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导师介绍

王韵 教授

发布日期：2014-10-14

王韵，北京大学博雅特聘教授，麦戈文脑研究院PI，国家杰出青年基金获得者，教育部长江特聘教授。现任北京大学临床医学高等研究院副院长，神经科学研究所副所长。


联系方式

地址：北京市海淀区学院路38号

电话：(010)-82801119 (O)

传真： (010)-82801119

电子邮箱：wangy66@bjmu.edu.cn


科研方向

课题组主要从事神经系统细胞信号转导的研究。综合利用多学科手段，整合分子生物学、生物化学、遗传学、电生理学、形态学和行为学等方法，主要进行以下两方面的工作：

1.  痛与痛觉调制的细胞信号转导通路：采用慢性病理性疼痛模型，研究痛觉传导通路中，外周和中枢神经元发生的可塑性变化，并围绕细胞信号转导的核心分子——蛋白激酶，深入探讨慢性痛，相关痛相关负性情绪及痛记忆产生的特异的信号通路，以期发现新的镇痛靶点或镇痛药物，为解决临床镇痛问题提供新思路。

2. 神经发育和损伤修复及脑重大疾病机制：采用体外培养细胞和在体动物模型，探讨参与神经元极性建立、迁移、树突发育、突触形成和修剪等神经发育过程，以及外周神经损伤后修复（与发育过程享有一些共同的分子机制）和神经元缺血损伤/抗损伤过程的关键分子，旨在阐明先天性神经发育疾病，神经退行性疾病及后天性神经损伤如机械、缺血损伤等过程的病理机制，找到其中的关键分子，设计可能的干预策略，从而为一些临床常见神经精神疾病的治疗提出新方法。


个人简介

王韵，北京大学博雅特聘教授、北京大学麦戈文脑研究院PI，国家杰出青年基金获得者，教育部长江特聘教授，北京大学临床医学高等研究院副院长，神经科学研究所副所长。兼任中国生理学会理事长、亚大生理科学联合会第一副主席、教育部高等学校基础医学类教学指导委员会副主任委员、国际神经肽协会中国分会秘书长和中国神经科学学会常务理事。长期致力于疼痛、神经发育、损伤、修复及神经系统发育障碍性疾病机制等研究领域。作为课题负责人主持了科技部科技创新2030-脑科学与类脑研究重大项目、国家自然科学基金重点、重大国际合作项目和科技部973子课题等30余项国家基金。共发表SCI论文近80篇，文章刊登在 Adv Sci.、Nat Communs.、Molecular Psychiatry、Sci Signal. 和 J Neurosci.等高水平国际知名期刊，多篇文章被Pain Research Forum、Faculty of 1000和Nature China等作为亮点文章给予介绍和重点推荐。申请中国发明专利9项，获批7项。


教育经历

1. 1984.9~1989.6，江西医学院医疗系临床专业，于1989.6获医学学士学位

2. 1989.9~1992.6，北京医科大学生理系，于1992.6获医学硕士学位

3. 1993.9~1996.6，北京医科大学生理系，于1996.6获医学博士学位


工作经历

1. 2023~至今，北京大学临床医学高等研究院副院长

2. 2013-2023，北京大学基础医学院教学副院长

3. 2004.8~至今，北京大学神经科学研究所，教授

4. 1999.1~2004.8，北京大学神经科学研究所，讲师，副教授

5. 2000.12~2002.12，美国国立卫生研究院（NIH），访问学者

6. 1993.9~1998.12，北京医科大学生理系神经科学研究中心，讲师

7. 1992.8~1993.9，北京医科大学生理系消化研究室，助教


教育经历

1. 1984.9~1989.6，江西医学院医疗系临床专业，于1989.6获医学学士学位

2. 1989.9~1992.6，北京医科大学生理系，于1992.6获医学硕士学位

3. 1993.9~1996.6，北京医科大学生理系，于1996.6获医学博士学位


在研科研项目

1. 国家自然科学基金国际合作重点项目：支架蛋白FRMD5与FKBP5互作调控应激相关精神障碍的机制及药物干预（W2411014），240万元，2025.1-2029.12，在研，主持。

