徐正仁

新体制助理教授，研究员，博士生导师

入选国家高层次人才计划

北京大学博雅青年学者

北京大学基础医学院中西医结合教研室

E-mail: zhengrenxu@bjmu.edu.cn

徐正仁博士长期从事天然产物/中药活性成分的发现、化学全合成、生物合成和化学-酶法合成等研究，同时通过结构改造提高天然产物/中药的活性和成药性，并阐明其作用靶点与机制，为创新药物的研发奠定基础。迄今为止，以责任/第一作者（含共同）在Angew. Chem. Int. Ed.，ACSCatal.，J. Am. Chem. Soc.，PNAS等专业期刊上发表论文60余篇；主持和参与国自然面上项目和重大项目，国家重点研发计划，北京市自然科学基金重点项目。

课题组长期招收研究生和博士后，欢迎各位同学加入！

研究方向：

1．天然产物/中药活性成分的化学-酶法合成和基因组挖掘；

2．新颖酶催化反应的开发；

3．活性天然产物的结构修饰和作用机制研究。

学习/工作经历：

2025.07-至今北京大学基础医学院，研究员

2018.04-2025.06 北京大学药学院，研究员

2014.10-2018.03 美国Scripps研究所，博士后

2011.10-2014.09 瑞士洛桑联邦理工学院（EPFL），博士后

2007.09-2011.07 北京大学药学院，化学生物学，博士

2001.09-2007.07 北京大学药学院，本硕六年制，药学学士，生药学硕士

代表性论文：

Zheng, Y.-Z.†; Kong, Y.†; Zhuo, F.-F.; Shen, Y.; Wang, Y.-q.; Yang, Z.; Wang, T.; Yu, S.-M.; Li, L.; Yu, M.; Wei, T.-T.; Liu, D.; Xu, L.-Z.; Han, B.; Liu, F.; Xu, Z.*; Zeng, K.-W.*; Tu, P.-F.* Discovery of sinomenine derivatives inhibiting macrophage polarization against rheumatoid arthritis through selectively targeting heme oxygenase-1. Eur. J. Med. Chem. 2025, 292, 117596.




Wang, T.†; Zou, J.†; Wang, K.†; Liu, Y.†; Zhang, S.; Kong, Y.; Xu, Z.* Chemoenzymatic synthesis of the cyclopiane family of diterpenoid natural products. Angew. Chem. Int. Ed. 2025, 64, e202419092.




Wang, L.†; Wei, S.†; Guan, M.; Li, Y.; Zheng, X.; Xu, Z.* Whole-cell biotransformation for the preparation of chromopyrrolic acid and 5,5’-dichloro-chromopyrrolic acid in Escherichia coli. ChemBioChem 2024, 25, e202400718.




Zhang, S.†; Wang, K.†; Liu, Y.†; Wang, T.; Kong, Y.; Zhang, P.; Zhang, B.; Yin, M.; Pan, G.; Xu, Z.* An isopentenol utilization pathway-based “deuterium-scanning” method for mechanistic investigations of terpene cyclases. ACS Catal. 2024, 14, 17598-17608.




Zhang, S.†; Wang, T.†; Kong, Y.; Zou, J.; Liu, Y.; Xu, Z.* Chemoenzymatic synthesis of natural products: evolution of synthetic methodology and strategy. Synth. Biol. J. 2024, 5, 913-940.




Kong, Y.†; Liu, Y.†; Wang, K.; Wang, T.; Wang, C.; Ai, B.; Jia, H.; Pan, G.; Yin, M.; Xu, Z.* Confirmation of the stereochemistry of spiroviolene. Beilstein J. Org. Chem. 2024, 20, 852-858.




