博士生导师
陈扬 副研究员
陈扬，副研究员，博士生导师
北京大学医学部精准医疗多组学研究中心
研究方向：细胞外囊泡发生的分子机制以及生理功能
办公地址：昌平医疗产业园12号楼1层
Email: chenyang1816185048@bjmu.edu.cn
研究领域及方向：
主要从事膜性细胞结构和细胞器生物膜动态变化的研究。研究外泌体、新细胞器迁移体等细胞外囊泡发生、物质分选运输、细胞间信号沟通的分子细胞生物学机制。应用蛋白质谱技术定量鉴定疾病样品中迁移体、外泌体的内容物，探索细胞外囊泡在疾病中的重要作用及疾病诊断中的功能。
简历：
2018—至今 副研究员（Tenure track）：北京大学医学部精准医疗多组学研究中心（副主任）／基础医学院
2016—2018 副研究员：清华大学生命科学学院
2014—2016 助理研究员：清华大学生命科学学院
2012—2014 博士后：清华大学生命科学学院（合作导师：俞立）
2008—2012 博士：北京大学医学部基础医学专业（美国国立卫生研究院）
（导师：柯杨、Matthias Machner）
2004—2008 本科：北京大学医学部基础医学专业
代表性论文：
研究性论文：“*”代表第一作者；“#”代表责任作者
1. Yang Chen*, Nan Zhang*, Jie Zhang*, Jiangtao Guo*, Shaobo Dong*,Heqiang Sun, Shuaixin Gao, Tingting Zhou, Min Li, Xueyuan Liu, Yaxin Guo, Beiwei Ye, Yingze Zhao, Tongqi Yu, Jianbo Zhan, Yongzhong Jiang,Catherine CL Wong#, George F. Gao#, William J. Liu#. Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19. Biochimica et Biophhysica Acta proteins and proteomics . 2022 Feb 1; 1870(2): 140736. Epub ahead of print. ( Cover story )
2. Wenmin Tian*, Delin Li*, Nan Zhang*, Guijie Bai, Kai Yuan, Haixia Xiao, Feng Gao, Yang Chen#, Catherine C L Wong#, George Fu Gao#. O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an "O-Follow-N" rule. Cell Research . 2021 Oct;31(10):1123-1125.
3. Yang Chen*, Hangping Yao*, Nan Zhang*, Jie Wu*, Shuaixin Gao, Jiangtao Guo, Xiangyun Lu, Linfang Cheng, Rui Luo, Xue Liang, Catherine CL Wong#, Min Zheng#. Proteomic analysis identifies prolonged disturbances in pathways related to cholesterol metabolism and myocardium function in the COVID-19 recovery stage. The Journal of Proteome Research . 2021 Jul 2;20(7):3463-3474
4. Wenmin Tian*, Nan Zhang*, Ronghua Jin*, Yingmei Feng*, Siyuan Wang*, Shuaixin Gao, Ruqin Gao, Guizhen Wu, Wenjie Tan*, Yang Chen#, George, Fu Gao#, and Catherine CL Wong#(corresponding author). Immune suppression in the early stage of COVID-19 disease. Nature Communications . 2020, 11(1):5859.
5. Puzhong Lu, Rui Liu, Di Lu, Yue Xu, Xueyi Yang, Zheng Jiang, Chun Yang, Li Yu#, Xiaoguang Lei#, Yang Chen# (2020). Chemical screening identifies ROCK1 as a regulator of migrasome formation. Cell Discovery , 2020 Aug 4;6:51.
6. Xiaoxin Zhao*, Yaxin Lei, Jiajia Zheng, Junya Peng, Ying Li, Li Yu#, and Yang Chen# (2019). Identification of markers for migrasome detection. Cell Discovery , 2019 May 21;5:27. (co-corresponding author)
7. Mi N*, Chen Y*, Wang S, Chen M, Zhao M, Yang G, Ma M, Su Q, Luo S, Shi J, Xu J, Guo Q, Gao N, Sun Y, Chen Z, Yu L. CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane. Nature Cell Biology . 2015 Jan; 25(1): 24-38 (co-first author)
8. Du W*, Su QP*, Chen Y*, Zhu Y, Jiang D, Rong Y, Zhang S, Zhang Y, Ren H, Zhang C, Wang X, Gao N, Wang Y, Sun L, Sun Y, Yu L. Kinesin 1 Drives Autolysosome Tubulation. Developmental Cell . 2016 May 23; 37(4): 326-36 (co-first author)
9. Neunuebel MR*, Chen Y*, Gaspar AH, Backlund PS Jr, Yergey A, Machner MP. De-AMPylation of the small GTPase Rab1 by the pathogen Legionella pneumophila. Science . 2011 Jul 22; 333(6041): 453-6 (co-first author)
10. Chen Y*, Tascón I*, Neunuebel MR, Pallara C, Brady J, Kinch LN, Fernández-Recio J, Rojas AL, Machner MP, Hierro A. Structural basis for Rab1 de-AMPylation by the Legionella pneumophila effector SidD. PLOS Pathogen . 2013 May 16; (co-first author)
11. Chen Y*, Machner MP. Targeting of the small GTPase Rab6A' by the Legionella pneumophila effector LidA. Infection and Immunity . 2013 Jun 881(6): 2226-35
综述和评论性文章：
1. Chen Y*, Su Q*, Sun YJ, Yu L. Visualizing autophagic lysosome reformation in cells using in vitro reconstitution systems. Current Protocols in Cell Biology , 2018 Mar;78(1):11.24.1-11.24.15.
2. Chen Y*, Li Y, Ma L, Yu L. Detection of migrasomes. Cell Migration: Methods and Protocols, Methods in Molecular Biology , vol. 1749, 2018
3. Chen Y*, Li Y. Development of research into autophagic lysosome reformation. Molecules and Cells . 2018 Jan 31;41(1):45-49.
4. Yu L, Chen Y, Tooze SA. Autophagy pathway: cellular and molecular mechanisms. Autophagy . 2017 Sep 21:1-9.
5. Chen Y*, Yu L, Recent progress in autophagic lysosome reformation. Traffic . 2017 Jun; 18(6): 358-361.
6. Chen Y*, Yu L, Research progress of membranous organelles and their subcellular structures in China. Chinese Science Bulletin 2017 May 12;
7. Chen Y*, Yu L, Scissors for autolysosome tubules. EMBO J . 2015 Sep 2; 34(17): 2217-8.
8. Chen Y*, Yu L. Autophagic lysosome reformation. Exp Cell Res . 2013 Jan 15;319(2):142-6
9. Machner MP*, Chen Y, Catch and release: Rab1 exploitation by Legionella pneumophila. Cell Logist . 2011 Jul 1; 1(4): 133-138.