2. 科技创新2030—“脑科学与类脑研究”重大项目：生理病理状态下痛觉-情绪交互作用的调控机制及干预策略（2021ZD0203200），3500万，2021.11-2026.11，在研，项目负责人及课题四负责人。

3. 国家自然科学基金重点项目：触诱发痛神经环路机制研究（32030052），298万元，2021.1-2025.12，在研，主持。


奖励及荣誉称号

2024年 北京大学教学成就奖

2024年  北京大学教材建设博雅特聘教授

2023年  教育部一流线下课程负责人

2022年  北京高校优质本科课程负责人

2020年  北京高校优秀本科育人团队带头人

2017年  中国女医师协会五洲女子科技奖

2016年  享受国务院政府特殊津贴专家

2013年  入选教育部长江学者奖励计划特聘教授

2013年  北京市高等教育教学名师奖

2013年 “基础医学阶段本科生创新人才培养体系的构建与实践”获北京市教育教学成果一等奖

2012年  北京大学十佳教师

2011年  荣获北京市教育工会“教育先锋教书育人先进个人”称号

2011年  荣获2011张香桐神经科学青年科学家


代表性科研论文（CA责任作者）

1. Xiang-Sha Yin, Bai-Rong Chen, Xi-Chun Ye, Yun WangCA. Modulating the Pronociceptive Effect of Sleep Deprivation: A Possible Role for Cholinergic Neurons in the Medial Habenula.  Neurosci Bull.  2024 Dec;40(12):1811-1825. doi: 10.1007/s12264-024-01281-4. Epub 2024 Aug 19.

2. Yaming Yang, Bai-Rong Chen Xi-Chun Ye, Liang-Yu Ni, Xi-Yin Zhang, Yun-Ze Liu, Tian-Jie Lyu, Yue Tian, Yun-Jie Fu, Yun WangCA. Chromodomain protein CDYL confers forebrain identity to human cortical organoids by inhibiting neuronatin.  Cell Reports  Cell Rep. 2024 Oct 22;43(10):114814. doi: 10.1016/j.celrep.2024.114814. Epub 2024 Oct 7.

3. Chen BR, Wu T, Chen TH, Wang YCA. Neuroimmune interactions and their roles in neurodegenerative diseases.  Fundamental Research . 2024 March 251-261. doi: 10.1016/j.fmre.2023.04.002 (invited review).

4. Lyu TJ, Ma J, Zhang XY, Xie GG, Liu C, Du J, Xu YN, Yang DC, Cen C, Wang MY, Lyu NY, Wang YCA, Zhang HQCA. Deficiency of FRMD5 results in neurodevelopmental dysfunction and autistic-like behavior in mice.  Mol Psychiatry . 2024, 29:1253–1264. Jan 16. doi: 10.1038/s41380-024-02407-w. Epub ahead of print. PMID: 38228891.

5. Huan-Yu Zheng, Yu-Meng Chen, Yao Xu, Cheng CenCA, Yun WangCA. Excitatory neurons in the lateral parabrachial nucleus mediate the interruptive effect of inflammatory pain on a sustained attention task.  J Transl Med.  2023 Dec 10;21(1):897. doi: 10.1186/s12967-023-04778-0.

6. Chen Q, Zhang XY, Wang YP, Fu YJ, Cao F, Xu YN, Kong JG, Tian NX, Xu Y, Wang YCA. Unveiling adcyap1 as a protective factor linking pain and nerve regeneration through single-cell RNA sequencing of rat dorsal root ganglion neurons.  BMC Biol.  2023 Oct 25;21(1):235.

7. Kong JG, Mei Z, Zhang Y, Xu LZ, Zhang JCA, Wang YCA. CDYL knockdown reduces glioma development through an antitumor immune response in the tumor microenvironment.  Cancer Lett.  2023 Jul 28;567:216265. doi: 10.1016/j.canlet.2023.216265. Epub 2023 Jun 9.PMID: 37302564.

