贾一挺  预聘制助理教授，副研究员

联系方式

邮箱：yitingjia@bjmu.edu.cn

手机：15201278161

座机：010-82801473

研究方向

代谢重编程及溶酶体稳态失衡与重大血管疾病

个人简介

贾一挺，北京大学基础医学院药理学系研究员，博士生导师。近五年围绕重大血管疾病（动脉粥样硬化、再狭窄、动脉瘤及血管钙化等）发病过程中的代谢重编程及溶酶体稳态失衡开展靶点研究及药物发现；主持国自然面上项目、青年项目，科技部四大慢病重大专项子课题等；近五年发表SCI论文20篇，其中以第一作者（含共同）及通讯作者（含共同）的工作发表于心血管权威期刊Circulation、Circ Res、Cell Discov、ATVB、JACCBTS等。先后获得第十七届张锡钧基金全国优秀青年生理学学术一等奖（唯一），龚兰生青年研究者奖，湖北省科技进步奖一等奖等。目前担任Adv Sci、Acta Pharm Sin B、Cell Rep、Am J Physiol Cell Physiol等学术期刊审稿专家，中国药理学会心血管药理专业委员会青年委员、生化与药理学专业委员会委员、教学与科普专委会青年委员、中国神经科学学会离子通道与受体分会委员等。

学习经历/工作经历

2023.04-今北京大学医学部药理学系副研究员

2018.09-2022.07 北京大学生理学与病理生理学系 博士后 合作导师：云彩红

2015.09-2018.07北京大学生理学与病理生理学系博士导师：孔炜

2010.09-2015.07北京大学基础医学专业（八年制）

授课课程

药理学，药物临床应用及治疗，PBL，科研思维训练，分子药理学

科研成果（基金、论文等）

基金

2025.01-2027.12科技部四大慢病重大专项子课题负责人

2024.01-2027.12国家自然科学基金面上项目主持人

2020.01-2021.12国家自然科学基金青年基金主持人

2023.01-2023.12北京大学医学青年科技创新“扬帆计划”主持人

论文

(1)Li Z, Gong Z, Li W, Chen Y, Dai R, Yang S, Chen Y, Yu F, Fu Y, Li W, Wang DW*, Jia Y*, Kong W. The Reduction of COMP Serves as a Predictor for Warning of Aortic Dissection Progression. JACC Basic Transl Sci. 2025 Aug;10(8):101329.

(2) Jia Y†*, Mao C†, Ma Z, Huang J, Li W, Ma X, Zhang S, Li M, Yu F, Sun Y, Chen J, Feng J, Zhou Y, Xu Q, Zhao L, Fu Y, Kong W*.PHB2 Maintains the Contractile Phenotype of VSMCs by Counteracting PKM2 Splicing. Circ Res. 2022 Oct 28;131(10):807-824.

(3) Jia Y†, Zhang †L, Liu Z†, Mao C, Ma Z, Li W, Yu F, Wang Y, Huang Y, Zhang W, Zheng J, Wang X, Xu Q, Zhang J, Feng W, Yun C, Liu C, Sun J, Fu Y, Cui Q*, Kong W*. Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm. Cell Discov.2022; 8(1):21.

(4) Mao C†, Ma Z†, Jia Y†, Li W, Xie N, Zhao G, Ma B, Yu F, Sun J, Zhou Y, Cui Q, Fu Y, Kong W*. Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling. Circulation. 2021; 144(15):1244-1261.

(5) Jia Y†, Wang M†, Mao C, Yu F, Wang Y, Xiao R, Jiang C, Zheng L, Xu Q, Zheng M, Fu Y, Hu Q, Kong W*. COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity. Cell Death Dis. 2018; 9(6):676.

(6) Jia Y, Kong W*. ADAM17: A Molecular Switch to Control TNFR2 During Atherogenesis In Vivo. Arterioscler Thromb Vasc Biol. 2017; 37(2):176-178.

(7) Ma Z†, Mao C†, Chen X, Yang S, Qiu Z, Yu B, Jia Y, Wu C, Wang Y, Wang Y, Gu R, Yu F, Yin Y, Wang X, Xu Q, Liu C, Liao Y*, Zheng J*, Fu Y, * Kong W*. Peptide Vaccine Against ADAMTS-7 Ameliorates Atherosclerosis and Postinjury Neointima Hyperplasia. Circulation. 2023 Feb 28;147(9):728-742.

(8)Ma Z†, Mao C†, Jia Y, Yu F, Xu P, Tan Y, Zou QH, Zhou XJ, Kong W*, Fu Y*. ADAMTS7-Mediated Complement Factor H Degradation Potentiates Complement Activation to Contributing to Renal Injuries. J Am Soc Nephrol. 2023 Feb 1;34(2):291-308.

(9)Chen Y†, Mao C†*, Gu R, Zhao R, Li W, Ma Z, Jia Y, Yu F, Luo J, Fu Y, Sun J*, Kong W*. Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification. Circ Res. 2022 Dec 2;131(12):1037-1054.

(10) Tang Y, Jia Y, Fan L, Liu H, Zhou Y, Wang M, Liu Y, Zhu J, Pang W*, Zhou J*. MFN2 Prevents Neointimal Hyperplasia in Vein Grafts via Destabilizing PFK1. Circ Res. 2022;130(11): e26-e43.

(11) Yang L, Dai R, Wu H, Cai Z, Xie N, Zhang X, Shen Y, Gong Z, Jia Y, Yu F, Zhao Y, Lin P, Ye C, Hu Y, Fu Y, Xu Q*, Li Z*, Kong W*. Unspliced XBP1 Counteracts β-Catenin to Inhibit Vascular Calcification. Circ Res. 2022;130(2):213-229.

(12) Fu Y†, Huang Y†, Yang Z, Chen Y, Zheng J, Mao C, Li Z, Liu Z, Yu B, Li T, Wang M, Xu C, Zhou Y, Zhao G, Jia Y, Guo W, Jia X, Zhang T, Li L, Liu Z, Guo S, Ma M, Zhang H, Liu B, Du J, Wang W, Tang C, Gao P, Xu Q, Wang X, Liu J, Sun J*, Kong W*. Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury. Cell Res. 2021;31(7):773-790.

(13) Li H, Guo J, Jia Y, Kong W, Li W*. LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice. Genes (Basel). 2021;12(4).

(14)Ma Z, Mao C, Jia Y, Fu Y*, Kong W*. Extracellular matrix dynamics in vascular remodeling. Am J Physiol Cell Physiol. 2020;319(3):C481-C499.

(15)Wang M, Fu Y, Gao C, Jia Y, Huang Y, Liu L, Wang X, Wang W, Kong W*. Cartilage oligomeric matrix protein prevents vascular aging and vascular smooth muscle cells senescence. Biochem Biophys Res Commun. 2016;478(2):1006-13.

(16)Fu Y†, Gao C†, Liang Y, Wang M, Huang Y, Ma W, Li T, Jia Y, Yu F, Zhu W, Cui Q, Li Y, Xu Q, Wang X*, Kong W*. Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification. Circ Res. 2016;119(2):261-76.

Complete List of Published Work in My Bibliography:

https://www.ncbi.nlm.nih.gov/myncbi/yiting.jia.1/bibliography/public/