中国科学院院士

　　

　　研究方向：

　　乳腺癌、子宫内膜癌等性激素相关肿瘤发生发展的分子生物学机理

　　基因表达调控的表观遗传学机制

　　新基因的克隆、鉴定和功能分析

　　电 话：010-82805118（办公室）

　　010-82801397（实验室）

　　传 真：010-82801355

　　Email：yshang@hsc.pku.edu.cn

　　

　　简 历：

　　博 士：美国宾夕法尼亚州立大学

　　博士后：美国哈佛大学医学院

　　主要职务：

　　北京大学基础医学院生物化学与分子生物学系主任

　　中国生物化学与分子生物学学会副理事长

　　《中国生物化学与分子生物学学报》副主编

　　《科学通报》（Chinese Science Bulletin）特邀编辑

　　《Journal of Biological Chemistry》编委

　　获得基金：

　　2002年“国家杰出青年基金”

　　核受体对基因表达的调控及其在肿瘤发生发展中的作用(国家自然科学基金重大资助项目)

　　人类重要生理活性及具有药物开发前景的功能基因研究(国家“863”计划研究项目)

　　肿瘤和神经系统疾病的表观遗传机制(国家“973”计划研究项目)

　　乳腺癌、子宫内膜癌相关功能基因的应用研究(国家“863”计划研究项目)

　　肿瘤发生/发展的分子生物学和表观遗传学基础(国家自然科学基金创新研究群体科学基金)

　　新基因ZIP的转录调控功能及其在肿瘤发生中的作用(国家自然科学基金重点资助项目)

　　“恶性肿瘤发生、发展的细胞表观遗传机制（国家“973”计划研究项目）”

　　近3年来发表论文：（带*号的为责任作者）

　　1.Xia Yi, Mei Hong, Bing Gui, Zhe Chen, Lei Li, Guojia Xie, Jing Liang, Wang X, Shang Y* (2012). RNA processing and modification protein, carbon catabolite repression 4 (Ccr4), arrests the cell cycle through p21-dependent and p53-independent pathway. The Journal of Biological Chemistry 287(25):21045-57

　　2.Dandan Wang, Jing Liang, Yu Zhang, Bin Gui, Feng Wang, Xia Yi, Luyang Sun, Zhi Yao, Yongfeng Shang* (2012). Steroid Receptor Coactivator-interacting Protein (SIP) Inhibits Caspase-independent Apoptosis by Preventing Apoptosis-inducing Factor (AIF) from Being Released from Mitochondria. The Journal of Biological Chemistry 287(16): 12612-21

　　

　　3.Fen Yang, Luyang Sun, Qian Li, Xiao Han, Liandi Lei, Hua Zhang*, and Yongfeng Shang* (2012). SET8 promotes epithelial-mesenchymal transition and confers Twist dual transcriptional activities. The EMBO Journal 31: 110-23

　　4.Xiaohan Yang, Wenhua Yu, Lei Shi, Luyang Sun, Jing Liang, Xia Yi, Qian Li, Yu Zhang, Fen Yang, Xiao Han, Di Zhang, Jie Yang, Zhi Yao, and Yongfeng Shang* (2011). HAT4, a Golgi Apparatus-anchored B-type Histone Acetyltransferase, Acetylates Free Histone H4 and Facilitates Chromatin Assembly. Molecular Cell 44: 39-50

　　5.Qian Li, Lei Shi, Bin Gui, Wenhua Yu, Jiamu Wang, Di Zhang, Xiao Han, Zhi Yao, and Yongfeng Shang* (2011). Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14. Cancer Research 71: 6899-908

　　6.Lei Shi, Luyang Sun, Qian Li, Jing Liang, Wenhua Yu, Xia Yi, Xiaohan Yang, Yanyan Li, Xiao Han, Yu Zhang, Chenghao Xuan, Zhi Yao, and Yongfeng Shang* (2011). Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. Proc Natl Acad Sci U S A. 108: 7541-7546

　　7.Yanyan Li, Luyang Sun, Yu Zhang, Dandan Wang, Feng Wang, Jing Liang, Bin Gui, and Yongfeng Shang* (2011). The histone modifications governing TFF1 transcription mediated by estrogen receptor The Journal of Biological Chemistry 286: 13925-13936

　　8.Luyang Sun, Lei Shi, Feng Wang, Peiwei Huangyang, Wenzhe Si, Jie Yang, Zhi Yao*, and Yongfeng Shang* (2011). Substrate Phosphorylation and Feedback Regulation in JFK-promoted p53 Destabilization. The Journal of Biological Chemistry 286: 4226-4235

　　9.Yu Zhang, Jing Liang, Yanyan Li, Chenghao Xuan, Feng Wang, Dandan Wang, Lei Shi, Di Zhang, and Yongfeng Shang* (2010). CCCTC-binding Factor Acts Upstream of FOXA1 and Demarcates the Genomic Response to Estrogen. The Journal of Biological Chemistry 285: 28604–28613

　　10.Wenhua Yu, Ruifang Li, Bin Gui, and Yongfeng Shang* (2010). sZIP, an Alternative Splice Variant of ZIP, Antagonizes Transcription Repression and Growth Inhibition by ZIP. Journal of Biological Chemistry 285: 14301-14307

　　11.Yan Wang, Hua Zhang, Yupeng Chen, Yimin Sun, Fen Yang, Wenhua Yu, Jing Liang, Luyang Sun, Xiaohan Yang, Lei Shi, Ruifang Li, Qian Li, Xia Yi, and Yongfeng Shang* (2009). LSD1 is a Subunit of the NuRD complex and Targets the Metastasis Programmes in Breast Cancer. Cell 138: 660-672