8. Sun ZW, Waybright JM, Beldar S, Chen L, Foley CA, Norris-Drouin JL, Lyu TJ, Dong A, Min J, Wang YP, James LICA, Wang YCA. Cdyl deficiency brakes neuronal excitability and nociception through promoting Kcnb1 transcription in peripheral sensory neurons.  Adv Sci  (Weinh). 2022 Feb 4:e2104317. doi: 10.1002/advs.202104317. Online ahead of print.PMID: 35119221.

9. Wang F, Yin XS, Lu J, Cen CCA and Wang YCA. Phosphorylation-dependent positive feedback on the oxytocin receptor through the kinase PKD1 contributes to long-term social memory.  Sci Signal.  2022 Feb;15(719):eabd0033. doi: 10.1126/scisignal.abd0033. Epub 2022 Feb 1.

10. Liu L, Liu TT, Xie GG, Zhu XQ, Wang YCA.  Ubiquitin ligase TRIM32 promotes dendrite arborization by mediating degradation of the epigenetic factor CDYL.  FASEB J.  2022 Jan;36(1):e22087. doi: 10.1096/fj.202100031RR.PMID: 34888944

11. Dong C, Liu Y, Lyu TJ, Beldar S, Lamb KN, Tempel W, Li Y, Li Z, James LI, Qin SCA, Wang YCA, Min JCA. Structural Basis for the Binding Selectivity of Human CDY Chromodomains.  Cell Chem Biol.  2020 Jul 16;27(7):827-838.e7. doi: 10.1016/j.chembiol.2020.05.007. Epub 2020 May 28.

12. Liu H, Su D, Liu L, Chen L, Zhao Y, Chan SO, Zhang W, Wang YCA, Wang JCA. Identification of a new functional domain of Nogo-A that promotes inflammatory pain and inhibits neurite growth through binding to NgR1.  FASEB J.  2020 Jun 29. doi: 10.1096/fj.202000377R. Online ahead of print.

13. Huang S, Zheng C, Xie G, Song Z, Wang P, Bai Y, Chen D, Zhang Y, Lv P, Liang W, She S, Li Q, Liu Z, Wang Y, Xing GGCA, Wang YCA. FAM19A5/TAFA5, a novel neurokine, plays a crucial role in depressive-like and spatial memory-related behaviors in mice.  Mol Psychiatry.  2020 Apr 21. doi: 10.1038/s41380-020-0720-x. Online ahead of print.

14. Yin XS, Yang JY, Cao S, Wang YCA. Failure of Placebo Analgesia Model in Rats with Inflammatory Pain.  Neurosci Bull.  2020 Feb;36(2):121-133. doi: 10.1007/s12264-019-00420-6. Epub 2019 Aug 21.

15. Li WQ, Luo LD, Hu ZW, Lyu TJ, Cen C, Wang YCA. PLD1 promotes dendritic spine morphogenesis via activating PKD1.  Mol Cell Neurosci.  2019 Sep;99:103394. doi: 10.1016/j.mcn.2019.103394. Epub 2019 Jul 26.

16. Liu J, Du J, Wang YCA. CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2μ2.  Sci Signal.  2019 Jun 11;12(585). pii: eaaw2040. doi: 10.1126/scisignal.aaw2040.

17. Xu Y, Tian NX, Bai QY, Chen Q, Sun XH, Wang YCA. Gait Assessment of Pain and Analgesics: Comparison of the DigiGait™ and CatWalk™ Gait Imaging Systems.  Neurosci Bull.  2019 Jun;35(3):401-418. doi: 10.1007/s12264-018-00331-y. Epub 2019 Jan 18.

