白云 教授

 

 

联系方式：

电话：010-82801495

Email: baiyun@bjmu.edu.cn

学习工作经历：

1993-1998年：北京大学医学部，学士

1998-2003年：北京大学医学部，博士

2010-2011年：美国国立卫生研究院（NIH）衰老研究所，访问学者

2003年-至今：北京大学基础医学院细胞生物学系，北京大学干细胞研究中心，讲师、副教授、教授、博士生导师

研究方向：

1．干细胞生物学

2．肿瘤免疫治疗

研究基金：

主持国家重点基础研究发展计划项目1项，国家自然科学基金5项，北京市自然科学基金2项，参与创新团体1项。

 

研究论文：（*责任作者）

1. Deng C, Zhao J, Zhou S, Dong J, Cao J, Gao J, Bai Y*, Deng H*. The Vascular Disrupting Agent CA4P Improves the Antitumor Efficacy of CAR-T Cells in Preclinical Models of Solid Human Tumors. Molecular Therapy. 2020, 28(1): 75-88.

2. Li H, Zhao C, Xu J, Xu Y, Cheng C, Liu Y, Wang T, Du Y, Xie L, Zhao J, Han Y, Wang X, Bai Y*, Deng H*. Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation. Protein Cell,2018, doi: 10.1007/s13238-018-0556-1.

3. Zhang S, Lin X, Li G, Shen X, Niu D, Lu G, Fu X, Chen Y, Cui M,Bai Y*. Knockout of Eva1a leads to rapid development of heart failure by impairing autophagy. Cell Death & Disease, 2017, 8(2): e2586.

4. Zhong L, Zhou J, Chen X, Liu J, Liu Z, Chen Y, Bai Y*. Quantitative proteomics reveals EVA1A-related proteins involved in neuronal differentiation. Proteomics, 2017, 17(5). doi: 10.1002/pmic.201600294.

5. Shen X, Kan S, Liu Z, Lu G, Zhang X, Chen Y, Bai Y*. EVA1A inhibits GBM cell proliferation by inducing autophagy and apoptosis. Experimental Cell Research, 2017, 352(1):130-138.

6. Wang X, Xia Y, Xu C, Lin X, Xue P, Zhu S, Bai Y*, Chen Y*. ER membrane protein complex subunit 6 (EMC6) is a novel tumor suppressor in gastric cancer. BMB Reports, 2017, 50(8): 411-416.

7. Li M, Lu G, Hu J, Shen X, Ju J, Gao Y, Qu L, Xia Y, Chen Y*, Bai Y*. EVA1A/TMEM166 Regulates Embryonic Neurogenesis by Autophagy. Stem Cell Reports, 2016, 6(3): 396-410.

8. Shen X, Kan S, Hu J, Li M, Lu G, Zhang M, Zhang S, Hou Y, Chen Y*, Bai Y*. EMC6/TMEM93 suppresses glioblastoma proliferation by modulating autophagy. Cell Death & Disease, 2016, 7: e2043.

9. Bai Y*, Kan S, Zhou S, Wang Y, Xu J, Cooke JP*, Wen J*, Deng H*. Enhancement of the in vivo persistence and antitumor efficacy of CD19 chimeric antigen receptor T cells through the delivery of modified TERT mRNA. Cell Discovery, 2015,1,15040.

10. Bai Y, Lathia JD, Zhang P, Flavahan W, Rich JN, Mattson MP. Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells. Glia, 2014, 62(10):1687-98.

11. MengZ, Li M, He Q, Jiang S, Zhang X, Xiao J, Bai Y*. Ectopic expression of human angiopoietin-1 promotes functional recovery and neurogenesis after focal cerebral ischemia. Neuroscience, 2014, 267: 135-46.

12. Yao J, Cui M, Li M, Liu Y, He Q, Xiao J, Bai Y*. Angiopoietin1 inhibits mast cell activation and protects against anaphylaxis. PLOS ONE, 2014, 9(2): e89148.

13. Bai Y, Meng Z, Cui M, Zhang X, Chen F, Xiao J, Shen L, Zhang Y. An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation. Neuroscience, 2009, 160 (2): 371-381.

14. Bai Y, Cui M, Meng Z, Shen L, He Q, Zhang X, Chen F, Xiao J. Ectopic expression of angiopoietin-1 promotes neuronal differentiation in neural progenitor cells through the Akt pathway. Biochemical and Biophysical Research Communications, 2009, 378 (2): 296-301.

15. BaiY, Du L, Shen L, Zhang Y, Zhang L. GPR56 is highly expressed in neural stem cells but downregulated during differentiation. NeuroReport, 2009, 20 (10): 918-22.

16. Bai Y, Zhang X, Lu A, Xiao J, Shen L. Generation of functionally mature neurons from a telomerase-immortalized human glial progenitor cell line. Neural Regeneration Research, 2009, 4 (2): 106-110.

17. Bai Y, Hu Q, Li X, Wang Y, Lin C, Shen L, Li L. Telomerase immortalization of human neural progenitor cells. NeuroReport, 2004, 15 (2): 245-249.