizhen Gao, Wenmin Tian#, Ning Shen#, Yang Chen#. Toward a comprehensive map of Rab-medated cargoo transport to migrasomes.  Science China Life Sciences ,  accepted in principle.

3. Yuxing Huang*, Xiaojie Yan*, Xing Liu*, Congcong Ji, Wenmin Tian, Haohao Tang, Yong Li, Yiling Wen, Peiyao Fan, Hongli Wang, Cankun Xi, Zhongtian Li, Tian Lu, Fuping You#, Xin Yin#, Yang Chen#. Migrion, a Migrasome-mediated unit for intercellular viral transmission.  Science Bulletin,  2025 Aug 23:S2095-9273(25)00870-9.

4. Rui Ji*, Hongli Wang*, Xia Zheng, Dongxue Shi, Wenmin Tian, Peizhen Gao, Yong Li, Yiling Wen, Jianjun Wang, Zhang Liu#, Catherine C. L. Wong#, and Yang Chen#. Tetraspanin 4 Mediates Cholesterol-Dependent Exosome Membrane Protection from Cryodamage.  Nano Letters . Epub 2025 May 19( Cover story )

5. Yong Li*, Yiling Wen*, Ying Li, Xinyi Tan, Shuaixin Gao, Peiyao Fan, Wenmin Tian, Catherine CL Wong#, Yang Chen#. Rab10-CAV1 mediated intraluminal vesicles transport to migrasomes.  PNAS . 2024 Jul 23;121(30);

6. Wenmin Tian*, DongXue Shi*, Yinmei Zhang*, Hongli Wang, Haohao Tang, Zhongyu Han, Catherine CL Wong, Liyan Cui#, Jiajia Zheng#, Yang Chen#. Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of large and small circulating extracellular vesicle enriched fraction.  Communications Biology . 2024 Jan 15;7(1):99.

7. Wenmin Tian*, Delin Li*, Nan Zhang*, Guijie Bai, Kai Yuan, Haixia Xiao, Feng Gao, Yang Chen#, Catherine C L Wong#, George Fu Gao#. O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an "O-Follow-N" rule.  Cell Research . 2021 Oct;31(10):1123-1125.

8. Wenmin Tian*, Nan Zhang*, RonghuaJin*, Yingmei Feng*, Siyuan Wang*, Shuaixin Gao, Ruqin Gao, Guizhen Wu, Wenjie Tan*, Yang Chen#, George, Fu Gao#, and Catherine CL Wong#(corresponding author). Immune suppression in the early stage of COVID-19 disease.  Nature Communications . 2020, 11(1):5859.

9. Puzhong Lu, Rui Liu, Di Lu, Yue Xu, Xueyi Yang, Zheng Jiang, Chun Yang, Li Yu#, Xiaoguang Lei#, Yang Chen# (2020). Chemical screening identifies ROCK1 as a regulator of migrasome formation.  Cell Discovery , 2020 Aug 4;6:51.

10. Xiaoxin Zhao*,Yaxin Lei, Jiajia Zheng, Junya Peng, Ying Li, Li Yu#, and Yang Chen# (2019). Identification of markers for migrasome detection.  Cell Discovery , 2019 May 21;5:27.

11. Na Mi*, Yang Chen*, Shuai Wang, Mengran Chen, Mingkun Zhao, Guang Yang, Meisheng Ma, Qian Su, Sai Luo, Jingwen Shi, Jia Xu, Qiang Guo, Ning Gao, Yujie Sun, Zhucheng Chen, Li Yu.  CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane.  Nature Cell Biology . 2015 Jan; 25(1): 24-38

12. Wanqing Du*, Qian Peter Su*, Yang Chen*, Yueyao Zhu, Dong Jiang, Yueguang Rong, Senyan Zhang, Yixiao Zhang, He Ren, Chuanmao Zhang, Xinquan Wang, Ning Gao, Yanfeng Wang, Lingfei Sun, Yujie Sun, Li Yu. Kinesin 1 Drives Autolysosome Tubulation.  Developmental Cell . 2016 May 23; 37(4): 326-36