18. Hu F, Liu HC, Su DQ, Chen HJ, Chan SO, Wang YCA, Wang JCA. Nogo-A promotes inflammatory heat hyperalgesia by maintaining TRPV-1 function in the rat dorsal root ganglion neuron.  FASEB J . 2019 Jan;33(1):668-682. doi: 10.1096/fj.201800382RR. Epub 2018 Jul 19. PMID:30024789

19. Guo YP, Zhi YR, Liu TT, Wang Y, Zhang YCA. Global Gene Knockout of Kcnip3 Enhances Pain Sensitivity and Exacerbates Negative Emotions in Rats.  Front Mol Neurosci.  2019 Jan 25;12:5. doi: 10.3389/fnmol.2019.00005. eCollection 2019. PMID: 30740043

20. Duo L, Hu L, Tian N, Cheng G, Wang H, Lin Z, Wang YCA, Yang YCA. TRPV1 gain-of-function mutation impairs pain and itch sensations in mice. Mol Pain. 2018 Jan-Dec;14:1744806918762031. doi: 10.1177/1744806918762031. Epub 2018 Feb 9.

21. Tian NX, Xu Y, Yang JY, Li L, Sun XH, Wang YCA and Zhang YCA. KChIP3 N-terminal 31-50 fragment mediates its association with TRPV1 and alleviates inflammatory hyperalgesia in rats.  J Neurosci.  2018 Jan 15. pii: 2242-17. doi: 10.1523/JNEUROSCI.2242-17.2018. [Epub ahead of print] PMID: 29335353.

22. Cen C, Luo LD, Li WQ, Li G, Tian NX, Zheng G, Yin DM, Zou YM, Wang YCA. PKD1 promotes functional synapse formation coordinated with N-cadherin in hippocampus.  J Neurosci.  2018 Jan 3; 38(1):183-199.

23. Luo LD, Li G, Wang YCA. PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage.  Scientific Reports.  2017 Jul 20; 7(1):6035. doi: 10.1038/s41598-017-06121-2.

24. Huang M, Cheng G, Tan H, Qin R, Zou Y, Wang YCA, Zhang YCA. Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors.  Exp Neurol.  2017 Sep;295:66-76. doi: 10.1016/j.expneurol.2017.05.001. Epub 2017 May 4.

25. Qin R, Cao S, Lyu T, Qi C, Zhang W, Wang YCA. CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy.  Cell Rep.  2017 Jan 10;18(2):380-390. doi: 10.1016/j.celrep.2016.12.043.

26. Zhang C, Lu J, Liu B, Cui QCA, Wang YCA. Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease.  Aging  (Albany NY). 2016 Feb;8(2):272-90.

27. Liu J, Du J, Yang Y, Wang YCA. Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia.  Exp Neurol  .  2015 Nov;273:253-62. doi: 10.1016/j.expneurol.2015.09.005. Epub 2015 Sep 12.

28. Wang Y. FXYD2: a promising drug target for inflammatory mechanical pain therapy.  Science Bulletin  2015, 60(9):896-898. (Research Highlight )

29. Wang GQ, Cen C, Cao S, Li C, Wang N, Zhou Z, Liu XM, Xu Y, Tian NX, Zhang Y, Wang J, Wang LPCA and Wang YCA. Deactivation of excitatory neurons in the contralateral prelimbic cortex via Cdk5 promotes pain sensation and anxiety. Nat Commun.  2015, Jul 16; 6: 7660. doi: 10.1038/ncomms8660.

30. Zhang Y, Wang N, Su P, Lu J, Wang YCA. Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice.  Neurosci Bull.  2014, 30(6):1025-35.

31. Li Y, Hu F, Chen HJ, Du YJ, Xie ZY, Zhang Y, Wang JCA, Wang YCA. LIMK-dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats.  Sci Signal.  2014 Jun 24;7(331):ra61. doi: 10.1126/scisignal.2005353.

32. Wang N, Su P, Zhang Y, Lu J, Xing BM, Kang K, Li WQ, Wang YCA. Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses.  Neuropsychopharmacol.  2014, 39(5):1290-301.

