李扬副教授  博士生导师

北京大学干细胞研究中心

联系方式：中心实验楼225（办公室） 227（实验室）

liyang@bjmu.edu.cn或yangli@pku.edu.cn

研究方向:

人多能干细胞（ES，iPS）罕见病模型的构建

人多能干细胞分化的分子调控机制

人多能干细胞定向NK、T细胞分化在肿瘤免疫治疗中的应用

个人简介：

内蒙古包头市人。2000年毕业于内蒙古农业大学生物工程系，获得学士学位；2003年毕业于内蒙古大学生命科学院生殖生物学专业，获得硕士学位，师从旭日干院士，期间主要从事体细胞核移植的研究；2007年毕业于北京大学基础医学院干细胞生物学专业，获得博士学位，师从李凌松教授，期间主要从事人多能干细胞分化调控的研究；博士毕业留校工作至今，工作期间，单位公派到加拿大多伦多大学sunnybrook 研究所进行两年博士后训练，师从Juan Carlos Zuniga-Pflucker 教授，从事人多能干细胞造血及免疫细胞分化调控的研究。相关研究工作以第一或通讯作者发表在Journal of Hematology & Oncology、Development、Acta Biomaterialia、Stem Cell Reports、Nucleic Acids Research、Journal of Immunology等专业杂志，他引将近1000次。主持国家重点研发、国家自然科学基金、北京市自然科学基金及北大医学-密西根临床与转化医学联合研究所基金等多个项目的研究工作。作为第二完成人参与的项目“自体经血源间充质干细胞治疗宫腔粘连的关键技术及临床推广应用”获得2022年中华医学科技奖三等奖。

讲授课程：

医学细胞生物学，高级细胞生物学，干细胞生物学，细胞生物学研究方法与技术

论文发表: *Corresponding Author ^#Co-first author

1. Liu R, Wubulikasimu Z, Cai R, Meng F, Cui Q, Zhou Y*, Li Y*. NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells. Nucleic Acids Research. 2023.51:8514–8531

2. Meng F, Zhang S, Xie J, Zhou Y, Wu Q, Lu B, Zhou S*, Zhao X*, Li Y*. Leveraging CD16 fusion receptors to remodel the immune response for enhancing anti-tumor immunotherapy in iPSC-derived NK cells. Journal of Hematology & Oncology. 2023. 16:62.

3. Deng L, Yi S, Yin X, Li Y*, Luan Q*. MFN2 knockdown promotes osteogenic differentiation of iPSC-MSCs through aerobic glycolysis mediated by the Wnt/β-catenin signaling pathway. Stem Cell Research & Therapy. 2022. 13:162.

4. Chen E, Brauer P, Martinez E, Huang X, Yu Y, Anderson M, Li Y*, Juan Carlos Zuniga-Pflucker JC*. T-cell receptor β-selection is required at the CD4⁺CD8⁺ stage of human T cell development. Journal of Immunology. 2021. 206:2271-2276.

5. Zhou S, Wu J, Huang X, Yu N, Zou X, Singh J, Bo Song B*, Li Y*.Cellular uptake of a cationic amphiphilic fluorophore in the form of assemblies via Clathrin-dependent endocytosis. Materials & Design. 2021. 200:109464.

6. Yi S, Huang X, Zhou Y, Zhou S, Anderson M, Juan Carlos Zuniga-Pflucker JC, Luan Q*, Li Y*. E2A regulates neural ectoderm fate specification in human embryonic stem cells. Development. 2020. 147:dev190298.

7. Zhou S, Zhao H, Feng R, Ding L, Li Z, Deng C, He Q, Liu Y*, Song B*, Li Y*. Application of amphiphilic fluorophore-derived nanoparticles to provide contrast to human embryonic stem cells without affecting their pluripotency and to monitor their differentiation into neuron-like cells. Acta Biomaterialia. 2018. 15:274-284.

8. Li Y^#, Brauer P^#, Jastaranpreet S, Xhiku S, Yoganathan K, Juan Carlos Zuniga-Pflucker JC, Anderson M. Targeted disruption in TCF12 reveals HEB as an essential for human mesodermal specification and hematopoiesis. Stem Cell Reports. 2017. 9:779-795.

9. Li Y^#, Qiu C^#, Tu J^#, Geng B, Yang J, Jiang T, Cui Q. HMDD v2.0: a database for experimentally supported human microRNA and disease association. Nucleic Acids Research. 2014. 38:D119-122.

10. Li Y, Li X, Zhao H, Feng R, Zhang X, Tan J. Efficient induction of pluripotent stem cells from menstrual blood. Stem Cells and Development. 2013. 22:1147-1158.

11. Li Y, Tan J, Li L. Comparison of three methods for cryopreservation of human embryonic stem cells. Fertility and Sterility. 2010. 93:999-1005.