13. Wanqing Du*, Qian Peter Su*, Yang Chen*, Yueyao Zhu, Dong Jiang, Yueguang Rong, Senyan Zhang, Yixiao Zhang, He Ren, Chuanmao Zhang, Xinquan Wang, Ning Gao, Yanfeng Wang, Lingfei Sun, Yujie Sun, Li Yu. Kinesin 1 Drives Autolysosome Tubulation.  Developmental Cell . 2016 May 23; 37(4): 326-36

14. M Ramona Neunuebel*, Yang Chen*, Andrew H. Gaspar, Peter S. Backlund Jr, Alfred Yergey, Matthias P. Machner. De-AMPylation of the small GTPase Rab1 by the pathogen Legionella pneumophila.  Science . 2011 Jul 22; 333(6041): 453-6

其他论文

15. Shiyan Huang*, Wenmin Tian*, Jing Tian, Haohao Tang, Man Qin, Bingqian Zhao, Jingyan Wang, Yang Chen# and He Xu#.Deep Saliva Proteomics Elucidating the Pathogenesis of Early Childhood Caries and Identifying Biomarkers for Early Prediction.  Journal of Proteom  e   Research . Epub before print.

16. Lin Wang*, Wenmin Tian*, Sen Wang, Yuhong Liu, Hongli Wang, Junjie Xiao, Zhongkuo Yu, Lixin Xie^#, Yang Chen^#.Serum Proteomics Identifies Biomarkers for Predicting non-survivors in Elderly COVID-19 Patients.  Journal of Proteomics . 311 (2025) 105356.

17. Wenmin Tian*, Zhongyu Han*, Dongxue Shi*, Hongli Wang, Haohao Tang, Zhenchao Wu, Yinmei Zhang, Liyan Cui#, Ning Shen#, Jiajia Zheng#, Yang Chen#. Indeterminate result of Interferon-γ Release Assay-a risk factor of mortality for COVID-19 and non-COVID-19 respiratory infection.  Journal of Medical Virology  . 2024; 96:e70058.  

18. Congyi Yang*, Jingyi Chen, Yuzheng zhao1, Jushan Wu1, Yalan Xu1, Jun Xu1, Feng Chen#, Yang Chen#, Ning Chen#. Salivary exosomes exacerbate colitis by bridging the oral cavity and intestine.  iScience .

19. Yinmei Zhang*, ShangjiaJin*, Wenmin Tian*, Dongxue Shi, Yang Chen#,Liyan Cui#, Jiajia Zheng#. Proteomic of serum samples for the exploration of the pathological mechanism of Obstetric Antiphospholipid Syndrome.  Journal of Proteom  e  Research . 2024 Jan 5;23(1):289-300. Selected Cover.

20. Yang Chen*, Nan Zhang*, Jie Zhang*, Jiangtao Guo*, Shaobo Dong*,Heqiang Sun, Shuaixin Gao, Tingting Zhou, Min Li, Xueyuan Liu, Yaxin Guo, Beiwei Ye, Yingze Zhao, Tongqi Yu, Jianbo Zhan, Yongzhong Jiang,Catherine CL Wong#, George F. Gao#, William J. Liu#. Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19.  Biochimica et Biophhysica Acta proteins and proteomics . 2022 Feb 1; 1870(2): 140736. Epub ahead of print. ( Cover story )

21. Yang Chen*, Hangping Yao*, Nan Zhang*, Jie Wu*, Shuaixin Gao, Jiangtao Guo, Xiangyun Lu, Linfang Cheng, Rui Luo, Xue Liang, Catherine CL Wong#, Min Zheng#. Proteomic analysis identifies prolonged disturbances in pathways related to cholesterol metabolism and myocardium function in the COVID-19 recovery stage.  Journal of Proteome Research . 2021 Jul 2;20(7):3463-3474

22. Yang Chen*, Igor Tascón*, M Ramona Neunuebel, Chiara Pallara, Jacqueline Brady, Lisa N. Kinch, Juan Fernández-Recio, Adriana L. Rojas, Matthias P. Machner, AitorHierro. Structural basis for Rab1 de-AMPylation by the Legionella pneumophila effector SidD.  PLOS Pathogen . 2013 May 16;  

23. Yang Chen*, Matthias P. Machner. Targeting of the small GTPase Rab6A' by the Legionella pneumophila effector LidA.  Infection and Immunity . 2013 Jun 881(6): 2226-35