33. Qi C, Liu SM, Qin R, Zhang Y, Wang GQ, Shang, YF, Wang YCA and Liang JCA. Coordinated Regulation of Dendrite Arborization by Epigenetic Factors CDYL and EZH2.  J Neurosci.  2014 March 26;34(13):4494-508.

34. Li G, Wang YCA. Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system.  Neurosci Bull.  2014 Jun;30(3):497-504. doi: 10.1007/s12264-013-1403-2. Epub 2014 Feb 13.

35. Xing BM, Yang YR, Du JX, Chen HJ, Qi C, Huang ZH, Zhang YCA and Wang YCA. Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B.  J Neurosci.  2012 Oct 17;32(42):14709-21.

36. Zhu YB, Kang K, Zhang Y, Qi C, Li G, Yin DMCA and Wang YCA. PLD1 negatively regulates dendritic branching. J Neurosci.  2012 Jun 6;32 (23):7960-9.

37. Wang KWCA, Wang YCA. Negative modulation of NMDA receptor channel function by DREAM/calsenilin/KChIP3 provides neuroprotection?  Front Mol Neurosci.  (Invited review) 2012 Mar 15;5:39.

38. Chen HJ, Xie WY, Hu F, Zhang Y, Wang J, Wang YCA. Disruption of δ-opioid receptor phosphorylation at Threonine 161 attenuates morphine tolerance in rats with CFA-induced inflammatory hypersensitivity.  Neurosci Bull.  April 1, 2012, 28(2): 182-192.

39. Zhang Y, Su P, Liang P, Liu T, Liu X, Liu XY, Zhang B, Han T, Zhu YB, Yin DM, Li JF, Zhou Z, Wang KW, Wang YCA. The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit.  J Neurosci.  2010 Jun 2;30(22):7575-86.

40. Xie WY, He Y, Yang YR, Li YF, Kang K, Xing BM, Wang YCA. Disruption of cdk5- associated phosphorylation of residue threonine-161 of the delta opioid receptor: impaired receptor function and attenuated morphine antinociceptive tolerance.  J Neurosci.  2009 Mar 18;29(11):3551-64.

41. Yin DM, Huang YH, Zhu YB, Wang YCA. Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus.  J Neurosci.  2008 Aug 27;28(35):8832-43.

42. Zhu HH, Yang YR, Zhang H, Han Y, Li YF, Zhang Y, Yin DM, He QH, Zhao ZQ, Blumberg PM, Han JS, Wang YCA. Interaction between protein kinase D1 and transient receptor potential V1 in primary sensory neurons is involved in heat hypersensitivity.  Pain.  2008 Jul 31;137(3):574-88.

43. He Y, Li HL, Xie WY, Yang CZ, Yu AC, Wang YCA. The presence of active Cdk5 associated with p35 in astrocytes and its important role in process elongation of scratched astrocyte.  Glia  .  2007 Apr 15;55(6):573-83.

44. Yang YR, He Y, Zhang Y, Li Y, Li YF, Han Y, Zhu HH, Wang YCA. Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia. Pain . 2007 Jan; 127(1-2):109-20. Full-text

45. Wang YCA, Kedei N, Wang M, Wang QJ, Huppler AR, Toth A, Tran R, Blumberg PM. The interaction between PKCmu and vanilloid receptor type 1.  J Biol Chem.  2004 Dec 17;279(51):53674-82.

46. Wang Y, Xie WY, He Y, Wang M, Yang YR, Zhang Y, Yin DM, Jordan-Sciutto KL, Han JS, Wang Y CA. Role of CDK5 in neuroprotection from serum deprivation by mu-opioid receptor agonist.  Exp Neurol.  2006 Dec;202(2):313-23.

47. Wang YCA, Zhang Y, Wang W, Cao Y, Han JS. Effects of synchronous or asynchronous electroacupuncture stimulation with low versus high frequency on spinal opioid release and tail flick nociception. Exp Neurol. 2005 Mar; 192 (1):156-62.