Zheng, X.†; Li, Y.†; Guan, M.; Wang, L.; Wei, S.; Li, Y.-C.; Chang, C.-Y.; Xu, Z.* Biomimetic total synthesis of the spiroindimicin family of natural products. Angew. Chem. Int. Ed. 2022, 61(38), e202208802. (†contribute equally)




Hsu, S.-H.; Zhang, S.; Huang, S.-C.; Wu, T.-K.; Xu, Z.*; Chang, C.-Y.* Characterization of enzymes catalyzing the formation of the nonproteinogenic amino acid L-Dap in capreomycin biosynthesis. Biochemistry 2021, 60, 77-84.




Xu, Z.†; Fang, S.-M.†; Bakowski, M. A.†; Rateb, M. E.; Yang, D.; Zhu, X.; Huang, Y.; Zhao, L.-X.; Jiang, Y.; Duan, Y.; Hull, M. V.; McNamara, C. W.; Shen, B.* Discovery of kirromycins with anti-Wolbachia activity from Streptomyces sp. CB00686. ACS Chem. Biol. 2019, 14, 1174-1182. (†contribute equally)




Xu, Z.†; Pan, G.†; Zhou, H.; Shen, B.* Discovery and characterization of 1-aminocyclopropane-1-carboxylic acid synthase of bacterial origin. J. Am. Chem. Soc. 2018, 140, 16957-16961. (†contribute equally)




Xu, Z.*; Wang, Q.; Zhu, J.* Metamorphosis of cycloalkenes for the divergent total synthesis of polycyclic indole alkaloids. Chem. Soc. Rev. 2018, 47, 7882-7898. 40




Pan, G.†; Xu, Z.†; Guo, Z.; Hindra; Ma, M.; Yang, D.; Zhou, H.; Gansemans, Y.; Zhu, X.; Huang, Y.; Zhao, L.-X.; Jiang, Y.; Cheng, J.; Nieuwerburgh, F. V.; Suh, J.-W.; Duan, Y.; Shen, B.* Discovery of the leinamycin family of natural products by mining actinobacterial genomes. Proc. Natl. Acad. Sci. USA 2017, 114, E11131-E11140. (†contribute equally)




Zhang, B.†; Xu, Z.†; Teng, Q.†; Pan, G.; Ma, M.; Shen, B.* A long-range acting dehydratase domain as the missing link for C17-dehydration in iso-migrastatin biosynthesis. Angew. Chem. Int. Ed. 2017, 56, 7247-7251. (†contribute equally)




Xu, Z.†; Bao, X.†; Wang, Q.; Zhu, J.* An enantioselective total synthesis of (-)-isoschizogamine. Angew. Chem. Int. Ed. 2015, 54, 14937-14940. (Highlighted: in Synfacts 2016, 12, 5.) (†contribute equally)




Tong, S.†; Xu, Z.†; Mamboury, M.; Wang, Q.; Zhu, J.* Aqueous titanium trichloride-promoted reductive cyclization of o-nitrostyrenes to indoles: development and application to the synthesis of rizatriptan and aspidospermidine. Angew. Chem. Int. Ed. 2015, 54, 11809-11812. (†contribute equally)




Xu, Z.; Wang, Q.; Zhu, J.* Total syntheses of (-)-mersicarpine, (-)-scholarisine G, (+)-melodinine E, (-)-leuconoxine, (-)-leuconolam, (-)-leuconodine A, (+)-leuconodine F, and (-)-leuconodine C: self-induced diastereomeric anisochronism (SIDA) phenomenon for scholarisine G and leuconodine A and C. J. Am. Chem. Soc. 2015, 137, 6712-6724.




Xu, Z.; Wang, Q.; Zhu, J.* Enantioselective total syntheses of leuconolam-leuconoxine- mersicarpine group monoterpene indole alkaloids. J. Am. Chem. Soc. 2013, 135, 19127-19130. (Highlighted: in Synfacts 2014, 10, 232.)




Xu, Z.; Wang, Q.; Zhu, J.* Palladium-catalyzed decarboxylative vinylation of potassium nitrophenyl acetate: application to the total synthesis of (±)-goniomitine. Angew. Chem. Int. Ed. 2013, 52, 3272-3276.