白云 教授

联系方式

邮箱：baiyun@bjmu.edu.cn

办公室电话：82801495

个人简介

白云，北京大学基础医学院细胞生物学系教授，博士生导师。专注于干细胞生物学与肿瘤免疫治疗领域，开发CAR-T和TCR-T细胞治疗实体瘤的联合疗法，推进其临床转化应用。主持科技部国家重点研发计划及基金委面上项目等多项基金。系列文章发表在Molecular Therapy、Nature Communications、Cell Discovery、Protein Cell等杂志。现任中华医学会医学细胞生物学分会委员、中国解剖学会再生医学分会委员。

教育与工作经历

1993-1998，北京大学医学部，学士

1998-2003，北京大学医学部，博士

2003-2009，北京大学基础医学院细胞生物学系，讲师

2009-2017，北京大学基础医学院细胞生物学系，副教授、

2010-2011，美国国立卫生研究院（NIH）衰老研究所，访问学者

2017-至今，北京大学基础医学院细胞生物学系，教授、博士生导师

研究方向

干细胞生物学与肿瘤免疫治疗。

代表性论文

1. Che X^#, Zheng S^#, Sun Y^#, Wang X, Zhang P, Cao J, Bai Y. Multi-engineered T cell vaccine boosting TCR-T cell therapy enhances anti-tumor function and eradicates heterogeneous solid tumors. Molecular Therapy, 2025, S1525-0016(25)00408-3.

2. Zheng S^#, Che X^#, Zhang K, Bai Y*, Deng H*. Potentiating CAR-T cell function in the immunosuppressive tumor microenvironment by inverting the TGF-β signal. Molecular Therapy, 2025, 33(2):688-702.

3. Jiang M^#, Chen X^#, Song Y, Wei M, Cao J, Lu W, Lan F, Bai Y*, Cui M*. NEXN deficiency leads to dilated cardiomyopathy in human pluripotent stem cell-derived cardiomyocytes.  Stem cell research & therapy , 2025,  16 (1), 402.

4. Li Z^#, Ma L^#, Gao Z^#, Wang X, Che X, Zhang P, Li Y, Zhang Q, Liu T, Sun Y, Bai Y*, Deng H*. Identification and validation of tumor-specific T cell receptors from tumor infiltrating lymphocytes using tumor organoid co-cultures. Cancer Immunology Immunotherapy, 2024, 73(9):164.

5. Zhao J^#, Dong J^#, Deng C^#, Zhang Q, Sun S, Li H, Bai Y*, Deng H*. Enhancing T cell anti-tumor efficacy with a PD1-TIGIT chimeric immune-checkpoint switch receptor. Oncoimmunology, 2023, 12(1):2265703.

6. Jiang M, Song Y, Chen X, Wen J, Zhu M, Wei M, Lan F, Cui M*, Bai Y*. COX6A2 deficiency leads to cardiac remodeling in human pluripotent stem cell-derived cardiomyocytes. Stem Cell Research & Therapy, 2023, 14, 357.  

7. Liu B^#, Chen S^#, Xu Y^#, Lyu Y^#, Wang J, Du Y, Sun Y, Liu H, Zhou H, Lai W, Xue A, Yin M, Li C, Bai Y*, Xu J*, Deng H*. Chemically defined and xeno-free culture condition for human extended pluripotent stem cells.  Nature Communications, 2021, 12(1): 3017.

8. Deng C^#, Zhao J^#, Zhou S, Dong J, Cao J, Gao J, Bai Y*, Deng H*. The Vascular Disrupting Agent CA4P Improves the Antitumor Efficacy of CAR-T Cells in Preclinical Models of Solid Human Tumors. Molecular Therapy. 2020, 28(1): 75-88.

9. Luo Z^#, Liu Z^#, Liang Z, Pan J, Xu J, Dong J, Bai Y*, Deng H*, Wei S*.Injectable Porous Microchips with Oxygen Reservoirs and an Immune-Niche Enhance the Efficacy of CAR T Cell Therapy in Solid Tumors. ACS Applied Materials & Interfaces. 2020, 12(51): 56712-56722.

10. Li H^#, Zhao C^#, Xu J, Xu Y, Cheng C, Liu Y, Wang T, Du Y, Xie L, Zhao J, Han Y, Wang X, Bai Y*, Deng H*. Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation. Protein Cell, 2019, 10(1): 20-30.

11. Zhang S^#, Lin X^#, Li G, Shen X, Niu D, Lu G, Fu X, Chen Y, Cui M*, Bai Y*. Knockout of Eva1a leads to rapid development of heart failure by impairing autophagy. Cell Death & Disease, 2017, 8(2): e2586.

12. Zhong L^#, Zhou J^#, Chen X, Liu J, Liu Z, Chen Y, Bai Y*. Quantitative proteomics reveals EVA1A-related proteins involved in neuronal differentiation. Proteomics, 2017, 17(5). doi: 10.1002/pmic.201600294.

13. Shen X^#, Kan S^#, Liu Z, Lu G, Zhang X, Chen Y, Bai Y*. EVA1A inhibits GBM cell proliferation by inducing autophagy and apoptosis. Experimental Cell Research, 2017, 352(1):130-138.

14. Li M^#, Lu G^#, Hu J^#, Shen X, Ju J, Gao Y, Qu L, Xia Y, Chen Y*, Bai Y*. EVA1A/TMEM166 Regulates Embryonic Neurogenesis by Autophagy. Stem Cell Reports, 2016, 6(3): 396-410.

15. Shen X, Kan S, Hu J, Li M, Lu G, Zhang M, Zhang S, Hou Y, Chen Y*, Bai Y*. EMC6/TMEM93 suppresses glioblastoma proliferation by modulating autophagy. Cell Death & Disease, 2016, 7: e2043.

16. Bai Y*, Kan S, Zhou S, Wang Y, Xu J, Cooke JP*, Wen J*, Deng H*. Enhancement of the in vivo persistence and antitumor efficacy of CD19 chimeric antigen receptor T cells through the delivery of modified TERT mRNA. Cell Discovery, 2015,1,15040.

17. Bai Y, Lathia JD, Zhang P, Flavahan W, Rich JN, Mattson MP. Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells. Glia, 2014, 62(10):1687-98.

18. Meng Z, Li M, He Q, Jiang S, Zhang X, Xiao J, Bai Y*. Ectopic expression of human angiopoietin-1 promotes functional recovery and neurogenesis after focal cerebral ischemia. Neuroscience, 2014, 267: 135-46.