48. Sun RH, Wang HC, Wan Y, Jing Z, Luo F, Han JS, and Wang YCA. Suppression of neuropathic pain by peripheral electrical stimulation in rats: mu-opioid receptor and NMDA receptor implicated.  Exp Neurol.  2004 May;187(1):23-9.

49. Wang YCA. The functional regulation of TRPV1 and its role in pain sensitization.  Neurochem Res  .  2008 Oct;33(10):2008-12. (review)

50. Li Y, Zhang Y, Han JS, Wang YCA. Distinct responses of DREAM to electroacupuncture stimulation with different frequency under physiological and inflammatory conditions in rats.  Neurochem Res.  2008 Oct;33(10):2070-7.

51. Zhang Y, Li Y, Yang YR, Zhu HH, Han JS, Wang YCA. Distribution of downstream regulatory element antagonist modulator (DREAM) in rat spinal cord and upregulation of its expression during inflammatory pain.  Neurochem Res . 2007, 32(9):1592-9. Full-text

52. Lazar J, Braun DC, Toth A, Wang Y, Pearce LV, Pavlyukovets VA, Blumberg PM, Garfield SH, Wincovitch S, Choi HK, Lee J. Kinetics of penetration influence the apparent potency of vanilloids on TRPV1. Mol Pharmacol.  2006 Apr;69(4):1166-73.

53. Zhang Y, Xiang B, Li YM, Wang Y, Wang X, Wang YN, Wu LL, Yu GY. Expression and characteristics of vanilloid receptor 1 in the rabbit submandibular gland.  Biochem Biophys Res Commun . 2006 Jun 23;345(1):467-73.

54. Toth A, Wang Y, Kedei N, Tran R, Pearce LV, Kang SU, Jin MK, Choi HK, Lee J, Blumberg PM. Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1.  Life Sci  .  2005 May 6; 76(25):2921-32.

55. Lee J, Jin MK, Kang SU, Kim SY, Lee J, Shin M, Hwang J, Cho S, Choi YS, Choi HK, Kim SE, Suh YG, Lee YS, Kim YH, Ha HJ, Toth A, Pearce LV, Tran R, Szabo T, Welter JD, Lundberg DJ, Wang Y, Lazar J, Pavlyukovets VA, Morgan MA, Blumberg PM. Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists.  Bioorg Med Chem Lett .  2005 Sep 15;15(18):4143-50.

56. Lee J, Kang SU, Kil MJ, Shin M, Lim JO, Choi HK, Jin MK, Kim SY, Kim SE, Lee YS, Min KH, Kim YH, Ha HJ, Tran R, Welter JD, Wang Y, Szabo T, Pearce LV, Lundberg DJ, Toth A, Pavlyukovets VA, Morgan MA, Blumberg PM. Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists.  Bioorg Med Chem L ett.  2005 Sep 15;15(18):4136-42.

57. Lee J, Kang SU, Lim JO, Choi HK, Jin MK, Toth A, Pearce LV, Tran R, Wang Y, Szabo T, Blumberg PM. N-[4-(Methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: analysis of structure–activity relationships for the ‘C-Region’.  Bioorg Med Chem.  2004 Jan 15;12(2):371-85.

58. Lee J, Kim SY, Lee J, Kang M, Kil MJ, Choi HK, Jin MK, Wang Y, Toth A, Pearce LV, Lundberg DJ, Tran R, Blumberg PM. Analysis of structure-activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism.  Bioorg Med Chem  .  2004 Jul 1;12(13):3411-20.

59. Lee J, Kang SU, Choi HK, Lee J, Lim JO, Kil MJ, Jin MK, Kim KP, Sung JH, Chung SJ, Ha HJ, Kim YH, Pearce LV, Tran R, Lundberg DJ, Wang Y, Toth A, Blumberg PM. Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity.  Bioorg Med Chem Lett.  2004 May 3;14(9):2291-7.

60. Tang XQ, Wang Y, Huang ZH, Han JS, Wan Y. Adenovirus-mediated GDNF ameliorates corticospinal neuronal atrophy and motor function deficits in rats with spinal cord injury.  NeuroReport.  2004 Mar 1;15(3):425-9.

