尹艳慧，研究员（博士生导师）

联系方式

yinyanhui@bjmu.edu.cn

研究方向

肿瘤免疫治疗及肿瘤微环境潜在治疗靶点筛选

个人简介

长期从事肿瘤免疫治疗靶点鉴定及其临床应用探索研究，鉴定多个新的肿瘤-睾丸抗原并开展了基因工程修饰T细胞及基于肿瘤新生抗原的个体化疫苗的临床前研究，发现肿瘤-睾丸抗原促进肿瘤发生发展的新机制。作为第一作者或责任作者在 Oncogene, International Journal of Cancer, British Journal of Cancer 等国际杂志发表文章多篇，获国家发明专利授权四项。作为课题负责人，承担科技部863专项课题、国家自然科学基金及北京市自然科学基金课题多项；获国家教育部自然科学奖一等奖、中华医学科技奖二等奖和北京市科学技术奖二等奖。现任中国免疫学会自身免疫病分会委员，中国食品药品监督管理局医疗器械评审专家。

基金

科技部863专项课题1 项 （课题负责人）

国家自然科学基金面上课题5项 （课题负责人）

北京市自然科学基金课题2项 （课题负责人）

方正药物创新研究基金1 项 （课题负责人）

近五年代表性论文

1. Song X, Guo C, Zheng Y, Wang Y, Jin Z, Yin Y*. Post-transcriptional regulation of cancer/testis antigen MAGEC2 expression by TRIM28 in tumor cells. BMC Cancer. 2018, 18: 971-980.

2. Zeng P, Wang Y, Zheng Y, Song X, Yin Y*. Cancer-testis antigen HCA587/MAGEC2 interacts with the general transcription coactivator TAF9 in cancer cells. Mol Med Rep. 2018; 17: 3226-3231.

3. Song X, Hao J, Wang J, Guo C, Wang Y, He Q, Tang H, Qing X, Li Y, Zhang Y*, Yin Y*. The cancer/testis antigen MAGEC2 promotes amoeboid invasion of tumor cells by enhancing STAT3 signling. Oncogene. 2017; 36, 1476–1486.

4. Wang J#, Song X#, Guo C, Wang Y, Yin Y*. Establishment of MAGEC2-knockout cells and functional investigation of MAGEC2 in tumor cells.Cancer Sci. 2016; 107(12): 1888-1897.

5. Xiao Song#, Wenjie Song#, Ying Wang, Jingjing Wang, Yan Li, Xiaoping Qian, Xuewen Pang, Yu Zhang, Yanhui Yin*. MicroRNA-874 functions as a tumor suppressor by targeting cancer/testis antigen HCA587/MAGE-C2.J Cancer. 2016 ;7(6):656-663..

6. Hao J, Song X, Wang J, Guo C, Li Y, Li B, Zhang Y*, Yin Y*. Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E. Oncotarget. 2015, 6(19):42028-42039.

7. Li X, Peng J, Pang Y, Yu S, Yu X, Chen P, Wang W, Han , Zhang J,Yin Y*, Zhang Y*. Identification of a FOXP3(+)CD3(+)CD56(+) population with immunosuppressive function in cancer tissues of human hepatocellular carcinoma. Sci Rep. 2015, 5:14757.

8. Sun X, Jin Z, Song X, Wang J, Li Y, Qian X, Zhang Y, Yin Y*. Evaluation of KF23 variant 1 expression and relevance as a novel prognostic factor in patients with hepatocellular carcinoma. BMC Cancer. 2015, 15:961.

9. Jiaqing Hao, Rui Shen, Yan Li, Yu Zhang, Yanhui Yin*. Cancer-testis antigen HCA587/MAGE-C2 interacts with BS69 and promotes its degradation in the ubiquitin-proteasome pathway. Biochem Biophys Res Commun. 2014, 449(4): 386-391.

10. Lijie Zhang, Juanjuan Chen, Xiao Song, Weigang Wen, Yan Li, Yu Zhang, Yanhui Yin*. Cancer/Testis antigen HCA587-derived long peptide vaccine generates potent immunologic responses and antitumor effects in mouse model. Oncol Res. 2014,21(4):193-200.