61. Wang Y, Toth A, Tran R, Szabo T, Welter JD, Blumberg PM, Lee J, Kang SU, Lim JO, Lee J.  High affinity partial agonists of vanilloid receptor.  Mol Pharmacol.  2003 Aug;64(2):325-33. Full-text

62. Wang Y, Szabo T, Welter JD, Toth A, Tran R, Lee J, Kang SU, Suh YG, Blumberg PM, Lee J.  High affinity antagonists of the vanilloid receptor.  Mol Pharmacol.  2002 Oct;62(4):947-56. Full-text

63. Fang M, Wang Y, He QH, Sun YX, Deng LB, Wang XM, Han JS. Glial cell line-derived neurotrophic factor contributes to delayed inflammatory hyperalgesia in adjuvant rat pain model.  Neuroscience.  2003;117(3):503-12.

64. Tóth A, Kedei N, Wang Y, Blumberg PM. Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat.  Life Sci.  2003 Jun 13;73(4):487-98.

65. Lee J, Lee J, Kang M, Shin M, Kim JM, Kang SU, Lim JO, Choi HK, Suh YG, Park HG, Oh U, Kim HD, Park YH, Ha HJ, Kim YH, Toth A, Wang Y, Tran R, Pearce LV, Lundberg DJ, Blumberg PM. N-(3-Acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl] thiourea Analogues: Novel Potent and High Affinity Antagonists and Partial Antagonists of the Vanilloid Receptor.  J Med Chem. 2003 Jul 3;46(14):3116-26.

66. Tóth A, Kedei N, Szabó T, Wang Y, Blumberg PM. Thapsigargin binds to and inhibits the cloned vanilloid receptor-1.  Biochem Biophys Res Commun.  2002 May 3;293(2):777-82.

67.  Huang C, Wang Y, Han JS, Wan Y. Characteristics of electroacupuncture-induced analgesia in mice: variation with strain, frequency, intensity and opioid involvement.  Brain Res.  2002 Jul 26;945(1):20-5.

68. Wang Y, Wang XM, Han JS. Discrimination between peptide and non-peptide opioid agonists on the transcription of opioid receptors in two cell lines.  Life Sci  .  2001 May 4;68(24):2731-40.

69. Chen ZW, Yang K, Wang YCA, Han JS. The metabolic evidence of synergistic interaction between DAMGO and DPDPE on undifferentiated SH-SY5Y cells.  NeuroReport.  2001 Mar 26;12(4):845-9.

70. Chen ZW, Yang K, Wang YCA, Han JS. The metabolic evidence of synergistic effect between ohmefentanyl and [D-Pen2, D-Pen5] enkephalin on differentiated SH-SY5Y cells in humans.  Neurosci Lett.  2001 Feb 9;298(3):199-202.

71. Sun R, Wang YCA, Zhao CS, Chang JK, Han JS. Changes in Brain content of   nocicepin/orphanin FQ and endomorphin 2 in a rat model of neuropathic pain.  Neurosci Lett. 2001 Sep 21;311(1):13-6.

72. Tang XQ, Wang Y, Han JS, Wan Y. Adenovirus-mediated GDNF protects cultured motoneurons from glutamate injury.  Neuroreport.  2001 Oct 8;12(14):3073-6.

73. Sun RQ, Zhao CS, Wang HJ, Jing Z, Wang W, Yang K, Wang Y, Chang JK, Han JS. Nocistatin, a peptide reversing acute and chronic morphine tolerance.  Neuroreport.  2001 Jun 13;12(8):1789-92.

74. Huang C, Wang YCA, Chang JK, Han JS. Endomorphin and mu-opioid receptors in mouse brain mediate the analgesic effect induced by 2 Hz but not 100 Hz electroacupuncture stimulation.  Neurosci Lett  .  2000 Nov 24;294(3):159-62.

75. Wang Y, Huang C, Cao Y, Han JS. Repeated administration of low dose ketamine for the treatment of monoarthritic pain in rat.  Life Sci . 2000 Jun 8;67(3):261-7.

76. Fang M, Wang Y, Liu HX, Liu XS, Han JS. Decreased GDNF expression in dorsal spinal cord of unilateral arthritic rat.  NeuroReport.  2000 Mar 20;11(4):737-41.

77. Zhao CS, Li BS, Zhao GY, Liu HX, Luo F, Wang Y, Tian JH, Chang JK, Han JS. Nocistatin reverses the effect of orphanin FQ/nociceptin in antagonizing morphine analgesia .   NeuroReport.  1999 Feb 5;10(2):297-9.

78. Han Z, Jiang YH, Wan Y, Wang Y, Chang JK, Han JS. Endomorphin-1 mediates 2 Hz but not 100 Hz electroacupuncture analgesia in the rat.  Neurosci Lett.  1999 Oct 22;274(2):75-8.


主编，主译及参编著作

1. 《神经系统》。樊东升，王韵 主编，北京大学医学出版社，北京，2025年1月，ISBN：978-7-5659-3096-6.

2. 《人体形态与功能总论》（教育部基础医学“101计划”核心教材）。王韵，闫剑群 主编，北京大学医学出版社，北京，2024年07月，ISBN：978-7-5659-3171-0.

3. 《神经系统》（教育部基础医学“101计划”核心教材）。王韵，鲁友明 主编，北京大学医学出版社，北京，2024年07月，ISBN：978-7-5659-3213-7.

4. 《神经科学》（第四版）韩济生 主编，北京大学医学出版社，北京，2022年11月，ISBN：978-7-5659-2735-6。王韵，第四篇第9章，神经肽II：阿片肽及其受体，p595-614。

5. 《神经与精神疾病》（第二版）（国家卫生健康委员会“十四五”规划教材及全国高等学校器官系统整合教材）. 闫剑群等主编。人民卫生出版社，北京，2021年10月，ISBN 978-7-117-31507-4. 王韵，第三章，神经生理。

6. 《疾病学基础》. 副主编，第二章疾病的神经内分泌机制及第十六章神经退行性疾病（国家卫生健康委员会“十三五”规划教材，专科医生核心能力提升导引丛书，供专业学位研究生及专科医生用）. 人民卫生出版社，北京，2021年11月第一版，ISBN：978-7-117-31569-2.

7. “以器官系统为中心”翻译教材，神经系统—基础与临床（第二版），主译，北京大学医学出版社，北京，2019年7月第一版，ISBN：978-7-5659-2002-8。

8. Y Xu and Wang Y*. Cocaine, Protein Kinase, and Phosphorylation of Neuronal Receptors. In: Victor R. Preedy, editors, The Neuroscience of Cocaine. Academic Press, 2017, pp. 183-194. ISBN: 978-0-12-803750-8. Copyright. 2017 Elsevier Inc. Academic Press.

9. 《疼痛学》（第一版），韩济生 主编，北京大学医学出版社，北京，2012年2月第1版，ISBN：978-7-5659-0198-0。王韵，第9章，阿片及阿片受体系统，p78-89。国家“十一五”重点图书。

10. 《神经生物学》（第一版），于龙川 主编，北京大学出版社，北京，2012年8月第1版，ISBN：978-7-301-21113-7。张瑛，王韵，第3篇第12章，神经系统的感觉功能，p287-329。适用于综合性大学本科生和研究生教材。

11. 《神经科学》第三版，韩济生 主编，北京大学医学出版社，北京，2009年1月第3版， ISBN：978-7-81116-605-7。王韵，第24章，神经肽II：阿片肽及其受体，p438-455。

12. 《镇痛药研究方法学》（第一版），洪庚辛 主编，人民卫生出版社，北京，2009年4月第1版，ISBN：978-7-117-11072-3。王韵，第3章，神经递质、调质与疼痛，p37-49。